JPS63277610A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, containing an extract prepared by extracting beer yeast fungal cells with absolute or hydrous ethanol, etc., and capable of suppressing depilation and promoting hair production. CONSTITUTION:A hair tonic in the form of shampoo, rinse, hair lotion, hair oil, pomade, liquid brilliantine, hair cream, hair tonic, etc., containing 0.001-5wt.% extract of beer yeast fungal cells with an organic solvent (preferably absolute or hydrous ethanol). In extraction, a dehydrated substance obtained by compressing beer yeast fungal cells with a filter press to provide a solid form with 20-30% moisture content of freeze-drying the fungal cells to afford dried fungal cells is used. An organic solvent in a volume of 0.1-5l based on 20g freeze-dried fungal cells is used to carry out the extraction at a temperature of room temperature - boiling point of the solvent for 1hr-3 weeks. Hormones, vitamins, crude drug extracts, menthol, perfumes, etc., can be contained in the above-mentioned hair tonic.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a hair nourishment containing a solvent extract of brewer's yeast, preferably a woody organic solvent extract.

(Conventional technology) ``Having thick hair throughout your life'' is a common desire of all humankind. For this reason, various types of hair loss products have been used to prevent hair loss and promote hair growth. No drug has yet been found that is truly effective in promoting hair growth.

(Problems to be Solved by the Present Invention) In view of the above circumstances, the present invention aims to provide an effective hair nourishing agent using brewer's yeast as a raw material.

(Means for Solving the Problems) As a result of intensive research to develop a truly effective hair nourishing agent, the inventors discovered a solvent for brewer's yeast, which had never been considered as a raw material for hair nourishing agents. The present invention was completed based on the discovery that the extract surprisingly has an extremely effective effect on promoting hair growth. That is, the present invention
This invention relates to a hair nourishing agent containing a solvent extract of beer yeast as an active ingredient.

The active ingredient here is "organic solvent extract of beer yeast cells" (hereinafter simply referred to as "beer yeast extract").

) means a component that transfers from beer yeast to an organic solvent when the beer yeast material is extracted with the organic solvent. This extract can be used in the form of a dry solid after removal of the solvent from the extract, or it can be used dissolved or suspended in the solvent. In the latter case, the extraction solvent is
In the hair nourishment of the present invention, it constitutes part of the base.

Examples of organic solvents include aliphatic or aromatic hydrocarbons such as hexane, benzene, toluene, petroleum ether, and liquid paraffin; aliphatic esters such as ethyl acetate, butyl acetate, propyl acetate, amyl acetate; Esters; aliphatic ketones, e.g. acetone, methyl ethyl ketone, acetylacetone; aliphatic ethers, e.g. diethyl ether, dimethyl ether; halogenated aliphatic hydrocarbons, e.g. chloroform, carbon tetrachloride; lower aliphatic alcohols, e.g. ,
Methanol, ethanol, impropatol, n-butanol, etc. can be used, but ethanol is most preferred for the reasons mentioned in ttP, provided that the solvent is hydrophilic such as a lower aliphatic ketone or alcohol. ,
A mixed solvent in which these and wood are mixed in any proportion can also be used.

In the following, when the solvent is once removed from the brewer's yeast extract and used as a dry product, any of the above-mentioned solvents can be used alone or in combination. However, when brewer's yeast extract is used dissolved or suspended in a solvent, it is necessary to use a solvent that does not have harmful effects on the human body, and in this case, ethanol or Preferably, aqueous ethanol is used.

During extraction, beer yeast cells are pressed using a filter press to form a solid or semi-solid product with a moisture content of 20 to 30%, or a dehydrated product that is freeze-dried to obtain dry cells is used for the extraction operation. It's convenient.

There is no particular limitation on the ratio of beer yeast cells to organic solvent, but from the viewpoint of extraction efficiency and convenience, it is recommended to use a ratio of 0.1 to 5 particles per 20 g of freeze-dried cells, in terms of freeze-dried cells. Good.

The extraction temperature may be any temperature from room temperature to the boiling point of the solvent, but even at low temperatures, a long period of time is required, and during that period,
The approximate time is 1 hour to 3 weeks.

