KR101513240B1 - A composition comprising extracts of herbal mixture for fatigue recovery as in gradient compounds - Google Patents

Abstract

The present invention relates to a composition containing an extract of a crude drug mixture comprising Hassuo, Manzan, Sansui, Sulfur and Sulfur, wherein the composition containing the extract of the crude drug mixture is excellent in the ability to maintain a motor function and to improve fatigue recovery , A candidate, a worker, a convalescent patient in a recovery period, or a health functional food.

Description

[0001] The present invention relates to a composition for extracting fatigue from fatigue,

TECHNICAL FIELD The present invention relates to a composition containing a herbal medicine as an active ingredient, and more particularly, to a composition containing a herbal composition containing an extract of a herbal medicine mixture containing Sasa, Mandarin, Sanshu Oil,

Today, as we move into a highly industrialized society, the number of people suffering from chronic fatigue has increased due to increased stress due to social life, accumulation of fatigue due to irregular eating habits and frequent drinking culture. Mental problems such as medical stress, depression, and anxiety disorder account for about 50% of the causes of these fatigue symptoms. Physical diseases include diabetes, thyroid disease, chronic respiratory disease, anemia, tuberculosis, hepatitis, kidney disease ) Or cancer can also cause chronic fatigue. Chronic fatigue syndrome (chronic fatigue syndrome) can be diagnosed if it is found that there is no such disease. Chronic Fatigue Syndrome is a condition in which the fatigue symptoms, such as easily tired and tired, the fatigue of the body is chronic, lasting more than six months, and the cause of the fatigue is unknown, and a fatigue occurs when there is a cold or body fatness in a normal healthy person .

These fatigue symptoms are a source of panic disease and also lead to obesity or excessive weight loss, leading to health problems.

Hwaseo ( Pleuropterus multflorus ) is a Chinese origin and is being cultivated as a medicinal plant. Root stalks are falling into the ground, and thick roots like sweet potatoes are formed. Reddish brown roots are called "Hashuo" in one room. They are used as tonic, laxative and laxative. Leaves are herbs and attached to the roasted leaves to absorb pus. Similar to me, I also have P. cilinervis , which grows in ridges and valleys of high mountains.

Ginseng (蔘 蔘, Codonopsis pilosula ) has a bell-shaped root and uses this root as a crude drug. The roots of manchans are called ginseng (蔘 蔘) or ginseng, and they are used as expectorants or edible.

Cornus officinalis is a fruit of a deer and a deciduous tree, Cornus officinalis. It is an oval nucleus and initially green, but ripens in August and October. Seeds are long oval and have ridges. It has a bitter sweetness and strong acidity. It is harvested after the frost fall in mid-October. The flesh is separated from the seeds and the meat is used as a material for sake, tea and Chinese medicine. The pulp contains the glycosides such as cornin, morroniside, loganin, tannin and saponin and organic acids such as wine, malic and tartaric acid. In addition, it contains vitamin A and a large amount of sugars. Seeds include palmitic acid, oleic acid, linoleic acid, and the like. Among the components, cornin is known to have an excitatory action of parasympathetic nerves. From the past, the pulp was weakened in one batch. It is said that it has efficacy such as strengthening of 阴 阴, 肾 精 and 肾气 reinforcement, convergence according to Dongbibogam, It is used for medicines such as headache, tinnitus, blood circulation, fever, and menstrual hyperactivity. It is also used for folk remedies such as cold sweat and enuresis. It can also be used as a tea or a drink, and has effects such as stopping sweat and consonant. Sansui is native to Korea and China, and is planted in the middle of South Korea. In Korea, Shandong, Gyeonggi Province, Gyeonggi Province, Gyeonggi Province, and Gyeongsangbukdo, Yusung Gun, and other local products are shipped every year.

