JPS5930844A - Medical packaging material - Google Patents

Abstract

PURPOSE:To prepare a packaging material at a low cost, having excellent shape- retainability and transparency, and suitable as a blister packaging container for radiation sterilization, by compounding polystyrene with a specific block star polymer. CONSTITUTION:The objective material is prepared by compounding (A) 20- 70wt%, preferably 40-60wt% of polystyrene with (B) 80-30wt%, preferably 60-40wt% of a block star copolymer of formula (St-Bu)xY (St is styrene polymer; Bu is butadiene polymer; Y is atomic group derived from the polyfunctional treating agent used in the formation of the star polymer; X is the number of the functional groups of the polyfunctional treating agent, and is integer of >=3), and (C) 0-20wt%, preferably 0-10wt% of other resin having no adverse effect to transparency of the material (e.g. styrene-butadiene rubber). The content of St in the (St-Bu) of the component (B) is 50-80wt%, preferably 65- 76wt%.

Description

[Detailed description of the invention] 1. Disobedience of invention Technical field The present invention relates to medical packaging materials.

Particularly suitable packaging (1 size) for blister packaging containers and the like for sterilizing medical instruments using radiation FA such as Gannn's.

Prior Art Conventionally, medical instruments such as disposable syringe nails and disposable syringes have been stored in packaging containers such as blister packaging and then sterilized with a sterilizing agent such as Dishin A Kizide may have an adverse effect on the human body. Radiation sterilization has recently been proposed as a sterilization method that does not use such a sterilizing agent. In the radiation sterilization method, medical instruments are placed in a packaging container and then irradiated with radiation. However, radiation radiation has adverse effects such as deteriorating or discoloring packaging containers. For example, in the above-mentioned blister packaging container C, hard vinyl chloride resin is used as the dome material because of its good shape retention and excellent transparency.

However, when medical instruments stored in such blister packaging containers are sterilized by air til'J lit, not only does the hard PVC resin that is the material of the dome become colored, but hydrogen chloride is generated, causing the buttons to rust. Due to these problems, it had the disadvantage that it could not be used for one-ray sterilization. Currently, the dome materials for blister packaging containers for radiation sterilization of medical instruments as described above include polycar, Bonnet 1 and polyester, but all of these are expensive. It has also been proposed to use high-impact polystyrene, but it has the disadvantage of low transparency.
Furthermore, polystyrene alone cannot be used as a material for blister packaging unless a method such as biaxial stretching is used, and stretched film for two wheels has problems such as shrinkage during the process, making it difficult to use and lacking in flexibility. There were problems such as difficulty in removing the product.

(1) Purpose of the Invention Therefore, the purpose of the present invention is to provide a novel medical packaging material. Another object of the present invention is to provide a medical packaging material 1 that is inexpensive, has shape-retaining properties, and has excellent transparency. Still another object of the present invention is to provide a dome material suitable for use as a dome material for medical packaging containers.

These specifications include (a) polystyrene 20-70fR
Amount %, (1)) General formula ■ (St BIJ)XY (1) (wherein, St is a styrene polymer, Bu is a butadiene polymer,
Y is an atomic group derived from the polyfunctional treatment agent used to form the radial polymer, and X represents the number of functional groups in the polyfunctional treatment agent and is an integer of 3 or more. ) 1i9. Sword-like branched copolymer 80~
30 weight is % and (C') (a) and (1) above)
Other resins O~2 that can be blended with the polymer to maintain transparency
Achieved by medical packaging monthly interest rate of 0 billion m%.

Further, the present invention provides that (St-Btl> in general formula l is 1
It is a packaging material whose pull-3t is 50 to 80,000 m%. Furthermore, the present invention provides that (a) polystyrene is 40 to 60% by weight, (1)) the radially branched block copolymer represented by general formula I is 60-/1. o1ffi% and (C)
This packaging material contains 0 to 10% by weight of another resin that can be blended with the polymers (a) and (b) to maintain transparency. The present invention also provides (SL-81) in general formula I
The packaging material has a St of 65 to 75%. Further, the present invention is a packaging material in which the other resin capable of maintaining transparency is styrene-butadiene rubber. moreover,
The present invention is a packaging material in which the packaging material is a dome material for a blister packaging container. Further, the present invention is a packaging material in which the dome material is in the form of a deep-drawn product having a thickness of 150 μm or less.

