KR100847307B1 - Functional body care composition containing platinum colloid as an active ingredient - Google Patents
Functional body care composition containing platinum colloid as an active ingredient Download PDFInfo
- Publication number
- KR100847307B1 KR100847307B1 KR1020060102361A KR20060102361A KR100847307B1 KR 100847307 B1 KR100847307 B1 KR 100847307B1 KR 1020060102361 A KR1020060102361 A KR 1020060102361A KR 20060102361 A KR20060102361 A KR 20060102361A KR 100847307 B1 KR100847307 B1 KR 100847307B1
- Authority
- KR
- South Korea
- Prior art keywords
- platinum
- added
- cyclodextrin
- hydroxypropyl
- ppm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims abstract description 149
- 229910052697 platinum Inorganic materials 0.000 title claims abstract description 69
- 239000000084 colloidal system Substances 0.000 title claims abstract description 50
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 239000004480 active ingredient Substances 0.000 title claims abstract description 10
- -1 super oxide Chemical class 0.000 claims abstract description 47
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 35
- 239000002453 shampoo Substances 0.000 claims abstract description 21
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 18
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 14
- 239000000344 soap Substances 0.000 claims abstract description 11
- 230000001877 deodorizing effect Effects 0.000 claims abstract description 9
- 235000015097 nutrients Nutrition 0.000 claims abstract description 6
- 239000002537 cosmetic Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 13
- 239000012153 distilled water Substances 0.000 claims description 13
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
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- 239000003638 chemical reducing agent Substances 0.000 claims description 9
- 230000006870 function Effects 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 8
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- 150000003058 platinum compounds Chemical class 0.000 claims description 7
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- 238000006722 reduction reaction Methods 0.000 claims description 6
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
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- 229940044591 methyl glucose dioleate Drugs 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- 239000004202 carbamide Substances 0.000 claims 1
- 190000012306 pyrithione zinc Chemical compound 0.000 claims 1
- NMJKIRUDPFBRHW-UHFFFAOYSA-N titanium Chemical compound [Ti].[Ti] NMJKIRUDPFBRHW-UHFFFAOYSA-N 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 abstract description 31
- 150000003254 radicals Chemical class 0.000 abstract description 24
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 백금콜로이드를 유효성분으로 하는 기능성 바디용품에 관한 것으로,The present invention relates to a functional body article containing a platinum colloid as an active ingredient,
초산화물 (Super oxide)과 같은 자유라디칼에 의해서 생성된 세포 또는 조직손상과 관련하여 자유라디칼의 스케빈저로 적합한 형태의 항산화제이며 항균 항취능력이 우수한 백금콜로이드를 제조한 후, After preparing a platinum colloid with excellent antibacterial and deodorizing ability as a scavenger of free radicals related to cell or tissue damage caused by free radicals such as super oxide,
이와같이 제조된 백금콜로이드의 농도를 1내지 100ppm의 저농도로 조절하여 담체, 유분, 방부제, 보습제, 계면활성제, 증점제, 항균제, 수용성고분자 및 생리활성물질이 함유된 각종 바디용품조성물에 첨가하여 줌으로써,By adjusting the concentration of the platinum colloid thus prepared to a low concentration of 1 to 100ppm added to various body care compositions containing a carrier, oil, preservatives, humectants, surfactants, thickeners, antibacterial agents, water-soluble polymers and bioactive substances,
항산화기능 및 항균 항취능력이 뛰어난 고품격 고품질의 바디용품 예컨데 영양화장수, 크린징크림, 바디샴푸, 헤어샴푸, 헤어트리트먼트, 세안크림, 비누 등의 다양한 형태의 바디용품을 제조할 수 있도록 한 것이다.High-quality, high-quality body products with excellent anti-oxidant and anti-bacterial ability to deodorize, for example, nutrient cosmetics, cleansing creams, body shampoos, hair shampoos, hair treatments, facial creams, soaps, etc.
본 발명에 따른 백금나노입자를 함유한 기능성 크린징조성물은 초산화물(Super oxide)과 같은 자유라디칼에 의해서 손상된 세포 또는 조직손상과 관련하여 자유라디칼의 스케빈저로 적합한 형태의 항산화제로서 유해한 자유라디칼 특히 초산화물과 과산화수소를 효율적으로 제거할 수 있다.Functional cleansing composition containing platinum nanoparticles according to the present invention is a free radical that is harmful as an antioxidant in a form suitable as a scavenger of free radicals in relation to cell or tissue damage damaged by free radicals such as super oxide. In particular, superoxide and hydrogen peroxide can be efficiently removed.
또한 안정하고 혈액-뇌장벽을 교차하여 조직에 침투하는 능력과 같은 유리한 약리학적 성질과 매우 우수한 항균 탈취성질을 가진다.It also has favorable pharmacological properties such as stable and ability to penetrate tissues across the blood-brain barrier and very good antibacterial and deodorant properties.
Description
본 발명은 백금콜로이드를 유효성분으로 하는 기능성 바디용품에 관한 것으로,The present invention relates to a functional body article containing a platinum colloid as an active ingredient,
더욱 상세하게는 초산화물 (Super oxide)과 같은 자유라디칼에 의해서 생성된 세포 또는 조직손상과 관련하여 자유라디칼의 스케빈저로 적합한 형태의 항산화제이며 항균, 항취능력이 우수한 백금콜로이드를 제조한 후, More specifically, in preparation of free radical scavenger related to cell or tissue damage caused by free radicals such as super oxide, a suitable type of antioxidant and antibacterial and anti-odorizing platinum colloid is produced. ,
이와같이 제조된 백금콜로이드의 농도를 1내지 100ppm의 저농도로 조절하여 바디샴푸, 헤어샴푸, 헤어트리트먼트 및 비누 등의 바디용품제조시 첨가하여 줌으로서 제조되는 항산화기능 및 항균 항취능력이 뛰어난 백금콜로이드를 유효성분으로 하는 기능성 바디용품에 관한 것이다.Platinum colloid with excellent antioxidant and antimicrobial anti-odor ability is prepared by adjusting the concentration of platinum colloid prepared in this way to a low concentration of 1 to 100 ppm and adding it in the manufacture of body products such as body shampoo, hair shampoo, hair treatment and soap. A functional body article comprising the active ingredient.
일반적으로 바디샴푸, 헤어샴푸, 화장수, 헤어트리트먼트 및 비누 등을 통칭하는 바디용품에 들어가는 각종 원료 중 유지류, 계면활성제, 향료, 비타민 등은 공기중에서 산패된다.In general, oils, surfactants, fragrances, vitamins, etc. among various raw materials contained in body products collectively referred to as body shampoos, hair shampoos, lotions, hair treatments and soaps are rancidized in the air.
