JPH09132517A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral cavity composition having improved application feeling, exactly screening the strange taste due to sodium hydrogen carbonate by formulating one or two kinds of specific compounds to a composition for oral cavity containing sodium hydrogen carbonate. SOLUTION: A combination of a salt of glycyrrhizic acid with 1,8-cineole are formulated to an oral cavity composition containing >=5wt.% of sodium hydrogen carbonate. These glycyrrhizic acid salt and 1,8cineole synerigistically act to screen the strange taste of sodium hydrogen carbonate. The glycyrrhizic acid salt is, for example, monoammonium glycyrrhizate or the like and its amount in the formulation is about 0.005-0.5wt.%. The 1,8-cineole is used as a perfume and the essential oil containing this compound may be used as it is and its amount in the formulation is at a level of 0.001-0.5wt.%. This composition may be prepared to mouth wash, chewing gum and the like.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing sodium hydrogen carbonate, which has a good feeling in use.

[0002]

2. Description of the Related Art
It is known that the composition for oral cavity contains sodium hydrogen carbonate for the purpose of obtaining a refreshing feeling of use, but the composition for oral cavity containing this sodium hydrogen carbonate has a peculiar taste. Especially when added in a large amount, there is a serious drawback that the usability is significantly impaired.

On the other hand, in order to improve the feeling of use by masking the bitterness and off-taste of abrasives, activators, active ingredients, etc. which are mixed in oral compositions such as toothpaste, it is necessary to add a sweetener. It is known to be effective.

However, in the oral composition containing sodium hydrogen carbonate, even if the above-mentioned sweetener is used, it is difficult to shield the off-taste peculiar to the composition, and it is difficult to improve the feeling of use. Particularly, in the oral composition containing sodium hydrogencarbonate at a high concentration of 5% by weight or more based on the whole composition, the aftertaste is strongly unpleasant and the improvement is satisfactory only by adding a general sweetener such as saccharin. The current situation is that no effect was obtained and no method for improving this point has been established.

[0005] The present invention has been made in view of the above circumstances,
Provided is an oral composition in which sodium hydrogen carbonate is blended at a high concentration of 5% by weight or more based on the entire composition, and which improves the peculiar taste of sodium hydrogen carbonate and gives an excellent usability. The purpose is to

[0006]

Means for Solving the Problems and Modes for Carrying Out the Invention The present inventor has conducted extensive studies to achieve the above object, and as a result, sodium hydrogencarbonate was added in an amount of 5% (% by weight,
The same applies to the following) Glycyrrhizinates are good for improving the feeling of use of the oral composition containing the above, and by using sodium hydrogencarbonate and glycyrrhizinate in combination in this manner, the above-mentioned problems are eliminated, and hydrogen carbonate There is no peculiar taste derived from sodium, and an oral composition having a good feeling of use can be obtained. Furthermore, by using together 1,8-cineole, glycyrrhizinates and 1,8-cineole are synergistic. It has also been found that the above-mentioned effect acts on the above-mentioned substance to surely shield the peculiar taste derived from sodium hydrogen carbonate, and to obtain a better usability.

That is, in oral compositions such as toothpaste,
For example, it is known to use a sweetening agent to reduce bitterness and the like of abrasives, surfactants, active ingredients, etc., but the present inventors have found that saccharin commonly used as a sweetening agent, saccharin sodium, Among Cyclo (artificial sweeteners), glycyrrhizates, stevia (natural sweeteners), etc., especially the glycyrrhizates are mixed with sodium hydrogen carbonate at a high concentration of 5% or more to reduce the off-taste peculiar to the oral composition. The present inventors have completed the present invention by finding that the effect is recognized.

Accordingly, the present invention provides an oral composition characterized by containing glycyrrhizinates in an oral composition containing 5% or more of the total composition of sodium bicarbonate.

The present invention will be described in more detail below. The oral composition of the present invention is a toothpaste such as toothpaste and liquid toothpaste, mouthwash, mouth freshener, troche, mouthwash, chewing gum and the like. It can be prepared as a composition for use, which is a combination of sodium hydrogen carbonate and glycyrrhizinates.

