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JPS5587721A - Anti-tumor agent - Google Patents

Anti-tumor agent

Info

Publication number
JPS5587721A
JPS5587721A JP15920878A JP15920878A JPS5587721A JP S5587721 A JPS5587721 A JP S5587721A JP 15920878 A JP15920878 A JP 15920878A JP 15920878 A JP15920878 A JP 15920878A JP S5587721 A JPS5587721 A JP S5587721A
Authority
JP
Japan
Prior art keywords
substituted
compound
formula
fluorouracils
uracils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15920878A
Other languages
Japanese (ja)
Other versions
JPS6227047B2 (en
Inventor
Setsuo Fujii
Yoshinori Sakai
Yutaro Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP15920878A priority Critical patent/JPS5587721A/en
Publication of JPS5587721A publication Critical patent/JPS5587721A/en
Publication of JPS6227047B2 publication Critical patent/JPS6227047B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To provide an anti-tumor agent having improved anti-tumor activity while keeping its original low toxicity and side-effects, by using 5-fluorouracils together with uracils.
CONSTITUTION: An agent containing (A) a 5-fluorouracil derivative selected from a compound of formula I [X, Z are O, S, or NH; A is 2W20C (substituted) polymethylene, 4W8C (substituted) cycloalkylene, etc.] and a compound of formula II [R is (substituted)alkyl, cycloalkyl, or aryl), and (B) a compound of formula III (R2,3 are H, Cl, carboxy, amide, alkyl, etc.), as effective components. For example, an agent containing 1,10-di(5-fluorouracil-N1-carboxy)-decane and uracil (or thymine). The addition of the uracils III improves the anti-tumor activity of the fluorouracils without increasing the toxicity and side effects.
COPYRIGHT: (C)1980,JPO&Japio
JP15920878A 1978-12-26 1978-12-26 Anti-tumor agent Granted JPS5587721A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15920878A JPS5587721A (en) 1978-12-26 1978-12-26 Anti-tumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15920878A JPS5587721A (en) 1978-12-26 1978-12-26 Anti-tumor agent

Publications (2)

Publication Number Publication Date
JPS5587721A true JPS5587721A (en) 1980-07-02
JPS6227047B2 JPS6227047B2 (en) 1987-06-12

Family

ID=15688675

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15920878A Granted JPS5587721A (en) 1978-12-26 1978-12-26 Anti-tumor agent

Country Status (1)

Country Link
JP (1) JPS5587721A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810790A (en) * 1986-10-09 1989-03-07 Daikin Industries Ltd. 5-fluorouracil derivatives useful as carcinostatic substances

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52118480A (en) * 1976-03-31 1977-10-04 Takeda Chem Ind Ltd Synthesis of uracil derivatives
JPS5331674A (en) * 1976-09-03 1978-03-25 Ono Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5359678A (en) * 1976-11-05 1978-05-29 Ono Pharmaceut Co Ltd 5-fluorouacil derivative compounds and their preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52118480A (en) * 1976-03-31 1977-10-04 Takeda Chem Ind Ltd Synthesis of uracil derivatives
JPS5331674A (en) * 1976-09-03 1978-03-25 Ono Pharmaceut Co Ltd 5-fluorouracil derivatives and their preparation
JPS5359678A (en) * 1976-11-05 1978-05-29 Ono Pharmaceut Co Ltd 5-fluorouacil derivative compounds and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810790A (en) * 1986-10-09 1989-03-07 Daikin Industries Ltd. 5-fluorouracil derivatives useful as carcinostatic substances

Also Published As

Publication number Publication date
JPS6227047B2 (en) 1987-06-12

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