JPS62286916A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:The titled composition stably keeping a soluble fluorine compound for a long period, effectively showing low abrasion-high cleaning effect after long-term preservation, using both a polishing agent obtained by calcining a specific calcium hydrogenphosphate.nonhydrate and a soluble fluorine compound. CONSTITUTION:A composition for oral cavity containing both a polishing agent obtained by calcining at 70-1,200 deg.C calcium hydrogenphosphate.nonhydrate (preferably spheres) which has 200-3,500Angstrom , especially 300-3,000Angstrom average value of crystal measured by X-ray diffraction method, preferably 2.500-2.885g/cm<3> density at 20 deg.C, 2.5-50m<2>/g, especially 5-30m<3>/g specific surface area of BET method and 2-30mum, especially 5-25mum average particle diameter measured by laser light scattering method and a soluble fluorine compound (e.g. alkaline metallic salt of monofluorophosphoric acid). In calcination, 0.5-10wt% magnesium and/or aluminum compound is preferably added to calcium hydrogenphosphate.

Description

Detailed Description of the Invention 3. Detailed Description of the Invention Industrial Field of Application The present invention maintains a soluble fluorine compound stably over a long period of time, and also has a low polishing and high cleaning effect even after long-term storage. The present invention relates to an oral composition that exhibits the following properties.

4. Conventionally, crystallites having an average crystallite size of 300 to 3500 as measured by X-ray diffraction method have been used as abrasives for oral compositions having low abrasiveness and high cleaning effects. Calcium hydrogen phosphate anhydrate consisting of the following is known to be useful (Japanese Patent Application Laid-open No. 188309/1983).

It has also been known that soluble fluorine compounds such as sodium monofluorophosphate 11 strengthen tooth structure and are used as active ingredients for caries prevention.

However, according to studies by the present inventors, the average crystallite size measured by X-ray diffraction is 200 to 35.
Calcium hydrogen phosphate anhydrate, which consists of 0.00 crystallites, has a relatively high solubility in water, and has the problem of elution of calcium ions in an aqueous suspension system. If the value is less than 1000 Å, the particle surface will dissolve over time when added to toothpaste compositions, the cleaning power will decrease over time, and the low-polishing and high-cleaning properties may be lost. Ta.

Furthermore, when this calcium hydrogen phosphate is used in combination with a soluble fluorine compound such as sodium monofluorophosphate, the soluble fluorine compound is likely to be deactivated by the action of the eluted calcium ions, causing problems in the stabilization of the soluble fluorine compound. There were cases where I was forced to do so.

The present invention was made in view of the above circumstances, and it is an object of the present invention to provide an oral composition that exhibits a low abrasive and high cleaning effect even after long-term storage, and in which a soluble fluorine compound is stably retained for a long period of time. With the goal.

. As a result of intensive studies to achieve the above object, the present inventors have developed a crystal with an average crystallite size of 200 to 3,500 crystallites measured by X-ray diffraction method. The abrasive obtained by firing the calcium hydrogen phosphate anhydrate having a carbonaceous substance at a temperature of 70°C to 1200°C does not impair the properties of the original calcium hydrogen phosphate anhydrate. It has excellent low-abrasive and high-cleaning properties, and
It has low solubility in water, is stable for a long time even in an aqueous suspension system, does not have the disadvantage of reducing cleaning power due to dissolution of the particle surface over time, and has low abrasiveness even after long-term storage in an aqueous suspension system. It effectively exhibits a high cleaning function, and when the above-mentioned calcium hydrogen phosphate anhydrate is fired at 350°C or higher, the resulting abrasive has a very high polishing effect and leaves the tooth enamel surface with an excellent gloss. It has been found that when this abrasive base material is blended into toothpaste, etc., the astringent taste is improved and the feeling of use is improved.

This abrasive has a low elution of calcium ions, and when used together with a soluble fluorine compound such as sodium monofluorophosphate, the deactivation of the soluble fluorine compound is prevented as much as possible, and the stabilization of the soluble fluorine compound is prevented. I found out that it is possible.