熟地 黄 (熟地黄) is a Chinese medicine dried by steaming the roots of geohang (黄黄), and is a medicinal plant of perennial herb attached to the ginseng root. Its root is used as a medicinal material in one room. Especially, it is said that it is made by repeating 9 times of steaming and drying after soaking in alcohol. It has a bitter taste with a bitter taste, but it has a warm temperament, and it replenishes its blood and replenishes its essence (a substance that is fundamental to life and activity). It causes back and knee pain, sore symptoms, menstrual disorder, dizziness It has the efficacy to cure the head and darken the head. Sukjipang is the main medicinal material of Sangmangtang, and it is used for symptoms such as inner heat, sore throat, and thirst which are manifested by weakness of various chronic diseases. Samtang is widely used for excessive bleeding, weakness and dizziness caused by women's birth or menstruation. It has been effective for treating Huhdam (虛 痰) for a long time. It was drunk on tea for a few months. It was used in combination with cough and asthma, 茯 笭 and half summer. In addition, boiled pork with broth is effective when taking habitual constipation. There is a lot of nutrients and greasy, and when taken for a long time causes digestive disorders, diarrhea, recurrence (腹 unction) and other side effects occur. Therefore, it should be used with caution in patients with no appetite, no digestion, and diarrhea.

Mountain medicine is the root of the root of the mosquito (Dioscorea japonica) or horse (Disocorea batatas) belonging to the family Dioscoreaceae. Starch, mucus, protein, fat, arginine choline, and diastase. There is almost no smell, the taste is sweet and the quality is warm. When the appetite is diminished by the effect, when it is lacking refreshing, it is taken in the month with white puffer, rice, ginseng, etc., and when you sweat when you sleep, Asthma, asthma, and sputum are removed, and symptoms such as petechiae, back and knee pain, wells, premature ejaculation, frequent symptoms of urination, weakness of the body and anemia, It is used for limb paralysis. The pharmacological action stimulated intestinal activity, decreased blood sugar, and anti-aging activity. When you see symptoms such as body dryness and lack of refreshing, it is good to mix it with ginseng, mackerel, bokyeong (茯 ??), and passenger (杏仁). Diabetes mellitus every day, taking a long-term tea instead of taking effect, but if you have inflammatory diarrhea or when the stool is stopped, stop taking. In addition, taking too much can cause gas (气 滯).

On the other hand, although the preference for health food products using various herbal medicines is increasing, its efficacy and effectiveness have not been scientifically proved, and medicines based on herbal medicines have been abused or misused abusively.

Accordingly, the inventors of the present invention have completed the present invention by confirming that the extract of herbal medicine mixture containing the above-mentioned Hassuo, Manzan, Sansui, Sukjiro,

On the other hand, Korean Patent No. 1198948 discloses a health drink composition containing Sulfuric Acid, Korean Patent No. 1090284 discloses extracts of red ginseng antler containing Sulfur Sulfur, Sodium Sulfate and Sulfuric Acid, and Korean Patent No. 1000528 discloses a liquid composition containing Sulfuric Acid and Sodium Sulphate Korean Patent Registration No. 998225 discloses an immunomodulating composition containing acidic milk and a herbal composition. It is disclosed that each composition has a fatigue recovery effect. However, the kind of herbal medicine contained in the composition of the prior art or the Since the compounding ratio is different from that contained in the extract of the herbal medicine mixture of the present invention, the present invention can be regarded as an invention having a different technical constitution from the above-mentioned prior arts.

Korean Registered Patent No. 1198948 (health beverage composition and its production method, registered on Nov. 1, 2012) Korean Patent No. 1090284 (Drinking agent containing red ginseng and deer antler extract and method for preparing the same, registered on November 30, 2011) Korean Patent No. 1000528 (natural health liquid extract and its preparation method, registered on December 6, 2010) Korean Registered Patent No. 998225 (registered with Nov. 29, 2010, registered as an active ingredient in the extracts of antler, corn oil, angelica, gugija, liquorice, dandelion, ginseng, chrysanthemum, cinnamon, red ginseng,

It is an object of the present invention to provide a fatigue-feeding composition comprising a herbal mixture as an active ingredient, and more particularly, to a fatigue-reducing composition containing an extract of a herbal medicine mixture containing a herbal mixture of Sasa, Mandarin, To provide a composition.

TECHNICAL FIELD The present invention relates to a composition containing a herbal medicine as an active ingredient, and more particularly to a composition for the depression containing an extract of a herbal medicine mixture, which comprises desserts, manmunks, sour milk,

50 to 200 parts by weight of mancham, 50 to 200 parts by weight of marine algae, 30 to 200 parts by weight of sorghum, and 10 to 50 parts by weight of marine algae can be mixed with the herbal mixture, based on 100 parts by weight of sodium chloride.

