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JPS6485975A - Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative - Google Patents

Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative

Info

Publication number
JPS6485975A
JPS6485975A JP62228679A JP22867987A JPS6485975A JP S6485975 A JPS6485975 A JP S6485975A JP 62228679 A JP62228679 A JP 62228679A JP 22867987 A JP22867987 A JP 22867987A JP S6485975 A JPS6485975 A JP S6485975A
Authority
JP
Japan
Prior art keywords
ylmethyl
imidazole
novel
benzimidazole derivative
substituted benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62228679A
Other languages
English (en)
Other versions
JPH0587071B2 (ja
Inventor
Heruman Marugareeta Arufuonsu
Jiyan Etogaruto Furaine Edei
Shiyaruru San Jieraaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JPS6485975A publication Critical patent/JPS6485975A/ja
Publication of JPH0587071B2 publication Critical patent/JPH0587071B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP62228679A 1986-09-15 1987-09-14 Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative Granted JPS6485975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15

Publications (2)

Publication Number Publication Date
JPS6485975A true JPS6485975A (en) 1989-03-30
JPH0587071B2 JPH0587071B2 (ja) 1993-12-15

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62228679A Granted JPS6485975A (en) 1986-09-15 1987-09-14 Novel (1h-imidazole-1-ylmethyl) substituted benzimidazole derivative

Country Status (23)

Country Link
EP (1) EP0260744B1 (ja)
JP (1) JPS6485975A (ja)
KR (1) KR960014353B1 (ja)
CN (1) CN1020903C (ja)
AU (1) AU595064B2 (ja)
BG (1) BG61321B2 (ja)
CA (1) CA1323366C (ja)
CY (1) CY1803A (ja)
DE (1) DE3783107T2 (ja)
DK (1) DK174728B1 (ja)
ES (1) ES2053524T3 (ja)
FI (1) FI87781C (ja)
GR (1) GR3006841T3 (ja)
HK (1) HK123694A (ja)
HU (1) HU198039B (ja)
IE (1) IE60514B1 (ja)
IL (1) IL83892A (ja)
NO (1) NO167202C (ja)
NZ (1) NZ221729A (ja)
PH (1) PH25022A (ja)
PT (1) PT85692B (ja)
SU (1) SU1662350A3 (ja)
ZA (1) ZA876881B (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0320273A (ja) * 1988-11-29 1991-01-29 Janssen Pharmaceut Nv 皮膚の変調の処置法
WO1995004723A1 (fr) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
WO2002046186A1 (fr) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Dérivés thiazole substitués porteurs de groupes 3-pyridyl, procédé d'élaboration et leur utilisation
JP2006513162A (ja) * 2002-11-01 2006-04-20 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用方法
EP1681290A2 (en) 2000-11-17 2006-07-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
JP2008514704A (ja) * 2004-09-30 2008-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター(sarm)として有用な新規なベンゾイミダゾール誘導体
JP2008514707A (ja) * 2004-09-30 2008-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター(sarm)として有用な新規なベンゾイミダゾール誘導体
JP2013540145A (ja) * 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的cyp11b1阻害剤
JP2014531459A (ja) * 2011-09-30 2014-11-27 エンドゥ ファーマシューティカルズ,インコーポレイティド 癌処置用cyp17阻害剤としてのイミダゾール誘導体
JP2017014191A (ja) * 2015-07-06 2017-01-19 三星エスディアイ株式会社Samsung SDI Co., Ltd. 化合物、有機膜組成物、有機膜、およびパターン形成方法