Furthermore, when calcining calcium hydrogen phosphate anhydrate having crystallites with an average crystallite size of 200 to 3,500 as measured by X-ray diffraction at a temperature of 70°C to 1200°C, magnesium The inventors discovered that by adding a compound or an aluminum compound, the stability of the resulting abrasive to water is further improved, and a stable combination of fluorine compounds can be achieved more effectively, leading to the creation of the present invention. be.

Therefore, the present invention provides calcium hydrogen phosphate anhydrate having an average crystallite size of 200 to 3,500 crystallites measured by X-ray diffraction at a temperature of 70°C to 1,200°C.
Provided is an oral cavity composition characterized in that an abrasive fired at a temperature of 0.degree. C. and a soluble fluorine compound are used in combination.

The present invention will be explained in more detail below.

The abrasive used in the present invention is calcium hydrogen phosphate anhydrate having crystallites with an average crystallite size of 200 to 3,500 as measured by X-ray diffraction method.
It is fired at a temperature of 1200°C.

Here, the calcium hydrogen phosphate anhydrate used in the present invention has an average crystallite size of 200 to 3,500 crystallites. It is suitably used in this respect.

In addition, the calcium hydrogen phosphate anhydrate used in the present invention has a density of 2.500 to 2.500 at 20"C.
2.885g/aI? , and the specific surface area is 2 by the BET method.
．． 5 to 50 rd'/g, particularly 5 to 3 rd'/g, and the average particle diameter measured by laser light scattering method is preferably 2 to 30 tones, particularly 5 to 2574111.

Furthermore, the calcium hydrogen phosphate anhydrate used in the present invention has an average particle size of 0.03 to 5I.
It is preferable to use JIM, which is a fixed aggregation of plate-like crystals. Note that the average size of the secondary particles referred to herein is a value measured and calculated from electron micrographs.

Among these, spherical calcium hydrogen phosphate anhydrate is particularly suitable.

Calcium hydrogen phosphate anhydrate having an average crystallite size of 300 to 3,500 people can be prepared using conventional methods 1, such as U.S. Pat. No. 2,287,699 (1942) and U.S. Pat.
No. 852 (1961), No. 3066056 (196
2), No. 3169096 (1965), Special Publication No. 39
In the neutralization reaction between phosphoric acid and milk of lime described in -3272.3273, etc., a modifier is added to control the growth of crystals or to affect the crystal properties and specific growth rate of individual crystal faces. It can be manufactured by In this case, as the crystal modifier, for example, a phosphoric acid condensate and its salt can be suitably used, and it is preferable that the addition is carried out once during the neutralization reaction between phosphoric acid and milk of lime.

The amount of crystallizing agent added is 0.1 to 40% by weight of the produced calcium hydrogen phosphate anhydrate, especially 0.5 to 30% by weight.
This calcium hydrogen phosphate anhydrate, which is preferably expressed as a percentage by weight, tends to inhibit the growth of crystals and reduce the size of crystallites as the amount added increases. By appropriately controlling the addition amount, addition timing, addition rate, phosphoric acid concentration, reaction temperature, reaction time, stirring speed, etc., various grades can be obtained. For example, calcium compounds mixed with electrolytes and phosphorus Calcium hydrogen phosphate anhydrate used in the present invention can be suitably obtained by reacting acid compounds at a temperature of 50 to 90°C and adding a phosphoric acid condensate.

The abrasive of the present invention has an average crystallite size of 20
Calcium hydrogen phosphate anhydrate of 0 to 3500 people, more preferably spherical, is calcined at a temperature of 70°C to 1200°C. Note that the firing time is usually 1 minute to 24 hours.

Here, when the firing temperature is 70°C to 400°C and the firing time is 1 minute to S hours, the fired product is made of calcium hydrogen phosphate.
It is mainly composed of anhydrous products, and the firing temperature is 40°C.
When the firing time is 3 minutes to 24 hours at 0° C. to 1200° C., the fired product will be mainly composed of calcium pyrophosphate. in this case.

In particular, it is preferable to use a product fired at a temperature of 700° C. or lower; if the firing temperature is high, the hardness of the fired product will increase and there is a risk of damaging the tooth.

Note that other firing conditions are not particularly limited, and for example, the firing atmosphere may be air or an inert atmosphere such as nitrogen or argon.