Since brewer's yeast extract is not toxic to the human body, the amount of beer yeast extract that can be added to the hair nourishment is arbitrary, but it must be at a concentration that is effective as a hair nourishing ingredient, and even if the concentration exceeds a certain level, the effect will increase. Considering the necessary and sufficient conditions such as not being able to expect
-10% by weight, preferably o, o ot to 5% by weight
It is.

The bases used in the hair nourishing composition of the present invention include those commonly used in current hair nourishing cosmetics, such as retained water, ethanol, glycerin, ethylene glycol, propylene glycol, liquid paraffin, beeswax, higher fatty acids, Oils and fats, surfactants, disinfectants, etc. can be used.

The hair nourishing agent of the present invention includes known hair nourishing agents and hair conditioners used in conventional hair nourishing agents to the extent that the desired hair nourishing effect is not impaired.
It can contain ia acid components, such as female hormones, vitamins such as pantothenic acid, amino acids, crude drug extracts, photosensitive pigments, hinoki senol, menthol, resorcinol, humectants, fragrances, etc. There are so many things I can list.

Brewer's yeast, which is the raw material for the hair tonic of the present invention, is a yeast used in the production of beer, and is rich in vitamins and high-quality protein, and has been used as a nutritional supplement and health food under trade names such as "Ebios" since ancient times. Therefore, it is clear that there are no safety issues for humans and animals, but just to be safe, 50 g of freeze-dried bacterial cells of brewer's yeast were immersed in 5001 75% ethanol for one day and then heated for an additional 4 hours. The extract obtained by refluxing was concentrated and dried under reduced pressure, and the obtained extract was dissolved in 75% ethanol 100+1, and this was applied to 10 mice once a day for 7 days. ,
Compared with a control area in which only 75% ethanol was applied,
No abnormalities were observed on the skin.

The hair growth agent of the present invention is provided for hair growth in the form of shampoo, hair rinse, hair lotion, hair oil, pomade, liquid brilliantine, hair cream, hair tonic, and the like.

Next, examples of manufacturing the five-hair material of the present invention, test examples of its effects, and examples will be given, but these do not limit the scope and scope of the invention.

[Production example] ◇Production example 1 of beer yeast extract Brewer yeast cells (water content 80%) 250g ethanol 5001 water
After extracting the mixture by heating and refluxing the mixture for 4 hours in a Kolben equipped with a Dimroth condenser, the remaining liquid was centrifuged to remove solids to obtain a ft-colored extract. This extract was concentrated and dried under reduced pressure in a rotary evaporator to obtain 12.7 g of a brown residual liquid (brewer's yeast extract).

(Icho margin) ◇Production of beer mother extract 2 Beer yeast R1 bacterial cells (water content 80%) 250g ethanol 7501 water
The mixture of 501 or more was extracted by refluxing for 4 hours in the same manner as in the above 1, and then centrifuged to obtain a yellow extract. This was concentrated under reduced pressure and dried to a brown residual liquid (brewery yeast extract) 8.5
I got g.

◇Manufacture example 3 of Heal yeast 6I extract Beer yeast dried bacterial cells 50g Ethanol 10100O The mixture of 1- was refluxed for 4 hours in the same manner as in Example 1 to perform extraction, and then filtered with suction to obtain a rare yellow extract. I got the liquid. Concentrate this under reduced pressure,
By drying, 2.8 g of a strong colored residue (brewer's yeast extract) was obtained.

◇Manufacture example 4 of beer yeast extract Brewer yeast cells (water content 80%) 125g ethanol 250g 1 water
The mixture of 1,501 or more was stirred gently once a day, and the mixture was heated at room temperature for 2
After weekly extraction, the mixture was centrifuged to obtain a yellow extract.

This was concentrated under reduced pressure and dried to obtain 5.7 g of a brown residue (brewer's yeast extract).

◇Manufacture example 5 of beer yeast cell extract Beer yeast cell (water content 80%) 125g - Ethanol 375 layers l water
A mixture of 25 layers or more was heated for 2' at room temperature with gentle stirring once a day.
After performing the i@-interval extraction, it was centrifuged to obtain a yellow extract. This was concentrated under reduced pressure and dried to obtain 3.8 g of a brown residue (brewer's yeast extract).

