JPS6327327B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a dry mouth recovery composition containing phytic acid, inorganic cations, and glucose as essential components. More specifically, the present invention relates to phytic acid 0.8 to 6.0
%, inorganic cations 0.8-8.4% and glucose
The present invention relates to a dry mouth recovery composition that can significantly promote the absorption of cations by containing 78.2 to 90.3% of the active ingredient. More specifically, the present invention relates to a composition for relieving dry mouth, which is capable of significantly promoting the absorption of cations using phytic acid. In general, dry mouth begins in mild cases during physical activities that increase metabolism and sweating, such as during high-temperature work, strenuous exercise, fever, burns, sunstroke, or severe diarrhea. fatigue, weakness, fatigue,
It is known that it can lead to various acute symptoms ranging from fainting, dehydration, and even shock symptoms in severe cases, and the main cause of these symptoms is the loss of water and electrolytes from other fluids, and It is also well known that it is caused by an imbalance in body fluid electrolyte balance. As a typical example, if we look at these in more detail during intense exercise, in addition to the above-mentioned loss of water and electrolytes from the body, acidification of body fluids, decrease in blood sugar concentration or depletion of blood energy sources, and hypertonicity of body fluids. , associated phenomena such as escape of K ⁺ from tissues, increased demand for oxygen in tissues, increased demand for anaerobic respiration, and decreased neural reflex function appear. Considering that such complex biological changes occur, it is difficult to relieve dry mouth caused by the various causes mentioned above by simply drinking large amounts of water, or as was done until recently. Methods such as using salt in combination are not necessarily appropriate. In fact, drinking large amounts of water on an empty stomach can cause nausea, gastrointestinal spasm, tachycardia, and collapse, but these are caused by the sudden exposure of the gastrointestinal wall to a hypotonic environment. This is thought to be caused by a sudden change in blood electrolyte concentration. In addition, if the amount of water consumed at the same time is too small, it may actually worsen the symptoms, leading to nausea, decreased blood pressure, and syncope. Blood levels are lowered due to
This appears to be caused by a further decrease in the K ⁺ /Na ⁺ ratio. In order to improve the symptoms of dry mouth, a dry mouth recovery drink containing glucose, Na ⁺ , K ⁺ , and Cl' as main ingredients, is prepared by dissolving it in water and drinking it as a solution with a near isotonic concentration. Several types have come on the market in recent years, but most of them have a blended amount of electrolyte that is so small that it is hardly useful for electrolyte replenishment.
Therefore, attempts have been made to increase the concentration of cations, but this has not been possible due to poor gastrointestinal absorption and causing symptoms such as diarrhea. The inventors aimed to develop a dry mouth recovery drink that quickly replenishes water and electrolytes lost through sweat during intense exercise, quickly recovers from various biological changes that occur at the same time, and is physiologically safe. As a result of extensive research, they succeeded in absorbing high concentrations of cations by incorporating phytic acid as an active ingredient into a dry mouth recovery composition. The present invention is a dry mouth recovery composition comprising phytic acid, inorganic cations, and glucose as essential components. When phytic acid is present in the dry mouth recovery composition, the -12-valent acidic functional group forms a soluble chelate with Mg ⁺⁺ etc. and is absorbed.
Even at high concentrations of cations, they are absorbed quickly and do not cause problems such as diarrhea. The composition for relieving dry mouth of the present invention generally relates to a solid drink composition for relieving dry mouth that is dissolved at the time of use and is dissolved in water for drinking, and preferably contains 0.8 to 6.0% of phytic acid. Potassium 0.24-5.25
%, sodium 0.14-7.35%, magnesium 0-5.25%, glucose 78.2-90.3%, and the total amount of inorganic cations is 0.3-3.7mg per gram.
The present invention relates to a dry mouth relief beverage composition comprising an equivalent amount of the composition. However, it goes without saying that the present invention may be applied to a beverage composition that can be drunk as it is as a liquid composition. In this case, the beverage composition is prepared by liquefying 40 to 60 g of the solid composition for drinking at a ratio of 1 part to 1 part water. In general, strenuous muscular exercise significantly disrupts the electrolyte balance in tissues and body fluids. In other words, intracellular K ⁺ and Mg ⁺⁺ leak into the blood, and Na ⁺ and Ca ⁺⁺
and Cl' seep into the cells, and as a result, the concentration of electrolyte components excreted in sweat is as shown in the table below, compared to the concentration of components in normal plasma, K ⁺ /Na ⁺ ratio and Mg ⁺⁺ /Ca ⁺⁺
is large.

