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JPS6335623B2 - - Google Patents

Info

Publication number
JPS6335623B2
JPS6335623B2 JP57117311A JP11731182A JPS6335623B2 JP S6335623 B2 JPS6335623 B2 JP S6335623B2 JP 57117311 A JP57117311 A JP 57117311A JP 11731182 A JP11731182 A JP 11731182A JP S6335623 B2 JPS6335623 B2 JP S6335623B2
Authority
JP
Japan
Prior art keywords
compound
reaction
acid
formula
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57117311A
Other languages
English (en)
Japanese (ja)
Other versions
JPS597168A (ja
Inventor
Minoru Uchida
Makoto Komatsu
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP57117311A priority Critical patent/JPS597168A/ja
Priority to US06/510,241 priority patent/US4578381A/en
Priority to FI832425A priority patent/FI80022C/fi
Priority to AU16536/83A priority patent/AU552717B2/en
Priority to BE0/211114A priority patent/BE897208A/fr
Priority to CH3667/83A priority patent/CH654578A5/de
Priority to SE8303813A priority patent/SE462848B/sv
Priority to KR1019830003040A priority patent/KR900006401B1/ko
Priority to AT0245183A priority patent/AT385506B/de
Priority to ES523838A priority patent/ES523838A0/es
Priority to PT76980A priority patent/PT76980B/pt
Priority to DE3324034A priority patent/DE3324034A1/de
Priority to CA000431763A priority patent/CA1247624A/en
Priority to DK307883A priority patent/DK168288B1/da
Priority to NO832431A priority patent/NO164835C/no
Priority to PH29177A priority patent/PH21650A/en
Priority to FR8311179A priority patent/FR2530626B1/fr
Priority to NL8302390A priority patent/NL194165C/nl
Priority to GB08318174A priority patent/GB2123825B/en
Priority to ZA834901A priority patent/ZA834901B/xx
Priority to IT67731/83A priority patent/IT1203676B/it
Publication of JPS597168A publication Critical patent/JPS597168A/ja
Priority to ES530716A priority patent/ES8504724A1/es
Priority to ES530715A priority patent/ES530715A0/es
Priority to ES530714A priority patent/ES530714A0/es
Publication of JPS6335623B2 publication Critical patent/JPS6335623B2/ja
Priority to MX9203021A priority patent/MX9203021A/es
Priority to US07/937,382 priority patent/USRE34722E/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP57117311A 1982-07-05 1982-07-05 カルボスチリル誘導体 Granted JPS597168A (ja)

Priority Applications (26)

Application Number Priority Date Filing Date Title
JP57117311A JPS597168A (ja) 1982-07-05 1982-07-05 カルボスチリル誘導体
US06/510,241 US4578381A (en) 1982-07-05 1983-07-01 Carbostyril derivatives
FI832425A FI80022C (fi) 1982-07-05 1983-07-01 Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
DK307883A DK168288B1 (da) 1982-07-05 1983-07-04 Analogifremgangsmåde til fremstilling af carbostyrilderivater
BE0/211114A BE897208A (fr) 1982-07-05 1983-07-04 Composes de carbostyryle
CH3667/83A CH654578A5 (de) 1982-07-05 1983-07-04 Carbostyrilderivate und verfahren zu deren herstellung.
SE8303813A SE462848B (sv) 1982-07-05 1983-07-04 Karbostyrilderivat, foerfarande foer framstaellning daerav samt farmaceutiska kompositioner
KR1019830003040A KR900006401B1 (ko) 1982-07-05 1983-07-04 카르보스티릴 유도체의 제조방법
AT0245183A AT385506B (de) 1982-07-05 1983-07-04 Verfahren zur herstellung von neuen carbostyrilderivaten und deren salzen
ES523838A ES523838A0 (es) 1982-07-05 1983-07-04 Un nuevo derivado de carbostirilo.
PT76980A PT76980B (en) 1982-07-05 1983-07-04 Carbostyril derivatives
DE3324034A DE3324034A1 (de) 1982-07-05 1983-07-04 Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
CA000431763A CA1247624A (en) 1982-07-05 1983-07-04 Carbostyril derivatives
AU16536/83A AU552717B2 (en) 1982-07-05 1983-07-04 Carbostyril pharmaceuticals
NO832431A NO164835C (no) 1982-07-05 1983-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyril-derivater.
FR8311179A FR2530626B1 (fr) 1982-07-05 1983-07-05 Composes de carbostyryle
PH29177A PH21650A (en) 1982-07-05 1983-07-05 Carbostyril derivatives
NL8302390A NL194165C (nl) 1982-07-05 1983-07-05 Carbostyrilderivaten, werkwijzen ter bereiding daarvan en farmaceutische samenstellingen, die deze derivaten bevatten. Derivaten van chinolonyl-2-aminocarbonzuren en farmaceutische preparaten die deze derivaten bevatten.
GB08318174A GB2123825B (en) 1982-07-05 1983-07-05 Carbostyril derivatives
ZA834901A ZA834901B (en) 1982-07-05 1983-07-05 Carbostyril derivatives
IT67731/83A IT1203676B (it) 1982-07-05 1983-07-05 Derivati carbostirilici relativo procedimento di fabbricazione e composizione farmaceutica per il trattamento dell ulcera peptica a base di tali derivati
ES530714A ES530714A0 (es) 1982-07-05 1984-03-16 Un procedimiento para la preparacion de un derivado de carbostirilo
ES530716A ES8504724A1 (es) 1982-07-05 1984-03-16 Un procedimiento de preparacion de un derivado de carbostirilo
ES530715A ES530715A0 (es) 1982-07-05 1984-03-16 Un procedimiento de preparacion de un derivado de carbostirilo
MX9203021A MX9203021A (es) 1982-07-05 1992-06-19 Derivados de carbostirilo y composicion farmaceutica que los contiene.
US07/937,382 USRE34722E (en) 1982-07-05 1992-08-31 Quinoline amino acid derivatives of carbostyril compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57117311A JPS597168A (ja) 1982-07-05 1982-07-05 カルボスチリル誘導体