In addition, as mentioned above, the firing raw material is calcium hydrogen phosphate anhydrate with an average crystallite size of 200 to 3,500 people, and this can be obtained by the above-mentioned production method, but especially the above-mentioned production method. In the process, calcium compounds such as calcium oxide, calcium hydroxide, calcium carbonate, and calcium chloride and phosphoric acid compounds such as phosphoric acid, ammonium phosphate, and alkali metal phosphates are combined with pyrophosphoric acid.

One or two selected from polyphosphoric acids such as tripolyphosphoric acid, tetrapolyphosphoric acid, hexapolyphosphoric acid, and decapolyphosphoric acid, phosphoric acid condensates and salts thereof such as salts of these polyphosphoric acids with alkali metals, alkaline earth metals, and aluminum group. The amount of crystallizing modifier at least 0.1% to 50%, preferably 0.5% to 40%, in terms of Ca○ of the calcium compound.
Add % by weight, more preferably 1 to 30% by weight, and heat at 60°C.
It is preferable to use calcium hydrogen phosphate anhydrate obtained by reacting at the above temperature as a firing raw material, and by using such a firing raw material, a polishing slurry with a higher degree of roundness can be reliably obtained.

Furthermore, in the present invention, it is preferable to add a magnesium compound and/or an aluminum compound to the raw material calcium hydrogen phosphate anhydrate during firing, thereby obtaining an abrasive that is more stable against water. . In this case, as the magnesium compound, one or more types of magnesium phosphate monobasic, magnesium phosphate dibasic, magnesium phosphate tertiary, magnesium chloride, magnesium sulfate, etc. can be used, but in particular magnesium phosphate tertiary. It is highly effective and suitable for use. Further, as the aluminum compound, aluminum phosphate, aluminum silicate, etc. can be suitably used. These magnesium compounds,
The amount of aluminum compound used is 0 to 20% by weight, preferably 0% by weight, based on the raw material calcium hydrogen phosphate anhydrate.
．． It is 5 to 1% by weight.

After firing, it is crushed to an appropriate particle size depending on the purpose, but the average particle size measured by laser light scattering method is 2 to 30.
7Jl, especially those with 5 to 25 tones are preferred as abrasives.

In this case, the average crystallite size, density, specific surface area, roundness, etc. of the abrasive used in the present invention depend on the properties of the raw material Calcilla hydrogen phosphate 11 anhydrate to be fired as described above. In particular, as the abrasive used in the present invention, the liquid absorption amount is 0.
．． Those having a specific surface area of 2 to 2 d/g and a specific surface area of 2.5 to 50 m/g are preferable.

The oral composition according to the present invention uses a soluble fluorine compound in combination with the above-mentioned abrasive.

Here, examples of the soluble fluorine compound include alkali metal salts of monofluorophosphate such as sodium monofluorophosphate, alkali metal fluorides such as sodium fluoride, and tin-containing fluorides such as stannous fluoride. One or more of these may be used.

Note that the amount of the abrasive compounded in the oral cavity composition of the present invention is 10 to 80% (weight %, the same applies hereinafter).

In particular, it is preferably 15 to 50%, and the content of the soluble fluorine compound is 0.1 to 3%, particularly 0.45 to 2.
% is preferable.

As other components of the oral composition of the present invention, appropriate components are used depending on the type of the oral composition.6For example, when preparing a toothpaste composition, a thickening agent, a viscous Binders, surfactants, fragrances, sweeteners, preservatives, various active ingredients, etc. may be blended, and if necessary, other abrasives may be blended in addition to the abrasive of the present invention.

The oral composition of the present invention maintains a soluble fluorine compound stably for a long period of time, and exhibits low abrasive and high cleaning functions even after long-term storage.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

Before explaining the experimental examples, calcium hydrogen phosphate anhydrate used in the production of the abrasive of the present invention and production examples of the abrasive of the present invention will be shown.

[Production Example 1] Milk of lime is sieved through a 100-mesh sieve to remove coarse particles to obtain milk of lime weighing 128 g/Q in terms of calcium oxide.

Then, 75% phosphoric acid aqueous solution IQ was heated to 78°C,
The milk of lime is added at a rate of 570 ntQ per hour while stirring. 60 minutes after the start of the neutralization reaction, 135 g of pyrophosphoric acid was added, followed by the addition of milk of lime, and the pH after the reaction was 6.
Continue until it reaches 0 (the total amount of milk of lime added is 5.3 breaths).

