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JPS5780319A - Anti-tumor agent having reduced toxicity - Google Patents

Anti-tumor agent having reduced toxicity

Info

Publication number
JPS5780319A
JPS5780319A JP15690680A JP15690680A JPS5780319A JP S5780319 A JPS5780319 A JP S5780319A JP 15690680 A JP15690680 A JP 15690680A JP 15690680 A JP15690680 A JP 15690680A JP S5780319 A JPS5780319 A JP S5780319A
Authority
JP
Japan
Prior art keywords
derivative
fluorouracil
carboxylic acid
toxicity
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15690680A
Other languages
Japanese (ja)
Other versions
JPH0120128B2 (en
Inventor
Setsuo Fujii
Norio Saimi
Setsuo Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP15690680A priority Critical patent/JPS5780319A/en
Publication of JPS5780319A publication Critical patent/JPS5780319A/en
Publication of JPH0120128B2 publication Critical patent/JPH0120128B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE:To prepare the titled anti-tumor agent by compounding a 5-fluorouracil derivative with a specific carboxylic acid as a toxicity-reducing agent. CONSTITUTION:The titled agent contains the carboxylic acid derivative of formula (R1 is amino, formyl, etc.; R2 is H or amino; n is 0 or 1) (e.g. ureidopropionic acid) or its salt, and a 5-fluorouracil derivative[e.g. 1-(2-tetrahydrofuryl)- 5-fluorouracil]. 5-Fluorouracil is a nucleic acid antimetabolite having excellent effect especially against adenocarcinoma, and at the same time, remarkable toxicity and side effects. The carboxylic acid derivative of formula and its salt are effective to remarkably reducing the toxicity of the 5-fluorouracil derivative without lowering its anti-tumor activity, and accordingly, increase the tolerance dose of the 5-fluorouracil derivative and imrpve the anti-tumor effect compared with the separate administration. The amount of the carboxylic acid derivative is 1-5pts.wt. per 1pt.wt. of the 5-fluorouracil derivative.
JP15690680A 1980-11-06 1980-11-06 Anti-tumor agent having reduced toxicity Granted JPS5780319A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15690680A JPS5780319A (en) 1980-11-06 1980-11-06 Anti-tumor agent having reduced toxicity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15690680A JPS5780319A (en) 1980-11-06 1980-11-06 Anti-tumor agent having reduced toxicity

Publications (2)

Publication Number Publication Date
JPS5780319A true JPS5780319A (en) 1982-05-19
JPH0120128B2 JPH0120128B2 (en) 1989-04-14

Family

ID=15637970

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15690680A Granted JPS5780319A (en) 1980-11-06 1980-11-06 Anti-tumor agent having reduced toxicity

Country Status (1)

Country Link
JP (1) JPS5780319A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004028A1 (en) * 1990-09-07 1992-03-19 Taiho Pharmaceutical Company, Limited Antineoplastic effect potentiator and antineoplastic agent
WO1993015729A1 (en) * 1992-02-07 1993-08-19 Tsumura & Co. Side-effect alleviant
JPH07117552A (en) * 1993-10-20 1995-05-09 Bunichi Yokoyama Motor truck for carrying heavy cargo

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004028A1 (en) * 1990-09-07 1992-03-19 Taiho Pharmaceutical Company, Limited Antineoplastic effect potentiator and antineoplastic agent
WO1993015729A1 (en) * 1992-02-07 1993-08-19 Tsumura & Co. Side-effect alleviant
JPH07117552A (en) * 1993-10-20 1995-05-09 Bunichi Yokoyama Motor truck for carrying heavy cargo

Also Published As

Publication number Publication date
JPH0120128B2 (en) 1989-04-14

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