Also, in the herbal medicine mixture, 50 to 200 parts by weight of chicken hair, 50 to 200 parts by weight of guinea pig, 50 to 200 parts by weight of guinea pig, 10 to 50 parts by weight of guinea pig, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of jujube, 10 to 30 parts by weight of jujube, 10 to 100 parts by weight of licorice and 10 to 50 parts by weight of sulfur.

The extract of the crude drug mixture can be prepared by extracting a crude drug mixture containing Sasa, Manzan, Sansui, Sulfur and Sucrose with water, C1 to C4 lower alcohol or a mixed solvent thereof.

In addition, the present invention relates to a composition containing a herbal medicine as an active ingredient, and more preferably to a health functional food containing an extract of a herbal medicine mixture, which comprises an extract of a herbal medicine, .

In another aspect, the present invention provides a method for preparing an extract of a crude drug mixture comprising Sasa, Manzan, Corn oil,

(1 step) preparing a herbal mixture by mixing 100 parts by weight of seaweed, 50-200 parts by weight of manchans, 50-200 parts by weight of marine oil, 30-200 parts by weight of Sulfuric Acid, and 10-50 parts by weight of Acid.

(Step 2) Mixing the crude drug mixture of the above-mentioned one step with an extraction solvent having a total weight of 1 to 10 times the total weight of the crude drug mixture and extracting the mixture at 70 to 130 ° C for 1 to 10 hours; And

(Step 3) Extracts of crude drug mixtures containing Hwaseo, Manchu, Sansui, Sukjiro, and Sangren can be prepared through the step of removing the solid content of the extracts of the two steps and collecting the filtrate.

Hereinafter, the present invention will be described in detail.

The raw sewage contained in the herbal mixture may be used directly in the dry state of the herbal medicine, but it is preferable that the pouring the sewage into the rice flour for 0.5 to 2 hours and then the steaming with steam for 10 to 60 minutes and the cooling for 1 to 5 hours By repeating the process, it is possible to maximize the extraction of active ingredients while lowering the mildew of the sewage. When the extract is directly extracted without being prescribed by law, the digestive disorder may occur in the subject to which the extract is administered. However, the digestive disorder hardly occurs due to the weakness after the law.

The chicken broth included in the herbal mixture may be chicken broth or frozen chicken broth of raw chicken, and chicken broth or frozen chicken broth of raw chicken may be used immediately. However, 100 to 500 parts by weight of chicken broth may be added to 100 to 500 parts by weight of boiled water, 20 to 20 parts by weight of ginger and 1 to 20 parts by weight of ginger are added to the chicken broth and boiled for 10 to 60 minutes. Other liquor may be used instead of the soju. When boiled chicken boiled with shochu and ginger, the fish 's fishy smell and grease are removed. The collagen ingredient contained in the chicken feet gives vitality to the skin and gives a feeling of life to the body.

The extract of the crude drug mixture may be used in the form of a concentrate obtained by concentrating the extract at a reduced pressure or a dried product thereof when a C1 to C4 lower alcohol or a mixed solvent with water is used. In addition, in the case of extracting with water, the filtrate from which the solid content has been removed can be immediately used, and it can be used in the form of a concentrated product or a dried product thereof.

The extract of the crude drug mixture may be isolated by known methods used for separation and extraction of plant components, such as extraction with an organic solvent (alcohol, ether, acetone, etc.), partition with hexane and water, Or may be fractionated or purified by a suitable combination method.

The chromatography can be carried out using silica gel column chromatography, LH-20 column chromatography, ion exchange resin chromatography, medium pressure liquid chromatography chromatography, thin layer chromatography (TLC), silica gel vacuum liquid chromatography, and high performance liquid chromatography.

In addition, the present invention provides a pharmaceutical composition containing a pharmaceutical composition containing the extract of the crude drug mixture as an active ingredient. The pharmaceutical compositions may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterilized injection solutions according to conventional methods. Examples of carriers, excipients and diluents that can be contained in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose , Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient, such as starch, calcium carbonate, sucrose, Or lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.

The dosage of the pharmaceutical composition of the present invention will depend on the age, sex, body weight of the subject to be treated, the particular disease or condition to be treated, the severity of the disease or condition, the route of administration and the judgment of the prescriber. Dosage determinations based on these factors are within the level of ordinary skill in the art and generally the dosage ranges from 0.01 mg / kg / day to approximately 2000 mg / kg / day, based on the composition comprising the concentrated dried product of the herbal mixture. A more preferable dosage is 1 mg / kg / day to 500 mg / kg / day. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

The pharmaceutical composition of the present invention can be administered to mammals such as rats, livestock, humans, and the like in various routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine dural or intracerebral injection. Since the compound of the present invention has little toxicity and side effects, it can be safely used even for long-term administration for preventive purposes.