■1 Specific details of the invention The polystyrene used in the present invention is a styrene homopolymer with a weight average molecular weight of 50,000 to 300,000, preferably 100,000 to 200,000. be.

The radially branched block represented by general formula I i1 coalescence c, m m average molecule @ 100,000-200,
000Q? Preferably 120,000-180,000
It is a block copolymer of Polyfunctional processing agents used to form radial polymers include epoxidized linseed oil and
, 2,5,6°9.10-1-epoxydenone, etc. Such a block copolymer is produced, for example, as follows. That is, a styrene pasting polymer is prepared using an anionic polymerization catalyst such as η~butyllithium, then block copolymerization is performed by adding butadiene, and the above-mentioned polyfunctional processing agent is added.

In the packaging monthly rate according to the present invention, the proportion of polyshoshin is 20 to 70% by weight, preferably 40 to 60% by weight, and the proportion of the block copolymer represented by general formula I is 80 to 30% by weight. %, preferably 60 to 40% by weight. When the proportion of polystyrene is less than 20% by weight, in other words, the proportion of the polymer exceeds 80% by weight,
Extrusion moldability is poor, blocking phenomenon of the film is observed, and discoloration is observed due to radiation irradiation. On the other hand, if the polystyrene content exceeds 70% by weight, in other words, if the block copolymer contains less than 30% by weight, the flexibility will be poor;
In addition, during the above-mentioned period when the release rate of bottle balls is high, 1 q of other resin is added to the material to maintain transparency.
It can be blended in an amount of 0%, preferably 0 to 10[1%]. Examples of such resins include styrene-butadiene rubber, acrylonitrile-styrene-butadiene copolymer, methyl methacrylate-styrene copolymer, and acrylic[1 nitrile-styrene copolymer. but,
If the content of such resin exceeds 20%, there will be disadvantages such as a decrease in resistance to sword irradiation, discoloration when exposed to radiation, and a decrease in transparency.

The packaging material according to the invention usually has a thickness of 80 to 200 μm,
It is preferably formed into a film having an extension of 100 to 150μ and used as the dome portion of a blister packaging container, a bag-like article, etc. Good results are particularly obtained when used as the dome portion of a blister packaging container.

When this packaging material is used as the dome part of a blister packaging container, for example, as shown in FIGS. The film of the packaging material made of another resin that can maintain the properties of the packaged object 1,
For example, the dome part 3 is formed so that a space 2 sufficient to accommodate a syringe is formed, and the space 2 of the dome part is
After the packaged object 1 is stored in the dome 3, a low melting point resin such as polyethylene, ethylene-vinyl acetate, T-thicine-unsaturated carboxylic acid (I-A Tsumar resin), adhesive or adhesive 4 is applied to make the dome part 3 adhere tightly. The flange portion 6 of the dome portion 3 is brought into contact with a base 1If15 of paper or plus book film or sheet made by coating or mixing with the above, and the flange portion 6 of the dome portion 3 is placed in a means such as high frequency heating or thermocompression bonding to be thermally fused or bonded. and seal.

FIG. 3 shows another embodiment of the present invention, in which polyethylene, dicine-acetic acid, etc. are added to the same packaging material as in FIG. A low melting point resin layer 17 such as a vinyl conjugate, an ethylene-unsaturated carboxylic acid conjugate (IΔTsummer resin), etc.
The dome part 13 is made of a laminate with a thickness of ~30 μm.
After the package 11 is stored in the space 12 of the dome portion 13, the flange portion 16 of the dome portion 13 is brought into contact with the package and thermally fused by means such as high frequency heating or thermocompression bonding. Glue and seal.

In this case, the mount may be a film or paper that can be bonded to a low melting point resin, a film coated with an adhesive, or a paper mixed with polyethylene or ethylene-vinyl acetate copolymer.

