JPS6136214A - Composition for oral cavity cleaning - Google Patents

Abstract

PURPOSE:To provide the titled composition containing miraculin, and capable of effectively improving the juice effect even in the presence of residual sodium laurylsulfate used as a foaming agent in the oral cavity. CONSTITUTION:Miraculin wich is a glycoprotein component existing in miracule fruit (grown in West Africa) is added to the base composition in an amount of 1-10<-4>wt%, preferably 10<-1>-10<-3>wt% in terms of pure compound. Pure miraculin separated from miracle fruit, or the powder or extract of the fruit may be used for the purpose. The compound is effective to suppress the juice effect- inhibiting activity of sodium laurylsulfate added to the composition as a foaming agent to improve the refreshness and feeling of the oral cavity and the cleaning effect, and gives excellent juice effect to the oral cavity.

Description

TECHNICAL FIELD OF THE INVENTION The present invention relates to mouthwash compositions such as mouthwashes, and more particularly to mouthwash compositions aimed at improving the juice effect.

Conventionally, in compositions applied to the oral cavity, such as toothpaste compositions, anionic activators have been used as foaming agents to increase the cooling sensation in the oral cavity when applied, to increase the feeling of use, and to improve the cleaning effect. Of these, sodium lauryl sulfate is the most commonly used. However, sodium lauryl sulfate worsens the juice effect. When a composition containing this is applied, there is a residual amount of sodium lauryl sulfate in the oral cavity, which changes the taste of the juice when it is drunk during application of this oral composition.

For this purpose, sodium lauryl sulfate has conventionally been used in combination with other activators (Japanese Patent Publication No. 35-3049, Japanese Patent Publication No. 52-24573, Japanese Patent Publication No. 113709-1982).
, a method that specifies the grade of sodium lauryl sulfate (Japanese Patent Publication No. 49-25337), and a method using a blowing agent in place of sodium lauryl sulfate (Japanese Patent Publication No. 52-34941, Japanese Patent Application Publication No. 54-117039). Other methods have also been proposed. These methods attempt to solve the problem of the juice effect by reducing or eliminating the amount of sodium lauryl sulfate remaining in the oral cavity. A composition that provides a good juice effect even when sodium lauryl sulfate remains in the oral cavity is desired.

SUMMARY OF THE INVENTION In view of the above circumstances, the present inventors have developed a composition for mouthwash that can improve the juice effect even if an anionic surfactant, particularly a water-soluble salt of an alkyl sulfate such as sodium lauryl sulfate, remains in the oral cavity. As a result of extensive research, we found that miraculin has a remarkable effect on improving the juice effect, and that when a mouthwash composition containing miraculin is applied, ingredients such as sodium lauryl sulfate that worsen the juice effect remain in the oral cavity. also often inhibits the juice effect,
The present invention was based on the discovery that a good juice effect can be exerted.

That is, miraculin is a miracle fruit (Synsepalum dulclficum) produced in West Africa.
The fruit itself has almost no taste, but it is known to have the effect of making sour foods sweet (Japanese Patent Laid-Open No. 46 -3976). However, according to the studies conducted by the present inventors, Miraculin is highly effective in improving the juice effect even when sodium lauryl sulfate and the like remain in the oral cavity, as described above, and is an excellent juice when incorporated into oral cleaning compositions. It is a new finding of the present inventors that miraculin provides a high juice effect.

The reason why miraculin exhibits an excellent juice effect is not necessarily clear, but since miraculin is a basic glycoprotein, it has a very good affinity with anionic foaming agents such as sodium lauryl sulfate, and it is adsorbed to the oral mucosa. It is thought that the juice effect is improved by reacting with sodium lauryl sulfate, etc., and removing sodium lauryl sulfate, etc. from the oral mucosa. Miraculin itself has a strong affinity with the oral mucosa and lasts for 2 to 3 hours, and sodium lauryl sulfate also has a strong binding force, so it can be applied at the same time as sodium lauryl sulfate. A good juicing effect can be achieved even when applied before or after the application of .

The present invention will be explained in more detail below.

Structure of the Invention The oral cleaning composition of the present invention is used as a mouthwash, liquid mouth freshener, liquid toothpaste, toothpaste, and other dentifrices, and is characterized by containing miraculin. .

Here, miraculin refers to miracle fruit (Synaepalum duleificum) as mentioned above.
In the present invention, a pure product isolated from miracle fruit may be used as miraculin, or a powder of the fruit of miracle fruit may be used as miraculin. Fruit extracts may also be blended. In addition, as a fruit extract of miracle fruit, for example, the fruit is
Extract with carbonate buffer of i-110,5, and further extract Pl(
After adjusting to 7, DEAE-5epha-dex-A
It is possible to use products purified by adsorbing impurity proteins other than miraculin in 25.

When miraculin is blended into a composition, there are no particular restrictions on its blending mode, and it may be blended in one form or, for the purpose of stably blending miraculin, a pure product of miraculin or a microcapsule of miracle fruit extract may be used. It can also be made by blending miracle fruit powder coated with dextran or the like.

The amount of miraculin to be blended is preferably 1 to 10% (wt%, same hereinafter), particularly 10 to 10%, of the entire composition as a pure product of miraculin.

