JPH03112913A - Emulsion type cosmetic - Google Patents

Abstract

PURPOSE:To provide an emulsion type cosmetic having highly excellent storage stability and good functional characteristics and appearance characteristics by containing a combination of a monoacyl phospholipid and a diacyl phospholipid. CONSTITUTION:The objective cosmetic contains at least one monoacyl phospholipid and at least one diacyl phospholipid of formula I or II (R is group of formula III or IV; X is group of formula V-VII) in amounts of 0.01-10 and 0.001-10wt.%, respectively, 3-80wt.% of an oily substance and, if necessary, a moisture-retaining agent, beauty-active ingredient, aromatic agent, antiseptic, colorant, UV absorbent, etc. The monoacyl phospholipid includes 2-palmitoyl-3- glycerol phosphoryl choline and the diacyl phospholipid includes 1,2- dipalmitoyl-3-glycerol phosphorylethanolamine. The cosmetic is prepared as a cosmetic such as massage cream, cleansing cream, skin cream or hair cream.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an emulsified cosmetic containing a combination of monoacyl phospholipids and diacyl phospholipids.

[Problems to be solved by conventional technology and invention]

In recent years, many studies on emulsification have been conducted. the result,
With advances in emulsifiers and emulsification technology, highly stable emulsified cosmetics are now being used in many fields.

Most of the emulsifiers are nonionic surfactants having polyoxyethylene chains, anionic surfactants such as fatty acid soaps, and cationic surfactants. However, emulsified cosmetics using these synthetic surfactants,
Generally, it has the disadvantage that it tends to irritate the skin and hair.

Against this background, phospholipids, particularly monoacyl phospholipids, have attracted attention.

JP-A-61-171407 discloses an emulsified cosmetic using a monoacyl phospholipid as an emulsifier.

However, conventional emulsion type cosmetics prepared using monoacyl phospholipids have had problems with storage stability, especially storage stability under low and high temperature environments. Further, there was a need for further improvement in terms of organoleptic properties (particularly lasting smoothness and finish) and appearance (texture).

That is, when emulsified cosmetics are stored under low temperature conditions (5° C. or lower) or high temperature conditions (40° C. or higher), there is a drawback that the appearance, such as viscosity and texture, changes.

On the other hand, diacyl phospholipids are amphiphilic, with a strongly lipophilic fatty acid at one end of the molecule and a strongly hydrophilic choline skeleton at the other end, so they are used as wetting agents or emulsifiers in fields such as food, medicine, and cosmetics. has been done.

However, depending on the oily substance, its emulsifying power is not sufficient, and when making an O/W type emulsion, W10
There was a phase inversion into a type emulsion, and the appearance and emulsification properties were not very good.

[Means to solve the problem]

As a result of intensive research to solve the drawbacks of emulsified cosmetics using monoacyl phospholipids, the present inventors found that monoacyl phospholipids and diacyl phospholipids represented by General 2 (11 or (2) below) When used in combination,
The present invention was completed based on the discovery that storage stability, sensory characteristics, and appearance are improved.

That is, the present invention provides cosmetics containing an oily substance and water containing at least one monoacyl phospholipid represented by the following general formula (11) or the following general formula (2) Hz -C-C+sH:++ (1). The present invention is an emulsified cosmetic containing at least one of diacyl-type phospholipids.

The compounds represented by the general formulas (1) and (2) in the present invention, i.e., mono 0-acyl-3-glycerylphosphorylcholine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono 0-acyl 3-glycerylphosphorylethanolamine, mono
Glycerylphosphorylinositol itself is known. Compounds represented by general 2 (1) include 1-valmitoyl-3-glycerylphosphorylcholine, 1-stearoyl-3-glycerylphosphorylcholine, 1-valmitoyl-3-glycerylphosphorylethanolamine,
(1)-stearoyl-3-glycerylphosphorylethanolamine, 1-valmitoyl-3-glycerylphosphorylinositol, and 1-stearoyl-3-glycerylphosphorylinositol. Examples of the compound represented by the general formula (2) include 2-valmitoyl-3-glycerylphosphorylcholine, 2-stearoyl-3-glycerylphosphorylcholine, 2-valmitoyl-3-glycerylphosphorylethanolamine, and 2-stearoyl-3-glycerylphosphorylethanol. Amine, 2-valmitoyl-3-glycerylphosphorylinositol,
2-stearoyl-3-glycerylphosphorylinositol is mentioned.

The compounds represented by the above general formulas +11 and (2) can be obtained by using, for example, phosphatidylcholine, phosphatidylethanolamine or phosphatidylinositol obtained from egg yolk as a raw material, treating it with, for example, pancreatin, an enzyme extracted from pig pancreas, and then using it by rapid liquid chromatography. Obtained by fractionation. Alternatively, it can be obtained by chemical synthesis.

In the present invention, the compounds represented by the above general formulas (1) and (2) are used singly or in combination as an emulsifier.