The amount of pyrophosphoric acid added to 100 parts by weight of Ca0 is 20
．． (equivalent to 0 parts by weight). After that, one reaction solution is passed through and washed with water, and then the P lump is dried and crushed to obtain calcium hydrogen phosphate anhydrate.

[Production Example 2] Calcium hydrogen phosphate anhydrate obtained in Production Example 1 was calcined at 450° C. for 2 hours to obtain a polishing slurry of the present invention.

[Production Example 3] Calcium hydrogen phosphate anhydrate obtained in Production Example 1 was calcined at 700° C. for 2 hours to obtain an abrasive of the present invention (spherical calcium pyrophosphate).

[Production Example 4] Calcium hydrogen phosphate anhydrate 1 obtained in Production Example 1
00 parts by weight and 1 part by weight of tertiary magnesium phosphate were added and mixed, and the mixture was fired at 180° C. for 2 hours to obtain a polishing slurry of the present invention.

[Experimental Example 13] The polishing power (RDA value) and cleaning power of abrasives having the properties shown below were investigated by the following method. The results are shown in Table 1 and the drawings.

Sarazugoran A Calcium hydrogen diphosphate dihydrate (DCP-D) Average aggregate particle size 14IJn B Calcium hydrogen diphosphate anhydrate (D CP-A)
Average crystallite size: 4550 people Average aggregate particle size: 16- Density: 2.89 g/aJ Specific surface area
1.2 bo/g C calcium hydrogen diphosphate anhydrate (in the above Production Example 1, the amount of pyrophosphoric acid added was
Calcium hydrogen phosphate anhydrate obtained by adjusting 20 parts by weight to 00 parts by weight) Average crystallite size 450 people Average agglomerated particle size 23 houses Density 2.60 g/cd Specific surface area
23rd/gD Calcium hydrogen diphosphate anhydrate (in the above Production Example 1, the amount of pyrophosphoric acid added was changed to CaO1
Calcium hydrogen phosphate anhydrate obtained by adding 5 parts by weight to 00 parts by weight) Average crystallite size 700 people Average agglomerated particle diameter 211 Jn Density 2.84 g/aj Specific surface area
9.2 bo/g E: Abrasive C baked at 150°C for 2 hours.

(This abrasive E essentially consists of calcium hydrogen phosphate anhydrate.) F: An abrasive sintered at 150° C. for 2 hours.

(This polishing agent F essentially consists of calcium hydrogen phosphate anhydrate.) G: Polishing agent C baked at 500° C. for 2 hours.

(This polishing agent G essentially consists of calcium pyrophosphate.) H: Abrasive agent baked at 500° C. for 2 hours.

(This abrasive H essentially consists of calcium pyrophosphate.) ■=Abrasive 0 100 parts by weight and magnesium phosphate tertiary.
1 part by weight was added and mixed and baked at 150'c for 2 hours.

J: 100 parts by weight of polishing agent and 1 part by weight of tertiary magnesium phosphate
Parts by weight were added and mixed and fired at 500"C for 2 hours.

K: 100 parts by weight of abrasive C was mixed with 1 part by weight of aluminum phosphate and fired at 150°C for 2 hours.

L: 100 parts by weight of abrasive C was mixed with 1 part by weight of aluminum phosphate and fired at 500°C for 2 hours.

M: Calcium pyrophosphate (conventional product) Among the above properties, the average crystallite size is measured by performing X-ray diffraction of the powder, and determining the crystallinity of the powder from the peak broadening. It was expressed quantitatively using the index as an index. here.

The X-ray source was measured using alpha rays for Cu-, and the X-ray diffraction data was analyzed for non-overlapping main peaks using Scherrer's equation D = λ/βCO5θ, and the average crystallite size was determined. I asked for In this case, the main peaks are 2
θ=53.1', 36.1".

The average was taken for 32.6', 30.25', and 13.15'. Here, D is the size of the crystallite [person].

λ is the measured X-ray wavelength [human], β is the spread of the diffraction line (ra d) purely based on the size of the crystallite (α-AI2.○
.

