KR101987559B1 - A cosmetic composition having excellent skin moisturizing effect - Google Patents

Abstract

The present invention relates to a cosmetic composition having an excellent moisturizing effect. According to an embodiment of the present invention, the cosmetic composition comprises mixtures of hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid as the active ingredients, wherein the hyaluronic acid mixture comprises hyaluronic acid with a molecular weight of 2 to 10 kDa, sodium hyaluronate of a molecular weight of 50 to 3,000 kDa, and sodium hyaluronate crosspolymer with a molecular weight of more than 3,000 kDa.

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition having excellent skin moisturizing effect,

The present invention relates to a cosmetic composition having excellent skin moisturizing effect.

Hyaluronic acid (HA) is a polymer compound in which N-acetyl glucosamine and gluconic acid are alternately bound, and 50% of the total hyaluronic acid present in the human body is distributed in the skin . In particular, the reduction of hyaluronic acid in the skin is suggested to be related to the qualitative change of the skin due to aging, and the anti-aging effect of the retinoid is also known to affect hyaluronic acid. In addition, in the dermatology, the skin is improved by injecting into the dermis for the purpose of improving the skin texture or improving the wrinkles. Hyaluronic acid is an important component of the extracellular matrix in the epidermis as well as in the dermis.

In addition to physical roles supporting tissue structure, hyaluronic acid plays various roles such as control of epidermal proliferation and differentiation, maintenance of water homeostasis, promotion of wound healing, homeostasis of epidermal permeation barrier, and immune response, .

Recently, it has been known that the molecular weight of hyaluronic acid has different effects on the structure and function of epidermis. Hyaluronic acid with a molecular weight of 25-100 kDa promotes proliferation and cell migration of keratinocytes and application of medium sized hyaluronic acid of 50-400 kDa to the skin prevents skin atrophy caused by aged skin and steroid treatment, It is reported that normal thickness can be restored. In addition, hyaluronic acid having a high molecular weight of 600 kDa or more regulates differentiation of keratinocytes. It is also known that polymer hyaluronic acid promotes endothelial cell proliferation and low molecular weight hyaluronic acid promotes angiogenesis through proliferative activity.

A prior art related to the present invention is disclosed in Korean Patent Publication No. 10-1737446 (published on Feb. 27, 201, entitled Cosmetic composition for skin moisturizing).

It is an object of the present invention to provide a cosmetic composition which is excellent in percutaneous penetration power of an active ingredient when applied to the skin, can moisturize the skin for a long time, and has an excellent skin moisture retaining effect.

Another object of the present invention is to provide a cosmetic composition free from skin irritation and harmless to human body.

It is still another object of the present invention to provide a cosmetic composition which is excellent in feeling and stability in formulation.

One aspect of the present invention relates to a cosmetic composition having excellent skin moisturizing effect. In one embodiment, the cosmetic composition comprises a mixture of hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid as an active ingredient, wherein the hyaluronic acid mixture comprises A hyaluronic acid having a molecular weight of 2 to 10 kDa, sodium hyaluronate having a molecular weight of 50 to 3,000 kDa and a sodium hyaluronate crosspolymer having a molecular weight of 3,000 kDa or more do.

In one embodiment, the hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid mixture may be included in a weight ratio of 1: 1 to 3: 0.1 to 8.

In one embodiment, the hyaluronic acid mixture may comprise hyaluronic acid, sodium hyaluronate, and sodium hyaluronate crosspolymer in a weight ratio of 1: 0.1-5: 1-15.

In one embodiment, 0.1 to 5 wt% of hydrolized glycosaminoglycan, 0.1 to 8 wt% of glyceryl glucoside, and 0.001 to 30 wt% of a hyaluronic acid mixture may be included relative to the total weight of the cosmetic composition.

In one embodiment, the cosmetic composition may be a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, have.

In one embodiment, the cosmetic composition comprises at least one of an oil-in-water (O / W), a water-in-oil (W / O), a water-in- / S), Oil-in-Water-in-Oil (O / W / O) or Water-in-Oil-in-Water (W / O / W) .

The cosmetic composition of the present invention is excellent in transdermal penetration ability of an active ingredient when applied to skin and has a long-term skin moisture content, dermal moisturizing persistence and transepidermal water loss (TEWL) reduction effect And is free of skin irritation, harmless to human body, and can be excellent in feeling and stability of formulation.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing changes in the moisture content of the skin over time according to the examples of the present invention and the comparative cosmetic composition of the present invention applied to the skin of the subjects. FIG.
FIG. 2 is a graph showing changes in moisture content of skin dermis over time, by applying the examples according to the present invention and the comparative cosmetic composition according to the present invention to the skin of the subjects.
FIG. 3 is a graph showing changes in the amount of water-loss of light-skinned skin according to the present invention and the time course of application of the cosmetic composition of the present invention to the skin of a subject.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed.