The diacyl phospholipid used in the present invention generally exists uniformly in biological systems and is known as a main component of biological membranes. In the present invention, the source and acquisition method are not particularly limited, but for example, animal brain/liver, egg yolk,
In the present invention, animal/plant extracts containing diacyl phospholipids extracted from the above-mentioned animals/plants and their tissues by known methods, or diacyl phospholipids obtained by purifying the same, are used. Lipids can be used.

Furthermore, diacyl-type phospholipids obtained by synthesis can also be used.

Examples of the above diacyl phospholipids include 1.2
-Dipalmitoyl-3-glycerylphosphorylethanolamine, 1,2-dipalmitoyl-3-glycerylphosphorylcholine, 1-oleoyl-2-stearoyl-
3-glycerylphosphorylcholine, 1,2-dihexadecenyl-3-glycerylphosphorylethanolamine,
1.2 Dioleoyl-3-glycerylphosphorylcholine.

l-valmitoyl-2-oleoyl-3-glycerylphosphorylethanolamine, 1,2-distearoyl-
Examples include 3-glycerylphosphorylinositol, 1-valmitoyl-2-stearoyl-3=glycerylphosphorylethanolamine, and 1-stearoyl-2-valmitoyl-3-glycerylphosphorylinositol.

The blending amount of the monoacyl phospholipids represented by the above formulas (1) and (2) is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight based on the total weight of the prescription components. The blending amount of the diacyl phospholipid is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight.

If the amount of either the monoacyl phospholipid or the diacyl phospholipid represented by formulas (1) and (2) is less than the above amount, the desired storage stability may not be obtained, which is undesirable. If the amount exceeds the amount, the cosmetic itself tends not to be completely dissolved in the system and separates, and the cosmetic composition tends to have a poor feel when used.

The oil-based substances used in the present invention broadly refer to oil-based substances, such as oil-soluble fragrances, oil-soluble vitamins, oil-soluble hormones, oil-soluble pigments, oil-soluble ultraviolet absorbers, and higher aliphatic hydrocarbons. , vegetable oils and fats, animal oils and fats, waxes, higher fatty acids, higher alcohols, synthetic ester oils, and the like.

More specifically, examples of oil-soluble fragrances include oil-soluble fragrances extracted from natural animals and plants and synthetic oil-soluble fragrances. Examples of oil-soluble vitamins include vitamin A, vitamin D1, vitamin E1, vitamin F, vitamins in the vitamin group, pyridoxine caprilate, pyridoxine cybalmitate, acid 11dj2-α-tocopherol, nicotine 5gdll-α-tocopherol, ascorbyl cybalmitate, Examples include vitamin derivatives such as ascorbyl monobalmitate and ascorbyl monostearate. Examples of oil-soluble hormones include estradiol, ethinyl estradiol, estrone,
Examples of oil-soluble pigments such as diethylstilbestrol include Sudan ■, tetrabromofluorescein, dibromefluorescein, fluorescein, and quinizarin green SS; examples of oil-soluble ultraviolet absorbers include oxybenzone and 2,5-diisopropyl. Examples include methyl cinnamate.

Examples of higher aliphatic hydrocarbons include liquid paraffin, squalane, microcrystalline wax, petrolatum, and ceresin; examples of vegetable oils include olive oil, castor oil, cacao butter, and palm oil; and examples of animal oils include cod liver oil. Waxes such as , beef tallow and butter fat include beeswax and carnauba wax, and higher fatty acids include lauric acid, myristic acid, palmitic acid,
Stearic acid, oleic acid, behenic acid, lanolin fatty acids, etc.; higher alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, oleyl alcohol; synthetic ester oils such as butyl stearate, hexyl laurate, octyldodecyl milli Examples include straight chain esters, branched chain esters such as state, diisopropyl adipate, and diisopropyl sebacate.

These oily substances may be used singly or in combination.

In the case of emulsified cosmetics such as creams and milky lotions, the amount of oily substances blended is approximately 3 to 80% by weight, preferably 10 to 60% by weight, based on the total weight of the prescription ingredients in the emulsified composition. If it is less than about 3% by weight, the storage stability will be somewhat poor and the finish will be unsatisfactory as an emulsified cosmetic amount, and if it is more than about 80% by weight, the oil will become extremely sticky, which is undesirable.

The cosmetics of the present invention may contain moisturizing agents, cosmetic medicinal ingredients, fragrances, preservatives, colorants, ultraviolet absorbers, astringents, synthetic surfactants, pigments (kaolin, mica, sericite, talc), as necessary. , yellow iron oxide, red iron oxide, etc.), water-soluble natural polymers (caseinate soda, pectin, xanthan gum, karaya gum, locust bean gum, carrageenan, etc.) can be added.

Cosmetics of the present invention include, for example, pine surge cream, cleansing cream, skin cream, skin milk, foundation makeup base,
Examples include, but are not limited to, hair creams and the like.

〔Example〕

Examples will be described below.

"Parts" shown in Examples mean parts by weight.

The properties of the cosmetics investigated in the Examples are storage stability, organoleptic properties, and appearance.

The test method is as follows.

