JPS62225240A - Oil-in-polyhydric alcohol type emulsion composition - Google Patents

Abstract

PURPOSE:To obtain the titled oil-in-polyhydric alcohol type emulsion composition having excellent stability, feeling, appearance, etc., by using a specified glycerin derivative and cholesterol or phytocholesterol to emulsify an oily substance and a polyhydric alcohol. CONSTITUTION:About 0.05-10wt% of the compd. shown by formula I or formular II is used as the emulsifier, cholesterol or phytocholesterol is used in about 1/5-5/1 weight ratio to the compd. as the emulsification assistant, and a public-known cosmetic oily substance is solubilized or emulsified and uniformly dispersed in a water-soluble polyhydric alcohol. The obtained oil-in- polyhydric alcohol emulsion composition is a uniform and transparent gel or viscous liq. The composition is appropriately used in the fields of cosmetics, medicine, food, etc., in such form or as an oil-in-water type emulsion composition obtained by adding water to the composition.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention uses at least one of the compounds represented by the general formula (1) or (2) below as an emulsifier, and cholesterol or phytosterol as an emulsifying aid. The present invention relates to an oil-in-polyhydric alcohol emulsion composition in which an oily substance (oil phase component) is solubilized or emulsified and uniformly dispersed in a polyhydric alcohol.

More specifically, it acts mildly without irritating the skin or hair, has excellent storage stability (stable over time), and has excellent texture, appearance (texture, transparency), and washability. This invention relates to an extremely good oil-in-polyhydric alcohol emulsion composition.

(Prior Art) In recent years, much research has been conducted on emulsification, and as a result, emulsifiers and emulsification technology have advanced, and extremely stable emulsions are now being used in all industries.

However, most of the emulsifiers used are nonionic surfactants with polyoxyethylene chains, anionic surfactants such as fatty acid soaps, cationic surfactants, and amphoteric surfactants. Emulsified compositions using these synthetic surfactants have the disadvantage that they tend to irritate the skin and hair.

Against this background, natural surfactants, especially phospholipids such as egg yolk lecithin and soybean lecithin, have recently attracted attention.

JP-A-56-70826 discloses an oil-in-polyhydric alcohol emulsion composition using lecithin as an emulsifier, but this emulsion composition lacks stability over time (storage stability) and cannot be put to practical use. lacking in sex. Also, JP-A-59-14
Publication No. 04 1 discloses an oil-in-polyhydric alcohol emulsion composition using a phospholipid or a salt thereof as an emulsifier and a protein or a salt thereof as an emulsification aid.
The protein has its own characteristics, and when it is emulsified, it is easily subject to system constraints (and it is difficult to obtain a product with good appearance (texture, transparency, etc.) and stability over time). .

(Problems to be Solved by the Invention) As a result of intensive research to improve the drawbacks of the prior art, the present inventors have found that the general formula (1) or (2) as an emulsifier is
) and cholesterol or phytosterol as an emulsifying agent to the polyhydric alcohol 18
By adding an oily substance 'R (oil phase component) to Mt, an oil-in-polyhydric alcohol emulsion composition in which the oily substance is dissolved or emulsified and uniformly dispersed in the polyhydric alcohol can be created. This emulsified composition has excellent effects on the skin and hair (mild action and oral stability),
feel.

It was discovered that the product has extremely good appearance (texture, transparency, etc.), washability, etc., and is useful as a cosmetic, etc., and the present invention was completed.

The purpose of the present invention is to have a mild effect without irritating the skin or hair, and to have excellent storage stability (oral stability), as well as good feel and appearance (texture, transparency, etc.).
An object of the present invention is to provide an oil-in-polyhydric alcohol emulsion composition that has extremely good water washability.

(Means for Solving the Problems) The present invention is based on the following general formula (1) % formula % or the following general formula (2) OH2-OH 0H-0-( 2)OH2
at least one of the compounds represented by -X, cholesterol or phytosterol, and at least one water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule,
This is an oil-in-polyhydric alcohol emulsion composition characterized by containing an oily substance.