산패는 산소, 열, 세균 효소, 습기 등의 작용에 의하여 화학변화를 일으킴으로써 발생하는 현상으로서 바디용품의 안정성 측면에서 영향이 크며, 이것 때문에 그 고유의 성질을 잃고 각종 성분을 파괴시키며 나아가 독성을 일으키기도 한다.Lattice is a phenomenon caused by chemical changes caused by the action of oxygen, heat, bacterial enzymes, moisture, etc., which has a great influence on the stability of body products, and because of this, it loses its own properties, destroys various components, and furthermore, It is also raised.
그러므로 바디용품에서 산패를 방지하기 위해서는 산화방지제를 첨가하여야 하는데 이와같은 산화방지제로는 토코페롤, BHT, BHA, 몰식자산 등이 있다.Therefore, to prevent rancidity in body products, antioxidants should be added. Such antioxidants include tocopherol, BHT, BHA, and moles.
산화방지제의 경우 단일의 산화방지제를 사용하는 것보다는 혼합해서 사용함으로써 상승효과를 유도할 수 있으며, 산화방지 보조제로는 인산, 구연산, 아스코르빈산, 말레산 및 EDTA 등이 있다.In the case of antioxidants, a synergistic effect may be induced by using a mixture rather than using a single antioxidant, and antioxidant supplements include phosphoric acid, citric acid, ascorbic acid, maleic acid, and EDTA.
한편, 우리 몸 속에서도 항상 산화현상이 일어나고 있어 끊임없이 활성산소가 발생하게 된다.On the other hand, oxidation occurs in our body all the time, and free radicals are constantly generated.
이것은 지질을 산화시켜 과산화지질을 만들게 되는데 이러한 과산화지질은 매우 유해한 물질로서 세포막을 파괴하고 세포의 움직임을 저하시켜는 노화의 원흉이 되기도 한다.This oxidizes lipids to make lipid peroxide, which is a very harmful substance that can be a source of aging, destroying cell membranes and slowing cell movement.
우리 몸은 이 활성산소를 무해화 하고, 과산화물을 환원하는 물질의 하나인 SOD라고 불리는 효소를 갖추고 있는데 이 효소는 적혈구 속에 많이 존재하고 있다.Our body is equipped with an enzyme called SOD, which is one of the substances that harms free radicals and reduces peroxides, which are present in many red blood cells.
그런데 혈당치가 높으면 이 효소와 당이 화합해서 효소 기능이 저하되고, 더욱 악화되면 기능을 상실하게 된다.However, if the blood sugar level is high, the enzyme and sugar combine to degrade the enzyme function, and if worse, the function is lost.
보통의 체내 반응은 효소를 촉매로 하여 효율적으로 행해지지만 메이라드 반응은 효소 없이 행해지는 반응으로 생체가 바라든 바라지 않던 관계없이 마음대로 반응이 일어난다.Normal reactions in the body are carried out efficiently with enzymes as catalysts, while the Mayrad reactions are reactions without enzymes.
효소가 없는 반응은 천천히 진행되며 신진대사 역시 천천히 행해지게 된다.Enzyme-free reactions are slow and metabolism is slow.
신진대사가 천천히 진행되는 것의 한 예로 콜라겐을 들 수 있지만 여기서도 메이라드 반응은 발생하여 가교가 일어나게 되는데 이것이 피부의 노화 현상이다.Collagen is an example of slower metabolism, but here too, the Mayrad reaction occurs and crosslinking occurs, which is the aging of the skin.
앞서 말한 것과 같이, 이러한 반응이 과도하게 발생되면 SOD의 역할을 해치고 만다.As mentioned earlier, excessive reactions can undermine the role of SOD.
SOD는 젊을 때는 많이 생성되나 나이를 먹음에 따라 생성되기 어려워지므로 나이를 먹는 만큼 산화를 방지하는 비타민 A, C, E, B2 나 베타카로틴, 또는 요오드, 플라보노이드 등의 항산화 물질을 많이 섭취할 필요가 있다.SOD is produced a lot in young age, but it is difficult to produce as you age, so you need to consume a lot of antioxidants such as vitamins A, C, E, B2 or beta-carotene, or iodine, flavonoids, etc. have.
또한, 피부노화 뿐만 아니라 자외선 등에 의한 피부색소 침착 역시 일종의 산화과정을 통해서 발생하며 이를 방지하기 위한 소재로 멜라닌의 합성을 저해하는 메커니즘 또는 타이로시나아제(tyrosinase)의 활성을 억제하는 기능을 갖는 소재를 사용한다.In addition, not only skin aging but also skin pigmentation due to ultraviolet rays occur through a kind of oxidation process and as a material to prevent this, a mechanism that inhibits the synthesis of melanin or a material having a function of inhibiting the activity of tyrosinase. Use
한편, 항산화제는 활성산소에 의한 산화적 손상을 방어하는 기구에 따라 활성산소 생성을 미연에 방지하는 예방적 항산화제(preventive antioxidant)와 이미 생성된 활성산소를 빠르게 소거하는 연쇄절단형 항산화제(chain-breaking antioxidant) 로 구분할 수 있는데, 전자인 예방적 항산화제에는 SOD, catalase, peroxidase 등의 효소류와 xanthine oxidase 저해제, 금속 chelator 등이 속하며, 후자인 연쇄절단형 항산화제는 일반적으로 협의의 항산화제로 불리는 지질 과산화를 방지하는 작용을 갖는 저분자 화합물에 해당된다.On the other hand, antioxidants are preventive antioxidants that prevent the formation of free radicals in accordance with a mechanism that protects against oxidative damage caused by free radicals, and chain-cutting antioxidants that quickly eliminate the active oxygen already produced ( The former preventive antioxidants include enzymes such as SOD, catalase, and peroxidase, xanthine oxidase inhibitors, and metal chelators. The latter chain-cutting antioxidants are generally negotiated antioxidants. It corresponds to the low molecular weight compound which has the effect | action which prevents lipid peroxidation called zero.
이들은 수용성계에서 생성된 라디칼(radical)을 포착하여 소거한다.They capture and eliminate radicals generated in the water-soluble system.
한편, 지용성 항산화제로는 비타민E를 비롯하여 ubiquinone (CoQ), carotenoid 등이 알려져 있는데, 이들은 지질막 내에서 지질 과산화 라디칼 (peroxy radical)을 소거함으로써 라디칼 연쇄반응(radical chain reaction)을 정지시키는 작용을 한다.On the other hand, fat-soluble antioxidants are known, such as vitamin E, ubiquinone (CoQ), carotenoid, etc., these act to stop the radical chain reaction by eliminating lipid peroxy radicals in the lipid membrane.
생체 내의 시스템에서는 양자가 상승적(相昇的)인 작용을 통해 라디칼 공격에 대처하는 것으로 여겨지고 있다. In in vivo systems, protons are thought to cope with radical attack through synergistic action.