A powder obtained by firing the powder at 1100° C. for 24 hours was used as a reference), where was the shape factor (constant = 0.9), and θ was the Bragg angle of the diffraction line. Further, β is the value obtained by subtracting the half-value width given by a material with very good crystallinity under the same conditions from the experimentally determined half-value width.

In addition, the average aggregate particle size is L eed F! t N or
Thrup's particle size distribution analyzer (product name: Microt)
rac) (laser method).

Danpuku Yusara Teikyou J, Dent, Res, Vol, 55. No, 4.
563-573 by Hefferen.
Dentin abrasion) values were measured.

Method for Measuring Cleaning Power Grass tar was collected in the usual manner, applied as a solution evenly on the tiles, heated and dried, set in a polishing container, and mixed with 5g of polishing agent at 0.3%. Using a suspension suspended in 15 g of a 60% glycerin aqueous solution containing sodium carboxymethyl cellulose, a load of 2 was applied.
The tiles were brushed 2000 times at 00 g, and the removal rate of tobacco tar from the tiles was visually evaluated after polishing.

In addition, as a brushing brush, there are 44 hairs per hair,
Hair thickness: 8 mil (approximately 0.2 mm), hair length: 12 m+a
The material used was nylon (62) with a hardness of M according to the Household Goods Quality Indication Law.

Evaluation Criteria Score 1: Cigarette tar removal rate 0-10% 2:
11 11~20%3: 2
1-30% 4: 31-40% 5: 41-50% 6: 51-60% 7: 61-70% 8: 71-80% 9: 81-90% 10: II 91-100%
From the results shown in Table 1 and the drawings, it is recognized that the abrasive according to the present invention has a low polishing and high cleaning effect.

[Experimental Example 2] The tooth enamel gloss improvement effects of the above-mentioned abrasives B, C, G, M and the following N were evaluated by the following method. The results are shown in Table 2.

Praise IN Abrasive C was fired at 900°C for 2 hours.

(This abrasive N essentially consists of calcium pyrophosphate.) Average aggregate particle size 25IJ! B Density 3.09g/aJ specific surface area
20rX? /g In addition, a raw tooth cut into a size of 5 x 5 mm was embedded in resin.
The tooth enamel surface was smoothed with a rotary polisher, and then N
Gloss meter (Nippon Heavy Industries Co., Ltd. (GLO5SMETERVG-10)
) (7) The enamel surface was treated to a gloss level of 1'80.0±2.0.

Next, add 5 g of abrasive to 60% glycerin aqueous solution 15IIQ.
The suspension prepared by suspending the test piece was poured into a polishing container set with the above-mentioned natural tooth test piece, and brushed using a horizontal polishing tester under the conditions of a load of 200 g and 7000 strokes/40 minutes. The same brush as in Experimental Example 1 was used for brushing. After 7,000 strokes of brushing, the gloss meter measures the increase or decrease in gloss,
The difference from the initial glossiness was defined as the degree of gloss improvement, and evaluation was made based on the following evaluation criteria.

O: Gloss improvement degree +20 or more 0: rJ +15 or more + less than +20 x:
tt Less than +ts In this case, the level that is visually recognized as sufficiently glossy is +20 or higher, and the level that is recognized as glossy is +15.
That's all.

Table 2 From the results shown in Table 2, it is recognized that the polishing agent according to the present invention has an excellent gloss improvement effect.

[Experimental Example 3] 5 g of the abrasive shown in Table 3 was suspended in 50 mN of water and left in a constant temperature bath at 20°C for 3 days.
The amount of calcium ions eluted from each polishing base was evaluated by passing it through paper and measuring the amount of calcium ions in the P solution by atomic absorption spectrometry.

The results are shown in Table 3.

Table 3 From the results shown in Table 3, it is recognized that the abrasive according to the present invention has a small amount of Ca"" eluted in an aqueous suspension system.

[Experimental Example 4] A toothpaste with the following formulation using the abrasive shown below was prepared, and after storing it at 40°C for a specified period, the cleaning power was examined using the following method, and the stability of the cleaning effect over time was evaluated. did. The results are shown in Table 4.

