KR101985277B1 - Vehicle for cosmetic composition having loading capacity of high-content pooly-soluble material and composition for cosmetics comprising the same - Google Patents

Abstract

The present specification discloses a vehicle for cosmetics having a high content of a poorly soluble substance-supporting force and a cosmetic composition containing the same. The vehicle, which is an aspect of the present invention, can carry a large amount of a poorly soluble substance therein, and when used, a cosmetic composition containing a poorly soluble substance among the effective materials can be produced. In addition, the vehicle has excellent dispersibility in a cosmetic composition and has high solubility, so that a cosmetic composition having a stable and transparent appearance can be produced. In addition, the use of the vehicle can minimize the skin irritation caused by the surfactant since the content of the surfactant for dissolving the poorly soluble substance can be minimized.

Description

TECHNICAL FIELD [0001] The present invention relates to a vehicle for cosmetics having a high insoluble substance-supporting ability and a composition for a cosmetic composition containing the same and a composition for a cosmetic composition containing the same. BACKGROUND ART < RTI ID = 0.0 >

The present specification discloses a vehicle for cosmetics having a high content of a poorly soluble substance-supporting force and a cosmetic composition containing the same.

Ceramide is one of the sphingolipids that have a structure in which fatty acids are linked to sphingosine or phytosphingosine. Ceramides account for more than 40% of the intercellular lipid constituents of the keratin layer of the skin, and are a component of bilayer membranes and skin lipid membranes. In addition, ceramides are indispensable components to show the structure and function of the stratum corneum, and ceramides present in the human body are classified into various types according to the degree of polarity.

Ceramide is an important element of skin barrier. It has a role of lipid barrier which suppresses evaporation of water and keeps the structure of stratum corneum square, so it is getting attention as a raw material of moisturizing cosmetics.

Recently, it has been reported that ceramide is decomposed into phytosphingosine from the skin surface and acts as an antimicrobial barrier against external harmful microorganisms, and plays an important role in the regulation of inflammation and wound healing, and the role of metabolites as a signal transducer to control cell metabolism , There have been various studies to utilize ceramide as an overall health improvement purpose of the skin.

However, since ceramide is a poorly soluble substance, it can not be dissolved in cosmetics, so that it is difficult to secure cosmetics usability, transparency, and formulation stability. Conventionally, a method of introducing ceramide into a liposome analogue prepared by using lecithin or the like and introducing it into cosmetics has been studied (KR2017-0038249A). However, in the method using lecithin, it is difficult not only to encapsulate ceramides in nano-sized liposome analogues, but also to reduce the amount of ceramides encapsulated in liposomal analogues, and the liposomal analog itself is unstable. In addition, cosmetic products are easily deteriorated due to the reactivity of lecithin itself.

Also, a method (KR10-2015-0022434A) of using ceramide as a nano-emulsion has been tried, but this also shows that the amount of ceramide which can be stably added in cosmetics is small and the surfactant used for emulsifying is stimulated To cause skin troubles.

In addition, although a method of using ceramide as a liquid crystal (KR10-0439595B1) has been studied, the process for producing the liquid crystal itself is too complicated, and it is difficult to obtain satisfactory level of liquid crystal stability, and a small amount of ceramide introduced into the liquid crystal There was a problem.

Finally, although a plan to utilize the so-called whitening interface (KR10-2014-0023669A) has been considered, ceramide can be incorporated in a high amount, but the manufacturing process is complicated and the prepared formulation is opaque, There is a problem in that skin troubles are caused by the surfactant used together, and cosmetic products including lecithin are easily deteriorated.

Therefore, it is urgent to develop a system capable of stably incorporating ceramide into cosmetics in a high content.

KR10-2017-0038249A KR10-2015-0022434A KR10-0439595B1 KR10-2014-0023669A

In one aspect, an object of the present invention is to stably dissolve an insoluble active substance in cosmetics.

In one aspect, an object of the present invention is to improve the dissolution rate of an insoluble active substance contained in cosmetics.

In one aspect, an object of the present invention is to provide a vehicle capable of supporting a large amount of an insoluble active substance.

In one aspect, an object of the present invention is to dissolve a large amount of an insoluble active substance in cosmetics.

In one aspect, an object of the present invention is to provide a cosmetic composition in which ceramides are dissolved in a large amount and stably.

In order to achieve the above object, in one aspect, the present invention provides a cosmetic vehicle comprising a shell containing a fatty acid ester and containing a high content of a poorly soluble substance .

Further, in one aspect, the present invention provides a composition for anhydrous gel type cosmetic comprising the vehicle.