The compounds represented by the general formulas (]) and (2) in the present invention are known compounds. The general formula (1)
Examples of the compound represented by 1-balmitoyl-8-
Glycerylphosphorylcholine, 1-stearoyl-8-
Glycerylphosphorylcholine, 1-valmitoyl-8-
Glycerylphosphorylethanolamine, ■-stearoyl-3-glycerylphosphorylethanolamine, 1
-Valmitoyl-3-glycerylphosphorylinositol, 1-stearoyl-3-glycerylphosphorylinositol, and compounds represented by the general formula (2) include 2-valmitoyl-3-glycerylphosphorylinositol, 2-stearoyl-3-glycerylphosphorylinositol, -glycerylphosphorylcholine, 2-valmitoyl-8-glycerylphosphorylethanolamine, 2-stearoyl-8-
Examples include glycerylphosphorylethanolamine, 2-valmitoyl-8-glycerylphosphorylinositol, and 2-stearoyl-8-glycerylphosphorylinositol.

The use 1 (amount) of the compounds represented by the general formulas (1) and (2) is 0.05 to 10% based on the total amount M (weight of the composition) of the prescription components in the emulsified composition.
1% by weight, preferably 0.1-5% by weight. 0.05
When Mil is less than 1%, the emulsification of the oily substance tends to be poor, and when it is more than 10% by weight, the solubility in the system decreases and the feel tends to be poor.

Cholesterol or phytosterol is a compound represented by the above general formula (1) or (2) in a ratio of 1
:5 to 5:1.

The polyhydric alcohol used in the present invention is a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, such as ethylene glycol.

Propylene glycol, 1,8-butylene gelicol,
dipropylene glycol, glycerin, diglycerin,
Polyglycerin such as triglycerin and tetraglycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol.

inositol, pentaerythritol, sorbitol,
Examples include maltotriose, threitol, starch decomposition sugar, #powder decomposition sugar reduced alcohol, and the like.

These polyhydric alcohols may be used singly or in combination. The usage amount (compounding amount) is 2 to 95 parts by weight based on the total weight of the prescription ingredients in the emulsified composition.
fi%, preferably 20 to 50% by weight.

The oily substances (oil phase components) that can be used in the present invention include known oily substances for cosmetics, including higher aliphatic hydrocarbons, amorphous oils and fats, and vegetable oils and fats.

These include waxes, higher alcohols, higher fatty acid 2 synthetic ester oils, and silicone oils.

Examples of higher aliphatic hydrocarbons include liquid paraffin, squalane, microcrystalline wax, petrolatum, and ceresin; examples of vegetable oils include olive oil, castor oil, cacao butter, and palm oil; and examples of animal oils include cod liver oil. .

Waxes such as beef tallow and butter fat include beeswax,
Carnauba wax: Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid,
Examples of higher alcohols include oleic acid, behenic acid, and lanolin fatty acids, and examples of chilled oil include butyl stearate.

hexyl laurate, octyldodecyl myristate,
Straight chain esters and branched chain esters such as diisopropyl adipate and diisopropyl sebacate can be mentioned.

These oily substances may be used alone or in combination of two or more. The amount used (formulation ff1) is 2 to 95% by weight, preferably 30 to 70% by weight, based on the total weight of the prescription components in the emulsified composition.

In addition to the above-mentioned components, the oil-in-polyhydric alcohol emulsion composition of the present invention may optionally contain a small amount of fragrance, preservative 2, colorant,
Water etc. can also be blended.

The oil-in-water emulsion composition of the present invention is a homogeneous, transparent gel or transparent viscous liquid, and can be used in food, cosmetics, as it is, or as a stable oil-in-water emulsion composition by adding water. It is suitably used in the preparation of materials, medicines, etc.

As cosmetics, it is useful as, for example, cleansing cream (cleansing sherry), pine surge cream, hair cream, nourishing oil, nourishing cream, and the like.

(Example) Examples will be described below.

Parts shown in Examples mean parts by weight.