Cosmetics  Composition

One aspect of the present invention relates to a cosmetic composition having excellent skin moisturizing effect. In one embodiment, the cosmetic composition comprises a mixture of hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid as an active ingredient, wherein the hyaluronic acid mixture comprises A hyaluronic acid having a molecular weight of 2 to 10 kDa, sodium hyaluronate having a molecular weight of 50 to 3,000 kDa and a sodium hyaluronate crosspolymer having a molecular weight of 3,000 kDa or more do.

When the hydrolyzed glycosaminoglycan is included, the transdermal penetration power of the active ingredient is improved to further improve the skin moisturizing effect.

In one embodiment, the hydrolized glycosaminoglycan may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability may not be deteriorated and the moisturizing effect may be excellent. For example, 0.1 to 3% by weight.

Glyceryl glucoside is a substance related to the activation of Aquaporins (AQPs), which is a water channel, and is known to activate AQP3, an excellent water channel in the epidermis among 13 known AQPs. When the glyceryl glucoside is contained, the moisture-retaining ability can be further improved. In addition, it has low molecular weight and can easily pass through the cell wall of skin. It has excellent feel and gives a feeling of lightness and freshness without stickiness when applied to skin. In addition, it has excellent freezing preservation ability and safety, has excellent self-repellency, and is excellent in skin-affinity.

In one embodiment, the glyceryl glucoside may be included in an amount of 0.1 to 8% by weight based on the total weight of the cosmetic composition. Within the above range, the feeling of use and the moisturizing effect can be excellent without lowering the formulation stability. For example, 0.1 to 5% by weight.

The hyaluronic acid mixture, together with collagen and elastin, acts as one of the skin components. In addition, hyaluronic acid is a major constituent of the dermis in the skin and is known to be involved in growth, division, and migration of cells as well as maintaining water retention and intercellular spacing as well as water retention ability.

The hyaluronic acid mixture of the present invention comprises hyaluronic acid having a molecular weight of 2 to 10 kDa, sodium hyaluronate having a molecular weight of 50 to 3,000 kDa and a sodium hyaluronate crosspolymer having a molecular weight of more than 3,000 kDa (Sodium hyaluronate crosspolymer).

The hyaluronic acid having a molecular weight of 2 to 10 kDa may have a structure represented by the following formula (1).

[Chemical Formula 1]

The hyaluronic acid having the above molecular weight may have moisturizing and hyaluronic acid synthesis promoting effect in the skin.

The sodium hyaluronate having a molecular weight of 50 to 3,000 kDa and the sodium hyaluronate cross polymer having a molecular weight of more than 3,000 kDa may have a structure as shown in the following Chemical Formula 2.

(2)

The sodium hyaluronate having a molecular weight of 50 to 3,000 kDa may have moisturizing and hyaluronic acid synthesis promoting effect in the skin.

The sodium hyaluronate crosspolymer having a molecular weight of more than 3,000 kDa can form a moisture film on the skin surface. For example, the molecular weight of the sodium hyaluronate crosspolymer may be greater than 3,000 kDa and 100,000 kDa.

In one embodiment, the hyaluronic acid mixture may be included in an amount of 0.001 to 30% by weight based on the total weight of the cosmetic composition. When included in the above range, it is possible to minimize tackiness without deteriorating formulation stability, and is excellent in feeling of use. Further, when applied to the skin, the skin moisture content, dermal moisture retention and transepidermal water loss (TEWL) The power effect can be excellent. For example, 0.05 to 20% by weight. For example, 0.1 to 10% by weight.

In one embodiment, the hyaluronic acid mixture may comprise hyaluronic acid, sodium hyaluronate, and sodium hyaluronate crosspolymer in a weight ratio of 1: 0.1-5: 1-15. When included in the above weight ratio, the formulation stability of the cosmetic composition is excellent, tackiness can be minimized, the feeling of use is excellent, an unpredictable synergistic effect occurs between hyaluronic acid mixture components, and skin moisture content, Can be maintained for a long time, and the amount of water-loss of the hard skin can be reduced. For example, in a weight ratio of 1: 0.5 to 3: 2 to 10.