Hoho-no-Katata Abrasive 30.0
%Amorphous abrasive silica 5.0
Sodium carboxymethylcellulose 1.0 Colloidal silica 1.5 Propylene glycol 2.0 Glycerin 18.0 Sodium lauryl sulfate 1.5 Sodium saccharin 0.1°Fragrance
1.0 Preservative Trace amount of sodium monofluorophosphate o, 741
00.0% Calcium hydrogen diphosphate anhydrate (In the above Production Example 1, the amount of pyrophosphoric acid added was
10ffl for 00 parts by weight! Calcium hydrogen phosphate (anhydrate) obtained by dividing the sample into 100% of the average crystallite size: 540 people Average agglomerated particle size: 25 μs Density: 2.70 g/ci Specific surface area: 18 bo/gP: Abrasive 0 at 150°C
Baked for 2 hours.

(This abrasive 0 essentially consists of calcium hydrogen phosphate anhydrate.) Q: Abrasive 0 is baked at 500°C for 2 hours.

(This polishing agent Q essentially consists of calcium pyrophosphate.) R: 100 parts by weight of new solvent to 1 part by weight of tertiary magnesium phosphate
Parts by weight were added and mixed and baked at 500°C for 2 hours.

S: One part of aluminum phosphate was added to and mixed with one part of abrasive 0100, and the mixture was fired at 500°C for 2 hours.

The procedure was the same as in Experimental Example 1 except that a suspension of toothpaste Log in a 60% glycerin aqueous solution was used as the suspension.

Table 4 From the results shown in Table 4, it is recognized that the abrasive according to the present invention has good stability over time in an aqueous suspension system.

[Experimental Example 5] 5 g of the abrasive shown in Table 5 was suspended in 50 mQ of water, and sodium monofluorophosphate was added as fluorine to 1100 mQ of water.
After adding 0pp, this was left to shake for 7 days in a constant temperature bath at 50°C.Then, the amount of water-soluble fluorine in the supernatant was measured using a fluorine electrode. The results are shown in Table 5.

Table 5 [Experimental Example 6] The amount of water-soluble fluorine was investigated in the same manner as in Experimental Example 5 using the following abrasives. The results are shown in Table 6.

Abrasive T Calcium hydrogen phosphate anhydrate In the above Production Example 1, the average crystallite size of calcium hydrogen phosphate anhydrate obtained by adding pyrophosphoric acid to 2 parts by weight per 100 parts by weight of CaO 2200 people average aggregate particle size 16.5μs density
2.86g/aI! Specific surface area 2.0
A/g Abrasive U: Abrasive T baked at 150°C for 2 hours.

(This abrasive U essentially consists of calcium hydrogen phosphate anhydrate.) Abrasive V: Abrasive T baked at 500° C. for 2 hours.

(This abrasive V essentially consists of calcium pyrophosphate.) Table 6 From the results shown in Tables 5 and 6, it is recognized that the abrasive according to the present invention enables the stabilization of a fluorine compound.

Examples of the present invention will be shown below.