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP62314429A Division JPS63190879A (ja) 1987-12-11 1987-12-11 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
JPS597168A JPS597168A (ja) 1984-01-14
JPS6335623B2 true JPS6335623B2 (es) 1988-07-15

Family

ID=14708605

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57117311A Granted JPS597168A (ja) 1982-07-05 1982-07-05 カルボスチリル誘導体

Country Status (5)

Country Link
JP (1) JPS597168A (es)
KR (1) KR900006401B1 (es)
BE (1) BE897208A (es)
MX (1) MX9203021A (es)
ZA (1) ZA834901B (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012182A1 (en) * 1992-11-26 1994-06-09 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating disturbances of intestinal mucous membrane
US5480891A (en) * 1991-06-07 1996-01-02 Otsuka Pharmaceutical Co., Ltd. Method for treating diabetes mellitus
WO2005070892A1 (en) 2004-01-21 2005-08-04 Otsuka Pharmaceutical Co., Ltd. Amine salt of carbostyril derivative
CN103113294A (zh) * 2013-03-11 2013-05-22 浙江远力健药业有限责任公司 瑞巴派特的合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01308258A (ja) * 1989-04-27 1989-12-12 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
WO2013108644A1 (ja) * 2012-01-20 2013-07-25 京都府公立大学法人 レバミピドのアレルギー性結膜炎治療剤
KR101965804B1 (ko) * 2016-09-09 2019-04-05 김영훈 환제의 물성 개선용 미생물 발효제 및 이를 이용한 소화흡수를 위한 환제의 제조방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065572A (en) * 1976-02-13 1977-12-27 Merck & Co., Inc. Amino acids and esters thereof useful as antihypertensive agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480891A (en) * 1991-06-07 1996-01-02 Otsuka Pharmaceutical Co., Ltd. Method for treating diabetes mellitus
WO1994012182A1 (en) * 1992-11-26 1994-06-09 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating disturbances of intestinal mucous membrane
WO2005070892A1 (en) 2004-01-21 2005-08-04 Otsuka Pharmaceutical Co., Ltd. Amine salt of carbostyril derivative
EP2253619A1 (en) 2004-01-21 2010-11-24 Otsuka Pharmaceutical Co., Ltd. Amine salt of carbostyril derivative
CN103113294A (zh) * 2013-03-11 2013-05-22 浙江远力健药业有限责任公司 瑞巴派特的合成方法

Also Published As

Publication number Publication date
KR900006401B1 (ko) 1990-08-30
JPS597168A (ja) 1984-01-14
KR840005427A (ko) 1984-11-12
BE897208A (fr) 1984-01-04
ZA834901B (en) 1984-03-28
MX9203021A (es) 1992-07-01

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