In addition, the present invention provides a health food containing fatigue containing an extract of the herbal medicine mixture and a pharmaceutically acceptable food-aid additive. The health functional food of the present invention includes forms such as tablets, capsules, pills, and liquids. Examples of the foods to which the extract of the present invention can be added include various foods, beverages, gums, tea, vitamins , And health functional foods.

Meanwhile, the fatigue-related composition or health functional food containing the extract of the herbal medicine mixture of the present invention may be provided as a form which is easily sterilized and packaged in a pouch form.

The present invention relates to a composition containing an extract of a crude drug mixture comprising Hassuo, Manzan, Sansui, Sulfur and Sulfur, wherein the composition containing the extract of the crude drug mixture is excellent in the ability to maintain a motor function and to improve fatigue recovery , A candidate, a worker, a convalescent patient in a recovery period, or a health functional food.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow chart showing a process for producing an extract of a crude drug mixture of the present invention. FIG.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the intention is to provide an exhaustive, complete, and complete disclosure of the principles of the invention to those skilled in the art.

EXAMPLES Example 1. Preparation of Extracts of Herbal Drugs Containing Sasa, Mandarin, Sansui Oil,

The crude drug mixture of Table 1 below was mixed with 6 kg of water and extracted with a herbal extractor at 120 ° C for 9 hours. The solid content was removed to obtain an extract of each herbal mixture. At this time, the total weight of the crude drug mixture was unified to 850 g.

At this time, the poultry was immersed in rice cakes for 1 hour, steamed for 20 minutes with water vapor and cooled for 2 hours, and used 5 times repeatedly. The broiler chickens used in the herbal mixture were thawed frozen chicken legs, 100 g of soju and 200 g of ginger were added to 5 kg of boiling water per 2 kg, and then the defrosted chicken broth was boiled for 20 minutes (boiled water was discarded and chicken broth was used for cold extraction after cold rinsing twice).

< Comparative Example  1. Preparation of comparative extracts>

An extract of the crude drug mixture was prepared in the same manner as in Example 1, and the extract for comparison was prepared by referring to Table 2 below.

< Experimental Example  1. Checking the improvement of metabolism by swimming exercise test>

The water tank was adjusted to a lukewarm temperature (about 30 ° C) using a water tank having a depth of 1 m or more. The lyophilized extract of the present invention was orally administered at a dose of 200 mg / kg to seven Sprague Dawley male rats (about 200 g) per group. After 30 minutes of oral administration, 10 g of metal weight was attached to the tail of the rat to immerse it in the water to prevent buoyancy by the tail, and the rat was kept in a water bath, immersed in water, Respectively. The determination of the loss of swimming ability of the rat was made at the moment when the entire body of the rat was completely submerged in the water, and the swimming time of the rats was shown in Table 3 as an average value.

As shown in the following Table 3, it was found that the swimming time of the rat administered with the herbal medicine extract of Example 1 of the present invention was significantly longer than that of the rats administered with the comparative group extract, The extracts could be expected to improve the metabolism of the rat by improving the fatigue hallway.

Condition Swimming time (min) Example 1-1 8.29 Examples 1-2 8.35 Example 1-3 9.46 Examples 1-4 8.55 Examples 1-5 9.88 Examples 1-6 8.55 Examples 1-7 9.97 Examples 1-8 9.81 Examples 1-9 8.58 Example 1-10 8.67 Comparative Example 1-1 6.43 Comparative Example 1-2 6.26 Comparative Example 1-3 6.09 Comparative Example 1-4 6.56 Comparative Example 1-5 6.65 Comparative Example 1-6 6.89 Comparative Example 1-7 6.87 5 points: Excellent, 4 points: Excellent, 3 points: Normal, 2 points: Poor, 1 point: Very poor

< Experimental Example  2. Confirmation of improvement of fatigue recovery>

From Sep. 2012, the extracts were administered to 10- to 60-year-olds for 7 days for each extract of Example 1 and Comparative Example 1, for 2 days after a meal for 20 days, three times a day for 3 days, and 20 days The degree of improvement in fatigue was expressed by the 5-point spot method (5 points: excellent, 4 points: excellent, 3 points: normal, 2 points: poor, 1 point: very poor) in Table 4 below. For this purpose, sleeping effect, helplessness improvement effect, and overall fatigue improvement effect were confirmed.