In one embodiment, the hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid mixture may be included in a weight ratio of 1: 0.5 to 3: 0.1 to 8. When the cosmetic composition of the present invention is contained in the above weight ratio, the cosmetic composition of the present invention is excellent in formulation stability, minimizes tackiness, and is excellent in feeling of use and has an unpredictable synergistic effect between the above- The water content and the skin dermis moisture content can be maintained for a long time, and the amount of water-loss of the epidermis can be reduced. For example, in a weight ratio of 1: 0.5 to 1.5: 0.2 to 6.

In one embodiment, the cosmetic composition may further comprise ingredients that can be formulated into conventional cosmetic compositions. It may further comprise water, a solubilizer, a surfactant, a moisturizer, an agitator, a pH adjuster, a preservative, an antioxidant, a sequestering agent, a bactericide, an anti-inflammatory agent, an antimicrobial agent, a solubilizing agent or a flavoring agent, .

Surfactants that can be included in the cosmetic composition according to the present invention include anionic surfactants such as ammonium laurylsulfosuccinate and ammonium lauryl sulfate and nonionic surfactants such as polyoxyethylene alkyl ether and polyoxyethylene fatty acid ester This is possible. Also, cationic surfactants such as tertiary aliphatic amine salts, alkyltrimethylammonium chloride and the like and amphoteric surfactants such as betaine, amide betaine and the like can be used.

The moisturizing agent may be sodium hyaluronate, glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol, etc. The thickener may be polyacrylate, xanthan gum, methyl cellulose, hydroxyethyl cellulose , Carrageenan, carboxymethylcellulose, hydroxymethylcellulose, and the like. The pH adjuster may specifically include citric acid, sodium hydroxide, triethanolamine, sodium citrate, phosphoric acid, sodium phosphate, lactic acid, and the like.

The preservative may be benzoic acid, paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, DMDM, and the like. Specific examples of the antioxidant include dibutylhydroxytoluene and ascorbic acid .

The metal ion sequestering agent may be disodium ethylenediaminetetraacetate, tetranodium ethylenediaminetetraacetate, and the like. Specifically, the disinfectant may be chlorhexidine gluconate, quaternary ammonium salt, pyrrothonol amine, zinc pyrithione suspension, urethropropylbutyl Carbamate, salicylic acid, and the like.

Examples of the anti-inflammatory component include monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, allantoin, and mixtures thereof. The antibacterial (antimicrobial) component specifically includes phenoxyethanol, chlorhexidine, chlorhexidine gluconate, benzoic acid and its salts, benzyl Alcohols, salicylic acid, trichlorocarbane, zinc pyrithione suspensions, and mixtures thereof.

The solubilizing agent may specifically be a phage 60-hydrogenated castor oil or the like, and the flavoring agent may be a conventional ingredient used in the cosmetic composition field of the present invention.

In one embodiment, the cosmetic composition may be a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, cleansing oil, foundation, wax or spray formulation. For example, Ampoules, Flexible lotion, Nourishing lotion, Nourishing cream, Massage cream, Essence, Eye cream, Cleansing cream, Cleansing foam, Cleansing water, Pack, Spray, Powder, Fact, Lip gloss, Lipstick, Shadow, Shampoo and Conditioner And the like.

In one embodiment, the cosmetic composition comprises at least one of an oil-in-water (O / W), a water-in-oil (W / O), a water-in- / S), Oil-in-Water-in-Oil (O / W / O) or Water-in-Oil-in-Water (W / O / W) .

The cosmetic composition of the present invention is excellent in transdermal penetration ability of an active ingredient when applied to skin and has a long-term skin moisture content, dermal moisturizing persistence and transepidermal water loss (TEWL) reduction effect And is free of skin irritation, harmless to human body, and can be excellent in feeling and stability of formulation.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. It is to be understood, however, that the same is by way of illustration and example only and is not to be construed in a limiting sense.

Example  And Comparative Example

Example  1 to 3 and Comparative Example  1-5

The components and the contents according to the following Table 1 were applied to prepare cosmetic compositions having cream formulations.

Experimental Example  One. On feeling  Comparative experiment for

For the cosmetic compositions of Examples 1 to 3 and Comparative Examples 1 to 5, stickiness, comprehensive feeling of use and moisturizing power were measured, and the results are shown in Table 2 below. The sensory evaluation was obtained through 20 subjects with healthy skin. The attributes of each item were '-' for 'no' and '+++' for 'very many'. The values between them are indicated as '+ (feel a little)' and '++ (feel somewhat)'.

