JPS59157014A - Dentifrice - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a polishing material containing at least seven compounds selected from guaiazulene and its sulfonate salts and an aluminum salt.

Guaiazulene and its sulfonate (hereinafter collectively referred to as "1 azulene compound") used in the present invention are represented by the following general formula.

In the formula, R represents a hydrogen atom or -803M. M represents all alkali metals or alkaline earth metals, such as Na, Ca5Mg, etc.

Azulene compounds have anti-inflammatory, anti-allergic, antibacterial, and tissue-regenerating properties, and are effective against oral diseases, especially stomatitis, cheilial conjunctivitis,
It has been confirmed that it is effective in the treatment and prevention of periodontitis, etc., and is widely used as a murge-containing agent. Therefore, it is clear that if an azulene compound having such properties is included in toothpaste, it will be beneficial for the prevention and treatment of oral diseases.

However, azulene compounds have the disadvantage that they are gradually decomposed and discolored by light and oxygen in the air. For this reason, even if an azulene compound is blended into regular toothpaste, it will be decomposed by light and air, changing the color tone of the product and reducing its medicinal efficacy.

K to prevent this requires complicated operations such as light shielding and oxygen removal. ■■■■■■■■■■■■■■■■Layer ■Meal■―■－■Layer■Meal■■■■■Column－■■■■−■■Setting-1-Equipment■■■ -111 Mati-ichi■■-■■■■■■-
■-■-■■■■1 Therefore, an object of the present invention is to provide an azulene compound-containing toothpaste that is stable against light and oxygen. Another object of the present invention is to provide an azulene compound-containing toothpaste that is effective in preventing or treating various oral diseases.

As a result of intensive research in view of the above-mentioned purpose, the present inventor obtained the knowledge that adding an aluminum salt to a toothpaste containing an azulene compound stabilizes the azulene compound blended in the toothpaste, and completed the present invention. I've reached it.

The toothpaste of the present invention is characterized in that the azulene compound and aluminum salt are blended into a regular toothpaste. Specific examples of the azulene compounds used in the present invention include the following compounds.

Guaiazulene Sodium guaiazulene sulfonate Potassium guaiazulene sulfonate Calcium guaiazulene sulfonate Magnesium guaiazulene sulfonate Specific examples of the aluminum salts used in the present invention include the following compounds.

Aluminum lactate, aluminum phosphate, aluminum sulfate, potassium aluminum sulfate, plantin hydroxychloraluminum, aluminum stearate, aluminum chloride Among the above aluminum salts,
Particularly preferred are aluminum phosphate and aluminum lactate.

The amount of addition of the azulene compound for m-polishing depends on the viscosity of the product,
Although it is limited by formulation issues such as uniformity, generally 0.00/~S, O weight% is appropriate, especially 0.
．． θ/~λ, θ weight f% is preferred. In addition, the amount of aluminum salt added to stabilize the azulene compound should be determined based on the amount of the azulene compound added, the viscosity of the product, the uniformity, etc.
70 weight+Jf+% is appropriate. In particular, the addition t1 of the azulene compound is θ. In the case of 0/~, θ weight %, the amount of aluminum salt added is preferably in the range of 0°7 to 3.0 weight %.

The dentifrice composition of the present invention has no difference in composition from general dentifrice compositions, except that it contains an azulene compound and an aluminum salt. Therefore, it may contain abrasives, wetting agents, binders, surfactants, etc. which are commonly used as a base.

The present invention will be specifically explained below using test examples and practical examples. Note that "1%" is all percentage by weight.

In the test examples, the residual rate of the azulene compound was measured as follows. Extract toothpaste/ri2 with methanol and use the extract as J,! −
Concentrate the solution under reduced pressure to 1.5-7% using a spectrophotometer.
．． The absorbance at tnm was measured to determine the residual rate of azulene in tooth brushing.

Test Example: A toothpaste with the following formulation was prepared by adding 0.02% each of guaiazulene and sodium guaiazulene sulfonate, and adding 2.0% aluminum lactate to this.
It was compared with that of heat-added aluminum lactate. These toothpastes were stored at a temperature of θ°C and a humidity of 73%, and changes in the azulene compound over time were observed.