Condition
Sleep effect Helplessness
Improvement effect Overall
Fatigue
Improvement effect Example 1-1 3.8 3.8 3.9 Examples 1-2 3.9 3.9 4.0 Example 1-3 4.1 4.0 4.2 Examples 1-4 4.0 3.9 4.2 Examples 1-5 3.9 3.9 4.2 Examples 1-6 3.8 4.2 4.1 Examples 1-7 4.2 4.3 4.2 Examples 1-8 4.3 4.2 4.4 Examples 1-9 3.8 3.8 3.8 Example 1-10 3.9 4.1 3.9 Comparative Example 1-1 2.1 2.2 2.3 Comparative Example 1-2 2.2 2.3 2.4 Comparative Example 1-3 1.9 1.9 2.2 Comparative Example 1-4 2.0 2.0 2.4 Comparative Example 1-5 2.1 2.1 1.8 Comparative Example 1-6 2.3 1.9 2.1 Comparative Example 1-7 1.9 2.2 2.0 5 points: Excellent, 4 points: Excellent, 3 points: Normal, 2 points: Poor, 1 point: Very poor

As shown in Table 4, the extract of the herbal medicine mixture of the present invention has a sleeping effect, an effect of reducing the helminth, and an excellent effect of improving the overall fatigue.

<Experimental Example 3> Toxicity test>

Experimental Example 3-1. Acute toxicity

The toxicity of the extracts (lyophilisates) of the herbal preparations of Examples 1-1 and 1-8 of the present invention to the animal body in an acute manner (within 24 hours) when an excessive amount of the extracts were taken in a short period of time and the mortality rate was determined This experiment was performed. Twenty mice of the general mouse ICR mouse line were assigned to each of the control and experimental groups. In the control group, only PEG-400 / tween-80 / EtOH (8/1/1, v / v / v) was administered and in the experimental group, the extract of the crude drug mixture of Examples 1-1 and 1-8 of the present invention, -400 / tween-80 / EtOH (8/1/1, v / v / v). As a result of examining the mortality rates after 24 hours of administration, it was confirmed that all the mice survived in the control group and in the experimental group administered with the herbal mixture extract of Examples 1-1 and 1-8 of the present invention at the concentration of 2 g / kg / day .

Experimental Example 3-2. Organ organs toxicity test in experimental group and control group

In the long-term toxicity test, the extracts (lyophilisates) of the herbal mixtures of Examples 1-1 and 1-8 of the present invention were administered to C57BL / 6J mice (10 rats per group) for 8 weeks at each concentration. In order to investigate the effects on the organs (tissues) of animals, the experimental group to which the extract of crude drug mixture of Examples 1-1 and 1-8 of the present invention and the PEG-400 / tween-80 / After 8 weeks from the control group, the blood concentration of glutamate-pyruvate transferase (GPT) and blood urea nitrogen (BUN) was measured by Select E (Vital Scientific NV, Netherland ) Instrument. As a result, GPT, which is known to be related to hepatotoxicity, and BUN, which is known to be related to renal toxicity, showed no significant difference compared to the control group. In addition, liver and kidney were cut from each animal, followed by a general tissue section preparation, histological observation with an optical microscope, and no abnormalities were observed in all tissues.

&Lt; Formulation Example 1 >

1-1. Manufacture of tablets

200g of the extract (lyophilized product) of the crude drug mixture of Examples 1-8 of the present invention was mixed with 175.9g of lactose, 180g of potato starch and 32g of colloidal silicic acid. To this mixture was added a 10% gelatin solution, which was pulverized and passed through a 14-mesh sieve. This was dried, and a mixture obtained by adding 160 g of potato starch, 50 g of talc and 5 g of magnesium stearate was made into tablets.

1-2. Injection preparation

1 g of the herbal mixture extract (lyophilized product) of Example 1-8 of the present invention, 0.6 g of sodium chloride and 0.1 g of ascorbic acid were dissolved in distilled water to make 100 ml. This solution was placed in a bottle and sterilized by heating at 20 DEG C for 30 minutes.

