JPS61186307A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:A composition for the oral cavity having extremely enhanced astringency of aluminum lactate, obtained by blending a composition for the oral cavity containing aluminum lactate with carboxymethyl cellulose or sodium alginate. CONSTITUTION:A composition for the oral cavity containing preferably 0.1-2wt% based on the total amount of the composition of aluminum lactate with blended with preferably 10-200wt% based on the content of aluminum lactate of sodium carboxymethyl cellulose or sodium alginate, to give a composition of the oral cavity having enhanced astringency to the gingiva. Sodium carboxymethyl cellulose having 0.5-1.2 deg. of etherification is especially preferable.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to an oral composition, and more particularly, the astringent action of aluminum lactate on the gingival tissue and oral mucosa makes it suitable for the treatment of oral diseases, particularly alveolar pyorrhea. The present invention relates to oral compositions containing aluminum lactate that provide beneficial effects.

BACKGROUND OF THE INVENTION In general, two diseases in the dental field are dental caries and periodontal tissue diseases. Of these, periodontal disease has a morbidity rate comparable to that of dental caries, as is clear from reports on its morbidity and tooth loss, as well as reports on the actual state of dental diseases in Japan. The impact is also extremely large. Such periodontal diseases are caused by a combination of several factors, and their occurrence is also related to individual differences in resistance to the disease, and is caused by extremely complex factors. However, among these various factors, the most important one is considered to be the local factor, the cleanliness of the oral cavity.

In other words, the mechanism of periodontal disease is that the gingival papilla and margins first become hyperemic and swollen, the gingival surface becomes swollen, becomes soft and easily bleeds, and then gingival inflammation occurs. It is normal for the disease to enlarge and eventually lead to alveolar pyorrhea. Therefore, in order to prevent periodontal disease, it is important to prevent the occurrence of papillary simplex and marginal gingivitis, which are the initial symptoms of periodontal disease. It is important to do it.

For this purpose, it is effective and rational to perform oral cleaning using oral compositions that are effective in preventing periodontal diseases, and it is effective and rational to perform oral cleaning using oral compositions that are effective in preventing periodontal diseases. Oral compositions have been proposed.

Among the drugs contained in these oral compositions, aluminum compounds such as aluminum lactate or aluminum allantoinate are effective for the prevention and treatment of oral diseases, especially gingival tightening, and periodontal diseases such as pyorrhea. It is widely acknowledged to be effective, and toothpastes containing aluminum lactate are already known for the purpose of preventing and treating periodontal diseases.

However, compared to aluminum allantoinate, aluminum lactate is less astringent to the gums, and in order to obtain the same astringency as aluminum allantoinate using aluminum lactate, approximately 10 times the amount is required. It is.

Summary of the Invention The present inventors have conducted intensive studies to enhance the astringent properties of aluminum lactate in oral compositions for the gums, and as a result, they have added carboxymethyl cellulose or sodium alginate to oral compositions containing aluminum lactate. The present inventors have surprisingly discovered that the astringency of aluminum lactate is significantly enhanced when aluminum lactate is added, leading to the completion of the present invention.

That is, the present invention provides an oral composition containing aluminum lactate, which is characterized in that it contains sodium carboxymethylcellulose or sodium alginate.

Therefore, according to the present invention, an excellent oral composition in which the astringency of aluminum lactate in the gums is enhanced is obtained, and its use shows favorable effects in the treatment of oral diseases, particularly alveolar pyorrhea.

There are other substances that enhance the astringency of aluminum lactate, such as sodium lauryl sulfate and benzalkonium chloride, but these all have astringent effects themselves, and the effect when combined with aluminum lactate is merely an additive effect. It's just that.

On the other hand, sodium carboxymethyl cellulose or sodium alginate has no astringent action by themselves, and therefore, the combination of these and aluminum lactate produces a completely new astringent activity-enhancing effect.