As other components of the oral cavity cleaning composition of the present invention, appropriate components are used depending on the type of composition, etc.

For example, in the case of liquid compositions such as mouthwashes, in addition to solvents such as water and ethyl alcohol, polyethylene glycol,
Thickening agents such as sorbitol, glycerin, and propylene glycol, water-soluble salts of alkyl sulfate esters with alkyl groups having 8 to 16 carbon atoms such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate. , surfactants such as sodium lauryl sulfoacetate, sodium lauroyl sarcosinate, N-acyl glutamate, lauryl jetanolamide, sucrose fatty acid ester,
In addition, essential oils such as peppermint and spearmint, fragrance materials such as t-menthol, carvone, eugenol, and anethole, sweeteners such as saccharin sodium, stevioside, neohesberidyl dihydrocachalcone, glycyrrhizin, perillartin, and p-methoxycinnamic aldehyde , preservatives, etc. may be added. In addition, in the case of dull or linear compositions, binders such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, alginates, caradanan, gum arabic, and polyvinyl alcohol may be added, and in toothpastes, calcium diphosphate, carbonate, etc. Calcium, calcium pyrophosphate, insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide,
An abrasive such as aluminum hydroxide or resin may be blended.

In the present invention, chlorhexidine salt, dextranase, mutanase, sorbic acid, alexidine,
hinokitiol, cetylpyridinyl muchloride,
Active ingredients include alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E1 water-soluble primary or diphosphate, quaternary ammonium compounds, sodium chloride, crude drug extracts, etc. can also be blended.

The mouthwash composition of the present invention can be applied by a known method depending on the type of mouthwash, but in this case, a juice effect inhibiting component such as sodium lauryl sulfate is blended into the composition, and this inhibiting component and miraculin are simultaneously mixed. Alternatively, miraculin and the juice effect inhibiting ingredient may be combined into separate compositions, and the composition containing the juice effect inhibiting ingredient may be applied before or after the composition containing the juice effect inhibiting ingredient is applied. The miraculin-containing composition of the present invention may be applied, and in either case, it provides a good Gies effect.

Effects of the Invention According to the oral cavity cleaning composition of the present invention, the combination of miraculin provides an excellent effect of improving the effect of juice.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to examples, but the present invention is not limited to the following examples.

[Example 1] Mouthwash Ethyl alcohol (90%) 20゜0 Thisodium lauroyl sarcosinate 0.5 Saccharin sodium 0.1 Fragrance
1.0 Sodium monofluorophosphate 0.15 Disodium phosphate
0.3 phosphate-sodium
0.7 Miracle Fruit Extract Concentrate 2.0100.0% [Example 2] Liquid Mouth Freshener Ethyl Alcohol (90%) 30.0%
Glycerin 15.0 Fragrance
3.0 Polyoxyethylene hydrogenated castor oil 0.5 Satucharin sodium
0.2 miracle fruit extract concentrate
1.5 water
Remaining 100.0% [Example 3] Liquid toothpaste glycerin 35.0% Sodium polyacrylate 5.0 Polyglycerin fatty acid ester 1.5 Sodium monofluorophosphate 0.76 Saccharin sodium 0.1 Fragrance
1.0 dipotassium phosphate
0.1 phosphate-potassium
0.2 miracle fruit extract concentrate
1.0100.0% In the above example, the miracle fruit extract concentrate was 0.1M carbonate buffer 2 of pi-110.5.
Extract the freeze-dried product 501 of Miracle Fruit at 50°C for 5 minutes, then centrifuge at -5°C for 20 minutes (1
0.000 rotations) After adjusting the pH to 7.0 with IN hydrochloride, DEAE-5ephadax-A 25
The extract obtained by adsorbing and purifying impure proteins other than miraculin was concentrated 20 times. This concentrate contains approximately 1200 ppm of miraculin.

Next, the effect of improving the juice effect of the composition of the above example was evaluated by the following method.

Using a panel of five experts, the students were first given a taste of the juice to memorize its taste. Next, the following prescription "Calcium 50 Tisolpit"
20 Sodium lauryl sulfate 2,0
Satucharin sodium 0.1 fragrance
If you taste the juice immediately after brushing your teeth with a toothpaste containing 0.9% sodium lauryl sulfate, or if you wash your mouth with the above composition containing miraculin after brushing your teeth ( In the case of mouth drops, after rinsing your mouth with 20 Mark, which is a 10-fold dilution of 20C,
In the case of liquid mouth fresheners, after taking one drop (approx. The participants were asked to compare the taste of the juice they had tasted before brushing their teeth and judge whether the taste had gotten worse or better. The results are shown in Table 1. The evaluation criteria are as follows.

Evaluation Criteria 5: Niji Youth effect has been significantly improved (same level as not brushing teeth) 4: Niji Youth effect has been slightly improved 3: Niji Youth effect has been improved 2: Juice effect has been slightly improved 1: Niji Youth The effect was not improved (same level as immediately after brushing teeth) Table 1 According to the results shown in Table 1, it was confirmed that the juice effect could be improved by applying a composition containing miraculin.

Claims (1)

[Claims] 1. An oral cavity cleaning composition characterized by containing miraculin.