The vehicle, which is an aspect of the present invention, can stably contain a large amount of a poorly soluble substance, and if used, a cosmetic composition containing a poorly soluble substance among the effective substances can be produced. In addition, the vehicle has excellent dispersibility in a cosmetic composition and has high solubility, so that a cosmetic composition having a stable and transparent appearance can be produced. In addition, the cosmetic composition prepared using the vehicle can minimize an uncomfortable use feeling such as separation of formulation and stickiness due to recrystallization or precipitation of the poorly soluble composition since the poorly soluble substance is not directly exposed in the cosmetic composition. In addition, the use of the vehicle can minimize the skin irritation caused by the surfactant since the content of the surfactant for dissolving the poorly soluble substance can be minimized.

FIG. 1 is a view showing microscopic observation of the formation of a vehicle
Fig. 2 is a chart for confirming the precipitation of ceramide or the like in a cosmetic composition containing an aqueous solvent. Fig.
3 is a graph showing the zeta potential of Example 2 (FIG. 3A) and Comparative Example 2 (FIG. 3B).

Hereinafter, the present invention will be described in detail.

In one aspect, the invention is a vehicle for cosmetic use comprising a high content of a poorly soluble substance, including a shell comprising a fatty acid ester.

In one aspect, the vehicle may include a shell and an interior shell capable of carrying a sparingly soluble material.

In this respect, the fatty acid ester may comprise a compound of glycerol and alpha hydroxy adic (AHA). The vehicle includes a fatty acid ester, which is a compound of glycerol and alpha hydroxy acid, so that a poorly soluble substance can be stably carried in the vehicle.

In this aspect, the alpha hydroxy acid may be selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid. In one embodiment, the compound may comprise glyceryl citrate / lactate / linolate / oleate or caprylic / capric glyceride, preferably glyceryl nitrate / lactate / linoleate / Lt; / RTI >

In addition, in one aspect, the poorly soluble substance is not limited as long as it is a substance having a low solubility in a solvent among the effective substances used in the cosmetic composition. Preferably, the poorly soluble substance is composed of ceramide, its precursor, its derivative, And < / RTI >

For example, the precursor of a ceramide may include a phytosphingosine. The ceramides or derivatives thereof are used as a broad concept including not only natural ceramides but also chemically synthesized ceramides. For example, ceramides include, but are not limited to, ceramide 1 (ceramide EOS), ceramide 2 (ceramide NS), ceramide 3 (ceramide NP), ceramide 4 (ceramide EOH), ceramide 5 (ceramide AS), ceramide 6 , Ceramide 7 (ceramide AP), ceramide 8 (ceramide AH), ceramide 9 (ceramide EOP), glucosyl ceramide, pseudoceramide, and the like.

The degradation products of the ceramides may also include sphingosine derivatives such as N-acetylphosphate sphingosine, stearyl phytosphingosine, tetraacetyl phytosphingosine, sphingosine 1-phosphate, and the like.

In one aspect, the average diameter of the vehicle may be 200 to 500 nanometers (nm). In the present specification, the average diameter may mean an average value of two diameters measured at any point except the shortest axis and the longest axis among the diameters of the vehicle.

If the diameter of the vehicle is less than 200 nm, the poorly soluble substance can not be stably trapped. If the diameter of the vehicle is more than 500 nm, the dispersibility becomes poor when the vehicle is used in a cosmetic composition.

In one aspect, the weight ratio of the poorly soluble substance carried on the vehicle to the fatty acid ester contained in the vehicle shell may be from 2: 8 to 8: 2. When the weight ratio of the poorly soluble substance to the fatty acid ester is within the above range, the vehicle is stably formed, and the vehicle can stably bear the poorly soluble substance. When the content of the fatty acid ester is in excess of the above range, a solid phase is formed together with a poorly soluble substance, and a process of re-dissolving the fatty acid ester when it is used in a cosmetic composition is required, have.

The weight ratio of the poorly soluble substance to the fatty acid ester is preferably 4: 6 to 6: 4.

In one aspect, the present invention provides a cosmetic composition comprising the vehicle, wherein the composition is an anhydrous gel type cosmetic composition. The composition for cosmetics does not contain water, so that a high amount of poorly soluble substance can be stably dissolved for a long period of time. In addition, the composition for cosmetics is a gel type, and when the cosmetic composition is prepared using the composition for cosmetics, the solubility of the cosmetic composition in the cosmetic composition is lower than that of nano-emulsion-type poorly soluble or liposomally- high.

The absolute value of the zeta potential of the cosmetic composition may be 30 to 70 mV.

In one aspect, the composition may further comprise at least one member selected from the group consisting of a solvent, a gelling agent, a gel stabilizing agent, and a solubilizing agent.

The solvent may include, but is not limited to, alcohol, and the alcohol is not limited, and may include polyhydric alcohols such as monohydric alcohols, trihydric alcohols in addition to divalent alcohols, and tetravalent alcohols. In one embodiment, the alcohol may be preferably dipropylene glycol.