The residual rate of aluminum lactate added is 79 after 77 days.
% and g2%, but the residual rate of the one containing 2.0% remained 9g% and 97% even after two months, indicating that the azulene compound was sufficiently stabilized. The toothpaste formulation and test results are shown in Tables 1 and 2, respectively.

Table 1 Toothpaste prescription Calcium hydrogen phosphate qθ0 Glycerin / OD-sorbitol solution / θO Sodium calgeximethylcellulose 0.7 Sodium saccharin
θ06 Sodium lauryl sulfate
/g methyl benzoate
θ／Fragrance
0. qjo water
Applicable 100.0% Table 2 Test Example λ Guaiazulene sulfonate sodium 1Jf for toothpaste in Table 1)
Add A402% to this! ! Acid aluminum was added at various concentrations, and changes over time were investigated under conditions of 173% humidity. The results are shown in Table 3.

It can be seen that the azulene compound is stable in the range of 070% to 500%.

Test Example 3 Next, the amount of sodium guaiazulene sulfonate added was varied to examine its stability. Using the toothpaste shown in Table 1, a predetermined amount of azulene compound was added to 2.0% aluminum lactate. The change over time of the azulene compound under r% humidity conditions was investigated. The results are shown in Table 1.

Test Example: 0.02% sodium guaiazulene sulfonate was added to the toothpaste shown in Table 1, and 2% of various aluminum salts were added to this.
The changes over time of the azulene compound under the humidity conditions of θC17% were investigated. The results are shown in Table 5.

Calcium diphosphate lI left θV
Glycerin /yoθf Sorbit (70% aqueous solution) /θθfMilupoxymethylcellulose /θ1Methylnoya Labenθ/f Aluminum lactate
709 Sodium guaiazulene sulfonate θo■ Sodium zacharin
θ/2 sodium lauryl sulfate
/gP fragrance
A total of 11001 with θ water.

Example cosodium chloride/θOfcalcium diphosphate 3! ,. V
Glycerin/gJfPyrene glycol 2. ! f carboxymethylcellulose sodium lof methyl noya laben θ/f aluminum lactate lst guaia
Sodium sulfonate θ/f2 Sodium uryl sulfate /, 3f fragrance
Total amount of θ is 100% with water.
9.

Example 3 Sodium chloride/θor calcium pyrophosphate, 3.3. Of silicic anhydride 3θV glycerin
abu or cal? oxymethylcellulose
109 Methylnoya Lapen
θ/f aluminum lactate θ,
tf Sodium guaiazulene sulfonate θ0
2tt2 sodium uryl sulfate /θV
Fragrance θq
Make the total amount *10 t with water.

Examples Calcium diphosphate 3.2゜2 Silicic anhydride Pθ1 Glycerin
/yo-o2 sorbitol (70% aqueous solution)/θθ2 sodium alginate a/;2 carayenan θSf alkytetra-rule amide, 2. Ot Sodium saccharin θ/f Sodium lauryl sulfate
l! rt sodium lauroyl sarcosinate θ3 to aluminum lactate
Left θ2 Sodium guaiazulene sulfonate θ/f fragrance
Make the total amount 100 t with θ water.

Example S Sodium chloride/θOF calcium diphosphate 3! f, θ2 glycerin
7g, θV propylene glycol
Hiro θf sodium alginate
θ3t carrageenan
θSt methyl arm labelaben o, iv
Sodium lauryl sulfate /, 3
f aluminum phosphate coOf sodium guaiazulene sulfonate 0.0 left? Fragrance Make total amount/θθ2 with θ water.

Example Birocalcium phosphate 3θ02 silicic anhydride, 20v glycerin
, 2 left Of carboxymethyl cellulose sodium /, Of methyl paraben
θ/2 saccharin sodium
θ/2 sodium lauryl sulfate
701 Sodium lauroyl sarcosine
θ32 aluminum phosphate
θArt Sodium Guaiazulene Sulfonate θ
To Oθ? fragrance
Make the total amount 10, Of with 09f water.