◇Production example 6 of beer yeast cell extraction 25g of beer yeast dried cells 500g of ethanol 1 or more mixture,
- Extraction was carried out at room temperature for 2 weeks with gentle stirring once a day, followed by suction filtration to obtain a colorless extract. This extract was concentrated under reduced pressure and dried to form a white residue (brewery yeast extract).
0.5g was obtained.

[Test Example] Using male c3H/HeNCrj' mice (58 days old), the method of Ogawa et al.
l and Abnormal [1iff@rent
iatian).

Edited by M, 5eiji and LA, Bernstein, edited by Isshudai Publishing Co., Ltd., published 11 times.

The hair on the back of the mouse was shaved to the size of approximately 2X Ac layer, and the sample was applied once a day from the next day to the area where the skin color started to change from pink to gray (the area where hair regeneration started). Changes in dead ratio were determined. Experiments were conducted on all mice until hair regeneration was observed on the entire shaved area, and the speed of hair regeneration was compared.

As samples, the extracts obtained in Production Examples 1, 2.4, and 5 were adjusted to the same concentration as the solution before being concentrated to dryness.

75% ethanol was used as a control (ethanol solutions have no effect on hair regrowth in mice, regardless of the concentration of ethanol).

Using 1610 tows in each treatment area, the average value of the rate of change for each area was determined. The results are shown in FIGS. 1 to 4.

As is clear from each figure, all the samples exhibited superior hair regeneration activity compared to the control, but in particular, the one in Production Example 5 in FIG. 4 was the most excellent.

[Example] Acetic acid/di/αφ tocopherol 0.05111/
V% vantothenyl alcohol 0. l W/
V% bio f 7 0.01 w
/vt beer yeast extract (manufacturing example 1) 0.011
/v% menthol 0.1 W/
V% Propylene Glycol 0.2 W/V
%95%Eng.1. / -k 7g, 95W
/V perfume 0.2V/
V% Purified water Amount to adjust the total amount to 100% (blank below) ○Example 2 (shampoo) Coconut oil 14.0111/V%
Olive oil 3. OW/V%
Castor oil 3. OW/V%
Brewer's yeast extract (Production example 2) 0.31/W% Potassium hydroxide 4.7 W/V% Glycerin 2.0 W/V% Ethanol 4.0 W/V% Sodium hexametaphosphate 10 W/V% fragrance
0.5 V/V% purified water
Adjust the total amount to 100%. 8. OW/V
% Sodium Sulfate 3. OW/
V% urea 2. OW/V%
Lanolin 4.0 W/V%
Bacyl glycol monooleate
1. OW/V% Brewer's yeast extract (Production example 4) 0.2W/V% Flavoring
0.3 V/V% purified water
Amount to adjust the total amount to 100% 〇 Knee 4 Hair Conditioner White Vaseline 6.
O111711% liquid paraffin 37
．． 5111/so% lanolin 3
．． 0%l/w%Mitsuu t'
, ow1w% sorbitan sesquioleate) 3.
011/%i% Sorbitan Monorate 2
．． OW/W% Polyoxyethylene sorbidan monolaurate 2.011/W%
Borax 0.5 W/%1%
Brewer's yeast extract (manufacturing example 5) 0.311/W%
Fragrance 0.21/w% Purified water Amount to adjust the total amount to 100% (Effect of the invention) As explained above, the present invention has brought hope and invention to many humankind through the result that it can provide an effective hair nourishing agent. I can give it.

[Brief explanation of drawings]

FIGS. 1 to 4 are graphs showing the state of hair growth in mice in test examples. llP Jinshu Q Eye Fuyi P Kyushu Q Old fu axe? Lens Jinshu C former fu buttocks

Claims (2)

[Claims] (1) A hair nourishing agent containing an organic solvent extract of beer yeast cells as an active ingredient. (2) The hair nourishment according to claim 1, wherein the organic solvent extract of brewer's yeast cells is obtained by extracting brewer's yeast cells with anhydrous or hydrous ethanol.