The solvent may be contained in an amount of 2 to 30% by weight, and preferably 2 to 15% by weight based on the total weight of the composition.

The gelling agent may be at least one selected from the group consisting of tribehenin, dextrin palmitate, dextrin palmitate / ethyl hexanoate, tribehenin, stearoyl inulin, and trihydroxystearate. And may be, preferably, dextrin palmitate.

The gelling agent may be included in an amount of 0.5 to 15% by weight, and preferably 0.5 to 10% by weight based on the total weight of the composition.

The gel-stabilizing agent may also include a surfactant having an HLB (lipophilic-hydrophilic ratio) of 5 or less, such as palmitic acid, polyglyceryl-10 oleate, polyglyceryl-10 stearate, ≪ / RTI > sorbitolate, and sorbitolate.

The gel stabilizer may be contained in an amount of 0.1 to 10% by weight, preferably 0.1 to 5% by weight based on the total weight of the composition.

In addition, the dissolution aid may include natural product derived oils. For example, the natural-derived oil may be selected from the group consisting of hydrogenated castor oil, grapeseed oil, avocado oil, Edo wax seed oil, truffle oil, maca deuteranut oil, cinnabar vegetable oil, green tea seed oil, Or more.

The dissolution aid may be included in an amount of 0.1 to 20% by weight, preferably 2 to 15% by weight, based on the total weight of the cosmetic composition.

In one aspect, the present invention is a cosmetic composition comprising the cosmetic composition. In one aspect, the cosmetic composition may contain 10 to 50% by weight, based on the total weight of the composition, of at least one selected from the group consisting of ceramides, derivatives thereof and decomposition products thereof. For example, the composition may stably contain ceramide in an amount of 10 wt% or more, 20 wt% or more, or 30 wt% or more based on the total weight of the composition, Respectively.

The cosmetic composition is not limited and may be formulated into lotion, cream, solid cosmetic (stick type cosmetic) or the like.

[Formulation example]

[Formulation Example 1] Lotion

[Table 1]

Raw materials 1 to 4 shown in Table 1 were heated to 90 ° C, and then the raw material 5 was added thereto to dissolve the raw materials. Then, raw materials 6 and 7 were added and dissolved. Finally, raw materials 8 to 11 were added and dissolved.

[Formulation Example 2] Cream

[Table 2]

The raw materials 1 to 4 shown in Table 2 were heated to 90 ° C, and the raw materials 5 were added to dissolve the raw materials. Then, the raw materials 6 to 10 were added and dissolved. Finally, the raw materials 11 to 13 were added and dissolved.

[Formulation Example 3] Lipgloss

[Table 3]

The raw materials 1 to 8 shown in Table 3 are heated to 90 degrees and then the raw material 9 is added to dissolve the raw materials 10 and 11 to dissolve.

Hereinafter, the constitution and effects of the present invention will be described in more detail with reference to examples and test examples. However, these examples and test examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope and scope of the present invention are not limited by the following examples.

[Experimental Example 1] Preparation of ceramide gel and confirmation of formation of a vehicle

Ceramide gels were prepared using the ingredients listed in Table 4 below. Concretely, Ingredients 1 to 5 were mixed by heating at 70 to 80 ° C, then Ingredients 6 to 8 were added and stirred. The mixture was then cooled to 50 DEG C and post-treated 2-3 times in microfudics at a pressure of 1000-1500 bar.

[Table 4]

As a result, in Example 1 and Example 2, anhydrous ceramide gel was formed, and the gel state was maintained even when stored for 3 months in a temperature change cycle (45 ° C -> 25 ° C -> 0 ° C -> - 10 ° C) Could know. On the other hand, in Comparative Examples 1 and 2 using hydrated lecithin instead of glyceryl ester, no anhydrous ceramide gel was produced.

In addition, the presence or absence of the formation of a vehicle in the gel was confirmed by using an electron microscope. As a result, a vehicle having an average particle size of 200 to 500 nm was formed in the anhydrous ceramide gel of Example 1 and Example 2, (FIG. 1).

On the other hand, the same effect was obtained even when the kind of the gelling agent was changed to dextrin palmitate, cetearoyl inulin, trihydroxystearate and tribehenin.

[Experimental Example 2] Confirmation of precipitation

It was confirmed whether or not the crystallization phenomenon occurred in Example 1, Example 2, and Comparative Examples 1 and 2 during storage at a low temperature, environmental cycle, and high temperature for a long period of time.

[Table 5]

(Precipitation: 5- very good, 4- good, 3- normal, 2- poor, 1- very poor)

As a result, it was found that in Examples 1 and 2, sediment was not generated even after storage at a low temperature, environmental change, and high temperature for a long period of time, whereas in Comparative Examples 1 and 2, precipitation occurred to a large extent and the formulation was unstable.