[Table] In order to extrinsically promote the recovery of body fluid electrolyte balance to a normal state, it is insufficient to simply replenish electrolytes lost in sweat, and the concentration gradient from the blood to the inside of cells is insufficient. It is necessary to particularly increase the levels of K ⁺ and Mg ⁺⁺ , and when replenishing these electrolytes in the form of drinks, the relative amounts of K ⁺ and Mg ⁺⁺ should be increased, taking into consideration the absorption dynamics from the gastrointestinal tract. There is a need. Na ⁺ and Cl′ are absorbed by active transport,
Ca ⁺⁺ is also actively absorbed when co-administered with sugars such as glucose, so simple supplementation can be considered for these three, but K ⁺ and Mg ⁺⁺ are difficult to absorb and require special consideration. is necessary. K ⁺
Since it is strongly absorbed by passive transport and is difficult to absorb unless the concentration in the gastrointestinal tract is 5mM or more, the concentration added to the drink needs to be the desired absorption concentration + 5mM. Furthermore, as is clear from the example of its use as a saline laxative, Mg ⁺⁺ is extremely difficult to absorb as it is. If phytic acid coexists in such a case, phytic acid forms a water-soluble chelate with these cations, which allows for easy absorption. One of the main purposes of the dry mouth recovery composition of the present invention is to quickly replenish water, and it is naturally intended for drinking as an aqueous solution. It is a solid composition, and when used, a predetermined amount of the product of the present invention is dissolved in a predetermined appropriate amount of drinking water and made available for drinking. In addition, the product of the present invention is composed of phytic acid and various inorganic cations as main ingredients, but in order to increase excipient volume, improve palatability, and assist in recovery from fatigue, the osmotic pressure concentration during use must be within a range that does not exceed isotonicity. The following ingredients can be blended. Excipient bulking - sugars such as glucose, fructose, sucrose, sorbitol, mannitol, xyrose, xylitol, galactose, and polysaccharides and derivatives such as pectin, dextran, mannan. Improved palatability - acids such as citric acid, tartaric acid, fumaric acid, malic acid, phosphoric acid, natural and artificial sweeteners and flavors. Fatigue recovery aids - vitamins and derivatives such as ascorbic acid, thiamine, riboflavin, pyridoxine, cyanocobalamin, pantothenic acid, thioctic acid, axelftol, tocopherol. Amino acids and derivatives such as taurine, arginine, histidine, glutamic acid, aspartic acid, gamma-aminobutyric acid. Central stimulants such as caffeine and theobromine. Choline, lecithin, sodium hyposulfite, chlorophyllin, glucuronic acid, glutathione,
Antidotes such as pemoline. Acid neutralizer such as THAM. The above composition for relieving dry mouth is dissolved in water and freeze-dried, spray-dried, or fluidized to obtain a solid composition for relieving dry mouth that can be dissolved at the time of use. As mentioned above, the dry mouth recovery composition of the present invention has the following features: (1) Since phytic acid has 12 acid groups in one molecule, the molar concentration per equivalent is extremely low, and the osmotic pressure concentration of the solution is set low. (2) It tastes good, and even if an equivalent amount of Na ⁺ or K ⁺ is added, it has a small salty taste, making it highly palatable. (3) The gastrointestinal tract of phytate anion Absorption is Na ⁺ ,