In the composition of the present invention, the content of sodium hydrogencarbonate is 5% or more, preferably 5 to 5% of the total composition.
60%. If the content of sodium hydrogencarbonate is less than 5%, a refreshing feeling of use cannot be obtained and the content is 6%.
If it exceeds 0%, the effect of reducing the off-taste peculiar to sodium hydrogen carbonate may not be sufficiently exhibited even if glycyrrhizates are added.

The glycyrrhizinates used in the present invention include ammonium glycyrrhizinate,
Potassium salts and the like are suitable, and specific examples thereof include monoammonium glycyrrhizinate and dipotassium glycyrrhizinate.

The amount of glycyrrhizic acid salt compounded is 0.005 to 0.5%, especially 0.01 to 0.1% of the total composition.
It is preferable that If the amount of glycyrrhizinate is less than 0.005%, the effect may not be sufficiently exhibited, and if the amount of glycyrrhizinate is more than 0.5%, it may have a peculiar penetrating taste peculiar to glycyrrhizinate. May occur.

Further, in the present invention, it is preferable to use 1,8-cineole together. This 1,8-cineole is
Usually, it is isolated from essential oils such as plants and used as a fragrance, and it may be used by itself or an essential oil containing 1,8-cineole may be used as it is.

Further, 1,8-cineole is usually added to a fragrance, and this fragrance is added to the oral composition. In this case, the compounding amount of 1,8-cineole is
It is desirable that the amount of the fragrance is 0.1 to 50%, especially 0.5 to 10%, and the amount thereof is 0.00 of the total composition.
It is preferably 1 to 0.5%, particularly preferably 0.005 to 0.1%. The amount of 1,8-cineole is 0.001%
If it does not meet the requirements, the refreshing feeling may be insufficient, or the off-taste peculiar to the oral composition containing sodium hydrogen carbonate may not be surely masked. Is strong, and a good feeling of use may not be obtained.

The oral composition of the present invention may contain other optional components depending on its dosage form.

In addition to the above-mentioned components, the oral composition of the present invention may further contain appropriate components depending on the purpose, type of composition and the like in a usual dose.

For example, in the case of dentifrice, dibasic calcium phosphate dihydrate and anhydrous dibasic calcium phosphate,
Tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid, aluminum silicate, insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite,
One or two of zirconium silicate and other synthetic resins
One or more species may be blended (usually the blending amount is 3-70%).

In the case of a paste-like composition such as toothpaste, as a binding agent, carrageenan, cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose, xanthan gum, tragacanth gum, karaya gum, Arabic. Mixture of one or more of gums such as gums, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer and polyvinylpyrrolidone, and inorganic binders such as silica gel, aluminum silica gel, bee gum, and laponite. It is possible (usually the compounding amount is 0.1 to 5%).

Further, for paste or liquid oral compositions such as toothpaste, sorbit, glycerin,
Ethylene glycol, propylene glycol, 1,3-
One or more of butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like may be blended (usually 1 to 70%).

The composition of the present invention contains menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, linalool, ethyl linalool, vanillin within a range that does not impair the effects of the present invention. , Thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil,
Fragrances such as cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil may be blended alone or in combination of two or more, as well as sodium saccharin, stevioside, neohesperidyl dihydrochalcone, perillartin, thaumatin, asparatyl phenylalanine. A sweetener such as methyl ester or p-methoxycinnamic aldehyde may be added.

In the present invention, as an active ingredient, enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dimstase, etc., sodium monofluorophosphate are used as long as the effects of the present invention are not impaired. , Alkali metal monofluorophosphates such as potassium monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, dihydrocholestanol, glycyrrhetinic acids, bisabolol, Isopropyl methylphenol, glycerophosphate, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, isopropylmethyi Phenol, benzalkonium chloride, may be incorporated one or more kinds of active ingredients, such as benzethonium chloride. In addition, the compounding amount of the active ingredient can be a usual amount as long as the effect of the present invention is not hindered.

As the surface active agent, an anionic surface active agent, a nonionic surface active agent, or a zwitterionic surface active agent can be used. Examples of the anionic surfactant include sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosinate such as sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, sodium dodecylbenzene sulfonate, hydrogen N-acylglutamic acid salts such as sodium coconut fatty acid monoglyceride monosulfate monosodium sulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, α-olefin sulfone For example, sodium acid is used.

Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid ester such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan monolaurate. Polyoxyethylene sorbitan monostearate and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil and other polyoxyethylene fatty acid esters, lauric acid mono- or diethanolamide, myristic acid mono- or diethanolamide fatty acid diethanolamide, Sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene Such as oxypropylene fatty esters are used.

As the zwitterionic surfactant, N-alkyldiaminoethylglycine such as N-lauroyldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, 2-alkyl-1- Hydroxyethyl imidazoline betaine sodium and the like are used.

In this case, an anionic surfactant is preferably used as the surfactant, and more desirably, sodium alkylsulfate such as sodium lauryl sulfate is used.

These surfactants may be used alone or in combination of two or more. Also,
The amount of the surfactant compounded is usually 0.01 to 5 of the total composition.
%, Particularly preferably 0.05 to 3%.

The composition of the present invention contains a dye and a colorant,
Can be dyed. In this case, various pigments and coloring agents are used.
No. 2, Red 226, Yellow 4, Yellow 5, Blue 1, Blue 2, Blue 201, Blue 204, Mica Titanium, Titanium Oxide, etc. are preferably used (usually 0.000).
1-1%).

[0028]

EFFECTS OF THE INVENTION The composition for oral cavity of the present invention is improved in the distinctive taste of sodium hydrogen carbonate and is excellent in the feeling of use. Toothpaste such as toothpaste and liquid toothpaste, mouthwash, mouthwash It can be suitably used as a cooling agent, troche, mouthwash, chewing gum and the like.

[0029]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to experimental examples and examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Experimental Example 1] Oral compositions (toothpaste) having the compositions shown in Tables 1 and 2 were prepared, and sensory evaluation was performed by 10 professional panelists according to the following criteria by a 5-step evaluation method. The results (average values are rounded off) are shown in Tables 1 and 2. Sensory evaluation: Rating 5: The off-taste peculiar to sodium hydrogencarbonate is recognized very strongly. 4: A distinctive taste peculiar to sodium hydrogen carbonate is strongly recognized. 3: Some off-taste peculiar to sodium hydrogencarbonate is recognized. 2: Almost no off-taste peculiar to sodium hydrogen carbonate is recognized. 1: No distinctive taste specific to sodium hydrogen carbonate is observed.

From the results of Tables 1 and 2, when glycyrrhizinates are used in combination with an oral composition containing sodium hydrogencarbonate in an amount of 5% or more, preferably 5 to 60% of the total composition, no glycyrrhizinates are blended. A significant difference was observed in the sensory test as compared with the above-mentioned products, and it was confirmed that an excellent taste improvement effect was brought about, and that the one to which 1,8-cineole was added exhibited a more excellent taste improvement effect.

[0032]

[Table 1]

[0033]

[Table 2]

[Experimental Example 2] Oral compositions (toothpaste) having the compositions shown in Tables 3 and 4 were prepared, and the same procedure as in Experimental Example 1 was repeated.
Sensory evaluation was performed by 10 professional panelists by the graded evaluation method. The results (average values are rounded off) are shown in Tables 3 and 4.

From the results shown in Tables 3 and 4, in the oral composition containing 5% or more of sodium hydrogen carbonate, the amount of glycyrrhizinates added was 0.
When it is 0005 to 0.5%, particularly 0.01 to 0.1%, it is possible to satisfactorily improve the off-taste peculiar to the oral composition containing sodium hydrogen carbonate, and further 1,8-
The amount of cineole is 0.001 to 0.5 based on the total composition.
%, Particularly 0.005 to 0.1%, and by using both glycyrrhizinates and 1,8-cineole in combination, it is possible to surely shield the peculiar taste of the oral composition containing sodium hydrogen carbonate. I knew that I could do it.