[Experimental Example 3] Zeta potential measurement - Determination of dispersibility

The zeta potential values (mV) of Example 2 and Comparative Example 2 were measured using a Marven zetasize ZS 90 device. As a result, the absolute value of the zeta potential of Comparative Example 2 was 30 to 40, while the absolute value of the zeta potential of Example 2 was 30 to 70, whereas the absolute value of the zeta potential of Comparative Example 2 was 30 to 40 . The larger the zeta potential absolute value is, the better the electrical double layer is formed and the dispersion stability is high.

[Experimental Example 4] Determination of solubility in cosmetics

It was confirmed whether or not the compositions of Example 2 and Comparative Example 2 were dissolved in a cosmetic composition containing water or a cosmetic solvent containing an oil-based solvent. The compositions of Examples and Comparative Examples were mixed with 1% of the solvent under the following conditions and mixed for 3 minutes using an agitator. The compositions of Comparative Examples were added in the same amount and mixed for 30 minutes.

[Table 6]

[Table 7]

MCT = Caprylic / Capric Triglyceride

As a result, in the case of the ceramide gel of the example, it was confirmed that even when mixed with the solvent for three minutes, it was completely dissolved. However, it was confirmed that the composition of the comparative example or the ceramide itself hardly dissolves even after mixing for 30 minutes.

[Experimental Example 5] Confirmation of the formation of a vehicle according to the content ratio of the poorly soluble substance and the glyceryl ester

The formation of the vehicle was confirmed by the content ratio (mass ratio) of the poorly soluble substance forming the vehicle to the glyceryl ester. The poorly soluble materials and the glyceryl esters were mixed at the ratios shown in Table 8 below, and after two months, the formation of precipitates (precipitation of poorly soluble substances) was confirmed.

[Table 8]

As a result, when the poorly soluble substance and the glyceryl ester are contained in a range of 2: 8 to 8: 2, precipitation occurs, and it is confirmed that a bead growth containing the poorly soluble substance is stably formed within the above- I could.

Claims (15)

A cosmetic composition comprising a vesicle for cosmetics containing a high content of a poorly soluble substance,
The vehicle comprises a shell comprising a fatty acid ester,
The poorly soluble substance is at least one selected from the group consisting of ceramide, a precursor thereof, a derivative thereof, and a decomposition product thereof,
The poorly soluble material is included in an amount of 30 to 50 wt% based on the total weight of the composition,
The composition further comprises 0.1 to 20% by weight of the natural product-derived oil based on the total weight of the composition,
Wherein the composition comprises an anhydrous type, and a high content of a poorly soluble substance carrier. The method according to claim 1,
Wherein the fatty acid ester comprises a compound of glycerol and alpha hydroxy adic (AHA), and a high insoluble substance-bearing ability. 3. The method of claim 2,
Wherein the alpha hydroxy acid is selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid. 3. The method of claim 2,
Wherein said compound comprises a vehicle for cosmetic use comprising a high content of a poorly soluble substance carrier, including glyceryl citrate / lactate / linolate / oleate or caprylic / capric glyceride. delete The method according to claim 1,
Wherein the vehicle has an average diameter of 200 to 500 nm, and a high content of a poorly soluble substance carrier. The method according to claim 1,
Wherein the poorly soluble substance and the fatty acid ester are in a weight ratio of 2: 8 to 8: 2. The composition for a cosmetic composition according to claim 1, wherein the composition is an anhydrous gel type, comprising a high content of a poorly soluble substance carrier. 9. The method of claim 8,
The composition may comprise,
Wherein the composition further comprises at least one member selected from the group consisting of a solvent, a gelling agent, and a gel stabilizer. 10. The method of claim 9,
Wherein the solvent comprises alcohols,
Wherein the gelling agent comprises at least one member selected from the group consisting of tribehenin, dextrin palmitate, dextrin palmitate / ethyl hexanoate, tribehenin, stearoyl inulin, and trihydroxystearate ,
Wherein the gel-stabilizing agent comprises a surfactant having a hydrophile-lipophile balance (HLB) of 5 or less. 10. The method of claim 9,
The solvent is contained in an amount of 2 to 30% by weight based on the total weight of the composition,
The gelling agent is contained in an amount of 0.5 to 15% by weight based on the total weight of the composition,
Wherein the gel-stabilizing agent comprises 0.1 to 10% by weight, based on the total weight of the composition, of a high-content insoluble substance-carrying ability. 11. The method of claim 10,
Wherein the gel-stabilizing agent is at least one selected from the group consisting of polyglyceryl-10 oleate, polyglyceryl-10 stearate, and sorbitolate, A composition for a cosmetic comprising a vehicle. 10. The method of claim 9,
Wherein the composition has a viscosity of from 5,000 to 100,000 cps and a high content of a poorly soluble substance. delete delete

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