정상적인 세포에서도 대사과정 중 어느 정도의 자유라디칼(free radical), 기타 활성산소, 과산화물 등이 생성되고 있으나 생체 내에는 이들에 대한 방어기구로서 superoxide dismutase(SOD), catalase, peroxidase 등의 항산화 효소와 함께 비타민E, 비타민C, glutathione, ubiquinone, 요산 등과 같은 항산화 물질이 존재하여 스스로를 보호하고 있다.In normal cells, some free radicals, other free radicals, and peroxides are produced during metabolism, but in vivo, as a defense against them, along with antioxidant enzymes such as superoxide dismutase (SOD), catalase, and peroxidase Antioxidants such as vitamin E, vitamin C, glutathione, ubiquinone and uric acid exist to protect themselves.
그러나 이와 같은 생체방어기구에 이상이 초래되거나 각종 물리적, 화학적 요인들에 의하여 활성산소의 생성이 생체방어계의 용량을 초과하게 될 경우 산화적 스트레스 (oxidative stress)가 야기된다.However, oxidative stress is caused when an abnormality occurs in such a bioprotective device or when the generation of active oxygen exceeds the capacity of the bioprotective system by various physical and chemical factors.
본 발명은 초산화물 (Super oxide)과 같은 자유라디칼에 의해서 생성된 세포 또는 조직손상과 관련하여 자유라디칼의 스케빈저로 적합한 형태의 항산화제이며 항균 항취능력이 우수한 백금콜로이드를 제조한 후, The present invention relates to a free radical scavenger in relation to cell or tissue damage produced by free radicals such as super oxide, and to prepare a platinum colloid having excellent antibacterial and deodorizing ability.
이와같이 제조된 백금콜로이드의 농도를 1내지 100ppm의 저농도로 조절하여 바디샴푸, 헤어샴푸, 화장수, 헤어트리트먼트 및 비누 등의 바디용품제조시 첨가하 여 줌으로써,By adjusting the concentration of the platinum colloid prepared in this way to a low concentration of 1 to 100ppm by adding in the manufacture of body products such as body shampoo, hair shampoo, lotion, hair treatment and soap,
항산화기능 및 항균 항취능력이 뛰어난 고품격 고품질의 바디용품을 제공하고자 함에 그 목적이 있는 것이다.Its purpose is to provide high quality and high quality body products with excellent antioxidant and antibacterial ability.
상기와 같은 목적을 달성하기 위한 본 발명의 백금콜로이드를 유효성분으로 하는 활성산소 소거제는 귀금속의 미립자를 유효성분으로 함유하는 것을 특징으로 한다.An active oxygen scavenger using the platinum colloid of the present invention as an active ingredient for achieving the above object is characterized by containing fine particles of a noble metal as an active ingredient.
이때 귀금속의 종류는 백금 또는 백금을 포함하는 합금이며 특히 바람직한 것은 백금이다.At this time, the kind of precious metal is platinum or an alloy containing platinum, and particularly preferred is platinum.
귀금속의 미립자로는 비표면적이 크고, 고활성을 지닌 백금콜로이드상이 바람직하다.As fine particles of a noble metal, a platinum colloidal phase having a large specific surface area and high activity is preferable.
미립자의 크기는 20nm이하의 평균 입경을 가지는 것을 사용할 수 있으나 바람직하게는 1 내지 5nm 정도의 미립자를 사용한다.The particle size may be one having an average particle diameter of 20 nm or less, but preferably, 1 to 5 nm fine particles are used.
여기에는 백금콜로이드란 백금 금속염이 용매에 용해되어 금속이온을 형성하고 상기 금속이온이 환원되어진 백금콜로이드 입자가 제공되며 금속콜로이드의 분산 및 저장안정성을 얻기 위하여 용액 중 백금콜로이드 입자와 안정제(착화제)가 공존하는 상태를 말한다.Platinum colloid is a platinum metal salt that is dissolved in a solvent to form metal ions, and the metal ions are reduced to provide platinum colloid particles. Platinum colloid particles and stabilizers (compounding agents) are used to obtain dispersion and storage stability of the metal colloid. State of coexistence.
이에 먼저 자유라디칼의 스케빈저로 적합한 형태의 항산화제인 백금콜로이드의 제조에 사용되는 금속염에 대하여 설명하기로 한다.First, the metal salt used in the preparation of platinum colloid, an antioxidant of a suitable form as a scavenger of free radicals, will be described.
금속염으로는 헥산클로로백금(Ⅳ)산 육수화물(염화백금산), 염화백금산칼륨, 헥사하이드로 옥소 백금산(Ⅳ), 에틸암모늄헥사하이드로 옥소 백금산, 질산테트라아민 백금, 질산백금, 수산화테트라 아민 백금(Ⅱ)용액 중에서 선택된 백금산 및 백금산염을 사용한다.Examples of the metal salts include hexanechloroplatinum (IV) hexahydrate (platinum chloride), potassium chloroplatinum, hexahydrooxoplatinic acid (IV), ethylammonium hexahydrooxoplatinic acid, tetranitrate nitrate, platinum nitrate, and tetraamine amine platinum (II). Use platinum acid and platinum salt selected from the solution.
본 발명의 활성산소 소거제 복합조성물에서 백금금속염은 마지막 금속이온이 조성물의 중량에 대하여 0.001wt% ~ 2wt%를 함유한다. 전형적으로 0.1wt% ~ 1wt%를 함유한다.In the active oxygen scavenger complex composition of the present invention, the platinum metal salt contains 0.001 wt% to 2 wt% of the final metal ion with respect to the weight of the composition. Typically 0.1 wt% to 1 wt%.
이번에는 자유라디칼의 스케빈저로 적합한 형태의 항산화제인 백금콜로이드의 제조에 사용되는 안정제(착화제)를 설명하기로 한다.This time, the stabilizer (complexing agent) used to prepare platinum colloid, an antioxidant of a suitable form as a scavenger of free radicals, will be described.
본 발명에서는 백금콜로이드를 안정화시키기 위하여 계면활성제, 폴리머화합물 폴리사카라이드 또는 아미노기를 갖는 고분자를 사용하지 않는다.In the present invention, a surfactant, a polymer compound polysaccharide, or a polymer having an amino group is not used to stabilize the platinum colloid.
본 발명에서는 백금콜로이드의 안정화제로 β-시클로덱스트린 에테르를 사용한다.In the present invention, β-cyclodextrin ether is used as a stabilizer of the platinum colloid.
β-시클로덱스트린은 실온에서 물에서의 포화 용해도가 1.8mg/ml인 글루코스 단위체 7개를 포함하는 α-1,4-결합고리형 올리고당이다.β-cyclodextrin is an α-1,4-linked oligosaccharide comprising seven glucose units with a saturated solubility of 1.8 mg / ml in water at room temperature.