Next, the results of testing sodium carboxymethyl cellulose, sodium alginate, and other additives blended in the composition of the present invention to determine the effect of these additives on enhancing the gingival astringent activity of aluminum lactate. Shown in Table 1.

The astringent activity of each additive was determined by Okuda et al.
3 (1976): Want, 12B? (1977)), it was measured as follows using the adsorption effect on hemoglobin.

Preparation of hemoglobin solution: Add water to fresh human blood to which sodium citrate has been added to obtain hemolysate, and the absorbance at 578 nm is 0.95-1.05.
It was prepared so that

Measurement of hemoglobin adsorption effect: 2 hemoglobin solutions, 1 aluminum lactate aqueous solution *
Q, sample solution IR (Ic sodium carboxymethylcellulose, etc.), 0.2M phosphate buffer (pH 6,0)
Mix 1 mQ, stir, and leave for 1 hour. 12. OOOrp
Centrifuge for 10 minutes and measure the absorbance of the supernatant at 578ru+
Measured as +. The difference between this absorbance and a similar absorbance without the addition of hemoglobin is defined as ΔODs. The ratio of ΔODs to the absorbance (ODc) when aluminum lactate and the sample were not added was defined as the supernatant hemoglobin amount (Hs) when the sample was cooled.

Supernatant hemoglobin amount H when using aluminum lactate alone in the same manner as above except that the sample was changed to purified water
L (HL=Δ0DI10DcX l 00) was obtained.

Calculation of astringent activity: The degree of enhancement of astringent activity was expressed as a percentage of the hemoglobin adsorption amount (100-Hs) of each sample relative to the hemoglobin adsorption amount (100-HL) of aluminum lactate as 100%.

Enhancement degree (%) - 硯吋"咀Xto.

100-HL (Note) CMC-Na... Sodium carboxymethyl cellulose (the number in parentheses indicates the degree of etherification) HEC... Hydroxyethyl cellulose PVP...
Polyvinylpyrrolidone Pv^...Polyvinyl alcohol*...Indicates the degree of enhancement relative to aluminum lactate of 1.0%, ie, hemoglobin adsorption amount of 53%.

As is clear from Table 1, sodium carboxymethyl cellulose, sodium alginate, and sodium lauryl sulfate have an enhancement degree of 100% or more.
%, indicating only an additive effect. In addition, other celluloses, ie, methylcellulose and hydroxyethylcellulose, as well as xanthan gum, polyvinyl alcohol, and polyvinylpyrrolidone, have no astringent action or enhancing effect. Contrary to these,
Sodium carboxymethylcellulose and sodium alginate have almost no astringent action when used alone, but when combined with aluminum lactate, they exhibit an effect of enhancing astringent activity.

Therefore, sodium carboxymethylcellulose or sodium alginate is used in the oral composition of the present invention. These may be mixed and blended.

In the case of a toothpaste composition, the content of aluminum lactate in the oral composition of the present invention is 0.1% based on the entire composition.
Preferably it is 2% by weight. If the content of aluminum lactate is less than 0.1% by weight, a sufficient astringent effect will not be exhibited, while if it exceeds 2% by weight, the taste during use will deteriorate,
The feeling of use is unbearable and undesirable.

The amount of sodium carboxymethylcellulose or sodium alginate is preferably 10 to 200% by weight based on the content of aluminum lactate. If the blending amount is less than 10% by weight, the astringent effect will not be sufficient, while if it exceeds 200% by weight, problems will occur with respect to property stability such as viscosity, which is not preferable.

Moreover, the degree of etherification of carboxymethylcellulose sodium is preferably 0.5 to 1.2. Etherification degree 0
．． If it is less than 5, the effect as a binder will be insufficient, while if it exceeds 1.2, no increase in astringency will be observed.

The oral composition of the present invention may contain any other known components that are normally used in oral compositions, depending on the type. For example, in the case of toothpaste, glycerin, sorbitol, etc. are used as humectants.

The blending amount varies depending on the shape of the product and is not particularly limited. Furthermore, abrasives, binders, foaming agents, fragrances, sweeteners, and other substances commonly used in toothpaste may be blended in the usual proportions.