[0036]

[Table 3]

[0037]

[Table 4]

Example 1 Liquid Toothpaste Sodium Bicarbonate 10.0 Zirconosilicate 5.0 Precipitating Silica 5.0 Glycerin 20.0 Propylene Glycol 2.0 Sodium Polyacrylate 0.3 Xanthan Gum 0.1 Sorbit 25 0.0 Sodium lauryl sulfate 0.8 N-lauroyl-N-methyltaurine sodium 0.8 Polyglycerin lauric acid ester 2.0 Sodium fluoride 0.2 l-Menthol 0.5 Anethole 0.1 Saccharin sodium 0.1 Glycyrrhizin dipotassium 0.08 purified water balance total 100.0 (wt%)

Example 2 Liquid Toothpaste Sodium Bicarbonate 20.0 Zirconosilicate 5.0 Precipitable Silica 5.0 Glycerin 10.0 Propylene Glycol 2.0 Sodium Polyacrylate 0.3 Xanthan Gum 0.1 Sorbit 25 0.0 Sodium lauryl sulfate 0.8 N-lauroyl-N-methyltaurine sodium 0.8 Polyglycerin lauric acid ester 2.0 Sodium fluoride 0.2 l-Menthol 0.5 Anethole 0.1 Saccharin sodium 0.1 Glycyrrhizin dipotassium 0.1 1,8-cineole 0.1 purified water balance total 100.0 (wt%)

[Example 3] Toothpaste Sodium hydrogen carbonate 10.0 Silica anhydride 10.0 Glycerin 25.0 Propylene glycol 3.0 Hydroxyethyl cellulose 1.0 Sorbit 10.0 Toxyl 5.0 Titanium oxide 0.3 Butyl paraben 0.01 Sodium fluoride 0.2 l-menthol 0.4 anethole 0.1 saccharin sodium 0.1 monoammonium glycyrrhizinate 0.05 tranexamic acid 0.05 purified water Balance total 100.0 (wt%)

[Example 4] Toothpaste Sodium hydrogen carbonate 50.0 Glycerin 15.0 Propylene glycol 3.0 Hydroxyethyl cellulose 1.0 Sorbit 10.0 Toxyl 5.0 Titanium oxide 0.3 Butylparaben 0.01 Fluoride sodium 0.2 l-menthol 0.4 anethole 0.1 saccharin sodium 0.1 dextranase 0.2 dipotassium glycyrrhizinate 0.06 eucalyptus oil (1,8 80% cineole content) 0.1 purified water Balance Total 100.0 (wt%)

Example 5 Mouthwash Sodium bicarbonate 5.0 Disodium phosphate 0.3 Citric acid 0.3 Glycerin (85%) 9.0 Ethyl alcohol 8.0 Sorbitan monooleate 1.0 Lauryl sulfate sodium 1.0 cetyl pyridinium chloride 0.1 l-menthol 0.1 anethole 0.01 saccharin sodium 0.03 dipotassium glycyrrhizinate 0.02 1,8-cineole 0.1 purified water balance total 100.0 (wt%)

[Example 6] troche sodium hydrogencarbonate 5.0 gum arabic 7.0 glucose 30.0 xylitose 40.0 magnesium stearate 1.0 sodium saccharin 0.02 l-menthol 0.2 monoammonium glycyrrhizinate 0. 04 1,8-cineole 0.01 purified water balance total 100.0 (wt%)

[Example 7] Candy Sugar 45.0 Starch syrup 35.0 Organic acid 1.5 Sodium hydrogen carbonate 10.0 l-Menthol 0.3 Lemon oil 0.1 Dipotassium glycyrrhizinate 0.1 1,8-Cineol 0.05 purified water balance total 100.0 (wt%)

[Example 8] Chewing gum Sugar 50.0 Gum base 24.0 Syringe 15.0 Glucose 10.0 Sodium hydrogen carbonate 5.0 l-Menthol 0.4 Anethole 0.07 Dipotassium glycyrrhizinate 0.05 Eucalyptus oil ( 1,8-Cineol 80% included) 0.06 total 100.0 (wt%)

Claims (2)

[Claims] 1. An oral composition comprising a glycyrrhizic acid salt compounded in an oral composition containing sodium hydrogencarbonate in an amount of 5% by weight or more based on the total weight of the composition. 2. A composition comprising 1,8-cineole.
The composition for oral cavity according to.