<Formulation Example 2: Food Preparation>

2-1. Manufacture of cooking seasonings

The livestock mixture extract (lyophilized product) of Examples 1-8 of the present invention was added to the cooking seasoning at 1 wt% to prepare a cooking sauce for health promotion.

2-2. Manufacture of flour food products

(Lyophilized product) of the herbal mixture of Examples 1-8 of the present invention was added to wheat flour at 0.1 wt%, and bread, cake, cookies, crackers and noodles were prepared using the mixture to prepare health promotion foods Respectively.

2-3. Manufacture of soups and gravies

The health enhancing soup and the juice were prepared by adding the extract (lyophilized product) of the herbal mixture of Examples 1-8 of the present invention to the soup and juice at 0.1 wt%.

2-4. Manufacture of dairy products

The lyophilized product extract (lyophilized product) of Examples 1-8 of the present invention was added to milk in an amount of 0.1% by weight, and various dairy products such as butter and ice cream were prepared using the milk.

2-5. Vegetable juice manufacturing

0.5 g of the herbal mixture extract (lyophilized product) of Examples 1-8 of the present invention was added to 1,000 ml of tomato juice or carrot juice to prepare vegetable juice for health promotion.

2-6. Manufacture of fruit juice

0.1 g of the extract (lyophilized product) of the crude drug mixture of Example 1-8 of the present invention was added to 1,000 ml of apple juice or grape juice to prepare health promotion fruit juice.

Claims (10)

Which comprises an extract of a herbal medicine mixture comprising 100 parts by weight of seaweed, 50-200 parts by weight of manchans, 50-200 parts by weight of marine oil, 30-200 parts by weight of sorghum, and 10-50 parts by weight of an acidic extract as an active ingredient Composition. delete In the first aspect,
The herbal medicine mixture contains 50 to 200 parts by weight of chicken hair, 50 to 200 parts by weight of guinea pig, 50 to 200 parts by weight of guinea pig, 10 to 50 parts by weight of guinea pig, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of jujube, 10 to 100 parts by weight of licorice, and 10 to 50 parts by weight of sulfur. The method according to claim 1,
Wherein the herbal mixture comprises 100 to 50 parts by weight of water, 50 to 200 parts by weight of mannitol, 50 to 200 parts by weight of citronellal oil, 30 to 200 parts by weight of Sulfuric acid, A lower alcohol, or a mixed solvent thereof. Which comprises an extract of a herbal medicine mixture comprising 100 parts by weight of seaweed, 50-200 parts by weight of manchans, 50-200 parts by weight of marine oil, 30-200 parts by weight of sorghum, and 10-50 parts by weight of an acidic extract as an active ingredient Health functional foods. delete 6. The method of claim 5,
The herbal medicine mixture contains 50 to 200 parts by weight of chicken hair, 50 to 200 parts by weight of guinea pig, 50 to 200 parts by weight of guinea pig, 10 to 50 parts by weight of guinea pig, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of ginger, 10 to 30 parts by weight of jujube, 10 to 100 parts by weight of licorice, and 10 to 50 parts by weight of sulfur. 6. The method of claim 5,
Wherein the herbal mixture comprises 100 to 50 parts by weight of water, 50 to 200 parts by weight of mannitol, 50 to 200 parts by weight of citronellal oil, 30 to 200 parts by weight of Sulfuric acid, A low-alcohol, or a mixed solvent thereof. (1 step) preparing a herbal mixture by mixing 100 parts by weight of seaweed, 50-200 parts by weight of manchans, 50-200 parts by weight of marine oil, 30-200 parts by weight of Sulfuric Acid, and 10-50 parts by weight of Acid.
(Step 2) Mixing the crude drug mixture of the above-mentioned one step with an extraction solvent having a total weight of 1 to 10 times the total weight of the crude drug mixture and extracting the mixture at 70 to 130 ° C for 1 to 10 hours; And
(Step 3) removing the solid content of the extract of the two steps and collecting the filtrate;
Wherein the extract is prepared from a mixture of herbal medicines containing at least one selected from the group consisting of seaweed, ginseng, corn oil, 10. The method of claim 9,
Wherein the extraction solvent of step 2 is selected from water, C1 to C4 lower alcohols or a mixed solvent thereof.

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