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US4826862A (en) * 1988-02-12 1989-05-02 Janssen Pharmaceutica, N.V. Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
AU679119B2 (en) * 1993-09-30 1997-06-19 Yamanouchi Pharmaceutical Co., Ltd. Azole derivative and pharmaceutical composition thereof
TW401415B (en) * 1994-02-18 2000-08-11 Janssen Pharmaceutica Nv Enantiomerically pure (+)-liarozole
NZ279228A (en) * 1994-02-18 1997-11-24 Janssen Pharmaceutica Nv Laevorotarory imidazoyl-methyl benzimidazole derivatives (liarozole)
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
PT800519E (pt) * 1994-12-22 2004-03-31 Ligand Pharm Inc Compostos moduladores de receptores de esteroides e metodos
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
TW316902B (ja) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
PL322028A1 (en) * 1995-03-01 1998-01-05 Yamanouchi Pharma Co Ltd Derivatives of imidazoles and pharmaceutic composition containing them
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
US6166219A (en) * 1995-12-28 2000-12-26 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
UA53649C2 (uk) * 1996-06-27 2003-02-17 Янссен Фармацевтика Н.В. N-[4-(гетероарилметил)феніл]гетероариламіни, композиція на їх основі та спосіб її одержання, спосіб одержання сполук (варіанти)
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
DK1037880T3 (da) 1997-12-11 2004-11-15 Janssen Pharmaceutica Nv Anilider som retinsyremimetika
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ATE256666T1 (de) * 1999-06-04 2004-01-15 Elan Pharma Int Ltd Zusammensetzungen und methoden zur verhinderung des zelltods
RU2268258C2 (ru) 2000-03-16 2006-01-20 Ф.Хоффманн-Ля Рош Аг Производные карбоновых кислот в качестве антагонистов ip
CA2429437A1 (en) 2000-11-20 2002-05-23 Takeda Chemical Industries, Ltd. Imidazole derivatives, process for their preparation and their use
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
ATE404541T1 (de) * 2001-11-16 2008-08-15 Nippon Chemiphar Co Xanthinoxidaseinhibitoren
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
CA2562763A1 (en) 2004-04-23 2006-07-20 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
WO2007087518A2 (en) * 2006-01-24 2007-08-02 Janssen Pharmaceutica N.V. 2-substituted benzimidazoles as selective androgen receptor modulators (sarms)
WO2007095124A2 (en) 2006-02-10 2007-08-23 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草(集团)公司 造纸法再造烟叶半逆流多级萃取工艺
EP1992228A1 (en) * 2007-05-14 2008-11-19 Bayer CropScience AG Insecticidal substituted thiourea derivatives
WO2008147786A1 (en) * 2007-05-23 2008-12-04 Allergan, Inc. ((bicylicheteroaryl) imidazolyl) methylheteroaryl compounds as adrenergic receptor agonists
DE102009038950A1 (de) 2009-08-26 2011-03-03 Bayer Animal Health Gmbh Neue antiparasitäre Kombination von Wirkstoffen
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
CA3233464A1 (en) * 2021-10-04 2023-04-13 Bolt Biotherapeutics, Inc. Asymmetric bis-benzimidazole sting agonist immunoconjugates and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (ja) * 1980-10-23 1984-07-13 Pfizer
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0320273A (ja) * 1988-11-29 1991-01-29 Janssen Pharmaceut Nv 皮膚の変調の処置法
WO1995004723A1 (fr) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
US6420375B1 (en) 1997-02-21 2002-07-16 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
EP1681290A2 (en) 2000-11-17 2006-07-19 Takeda Pharmaceutical Company Limited Imidazole derivatives, production method thereof and use thereof
WO2002046186A1 (fr) 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Dérivés thiazole substitués porteurs de groupes 3-pyridyl, procédé d'élaboration et leur utilisation
JP2006513162A (ja) * 2002-11-01 2006-04-20 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用方法
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
JP2008514704A (ja) * 2004-09-30 2008-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター(sarm)として有用な新規なベンゾイミダゾール誘導体
JP2008514707A (ja) * 2004-09-30 2008-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター(sarm)として有用な新規なベンゾイミダゾール誘導体
JP2013540145A (ja) * 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的cyp11b1阻害剤
JP2014531459A (ja) * 2011-09-30 2014-11-27 エンドゥ ファーマシューティカルズ,インコーポレイティド 癌処置用cyp17阻害剤としてのイミダゾール誘導体
JP2017014191A (ja) * 2015-07-06 2017-01-19 三星エスディアイ株式会社Samsung SDI Co., Ltd. 化合物、有機膜組成物、有機膜、およびパターン形成方法

Also Published As

Publication number Publication date
DK479487A (da) 1988-03-16
JPH0587071B2 (ja) 1993-12-15
ES2053524T3 (es) 1994-08-01
FI87781C (fi) 1993-02-25
DK479487D0 (da) 1987-09-14
SU1662350A3 (ru) 1991-07-07
FI87781B (fi) 1992-11-13
KR960014353B1 (ko) 1996-10-15
IE60514B1 (en) 1994-07-27
EP0260744B1 (en) 1992-12-16
GR3006841T3 (ja) 1993-06-30
ZA876881B (en) 1989-04-26
AU595064B2 (en) 1990-03-22
PH25022A (en) 1991-01-28
NO167202B (no) 1991-07-08
FI873977A0 (fi) 1987-09-14
CN87106423A (zh) 1988-04-20
EP0260744A2 (en) 1988-03-23
KR880003935A (ko) 1988-06-01
DE3783107D1 (de) 1993-01-28
CN1020903C (zh) 1993-05-26
HUT45051A (en) 1988-05-30
PT85692A (en) 1987-10-01
NO873840D0 (no) 1987-09-14
IL83892A (en) 1991-11-21
IE872487L (en) 1988-03-15
EP0260744A3 (en) 1989-01-18
CA1323366C (en) 1993-10-19
BG61321B2 (bg) 1997-05-30
NO873840L (no) 1988-03-16
NZ221729A (en) 1989-07-27
PT85692B (pt) 1990-06-29
DE3783107T2 (de) 1993-04-22
DK174728B1 (da) 2003-10-06
FI873977A (fi) 1988-03-16
HU198039B (en) 1989-07-28
NO167202C (no) 1991-10-16
IL83892A0 (en) 1988-02-29
HK123694A (en) 1994-11-18
CY1803A (en) 1987-09-09
AU7838587A (en) 1988-04-14

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