β-시클로덱스트린의 각각의 (무수)글루코스 단위체는 2-,3- 및 6- 위치에 자유 히드록실기를 함유하며 이들의 각각 에테르화 되어 있을 수 있다.Each (anhydrous) glucose unit of β-cyclodextrin contains free hydroxyl groups in 2-, 3- and 6-positions and may be etherified respectively of them.
글루코스 단위체의 자유 히드록실기의 전부 또는 일부를 하나 이상의 극성의 즉, 쉽게 물에 녹는 기, 예컨대 히드록시알킬기를 포함하는 알킬기로 에테르화한 경우 순수한 β-시클로덱스트린과 비교하여 수용해도가 증가한 에테르화된 β-시클로덱스트린이 형성된다.Ethers having increased water solubility compared to pure β-cyclodextrins when all or part of the free hydroxyl groups of the glucose unit are etherified with at least one polar, ie, alkyl group comprising easily soluble groups such as hydroxyalkyl groups. Formated β-cyclodextrin is formed.
수용해도를 증가시키는 적당한 히드록시알킬기로는 예컨대 히드록시에틸 또는 히드록시프로필기가 있으며 β-시클로덱스트린을 해당하는 알킬렌 옥시드 예컨대 에틸렌 옥시드 또는 프로필렌 옥시드와 반응시킴으로써 이들을 β-시클로덱스트린에 도입할 수 있다.Suitable hydroxyalkyl groups which increase the water solubility are, for example, hydroxyethyl or hydroxypropyl groups and introduce them into β-cyclodextrin by reacting β-cyclodextrin with the corresponding alkylene oxide such as ethylene oxide or propylene oxide. can do.
즉, 본 발명에서는 백금콜로이드를 안정화시킴과 동시에 백금콜로이드의 백금 나노입자가 에테르화된 시클로덱스트린 고리 시스템의 소수성공동 (cavity)에 침투하여 내포화합물을 형성하는 역할을 한다.That is, the present invention stabilizes the platinum colloid and at the same time, the platinum nanoparticles of the platinum colloid penetrate into the hydrophobic cavity of the etherified cyclodextrin ring system to form an inclusion compound.
본 발명에 따른 백금콜로이드용액은 냉장온도(2-8℃) 및 실온(25℃, 60%roh)에서 안정한 형태로 6개월 이상의 기간 동안 저장할 수 있다.Platinum colloidal solution according to the present invention can be stored for a period of 6 months or more in a stable form at a refrigeration temperature (2-8 ℃) and room temperature (25 ℃, 60% roh).
본 발명에서 안정화제인 에테르화된 β-시클로덱스트린 (2-하이드록시프로필-β-시클로덱스트린)의 사용량은 1wt%~20wt%의 양으로 존재한다.The amount of etherified β-cyclodextrin (2-hydroxypropyl-β-cyclodextrin) that is a stabilizer in the present invention is present in an amount of 1 wt% to 20 wt%.
전형적으로 5wt%~10wt%의 양으로 조절하는 것이 바람직하다.Typically, it is desirable to adjust the amount to 5wt% -10wt%.
이번에는 자유라디칼의 스케빈저로 적합한 형태의 항산화제인 백금콜로이드의 제조에 사용되는 환원제에 대해 설명하기로 한다.This article describes the reducing agents used to make platinum colloids, which are suitable antioxidants as scavengers of free radicals.
상기 백금화합물은 상술한 안정제(착화제) 존재 하에서 환원성화합물을 이용하여 금속으로 환원될 수 있다.The platinum compound may be reduced to a metal using a reducing compound in the presence of the stabilizer (complexing agent) described above.
종래의 환원제로의 예로는 수소, 저급지방족알콜(에탄올, 이소프로탄올), 수소화붕소나트륨, 히드라진, 구연산, 주석산, 아스코르빈산, 포름산, 포름알데히드 등을 사용하여 왔으나 본 발명의 환원성화합물로는 아민류를 사용한다.Examples of conventional reducing agents include hydrogen, lower aliphatic alcohols (ethanol, isoprotanol), sodium borohydride, hydrazine, citric acid, tartaric acid, ascorbic acid, formic acid, formaldehyde, and the like. Amines are used.
상기 백금화합물 및 안정제(착화제)의 용액에 아민을 첨가하여 교반, 혼합함 으로써, 금속이 30 ~ 80℃정도의 반응온도에서 금속으로 환원된다. 아민을 사용함으로서 위험성이나 유해성이 높은 환원제를 사용할 필요가 없다.By adding, stirring and mixing the amine to the solution of the platinum compound and the stabilizer (complexing agent), the metal is reduced to the metal at a reaction temperature of about 30 to 80 ° C. By using an amine, there is no need to use a high risk or hazardous reducing agent.
아민의 예로는 알킬아민(예 : 메틸아민, 디메틸아민, 트리부틸아민, 디-이소프로필아민), 아릴아민(예: 아닐린, 톨루이딘, 아미노나프탈렌 및 아미노안트라센), 헤테로사이클릭아민(예: 피페리딘, 피페라진 및 피롤리딘) 및 헤테로방향족아민(예: 피리딘, 피라졸, 이미다졸, 옥사졸, 이소-옥사졸, 피리미딘 및 피라진)과 알칸올아민(예: 메틸아미노에탄올, 디메틸아미노에탄올, 트리에탄올아민, 에탄올아민, 디에탄올아민, 메틸디에탄올아민, 프로탄올아민, 디메틸아미노프로판올)이 포함된다.Examples of amines include alkylamines (e.g. methylamine, dimethylamine, tributylamine, di-isopropylamine), arylamines (e.g. aniline, toluidine, aminonaphthalene and aminoanthracene), heterocyclic amines (e.g. Ferridine, piperazine and pyrrolidine) and heteroaromatic amines (e.g. pyridine, pyrazole, imidazole, oxazole, iso-oxazole, pyrimidine and pyrazine) and alkanolamines (e.g. methylaminoethanol, dimethyl Aminoethanol, triethanolamine, ethanolamine, diethanolamine, methyldiethanolamine, protanolamine, dimethylaminopropanol).
상기 환원성화합물의 첨가량은 상기금속화합물중의 금속을 환원하는데 필요한 양이상인 것이 바람직하다.The amount of the reducing compound added is preferably more than the amount necessary to reduce the metal in the metal compound.
상기한 양 미만이면 환원이 불충분하게 될 우려가 있다.There exists a possibility that reduction may become inadequate when it is less than the said amount.
상한은 특별히 규정되는 것은 아니지만 금속나노입자 대 환원제를 5 : 1 내지 1 : 5로 바람직하게는 1 : 1의 값으로 조절하는 것이 바람직하다.The upper limit is not particularly defined, but it is preferable to adjust the metal nanoparticles to the reducing agent from 5: 1 to 1: 5, preferably to a value of 1: 1.