Therefore, the oral composition of the present invention can be used as a toothpaste or a powder toothpaste that does not contain water, and can also be used as a product such as a rutting agent, chewing gum, tablet, or troche. In these cases, ordinary effective bases may be used as the base for each product, and these are processed according to a conventional method.
Processing yields an oral composition.

Next, the present invention will be explained in more detail with reference to Examples. In addition, all % means weight %.

Example 1 A toothpaste containing aluminum lactate and sodium carboxymethyl cellulose was prepared according to the following recipe according to a conventional method.

Ingredients Amount (%) Calcium carbonate 35.0 Sorbitol 30.0 Glycerin
8.0 Sodium carboxymethyl cellulose 1.6 (degree of etherification 0.6) Sodium saccharin 0.1 Flavor 1.0 Aluminum lactate 1.0 Sodium lauryl sulfate 1.2 Water
The astringent activity of the toothpaste adjusted to 100% was measured in the same manner as in the test example, and the degree of enhancement (%) of sodium carboxymethyl cellulose was determined, and a large enhancement effect of 162% was observed.

Comparative example! A toothpaste was prepared in the same manner as in Example 1 except that methylcellulose was used instead of sodium carboxymethylcellulose. When the degree of enhancement was measured in the same manner as in Example 1, the degree of enhancement was 126%.

Example 2 A toothpaste was manufactured according to a conventional method using the following formulation.

Ingredients Amount (%) Calcium diphosphate 45.0 Sorbitol
25.0 Sodium carboxymethyl cellulose 0.2 (degree of etherification 1.0) Methyl cellulose 1.2 Sodium N-lauroyl sarcosine 0.5 Sodium saccharin 0.1 Aluminum lactate 2.0 Fragrance
0.9 Sodium lauryl sulfate
0.7 water
The degree of enhancement of the astringent activity of the toothpaste adjusted to 100% was 130%.

Example 3 A toothpaste was manufactured according to a conventional method using the following formulation.

Ingredients Amount (%) Calcium diphosphate 40.0 Sorbitol 20.0 Glycerin
10.0 Sodium carboxymethyl cellulose 1.0 (degree of etherification 1,2) Sodium lauryl sulfate 1.2 Sodium saccharin 0.1 Aluminum lactate 0.5 Flavor
l・0 water
The degree of enhancement of the astringent activity of the toothpaste adjusted to 100% was 146%.

Example 4 Oral pasta was produced according to a conventional method using the following recipe.

Ingredients Amount (%) Polyoxyethylene monostearate 3 Sorbitan monooleate 2 Cetyl alcohol
5 propylene glycol
15 Sodium alginate 3 Sodium saccharin 0.2 Flavoring
0.3 Aluminum lactate 1.5 Hydroxyethyl cellulose 2 Water
The astringent activity enhancement degree of the obtained oral pasta adjusted to 100% was 142%.

Example 5 Tablets were manufactured according to the conventional method according to the following formulation, and the ingredients were
Blend amount (%) Sorbitol
88.3 Sodium carboxymethyl cellulose 1.0 (degree of etherification 0.5) Citric acid 0.01
Aluminum lactate 1.0 Methylcellulose 4.0 Water
The degree of enhancement of the astringent activity of the tablets adjusted to 100% was 158%.

Claims (4)

[Claims] (1) An oral composition containing aluminum lactate, which contains sodium carboxymethyl cellulose or sodium alginate. (2) The oral composition according to item 1 above, wherein the content of aluminum lactate is 0.1 to 2% by weight based on the total weight of the composition. (3) The oral composition according to Items 1 and 2 above, wherein the amount of sodium carboxymethyl cellulose or sodium alginate is 10 to 200% by weight based on the content of aluminum lactate. (4) The oral composition according to item 3 above, wherein the degree of etherification of sodium carboxymethyl cellulose is 0.5 to 1.2.