[Example 1] Toothpaste Invention Abrasive: 50% anhydrous silicon, 1.5 sodium carboxymethyl cellulose, 1.0 lagenane. , 2 sorbitol 18 propylene glycol 2 sodium lauryl sulfate 1.5 sodium saccharin
0.2 tranexamic acid
0.2 Sodium monofluorophosphate 0.76 Sodium pyrophosphate
1.0 fragrance 1
．． 0 100, 0% [Example 2] Toothpaste Invention Abrasive 30% Calcium pyrophosphate 10 Silicic anhydride 2.O Sodium carboxymethylcellulose 0.8 Sodium alginate 0.4 Sorbit 30 Glycerin
10 propylene glycol
3 Sodium lauryl sulfate
1.5POE (20) hydrogenated castor oil
1.0 Satucalin Sodium
0.1 dextranase
0.2 Sodium monofluorophosphate
0.76 Sodium pyrophosphate
1.5 Fragrance 1.5 100.0% [Example 3] Toothpaste Invention Abrasive 20% Agglomerated Anhydrous Calcium Phosphate 30 Silicic Anhydride 2.0 Xanthan Gum 0.5 Gelatin
0.5 sorbit
20 glycerin
5 polyethylene glycol
4 Sodium lauryl sulfate
1.0 myristic acid diethanolamide
0.3 Satucalin Sodium
0.1 tranexamic acid
Chlorhexidine 0.2 hydrochloride
0.01 Sodium monofluorophosphate
0.76 hexametaphosphoric acid
2.0 fragrance 0.8 purified water remaining 100
．． 0% [Example 4] Toothpaste Invention abrasive 30% Calcium hydrogen phosphate anhydrate 20 Sodium carboxymethylcellulose 0.9 Lagenan
0.3 sorbit
2゜Polyethylene glycol 3Sodium lauryl sulfate
1.2 Satucalin Sodium
0.1 Stevioside
0.1 tranexamic acid
0.05 Sodium monofluorophosphate 0.76 Sodium pyrophosphate
1゜5 Fragrance 1.0 100.0% [Example 5] Toothpaste Abrasive of the present invention 30% Calcium hydrogen phosphate dihydrate 2゜Sodium carboxymethyl cellulose 1.2 Sorbit
15 Glycerin
10 propylene glycol
3 Sodium lauryl sulfate
1.0 Lauric acid diethanolamide
0.5 Satucalin Sodium
0.1 Sodium monofluorophosphate
0.76 tertiary magnesium phosphate
1.0 Fragrance 1.0 100, 0% [Example 6] Toothpaste Invention Abrasive 20% Aluminum hydroxide 10 Silicic anhydride 30 Sodium carboxymethyl cellulose 0.8 Hydroxyethyl cellulose 0.3 Glycerin
25 polyethylene glycol
3 Sodium lauryl sulfate
1.0 Sodium lauroyl sarcosine
0.3 Satsukarinnato i merit
0.2 Sodium monofluorophosphate
. , 76 sodium metaphosphate
0.5 Fragrance 0.5 100.0% [Example 7] Toothpaste Invention Abrasive 30% Calcium Carbonate 1° Silicic Anhydride 2° Sodium Carboxymethyl Cellulose 1.0 Gelatin
0.3 sorbit
1゜glycerin
10゜Polyethylene glycol
3 Sodium lauryl sulfate
1.5 Satucalin Sodium
0.2 tranexamic acid
0.05 Sodium monofluorophosphate
0.76 Sodium pyrophosphate
0.3 Sodium metaphosphate
0.5 Fragrance 1.0 [Example 8] Toothpaste Invention Abrasive 30% Insoluble Sodium Metaphosphate 20 Sodium Carboxymethyl Cellulose 1.0 Lagenan
0.1 sorbitol
10 glycerin
15 polyethylene glycol
3 Alcohol Sodium Lauryl Sulfate 1.2 Sodium Saccharin 0.1 Tranexamic Acid 0.1 Sodium Monofluorophosphate 0.56 Sodium Fluoride 0.2 Sodium Tripolyphosphate. , 2 fragrance 0.5 purified water remaining 10
0.0% [Example 9] Junsei Toothpaste Invention Abrasive 80% Glycerin 1.

Lauric acid jetanolamide 0.1 Sodium saccharin 0.1 Sodium monofluorophosphate. , 76 tertiary magnesium phosphate 0.5 fragrance 1.0 M water remaining 10
0,0%

[Brief explanation of drawings]

The drawing is a graph showing the relationship between the polishing power and cleaning power of various abrasives.

Claims (1)

[Claims] 1. Calcium hydrogen phosphate anhydrate having crystallites with an average crystallite size of 200 to 3500 Å measured by X-ray diffraction at a temperature of 70°C to 1200°C. An oral cavity composition characterized by using a fired abrasive and a soluble fluorine compound in combination. 2. Density of calcium hydrogen phosphate anhydrate is 2.50
0 to 2.885g/cm^3, and the specific surface area is BET
2. The oral cavity composition according to claim 1, which has an average particle diameter of 2.5 to 50 m^2/g and an average particle diameter of 2 to 30 μm. 3. The oral cavity according to claim 1 or 2, wherein the abrasive is obtained by adding a magnesium compound and/or an aluminum compound to calcium hydrogen phosphate anhydrate and firing the mixture. Composition. 4. The oral composition according to any one of claims 1 to 3, wherein the soluble fluorine compound is an alkali metal monofluorophosphate.