Since it lags behind the absorption of K ⁺ etc., it rapidly relieves acidosis and then becomes one of the reserve alkalis. (4) Attenuates the affinity of oxyhemoglobin and promotes oxygen release at cell sites. So it increases the efficiency of aerobic respiration. This action is further promoted by the synergistic action with L-ascorbic acid. (5) It is nutritionally significant as a source of inositol and phosphate. (6) It is a precursor of phosphatidylinositol, which has a neurostimulatory effect. It has a meaning as a body. (7) It has excellent effects such as being significant as a source of myo-inositol, which protects the brain, liver, and eyes and has function-activating effects. The dry mouth recovery composition of the present invention is useful, for example, in the following cases. (a) Preventing fatigue during sports and promoting recovery from fatigue. (b) Hydration and electrolyte replenishment during work in high heat or low humidity environments. (c) Prevention and first aid for burns and burns. (d) Alleviation of dehydration symptoms during burns. (e) Remission of hypokalemia symptoms. (f) Promote recovery from physical and mental fatigue. (g) Remission of hangover. (h) Remission of dehydration symptoms in infant diarrhea. (i) Dietary therapy for ischemic heart failure. Example 1 Formulation: Phytic acid (solid equivalent) 4.00% Potassium hydroxide (100% equivalent) 1.36% Magnesium oxide (100% equivalent) 0.48% L-arginine 0.20% Sodium chloride 2.00% Taurine 0.20% Anhydrous caffeine 0.02% Anhydrous Sorbitol 5.60% Anhydrous glucose 80.00% Anhydrous citric acid 3.60% L-ascorbic acid 0.40% Water 2.14% Preparation method: First, add hydrated magnesium oxide to a 50% phytic acid solution with stirring until it dissolves clearly, then 50% Add potassium hydroxide solution. water in a separate container
Take 20 parts, add 0.2 parts of L-arginine, 2.0 parts of sodium chloride, 0.2 parts of taurine, and 0.02 parts of anhydrous caffeine.
part, anhydrous sorbitol 5.6 parts, anhydrous citric acid 3.6 parts
1 part and 0.4 parts of L-ascorbic acid to make a dissolved solution, combine both solutions, mix uniformly, and freeze-dry at a freezing temperature of -20 to -30°C and a secondary drying temperature of 50°C.
The resulting cake is granulated using a 40 mesh sieve, and 20 parts of this granulated powder is uniformly mixed with 80 parts of crystalline anhydrous glucose to obtain the desired formulation. Dissolve 50 g of this preparation in water to make 1 and use it for drinking. Physical properties: The sample of Example 1 is a mixture of brown grains and pure white grains, and has extremely good fluidity. When 50g of this is dissolved in water to make 1, it quickly dissolves when shaken to form a clear, colorless liquid with a pH of 3.60 and a freezing point of -0.52℃.
It is approximately isotonic with body fluids. Test results: 250ml each of the above solutions and 250ml each of cold water for boy 3.
A panel of 7 women and women sampled the product during light work, and the following results were obtained with a 95% confidence limit. (1) It is easier to drink than water and causes less resistance. (2) Both sourness and sweetness are light, refreshing, and appropriate. The salty and bitter tastes are only slightly perceptible and do not particularly interfere with drinking. There is no aftertaste, but rather a refreshing feeling. In other words, the taste is determined to be good. (3) Regarding promotion of dry mouth recovery or fatigue recovery,
Since this panel was subjected to light work, its effectiveness was unclear. (4) One male sampled the product after running at full speed until he was nearly exhausted, and reported that his recovery from fatigue was significantly faster than when he simply drank water. I am getting . Example 2 Formulation: Phytic acid (solid equivalent) 4.31% Potassium hydroxide (100% equivalent) 1.46% Magnesium oxide (100% equivalent) 0.51% L-arginine 0.22% Sodium chloride 2.15% Taurine 0.22% Anhydrous glucose 86.12% Anhydrous Citric acid 3.94% L-ascorbic acid 0.43% Water 0.64% Preparation method: Using almost the same technique as in the example, 8.62 parts of 50% phytic acid solution, 1.46 parts of potassium hydroxide, 0.51 part of magnesium oxide, L-arginine 0.22 parts, sodium chloride 2.15 parts, taurine 0.22 parts, citric acid anhydride
A mixture of 3.94 parts of L-ascorbic acid, 0.43 parts of L-ascorbic acid, and 20 parts of water was prepared, and this was heated to an inflow air temperature of 110 to 130 parts.
Spray dry the obtained powder using a spray dryer at ℃
Uniformly mix 13.88 parts with 86.12 parts of crystalline anhydrous glucose to obtain the desired formulation. Dissolve 46.4 g of this preparation in water to make 1 and use it for drinking. Physical properties: Comparison with commercially available similar products is shown in the table below.