본 발명에 따르는 백금 나노입자의 농도는 0.01mg 내지 10g/L의 농도를 갖는다.The concentration of platinum nanoparticles according to the invention has a concentration of 0.01 mg to 10 g / L.
이하에서는 자유라디칼의 스케빈저로 적합한 형태의 항산화제인 백금콜로이드를 제조하기 위한 일 실시예를 상세히 설명하고자 한다.Hereinafter will be described in detail an embodiment for preparing a platinum colloid, an antioxidant of a suitable form as a scavenger of free radicals.
200ml플라스크에 안정제(착화제)로 2-하이드록시프로필-β-시클로덱스트린 7g 및 증류수 90.68ml를 첨가하여 2-하이드록시프로필-β-시클로덱스트린이 용해될 때까지 50℃에서 교반하였다.To the 200 ml flask was added 7 g of 2-hydroxypropyl-β-cyclodextrin as a stabilizer (complexing agent) and 90.68 ml of distilled water, followed by stirring at 50 ° C until 2-hydroxypropyl-β-cyclodextrin was dissolved.
이후 백금화합물로 비스(에탄올암모늄) 헥사하이드로 옥소 플라티네이트(Pt함량 5%)용액 2ml를 상기 2-하이드록시프로필-β-시클로덱스트린이 용해된 용액에 첨가하여 상온에서 10분간 교반하였다.Then, 2 ml of bis (ethanolammonium) hexahydro oxo platinum (Pt content 5%) solution as a platinum compound was added to the 2-hydroxypropyl-β-cyclodextrin solution, followed by stirring at room temperature for 10 minutes.
이어 환원제로서 2-아미노에탄올 0.32g을 첨가하고 용액 온도를 70℃로 유지한체 6시간동안 교반하면서 환원반응을 실시하여 백금농도 1000ppm의 백금콜로이드를 제조하였다.Subsequently, 0.32 g of 2-aminoethanol was added as a reducing agent, and a reduction reaction was performed while stirring for 6 hours while maintaining the solution temperature at 70 ° C to prepare a platinum colloid having a platinum concentration of 1000 ppm.
상기와 같은 일 실시예에 의해 제조된 백금콜로이드는 자유라디칼의 스케빈저로 적합한 형태의 항산화제로서 유해한 옥시라디칼, 특히 초산화물과 과산화수소를 효율적으로 제거할 수 있다.The platinum colloid prepared according to one embodiment as described above can effectively remove harmful oxy radicals, in particular superoxide and hydrogen peroxide, as an antioxidant in a suitable form as a scavenger of free radicals.
또한, 제조비용이 저렴하면서도 안정하고 혈액-뇌 장벽을 교차하여 조직에 침투하는 능력과 같은 유리한 약리학적 성질을 가진다.In addition, the manufacturing cost is low, yet stable, and has advantageous pharmacological properties such as the ability to penetrate tissues across the blood-brain barrier.
따라서, 이와같은 본 발명의 실시예들에 의해 제조되는 백금콜로이드는 농도를 1~100ppm으로 선택적으로 조정하여 화장수, 크린징크림, 헤어샴푸, 헤어트리트먼트, 세안크림, 비누 등의 바디용품의 형태로 제조되어 이용될 수 있다.Therefore, the platinum colloid prepared by the embodiments of the present invention in the form of body products such as lotion, cleansing cream, hair shampoo, hair treatment, face cream, soap by selectively adjusting the concentration to 1 ~ 100ppm It can be manufactured and used.
즉, 본 발명의 실시예에 의해 제조된 백금콜로이드의 백금고형분함량은 1000ppm으로서 백금콜로이드의 농도를 1~100ppm의 저농도로 하여 바디용품 조성물에 첨가하여 줌으로써 항산화기능을 증강시키는 기능성 바디용품을 제조할 수 있을 것이다.That is, the platinum solid content of the platinum colloid prepared by the embodiment of the present invention is 1000ppm to prepare a functional body article to enhance the antioxidant function by adding to the body care composition with a low concentration of platinum colloid 1 ~ 100ppm Could be.
이번에는 임의 성분으로서의 의학적으로 피부외용으로 허용된 첨가제 및 용매에 관하여 더욱 상세히 설명한다.This time, the additives and solvents that are medically acceptable for external skin as optional ingredients will be described in more detail.
본 발명의 효과를 손상시키지 않는 범위에서 공지의 의학적으로 피부외용으로 허용된 기제 및 또는 첨가제, 예컨대 바디용품재료성분으로는 물, 알콜류, 유분, 계면활성제, 방부제, 향료, 색소, 보습제, 증점제, 수용성고분자, 산화방지제, 킬레이트제 PH조정제, 발포제;(안료, 자외선흡수, 산란제, 분체,), 비타민류, 아미노산류, 항균제, 해조추출물, 각종 약제, 첨가제 등을 배합할 수 있다.Known medically acceptable bases and / or additives such as body care ingredients, such as water, alcohols, oils, surfactants, preservatives, flavorings, pigments, humectants, thickeners, to the extent that they do not impair the effects of the present invention Water-soluble polymers, antioxidants, chelating agents, PH modifiers, blowing agents; (pigments, ultraviolet absorbers, scattering agents, powders), vitamins, amino acids, antibacterial agents, seaweed extracts, various drugs, additives and the like can be blended.
구체적으로 상기 유분으로는 마카데미아넛유, 파자마유, 올리브유, 카카오유, 동백유, 팜유, 목랍, 호호바유, 포도씨유, 아보가드유, 등의 식물유지류와, 밍크유, 난황유 등의 동물유지류와, 밀랍, 경랍, 라놀린, 카르나바왁스, 칸데릴라왁스 등의 왁스류와, 유동파라핀, 스쿠알렌, 마이크로크리스탈린왁스, 셀레신왁스, 파라핀왁스, 바세린 등의 탄화수소류와, 카프린산, 미리스트산, 팔미트산, 스테아르산, 베헨산, 라놀린 지방산, 리놀산, 리놀렌산, 라우르산, 미리스트산, 올레인산, 이소스테아르산 등의 천연 및 합성지방산류와, 세타놀, 스테아릴알콜, 헥실데칸올, 옥틸도데칸올, 라우릴알콜, 카프릴알콜, 미리스틸알콜, 세틸알콜, 콜레스테롤 등의 천연 및 합성 고급알콜류와, 미리스트산이소프로필, 팔미트산이소프로필, 미리스트산옥틸도데실, 올레인산옥틸도데실, 콜레스테롤올레이트 등의 에스테르류 등을 예시할 수 있다.Specifically, the oils include vegetable oils such as macadamia nut oil, pajama oil, olive oil, cacao oil, camellia oil, palm oil, wax, jojoba oil, grape seed oil, avocado oil, animal oils such as mink oil and egg yolk oil, Waxes such as beeswax, spermatozoa, lanolin, carnava wax and candelilla wax, hydrocarbons such as liquid paraffin, squalene, microcrystalline wax, selesin wax, paraffin wax and petrolatum, caprinic acid and myristic acid Natural and synthetic fatty acids such as palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid, lauric acid, myristic acid, oleic acid, isostearic acid, and cetanol, stearyl alcohol, hexyldecanol , Natural and synthetic higher alcohols such as octyldodecanol, lauryl alcohol, capryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, isopropyl myristate, isopropyl palmitate, octylate dodecyl, Ole It may be exemplified by esters such as octyldodecyl, and cholesterol oleate.