Execution row (outer f!! (texture, transparency), feel.

Washability, emulsification state, and storage stability were examined by eight specialized inspectors.

Texture and transparency were determined visually. The tactile effects were examined by examining the release and spread of the sample when applied to the skin, and the finish feeling after application.

Washability was evaluated by applying a sample (0.8F) to the back of the hand, applying a constant stream of water m (100 m 17 seconds) to that area for 5 seconds, and evaluating the amount of sample remaining.

The emulsified state indicates the state immediately after preparation of the emulsified composition, and the storage stability was determined from the emulsified state after storage for 4 months in a constant temperature bath at 40°C.

The evaluation of the results of the above tests is shown in the table with ◎ for extremely good, ◯ for good, Δ for slightly poor, and X for poor.

Example 1. Comparative Examples 1 to 2 In Example 1, oily substances (cholesterol, olive oil, liquid halafine, batyl alcohol) were first uniformly dissolved in SO'C using a recipe based on Table 1 (solution 1).

In addition, about 80% of 1-valmitoyl-8-chrycerylphosphorylcholine, glycerin, and methyl paraoxybenzoate
Dissolve uniformly at °C (molten PIX2).

Next, while stirring Solution 2, molten tL1 is added little by little to emulsify it, and then cooled. In addition, 70° of the cooling process
A fragrance was added at C, and after the temperature was lowered to 80°C, stirring was stopped to prepare cleansing sherry.

Comparative Example 1 is the same as Example 1 except that phosphatidylcholine (1-palmyl-2-oleoyl-8-glycerylphosphorylcholine) is used instead of 1-valmitoyl-3-glycerylphosphorylcholine, and Comparative Example 2 is the same as Example 1 except that soybean lecithin is used. A cleansing sherry for comparison was prepared in the same manner. The characteristics of each are shown in Table 2.

Table 1 Table 2 Examples 2-4. Comparative Example 8 An oil-in-polyhydric alcohol emulsion composition (nourishing cream) was prepared according to Example 1 using the formulation shown in Table 8. The characteristics of each are shown in Table 4.

Table 8 @ Table 4 Examples 5 to 8 An oil-in-polyhydric alcohol emulsion composition (pine surge cream) was prepared according to Example 1 using the formulations shown in Table 5.

The characteristics of each are shown in Table 6.

From Table 5, Table 6 shows that the compound represented by the above general formula and cholesterol are blended in a weight part ratio of 1:5 to 5:1. An oil-in-polyhydric alcohol emulsion composition is obtained.

Examples 9 to 11 Oil-in-polyhydric alcohol emulsion compositions (nourishing creams) were prepared according to Example 1 using the formulations shown in Table 7.

The characteristics of each are shown in Table 8).

Table 7 Table 8 Example 12 (Hair Cream) A hair cream was prepared according to Example 1 with the following formulation.

2-stearoyl-3-glycerylphosphorylcholine
1 part glycerin 20 parts sorbitol solution 8.2 parts castor oil
40 parts liquid paraffin
25 parts cetanol
5 part cholesterol
0.8 parts The hair cream thus obtained is an oil-in-polyhydric alcohol emulsion composition and has a smooth texture (texture).

Excellent appearance, feel, and storage stability including transparency (
◎), the effect of adding luster to the hair, improving combability, and hair styling ability were also good.

Example 13 (Nourishing Oil) A nourishing oil was prepared according to Example 1 with the following formulation.

2-stearoyl-3-glyceryl 0.2 parts Phosphorylethanolamine glycerin 15 parts Sorbitol solution 11 parts Dipropylene glycol 3.65 parts Cholesterol
0.15 parts liquid paraffin
30 parts olive oil
40 parts The thus obtained nourishing oil is an oil-in-polyhydric alcohol emulsion composition, and has a smooth texture (texture).

Excellent appearance including transparency, touch and storage stability (
◎).