Example 7 Calcium diphosphate RiθO furnace Silicic anhydride YoOt polyethylene glycozug θQ j;, Of glycerin KoθQ? Caldexymethyl cellulose θ3t carrageenan
θgf Sodium lauryl sulfate
13f Aluminum stearate θ/f Sodium guaiazulene sulfonate θθSf Fragrance
70? Total amount with water 1
0θ2 〇Example g Sodium chloride ″-Of calcium pyrophosphate 3θOf silicic anhydride !, ot Griyari y/9!
θ2 Sorbit (70% aqueous solution) Mu02 Sodium lauryl sulfate
7!1 Sodium lauroyl sarcosine
0.29 cal is oxymethyl cellulose sodium
70? Methylparaben
θ/f Saccharin sodium θ
/f Potassium aluminum sulfate θ
0jSrf Sodium Guaiazulene Sulfonate
θ/f fragrance
Set total amount/θOf with θdef water.

Example Calcium diphosphate 3θθV aluminum hydroxide / 0. Of glycerin 2pθfka/L/f Sodium oxymethyl cellulose lOtSodium lauryl sulfate 1.2f Methylnoya Lapen θ/f Allantoinhydrocycloaluminum 0.2f Sodium guaiazulene sulfonate θ0/? fragrance
09 is made into a total amount of 1009 with water.

Example 10 Aluminum hydroxide 3! r, of
Silicic anhydride S, Ot glycerin, 2 o Of carboxymethylcellulose θtt carrageenan
θ3t methyl mother lapen
θ/f saccharin sodium
θ/f Sodium lauryl sulfate
1gf aluminum lactate
Sodium guaiazulene sulfonate / θf fragrance
θ9f Make total amount/θor with water 0 Example // Aluminum hydroxide 3θθf Sodium chloride YoOf glycerin
θOf Sorbit (7θ% aqueous solution)
Left θV Caldexymethylcellulose Sodium 701 Satucharin Sodium
θ/f Methylparaben
θ/l sodium lacryl sulfate
/Left f Aluminum lactate θ
V Sodium guaiazulene sulfonate θ
Jf fragrance
Set all valves to -/θOf with θ9f water.

Example 7.2 Calcium diphosphate 31AOf silicic anhydride or glycerin
/qOf propylene glycol
Yoθ2 carrageenan
05g Sodium alginate θA
f Alkylolamide Coθ2 Methylparaben 003? Sodium lauryl sulfate / Sodium lauroyl sarcosine θ3f Aluminum chloride i0f Guaiazulene
0θ/f fragrance
Make the total amount 100f with 09F water.

Example/3 Calcium pyrophosphate riθθ1θ
f Silicic anhydride iff Water-intoxicated aluminum, 3.0f Glycerin
/gO? Sorbit <70% aqueous solution) Of carboxymethyl cellulose sodium 702 methyl nolipene θ/f Sodium lauryl sulfate IgW allantoin hydroxychloraluminum θSP Guaiazulene
θ/f fragrance
The total voltage is 100V with θq2 water.

Example/ll Sodium chloride F02 Calcium carbonate 3Fθf Silicic anhydride
Ko, θ2 glycerin
/Left θV propylene glycol
Left 02 Carboxymethylcellulose
/θV Sodium lauryl sulfate
151 Aluminum phosphate Fuθ2 Guaiazulene θ/
f fragrance
Make the total volume 700F with θ 2 water.

Example/S Calcium pyrophosphate θOf Sodium chloride θOf Silicic anhydride 2. Of glycerin
, 2 θV carboxymethyl cellulose sodium / 2 ethyl
θ/f saccharin sodium
θ/2 sodium lauryl sulfate
/gf lauroylsarcosinate sodium θ
jv aluminum lactate 709 guaiazulene θsr fragrance
Make all needles 100t with θ9v water.