상기 계면활성제로는 모노라우르산소르비탄, 모노팔미트산소르비탄, 세스키올레인산소르비탄, 트리올레인산소르비탄, 모노라우르산폴리옥시에틸렌소르비탄, 모노스테아르산폴리옥세틸렌소르비탄, 폴리에틸렌글리콜모노올레이트, 폴리에틸렌글리콜알킬레이트, 폴리옥시에틸렌알킬에테르, 폴리글리콜디에테르, 라우로일디에탄올아마이드, 지방산, 이소프로판올아마이드, 말티톨히드록시지방산에테르, 알킬화 다당, 알킬글루코시드, 슈가에스테르 등의 비이온성 활성제와, 친유형 글리세린모노스테아레이트, 자기유화형 글리세린모노스테아레이트, 폴리글리세린모노스테아레이트, 폴리글리세린알킬레이트, 소르비탄모노올레이트, 폴리에틸렌글리콜모노스테아레이트, 폴리옥시에틸렌소르비탄모노올레이트, 폴리옥시에틸렌세틸에테르, 포리옥시에틸렌화 스테롤, 폴리옥시에틸렌화 라놀린, 폴리옥시에틸렌화 밀랍, 폴리옥시에틸렌경화 피마자유 등의 비이온성 계면활성제와, 스테아르산나트륨, 팔미트산칼륨, 세틸황산나트륨, 라우릴인산나트륨, 팔미트산트리에탄올아민, 폴리옥시에틸렌라우릴인산나트륨, N-아실글루타민산나트륨, 팔미트산나트륨, 라우르산나트륨, 라우릴황산칼륨, 알킬황산트리에탄올아민에테르, 선형 도데실벤젠황산, 폴리옥시에틸렌경화 피마자유 말레산, 아실메틸타우린산 등의 음이온 계면활성제와 염화스테아릴디메틸벤질암모늄, 염화스테아릴트리메틸암모늄, 스테아릴트리메틸암모늄클로라이드, 염화벤잘코늄, 라우릴아민옥사이드 등의 양이온 계면활성제 및 염화알킬아미노에틸글리신액, 레시틴 등의 양성 계면활성제 등을 예시할 수 있다.Examples of the surfactant include sorbitan monolaurate, sorbitan monopalmitate, sorbitan sorbitan sulphate, sorbitan sorbate trioleate, polyoxyethylene sorbitan monolaurate, polyoxetylene sorbitan monostearate and polyethylene B, such as glycol monooleate, polyethylene glycol alkylate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanol amide, fatty acid, isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, and sugar ester Thermophilic active agent, lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerol monostearate, polyglycerin alkylate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate , Polyoxyethylene cetyl ether, polyoxyl Nonionic surfactants such as ethylene sterol, polyoxyethylenated lanolin, polyoxyethylenated beeswax and polyoxyethylene-cured castor oil, sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, and palmitic acid Triethanolamine, sodium polyoxyethylene lauryl phosphate, sodium N-acyl glutamate, sodium palmitate, sodium laurate, potassium lauryl sulfate, alkyl ethanol triethanolamine ether, linear dodecylbenzene sulfate, polyoxyethylene hardened castor oil Anionic surfactants such as maleic acid and acylmethyltauric acid, cationic surfactants such as stearyldimethylbenzyl ammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium chloride, benzalkonium chloride and laurylamine oxide and alkylaminoethyl chloride Amphoteric surfactants, such as glycine liquid and lecithin, etc. can be illustrated.
상기 방부제로는 안식향산염, 살리실산염, 소르브산염, 데하이드로아세트산염, 파라옥시안식향산에스테르, 2,4,4-트리클로로-2-히드록시디페닐에테르, 3,3,4-트리클로로카바닐리드, 염화벤잘코늄, 히노키티올, 레소르신, 에탄올 등을 예시할 수 있다.Examples of the preservative include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4,4-trichloro-2-hydroxydiphenyl ether, 3,3,4-trichlorocarba Nilide, benzalkonium chloride, hinokithiol, resorcin, ethanol, etc. can be illustrated.
상기 보습제는 글리세린, 에리스리톨, 크실리톨, 말티톨글리세린, 프로필렌글리콜, 1,3-부틸렌글리콜, 소르비톨, 폴리글리세린, 폴리에틸렌글리콜, 1,2-펜탄디올, 이소프렌글리콜 등의 다가 알콜류와 아미노산, 유산나트륨, 피롤리돈카르복실산나트륨 등의 NMF성분과 크실로글루칸, 모과씨, 카라기난, 펙틴, 만난, 카드란, 갈락탄, 델만탄황산, 글리코켄, 케라탄황산, 콘드로이틴, 뮤코이틴황산, 케라토황산, 콘드로이틴, 뮤코이틴황산, 케라토황산, 로커스트빈검, 숙시노글루칸, 카로님산(Calonym acid), 히알론산, 헤파란황산, 히알론산나트륨, 콜라겐, 뮤코다당류, 콘드로이틴황산 등의 수용성 고분자 물질과 디메틸폴리시록산, 메틸페닐시록산 등의 실리콘류 및 유산균ㆍ비피더스균 등의 배양상청 등을 예시할 수 있다.The moisturizing agent, polyhydric alcohols such as glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerol, polyethylene glycol, 1,2-pentanediol, isoprene glycol, amino acids, lactic acid NMF components such as sodium and sodium pyrrolidone carboxylate, xyloglucan, quince seed, carrageenan, pectin, mannan, cedlan, galactan, delmantan sulfate, glycoken, keratan sulfate, chondroitin, mucoitin sulfate , Keratosulfate, chondroitin, mucoitin sulfate, keratosulfate, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharide, chondroitin sulfate The water-soluble high molecular substance of the above, silicones, such as dimethyl polysiloxane and methylphenyl siloxane, and culture supernatant, such as lactic acid bacteria and bifidus bacteria, etc. are mentioned.