【table】

[Table] Tasting results: (1) 10 rugby players between the ages of 22 and 50 were asked to perform a wall push exercise until exhaustion, creating pairs with similar durations, and one of them was given the drinking solution of Example 2.
Pour 500ml of water into the other hand, rest for 2 minutes, then resume the wall pushing exercise. Measure the number of times you can continue until you are exhausted again. When expressed as fatigue recovery rate (%), the group that drank Example 2 had a higher recovery rate as shown below.

[Table] (2) A 50-year-old male subject was made to urinate after fasting for 12 hours, and administered 300 ml each of the drinking solution of Example 2 or water.
The patient was kept at rest, and urine was collected every 15 minutes and the amount of urine was measured as shown in the table below. This suggests that water absorption is much faster when drinking this product.

[Table] Example 3 Prescription: Phytic acid (solid equivalent) 2.10% Potassium hydroxide (100% equivalent) 0.92% Sodium hydroxide (100% equivalent) 1.22% L-arginine-L-glutamate 0.21% Anhydrous glucose 83.86% Anhydrous citric acid 7.67% L-ascorbic acid 0.21% Flavor powder 1.26% Water 2.55% Preparation method: Using almost the same technique as in Example 1, 4.20 parts of 50% phytic acid solution, 0.92 parts of potassium hydroxide, hydroxide A mixed solution consisting of 1.22 parts of sodium, 0.21 parts of L-arginine-L-glutamate, 7.67 parts of anhydrous citric acid, 0.21 parts of L-ascorbic acid and 25 parts of water was prepared,
Anhydrous glucose 83.86 with an inflow air temperature of 70 to 80℃.
1.26 parts of perfume powder is uniformly mixed with the resulting dry powder to obtain the desired formulation. Dissolve 53 g of this preparation in water to make 1 and use it for drinking. Physical properties: The sample of Example 3 is a pure white granular powder with extremely good flowability, and the bulk density is 0.554 when flowing and 0.622 when tapping. When 53g of this is dissolved in water to make 1, it quickly dissolves to form a clear, colorless liquid with a pH of 3.35 and a freezing point of -0.53°C. Example 4 Formulation: Phytic acid (solid equivalent) 4.19% Anhydrous potassium carbonate 1.59% Sodium hydroxide (100% equivalent) 1.30% L-Arginine-L-Glutamate 0.21% Anhydrous glucose 83.86% Anhydrous citric acid 4.19% L-Ascorbine Acid 0.21% Flavor powder 1.26% Water 3.19% Preparation method: Using almost the same technique as in Example 1, 4.19 parts of 50% phytic acid, 1.30 parts of sodium hydroxide, 0.21 part of L-arginine-L-glutamate, anhydrous citric acid
Make a mixture of 4.19 parts of L-ascorbic acid, 0.21 parts of L-ascorbic acid, and 5 parts of water, and heat this solution on a hot plate at a temperature of 60 to 70℃.
Dry under reduced pressure using a vacuum dryer, and refine the resulting dry mass using a 40-mesh sieve.
The desired formulation is obtained by uniformly mixing 13.29 parts with 1.59 parts of anhydrous potassium carbonate, 83.86 parts of crystalline anhydrous glucose, and 1.26 parts of flavor powder. Dissolve 53 g of this preparation in water to make 1 and use it for drinking. Physical properties: The sample of Example 4 is a mixture of brown grains and pure white grains, has extremely good fluidity, and has a bulk density of 0.682 when fluidized.
It is 0.723 when tapping. When 53g of this is dissolved in water to make 1, if you shake it, it will quickly dissolve and become a clear, pale yellow liquid, with a pH of 3.48 and a freezing point of -0.53℃.
It is. The component concentrations of this liquid are as shown below. Phytic acid ^-12 40.40meq Ascorbic acid ^-1 0.63meq Citric acid ^-3 10.58meq CO ₃ ^-2 12.22meq K ⁺ 12.22meq Na ⁺ 17.21meq Glucose 246.69mM L-Arginine-L-Glutamate 0.35mM.

Claims (1)

[Claims] 1. Phytic acid 0.8-6.0%, inorganic cations 0.8-6.0%
A dry mouth recovery composition comprising 8.4% and 78.2 to 90.3% glucose as essential ingredients. 2. The dry mouth recovery composition according to claim 1, wherein the inorganic cations are potassium (K ⁺ ), sodium (Na ⁺ ), and magnesium (Mg ⁺⁺ ). 3 Blending ratio of inorganic cations, K ⁺ :Na ⁺ :Mg ⁺⁺
The dry mouth recovery composition according to claim 1 or 2, wherein the ratio is 1.0:0.6 to 1.4:0 to 1.0. 4 The total amount of inorganic cations is 0.3 to 3.7 per gram.
The dry mouth recovery composition according to claim 1, 2 or 3, which is mg equivalent.