Example 14 1-stearoyl-8-glycerylphosphorylcholine, 1-valmitoyl-8-glycerylphosphorylethanolamine, 1-stearoyl-3-glycerylphosphorylethanolamine, 1-valmitoyl instead of 1-parcytoyl-3-glycerylphosphorylcholine -3-
Glycerylphosphorylinositol, 1-stearoyl-3-glycerylphosphorylinositol, 2-valmitoyl-3-glycerylphosphorylcholine, 2-stearoyl-8-glycerylphosphorylcholine.

2-valmitoyl-3-glycerylphosphorylethanolamine, 2-stearoyl-8-glycerylphosphorylethanolamine, 2-valmitoyl-8-glycerylphosphorylinositol.

Each cleansing sherry was prepared in the same manner as in Example 1, except that 2-stearoyl-8-glycerylphosphorylinositol was used.

Each of the obtained cleansing sherrys is an oil-in-polyhydric alcohol emulsion composition similar to the cleansing sherry of Example 1, and has a fine texture (texture).

Appearance such as transparency, feel, washability, and storage stability were good (◎).

Patent applicant: Kanebo Co., Ltd., PA;,'l(,.

Procedural amendment (spontaneous) February 1, 1985 + Date Patent Application No. 17498, 1988 2, Title of invention: Multi-picture oil-in-alcohol emulsion composition 8, Relationship with the person making the amendment Patent applicant address: Tokyo Sumida 5-17-4, Sumida-ku Name (095
) Kanebo Co., Ltd. Representative Susumu Okamoto:::':゛'-,l゛"Contact address: 1-5-90 Tomobuchi-cho, Bejima-ku, Osaka 534 Kanebo Co., Ltd. Patent Department Telephone (06) 921- 1251 In Column 6 of “Detailed Description of the Invention” of the Specification, Contents of Amendment (1) “Branched ester etc.” described in the specification, page 10, line 3 to line 14 of the same page, has been replaced with “branched chain ester, etc.” Examples of silicone oils such as esters include methylpolysiloxane and methylphenylpolysiloxane.

Cyclic silicone oil, polyoxyethylene (20E・0
) dimethylpolysiloxane, polyoxypropylene (2
0P・0) dimethylpolysiloxane, etc.”

(2) Insert the following "Example 15" after "is in good condition (Q) and 9." written on page 21, line 12 of the specification.

Example 15 A hair cream was prepared in the same manner as in Example 12, except that 20 parts of liquid paraffin was used and 5 parts of methylphenyl polysiloxane were added. It is a type emulsion composition with extremely good appearance and feel such as texture (grain), transparency, and storage stability (Q), and also has good effect on giving shine to hair, improving combability, and hair styling ability. ” Procedural amendment (method) % formula % 1. Indication of the case 1985 Patent Application No. 17498 2. Name of the g-mei Oil-in-Polyhydric Alcohol Emulsion Composition 3. Person making the amendment Related Patent Applicant Address 5-17-4 Sumida, Sumida-ku, Tokyo 534
Kanebo Co., Ltd. 1-5-90 Tomobuchi-cho, Bejima-ku, Osaka City
Patent Department Telephone (06) 921-1251 5. Number of inventions increased by amendment None 6. Subject of amendment Column 7 "Contents of amendment" of written procedural amendment submitted on February 14, 1988, Contents of amendment ( 1) Change “Line 14” stated in (1) of “Contents of amendment” column of the written amendment submitted on February 14, 1986 to “Line 4”
Correct to "row".

Claims (1)

[Claims] The following general formula (1) ▲There are mathematical formulas, chemical formulas, tables, etc.▼・・・・・・・・・
(1) Or the following general formula (2) ▲There are mathematical formulas, chemical formulas, tables, etc.▼・・・・・・・・・
(2) (In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼, ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ X is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼, ▲ Mathematical formulas, Chemical formulas , tables, etc.▼, ▲Mathematical formulas, chemical formulas, tables, etc.▼), cholesterol or phytosterol, and a water-soluble polyhydric compound having two or more hydroxyl groups in the molecule. at least one of alcohol;
An oil-in-polyhydric alcohol emulsion composition characterized by containing an oily substance.