상기 증점제로는 알긴산나트륨, 키산탄검, 규산알루미늄, 모과종자 추출물, 아라비아검, 히드록시에틸구아검, 카르복실메틸구아검, 구아검, 텍스트란, 트라가칸스검(tragacanth gum), 전분, 키틴, 키토산, 카르복시메틸키틴, 한천(寒天) 등의 천연고분자 물질과 셀룰로오스, 히드록시프로필셀룰로오스, 메틸히드록시프로필셀룰로오스, 메틸셀룰로오스, 카르복시메틸셀룰로오스, 히드옥시엘틸셀룰로오스, 가용성 전분, 양이온화 셀룰로오스 등의 반합성 고분자 물질과 카르복시비닐폴리머, 폴리비닐알콜, 폴리비닐피롤리돈, 비닐알콜ㆍ아세트산비닐 공중합체 등의 합성고분자 물질 등을 예시할 수 있다.Examples of the thickener include sodium alginate, chitantan gum, aluminum silicate, quince seed extract, gum arabic, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, textan, tragacanth gum, starch, Natural polymer materials such as chitin, chitosan, carboxymethyl chitin and agar, cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxyoxytyl cellulose, soluble starch, cationic cellulose, etc. And synthetic polymer materials such as semisynthetic high molecular material, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, vinyl alcohol and vinyl acetate copolymer.
상기 산화방지제로는 디부틸히드록시톨루엔, 부틸히드롯시아니솔, 몰식자산프로필, 아스코르브산 등을 예시할 수 있다.Examples of the antioxidants include dibutyl hydroxytoluene, butyl hydroxycyanisole, molybdenum propyl, ascorbic acid and the like.
킬레이트제로는 에데트산2나트륨, 에틸렌디아민4아세트산염, 피롤인산염, 헥사메타인산염, 쿠엔산, 주석산, 글루콘산 등을 예시할 수 있으며, pH 조정제로는 수산화나트륨, 트리에탄올아민, 쿠엔산, 쿠엔산나트륨, 붕산, 붕사, 인산수소칼륨 등을 각각 예시할 수 있다.Examples of the chelating agent include disodium edetic acid, ethylenediamine tetraacetic acid, pyrrole phosphate, hexametaphosphate, quenoic acid, tartaric acid, gluconic acid, and the like, and pH adjusting agents include sodium hydroxide, triethanolamine, quenoic acid, and cuenoic acid. Sodium, boric acid, borax, potassium hydrogen phosphate, etc. can be illustrated, respectively.
상기 자외선흡수ㆍ산란제로는 파라아미노안식향산계 자외선 흡수제, 아트라닐산계 자외선 흡수제, 살리실산계 자외선 흡수제, 계피산계 자외선 흡수제, 벤조페논계 자외선 흡수제, 당계 자외선 흡수제, 3-(4-메틸벤질리덴)-d-캠퍼, 3-벤질리덴-d, 1-캠퍼, 우로칸산(urocanic acid), 우로칸산에틸에스테르, 2-페닐-5-메틸벤벤즈옥사졸, 2,2-히드록시-5-메틸페닐벤조트리아졸, 2-(2-히드록시-5-t-옥틸페닐)벤조트리아졸, 2-(2-히드록시-5-메틸페닐)벤조트리아졸, 디벤즈알라진(dibenzalazine), 디아니소일메탄(dianisoylmethane), 4-메톡시-4-t-부틸벤조일메탄, 5-(3,3-디메틸-2-노르보르닐리덴)-3-펜탄-2-온, 2-히드록시-4-메톡시벤조페논, 옥틸디메틸파라아미노벤조에이트, 에틸헥실파라메톡시사이나메이트, 산화티탄, 카올린, 탤크 등을 예시할 수 있다.As said ultraviolet absorber and scattering agent, a paraamino benzoic acid type ultraviolet absorber, an atlanic acid type ultraviolet absorber, a salicylic acid type ultraviolet absorber, a cinnamic acid type ultraviolet absorber, a benzophenone type ultraviolet absorber, a sugar type ultraviolet absorber, 3- (4-methylbenzylidene)- d-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenbenoxazole, 2,2-hydroxy-5-methylphenylbenzo Triazole, 2- (2-hydroxy-5-t-octylphenyl) benzotriazole, 2- (2-hydroxy-5-methylphenyl) benzotriazole, dibenzalazine, dianisoylmethane (dianisoylmethane), 4-methoxy-4-t-butylbenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, 2-hydroxy-4-meth Oxy benzophenone, octyl dimethyl para amino benzoate, ethylhexyl para methoxy phosphate, titanium oxide, kaolin, talc and the like.
상기 비타민류로는 비타민A 및 그 유도체와 비타민B 6 염산염, 비타민B 6 트리팔미테이트, 비타민B 6 디옥타노에이트, 및 비타민B 6 그유도체, 비타민B 12, 비타민B 15 및 그 유도체 등의 비타민B류와 아스코르브산, 아스코르브산황산에스테르 및 그 염, 아스코르브산인산에스테르 및 그 염, 아스코르브산디팔미테이트류, 아스코르브산글루코시드, 아실아스코르브산글루코시드, α-토코페놀, β-토코페놀, γ-토 코페놀, 비타민E 아세테이트 등의 비타민E류와 그 밖에 비타민D류, 비타민H, 판토텐산, 판테틴, 비타민F, 비타민K, 비타민P, 비타민U, 카르니틴, 페롤산, γ-오리자놀, α-리포산, 오로트산 및 그들의 유도체 등을 예시할 수 있다.Such as the vitamins include vitamin A and its derivatives, and vitamin B 6 hydrochloride, vitamin B 6 tree palmitate, vitamin B 6 di-octanoate, and the vitamin B 6 derivative thereof, vitamin B 12, vitamin B 15 and its derivatives Vitamin B, ascorbic acid, ascorbic acid sulfate and salts thereof, ascorbic acid phosphate ester and salts, ascorbic acid dipalmitates, ascorbic acid glucoside, acyl ascorbic acid glucoside, α-tocophenol, β-tocophenol, Vitamin E, such as γ-tocophenol and vitamin E acetate, and other vitamins D, vitamin H, pantothenic acid, panthetin, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, peroleic acid, γ-orizanol, α-lipoic acid, orotic acid and derivatives thereof can be exemplified.
상기 아미노산류로는 글리신, 알라닌, 발린, 로이신, 이소로이신, 세린, 트레오닌, 페닐알라닌, 티로신, 아스파라긴, 글루타민, 타우린, 트립토판, 시스틴, 시스테인, 메티오닌, 히드록시프롤린, 아스파라긴산, 글루탐산, 아르기닌, 히스티딘, 라이신 및 그들의 유도체 등을 예시할 수 있다.The amino acids include glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, asparagine, glutamine, taurine, tryptophan, cystine, cysteine, methionine, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine Lysine, derivatives thereof, and the like.
상기 항균제로는 안식향산, 살리실산, 소르브산, 라라옥시안식향산알킬에스테르, 헥사크로로펜 등을 예시할 수 있다.Examples of the antimicrobial agent include benzoic acid, salicylic acid, sorbic acid, laraoxybenzoic acid alkyl ester, hexacrofen, and the like.