Medical devices that are packaged in this way are
°Then, it is sterilized by irradiation with radiation. The radiation used includes electromagnetic radiation such as gamma rays and electron beams, preferably gamma rays. The irradiation intensity is 1
~5 Mrad, preferably 2-3 Mrad.

Therefore, medical devices that can be subjected to radiation sterilization using the packaging material of the present invention include, for example, disposable needles, disposable syringes, disposable blood collection kits, sutures, medical nonwoven fabrics, absorbent cotton, artificial blood vessels, and catheters. etc.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Weighted average molecular iJi 150,00 in the proportions shown in Table 1
The polyfunctional processing agent is 1,2,5,6,9.10-triepoxydecane,
Contains styrene (FF 170% by weight) mixed wire blend, thickness 130
A μm film was extruded. In addition, one of the films was made of poly(ethylene ethylene) having an average molecular weight of 190,000 to a thickness of 20 μm.

The above-mentioned film is deep-drawn as shown in Figs. 1 and 2 to produce a dome part 3, and the syringe 1 is housed in the space 2, and an adhesive (ethylene-vinyl acetate adhesive,
Cemedine HM C-4050 (trade name, manufactured by Cemedine Co., Ltd.) was applied to a thickness of 5 μm and attached to the paper mount 5 at the flange portion 6. Then, 2.5 Mra
30 months after irradiation with gamma rays at room temperature, i ooo
The bookcase was dropped 5 times from a height of 5m, and then a forced sterility test was performed (inspecting for 1 pinhole), and the results shown in Table 2 were obtained. It also shows chromaticity.

(Left below) ■1 Specific effects of the invention - The medical packaged feed according to the present invention contains (a) polysteel 1220 to 0 weight percent, (b) general formula ■. Radial branched block copolymer represented by 80-30
Chizuru% and (C) Sen's resin that maintains transparency 0-2
Since it is composed of 0% by weight, it has excellent transparency, does not change color when sterilized by irradiation with radiation, and does not deteriorate physical properties such as pinholes, so it can be used as a packaging container for radiation sterilization. It is suitable as a material for one-lister packaging containers.

[Brief explanation of drawings]

FIG. 1 is a perspective view showing an example of a blister packaging container using the medical packaging material 1 according to the present invention, FIG. 2 is a sectional view taken along the line If-If in FIG. 1, and FIG. is a sectional view similar to FIG. 2 showing another example. 1.11... Item to be packaged, 3,13... Dome part,
5.15... Mount.

Claims (1)

[Claims] 1. (a) 20-70% polystyrene (b) General formula 1% formula % () (In the formula, St is a styrene 1 combination, 8 is a butadiene polymer, and Y is a It is an atomic group derived from the polyfunctional processing agent used to form the radial polymer, and X represents the number of functional groups in the polyfunctional processing agent and is an integer of 3 or more. Brass-like technique parting block bar polymer 80-30
weight ffi% and (c) 0 to 20 of other resins that can be blended with the above polymers (a) and (b) to maintain transparency.
Medical packaging material consisting of % by weight. 2. Add J3G to (St −Bu ) in general formula 1 and add S[
The packaging material according to claim 1, wherein the amount is 50 to 80% by weight (6)%. 3, (a) polystyrene 40-6 ozm%, (b)
The radially branched block copolymer represented by the general formula I is 6
0-400-40 weight<C) (a) and (1) above
) Pond resin that can be blended with the polymer to maintain transparency is 0.
Packaging material according to claim 1 or 3, wherein the amount is 10% by weight. 4. In (St-Bu) in general formula I, [St is 65]
3. A packaging material according to claim 3, wherein the amount is 76% by weight. 5. The packaging material according to any one of claims 1 to 4, wherein the other resin capable of maintaining transparency is styrene-butadiene rubber. 6. The packaging material Fl according to any one of claims 1 to 5, wherein the packaging material is a dome material for a blister packaging container. 7. The packaging material according to claim 6, wherein the dome material is in the form of a deep-drawn product with a thickness of 1.50 μm or less.