(1) Storage stability was evaluated by leaving the sample composition in a constant temperature bath at 45°C (high temperature) or 0°C (low temperature) for 1 to 6 months, and examining its viscosity.

(2) Sensory properties were evaluated by examining the feel during application (duration of smoothness) by three specialized inspectors.

(3) Appearance was determined by the naked eye.

Examples 1-6. Comparative Examples 1-2 Skin Milk Skin milk was prepared using the formulation (parts by weight) shown in Table 1.

As a monoacyl phospholipid, 2-valmitoyl-3-
Glycerylphosphorylcholine was used.

As a diacyl phospholipid, 1,2-dipalmitoyl-
3-Glycerylphosphorylethanolamine was used.

Oily components 1 to 6 listed in the table were uniformly mixed and dissolved at about 80°C (solution 1). Water-soluble components 7 to 10 and 12 in the table were uniformly dissolved at approximately 80°C (solution 2).
Next, Solution 1 was added to Solution 2 while stirring with a homomixer, emulsified, and then cooled. In addition, 70° of the cooling process
Component 11 was added at C. After the temperature was lowered to 30.degree. C., stirring was stopped.

The properties of the obtained skin milk are shown in Table 1.

The skin milks of Examples 1 to 6 had good storage stability. However, among the skin milks of Comparative Examples 1 and 2 lacking either monoacyl phospholipid or diacyl phospholipid, the former significantly thickened during storage for 3 months at O''C and did not come out of the container.

In the latter case, the phase separated during storage at 45° C. for 3 months and the emulsified state was unstable.

Examples 7-12. Comparative Examples 3 to 4 Skin Cream Skin creams were prepared using the formulations (parts by weight) shown in Table 2.

As a monoacyl phospholipid, 1-stearoyl-3-
Glycerylphosphorylethanolamine, diacyl phospholipid, l-stearoyl-2-valmitoyl-
3-Glycerylphosphorylinositol was used.

Among the components listed in the table, oily components 1 to 7 were uniformly mixed and dissolved at approximately 80°C (solution 1), and water-soluble component 8 of the above components was mixed and dissolved uniformly at approximately 80°C.
10 and 12 were uniformly mixed and dissolved at about 80° C. (Solution 2) Next, while stirring Solution 2 with a homomixer, Solution 1 was added, emulsified, and then cooled. During the cooling process, one component was added at 70°C, and after the temperature was lowered to 30°C, stirring was stopped.

The properties of the obtained skin cream are shown in Table 2.

The skin creams of Examples 7 to 12 had good storage stability, pentasensory properties, and appearance. However, Comparative Example 3 lacking either monoacyl phospholipid or diacyl phospholipid
Regarding the skin creams No. 4 and 4, the former phase separated during storage at 45" CI, and the latter phase separated during storage at 45°C for 3 days. Thus, there were problems with their storage stability. On the other hand, , the skin cream of the present invention has storage stability,
Example 13 Make-up Base A make-up base was prepared using the following formulation (parts by weight).

As monoacyl phospholipids, 2-valmitoyl-3-glycerylphosphorylinositol and 1-stearoyl-
3-glycerylphosphorylcholine was used, and 1,2 dioleoyl-3-glycerylphosphorylcholine and 1-valmitoyl-2-stearoyl-3-glycerylphosphorylethanolamine were used as diacyl phospholipids.

1. Liquid paraffin 12.02.
Squalane 3.03, glyceryl monostearate 1.54, cholesterol 0.25, cetyl alcohol 0.38, glycerin 9, carrageenan 5.0 0.5 12, methyl paraoxybenzoate 0.113
, dipropylene glycol 3.014, titanium oxide 0.515, fragrance
0.116, purified water
71.8 Among the above components, oily components 1 to 7 were uniformly mixed and dissolved at about 80°C (melt WL1
). Among the above components, aqueous components 8 to 12 and 16 were uniformly mixed and dissolved at about 80°C (solution 2), and component 14 was uniformly dispersed in component 13 (dispersion 3).Next, solution 2
While stirring with a homomixer, Solution 1 was added and emulsified, then Dispersion 3 was added, further stirred, and then cooled.

In addition, component 15 was added at 70°C during the cooling process, and the temperature was increased to 30°C.
After the temperature was lowered to 1, stirring was stopped.

The makeup base of Example 13 thus obtained was as follows:
It is an O/W type emulsion, and it is heated in a constant temperature bath at 45℃.
The stability was excellent when stored for several months. It was also extremely stable even after storage for 6 months at 0°C and 5°C. In addition, the organoleptic characteristics were good, and the appearance (texture) was also good.

〔Effect of the invention〕

The emulsified cosmetic composition of the present invention has extremely excellent storage stability, and also has extremely good sensory characteristics and appearance.

Claims (1)

[Scope of Claims] In cosmetics containing oily substances and water, the following general formula (1) ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (1) or the following general formula (2) ▲ Numerical formulas, chemical formulas, etc. , tables, etc. ▼...(2) (In the above formula, R is ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ Or ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ or ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ ) A distinctive emulsified cosmetic.