상기 해조추출물로는 갈조, 홍조, 녹조, 남조 등으로 부터의 추출액이 있고, 구체적으로는 다시마, 켈프(kelp), 미역, 녹미채, 우뭇가사리, 산호말, 팔마리아, 김, 파래, 구멍갈파래, 아스코필럼(Ascophyllum), 퓨커스(Fucus), 큰실말, 오키나와큰실말, 히만탈리아(Himanthalia)등으로 부터의 추출물을 예시할 수 있다.The seaweed extracts include extracts from brown algae, red algae, green algae, south algae, and the like, specifically kelp, kelp, seaweed, green cabbage, sea urchin, coral horse, palmaria, seaweed, green seaweed, and green onions, Examples of extracts from Ascophyllum, Fucus, large horsetail, Okinawa large horsetail, Himanthalia and the like can be exemplified.
상기 각종 약제로는 니코틴산아미드, 니코틴산벤질, γ-오리자놀, 알란트린, 글리시리진산(염), 글리시레틴산 및 그 유도체, 히노키티올, 비사보롤, 유카르프톤, 티몰, 이노시톨, 사이코사포닌, 인삼 사포닌, 수세미 사포닌, 무환자나무사포닌 등의 사포닌류, 판토테닐에틸에테르, 에티닐에스라디올, 트라넥삼산, 알부틴, 세파란틴, 플라센타엑기스 등을 예시할 수 있다.Examples of the various agents include nicotinic acid amide, nicotinic acid benzyl, γ-orizanol, allantrin, glycyrrhizin acid (salt), glycyrrhetinic acid and derivatives thereof, hinokithiol, bisabolol, eucarpton, thymol, inositol, psychosaponin, Saponins, such as ginseng saponin, a scrubber saponin, and an aquatic tree saponin, pantothenyl ethyl ether, ethynyl esradiol, a tranexamic acid, arbutin, a separanthin, a placenta extract, etc. can be illustrated.
하기 실시예들은 나노에멀전을 함유시켜 다음에 기재된 조성 및 함량으로 통상적인 방법에 따라 영양화장수, 헤어샴푸, 바디샴푸, 비누를 제조하는 실시예에 관한 것이다.The following examples pertain to examples which contain nanoemulsions to produce nutrient cosmetics, hair shampoos, body shampoos, soaps according to conventional methods in the compositions and contents described below.
(영양 화장수를 제조하는 일 실시예)(Example of preparing a nutritional lotion)
(헤어샴푸를 제조하는 일 실시예)(Example of Making Hair Shampoo)
(바디샴푸를 제조하는 일실시예)(Example of preparing a body shampoo)
(비누를 제조하는 일실시예)(Example of Making Soap)
상기와 같은 성분 및 함량으로 제조된 영양화장수, 헤어삼퓨, 바디삼퓨, 비누들은 자유라디칼의 스케빈저로 적합한 형태의 항산화제이며 항균 항취능력이 우수한 백금콜로이드가 함유되어 있으므로 자유라디칼의 스케빈저로 적합한 형태의 항산화제로서 유해한 옥시라디칼, 특히 초산화물과 과산화수소를 효율적으로 제거할 수 있으며,Nutrients, hair shampoo, body shampoo, and soaps prepared with the same ingredients and contents are free radical scavengers, and are suitable antioxidants and contain platinum colloids with excellent antibacterial and deodorizing ability. As a suitable form of antioxidant, it can efficiently remove harmful oxyradicals, especially superoxides and hydrogen peroxide,
제조비용이 저렴하면서도 안정하고 혈액-뇌 장벽을 교차하여 조직에 침투하는 능력과 같은 유리한 약리학적 성질을 가진다.The cost of manufacture is low, yet stable and has advantageous pharmacological properties such as the ability to penetrate tissues across the blood-brain barrier.
상기와 같은 본 발명은 초산화물 (Super oxide)과 같은 자유라디칼에 의해서 생성된 세포 또는 조직손상과 관련하여 자유라디칼의 스케빈저로 적합한 형태의 항산화제이며 항균 항취능력이 우수한 백금콜로이드를 제조한 후, As described above, the present invention provides a platinum colloid having excellent antibacterial and deodorizing ability as a scavenger of free radicals related to cell or tissue damage produced by free radicals such as super oxide. after,
이와같이 제조된 백금콜로이드의 농도를 1내지 100ppm의 저농도로 조절하여 바디샴푸, 헤어샴푸, 화장수, 헤어트리트먼트 및 비누 등의 바디용품제조시 첨가하여 줌으로써 By adjusting the concentration of the platinum colloid prepared in this way to a low concentration of 1 to 100ppm by adding in the manufacture of body products such as body shampoo, hair shampoo, lotion, hair treatment and soap
항산화기능 및 항균, 항취능력이 뛰어난 바디용품이 제조된다.Body products with excellent antioxidant function, antibacterial and anti-odor ability are manufactured
따라서, 본 발명에 의해 제조된 영양화장수, 헤어삼퓨, 바디삼퓨, 비누들과 같은 바디용품을 사용하게 되면 백금콜로이드가 가지고 있는 자유라디칼의 스케빈저로 적합한 형태의 항산화제로서 유해한 옥시라디칼, 특히 초산화물과 과산화수소를 효율적으로 제거할 수 있는 효과와 Therefore, when using the body products such as nutrient cosmetics, hair shampoo, body shampoo, soaps prepared by the present invention as scavengers of free radicals possessed by platinum colloids, oxyradicals, which are harmful as antioxidants, are particularly suitable. To effectively remove superoxide and hydrogen peroxide
제조비용이 저렴하면서도 안정하고 혈액-뇌 장벽을 교차하여 조직에 침투하는 능력과 같은 유리한 약리학적 성질과,Advantageous pharmacological properties such as low cost of manufacture, stable and ability to penetrate tissues across the blood-brain barrier,
매우 우수한 항균, 항취능력의 발현으로 이들 바디용품에 들어가는 각종 원료 중 유지류, 계면활성제, 향료, 비타민들의 산패를 막아주어 이들 고유의 성질을 잃지 않도록 하여 주고 각종 유익한 성분의 파괴를 막아줌은 물론 유리한 약리활성작용으로 피부 및 모발등에 영양이 그대로 전달되어 피부노화가 방지되고 항상 깨끗하며 위생적인 건강한 신체를 유지할 수 있게 하여 준다.The excellent antibacterial and deodorizing ability prevents the fat and oil of oils, surfactants, fragrances, and vitamins from various raw materials in these body products, so that they do not lose their own properties and prevent the destruction of various beneficial ingredients. With pharmacological activity, nutrients are delivered to the skin and hair as it is, preventing skin aging and maintaining a healthy body that is always clean and hygienic.
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