Referring to Table 2, Examples 1 to 3 showed less tackiness and excellent moisturizing feeling and excellent feeling of use. On the other hand, in the case of Comparative Examples 1 to 3 in which the hyaluronic acid mixture component of the present invention was solely applied, it was found that the moisturizing feel was reduced or the stickiness was generated. It was also found that Comparative Examples 4 and 5, which did not contain the hydrolized glycosaminoglycan and glyceryl glucoside, respectively, of the present invention were reduced in stickiness, moisturizing feeling, or feeling of use.

Experimental Example  2. Skin moisture content over time

The skin moisture content according to the time course (before use, immediately after use, after 4 hours, and after 24 hours) of the Example 2 and the Comparative Example 3 was measured, and the results are shown in Fig. 1 Respectively. The skin moisture content test was conducted on 20 adult women aged 19 to 59 years. The measurement was performed by using a Corneometer 825, which measures the skin moisture content, in order to adapt to the measurement environment by taking the skin stability for about 30 minutes in a space of constant temperature and humidity (temperature 20 to 24 ° C., humidity 40 to 60% Respectively. The measured moisture content of the skin is A.U (Arbitrary Unit) and the measured value is proportional to the skin moisturizing value.

Referring to the results of FIG. 1, it can be seen that the skin moisture content of Example 2 is higher than that of the non-treated skin and Comparative Example 3.

Experimental Example  3. Skin moisture content over time

With respect to Example 2 and Comparative Example 3, the same subjects as in Experimental Example 2 were subjected to constant temperature and humidity conditions (temperature 20 to 24 ° C, humidity 40 to 60%) using Moisturemeter D compact, The skin dermis moisture content was measured and the results are shown in Fig. The measured moisture content of the dermis is in% and the measured value is proportional to the dermis moisture content.

Referring to FIG. 2, it can be seen that the dermal moisture content of Example 2 is higher than that of the non-dermal preparation and Comparative Example 3.

Experimental Example  4. Over time Light skin moisture loss  Measure

With respect to Example 2 and Comparative Example 3, the same subjects as in Experimental Example 2 were subjected to constant temperature and humidity conditions (temperature 20 to 24 ° C, humidity 40 to 60%) using a vapometer, The loss was measured and the results are shown in FIG. The measured unit of water loss of the hard-surface skin is g / m ² h. The measured values are proportional to the amount of water loss in the epidermis, indicating that the lower the measured value, the lower the water loss in the epidermis and the lower the water loss in the epidermis.

Referring to FIG. 3, it was found that the water-loss of the hard-skin layer was superior to that of the non-water-soluble group of Example 2 and that of the water-loss of the hard-skin layer.

Experimental Example  5: Formulation stability evaluation

The separation and discoloration degree of each of Examples 1 to 3 and Comparative Examples 1 to 5 were measured after storage at 50 ° C, 40 ° C, 25 ° C and 5 ° C for 4 weeks, respectively, and the results are shown in Table 3 . The degree of separation and discoloration of the product was classified into the following six grades and evaluated.

* Separation and discoloration evaluation criteria

4: Severely separated (discolored), 5: Severely separated (discolored), 2: slightly separated (discolored), 3: slightly separated (discolored)

The results are shown in Table 3. Referring to Table 3, the formulation stability of the cosmetic composition was excellent in Examples 1 to 3, and in Comparative Examples 1 to 5, the viscosity of the formulation increased, The stability of the formulation was deteriorated.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (6)

0.1 to 5% by weight of hydrolyzed glycosaminoglycan, 0.1 to 8% by weight of glyceryl glucoside and 0.001 to 30% by weight of a mixture of hyaluronic acid as an active ingredient In addition,
The hyaluronic acid mixture may contain hyaluronic acid having a molecular weight of 2 to 10 kDa, sodium hyaluronate having a molecular weight of 50 to 3,000 kDa and sodium hyaluronate having a molecular weight of 3,000 kDa or more hyaluronate crosspolymer) in a ratio of 1: 0.5 to 3: 2 to 10 by weight.
The cosmetic composition according to claim 1, wherein the hydrolyzed glycosaminoglycan, glyceryl glucoside, and hyaluronic acid mixture are contained in a weight ratio of 1: 1 to 3: 0.1 to 8.
delete delete The cosmetic composition according to claim 1, wherein the cosmetic composition is in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, Or a pharmaceutically acceptable salt thereof.
The cosmetic composition according to claim 1, wherein the cosmetic composition is at least one selected from the group consisting of Oil-in-Water (O / W), Water-in-Oil (W / O), Water-in- (W / O), Water-in-Water-in-Oil (W / O) Wherein the composition is a formulation.

Images