Example/A Calcium diphosphate 32θ2 Sodium chloride Yoθf Silicic acid anhydride
θV glycerin
/θOf polyethylene glycol two 00
/ 5.01 Cal? Sodium oxymethylcellulose lOF Sodium saccharin θ/f Aluminum phosphate
/θf guaiazulene
θOri V fragrance
Make the total 1/θ01 with θ9F water.

Example/7 Calcium pyrophosphate i left oy crystalline cellulose / θOg sodium chloride left θ2g
auctioneer/
2&Of carboxymethylcellulose
/Left 2 Saccharin Sodium
θ0ri2 sodium lauryl sulfate
/gt aluminum lactate
λθ2θf Guaiazulene θo
it fragrance
The total amount is 100V with θ9f water.

Example/g Calcium carbonate θθ2
Silicic anhydride 3. Of glycerin -〇or sodium carboxymethyl cellulose /θV sodium saccharin θ/゛? Aluminum chloride θ/f guaiazulene
θθ/f fragrance
Total amount 10θ with θriV water
Let it be V.

Example/9 Calcium diphosphate CoθOf Crystalline cellulose /θo2 Anhydrous silicic acid CoθV Sodium chloride Left θfCal xymethyl cellulose sodium 109 Glycerin
koθor methyl yarapen
θ/f Sodium lauryl sulfate
a, θ are aluminum lactate
lkt guaia azulene
θ/f fragrance
Make the total amount 10θV with θ9f water.

Example λθ Calcium pyrophosphate 3') θ2
Silicic anhydride Yoθtaglycerin YusadoOfzatukarin sodium
0. ／ F Meterno's Pen
θO3t Sodium lauroyl sarcosine θ32 Sodium lauryl sulfate
/gv aluminum phosphate
Ko or guaia azulene
θθsr fragrance
Total amount/θor with 092 water.

Example 2/ Silicic anhydride λθOv Glycerin Koyoθ2 Sorbit (70% aqueous solution) YoQ? Calgoxymethyl cellulose i2f saccharin sodium θ/f methylparaben
θ03 is aluminum lactate
lOf Sodium Guaiazulene Sulfonate
00 left v Sodium lauryl sulfate
Of fragrance
Let θ9 be the total t10θf with water.

Example Coco dicalcium phosphate l13. Of
Silicic anhydride Left θV Glycerin 790f Sodium carboxymethylcellulose /=2f Methylnoya Lapen θ/V Aluminum lactate
lθ2 Potassium guaiazulene sulfonate θ/f Sodium lauryl sulfate
θ9f inspection fee
Make the total volume 1 ooy with θter and 2 water.

Example 23 Calcium pyrophosphate tia,
ov silicic anhydride left θ1 glycerin /90f sorbitol (
70% aqueous solution)
1/xymethylcellulose/
θ2 aluminum lactate, 2of calcium guaiazulene sulfonate θ
/ flavor
θ9F sodium lauryl sulfate
/θf Make the total amount /θor with water.

Example - Calcium diphosphate 3Fθ Sodium chloride FOf Glycerin CoθθV Sodium caldexymethylcellulose lθV Methylparaben θθ,! rf Aluminum lactate /31 Magnesium guaiazulene sulfonate θ3F Sodium lauryl sulfate θgt Sodium laautetrayl sarcosinate θ, ? ? fragrance
θ9f All needles with water/θ
Let it be θV.

Claims (6)

[Claims] (1) A toothpaste containing at least seven types of guaiazulene and its sulfonate represented by the following general formula and an aluminum salt. In the formula, R represents a hydrogen atom or 18o3M (M represents an alkali metal or alkaline earth metal). (2) The toothpaste according to claim 1/4, wherein R is a hydrogen atom. (3) The toothpaste according to Claim 11J4, wherein R is -8O3Na. (4) The toothpaste according to claim 7, wherein R is -505. (5) Claim 1, which includes at least 1% by weight of guaiazulene and its sulfonate/glaze θ, 0/~2.0% by weight, and 0.7~5.0% by weight of aluminum base. toothpaste. (6) The toothpaste according to claim 1, wherein the aluminum salt is aluminum lactate. (Ca) The toothpaste according to claim S, wherein the aluminum salt is aluminum phosphate.