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JPS5775968A - 4,5-dehydro-6-oxoprostaglandin e1 and its preparation - Google Patents

4,5-dehydro-6-oxoprostaglandin e1 and its preparation

Info

Publication number
JPS5775968A
JPS5775968A JP55150799A JP15079980A JPS5775968A JP S5775968 A JPS5775968 A JP S5775968A JP 55150799 A JP55150799 A JP 55150799A JP 15079980 A JP15079980 A JP 15079980A JP S5775968 A JPS5775968 A JP S5775968A
Authority
JP
Japan
Prior art keywords
oxoprostaglandin
dehydro
protecting group
action
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55150799A
Other languages
Japanese (ja)
Inventor
Kiyoshi Sakauchi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Seiji Kurozumi
Akira Otsu
Fukuyoshi Kamimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55150799A priority Critical patent/JPS5775968A/en
Publication of JPS5775968A publication Critical patent/JPS5775968A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A 4,5-dehydro-6-oxoprostaglandin E1 shown by the formulaI (R1 and R2 are H or OH-protecting group; R3 is H or 1W10C lower alkyl) and its acid addition salt when R3 is H.
EXAMPLE: (E)-Δ4-6-Oxoprostaglandin F1α methylester 11, 15-bis t-butylsilyl ether.
USE: A remedy or preventive for diseases caused by thrombotic diseases, antiasthmatic antiulcer, and hypotensor. Having inhibiting action on blood platelet aggregation, hypotensive action, and relaxing action on smooth muscle.
PROCESS: A 4,5-dehydro-6-oxoprostaglanidin F1α shown by the formula II (R11 and R21 are OH-protecting group; R31 is H or 1W10C lower alkyl) is oxidized, and if necessary, the protecting group is removed, the oxidized compound is hydrolyzed and esterified, to give a compound shown by the formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP55150799A 1980-10-29 1980-10-29 4,5-dehydro-6-oxoprostaglandin e1 and its preparation Pending JPS5775968A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55150799A JPS5775968A (en) 1980-10-29 1980-10-29 4,5-dehydro-6-oxoprostaglandin e1 and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55150799A JPS5775968A (en) 1980-10-29 1980-10-29 4,5-dehydro-6-oxoprostaglandin e1 and its preparation

Publications (1)

Publication Number Publication Date
JPS5775968A true JPS5775968A (en) 1982-05-12

Family

ID=15504677

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55150799A Pending JPS5775968A (en) 1980-10-29 1980-10-29 4,5-dehydro-6-oxoprostaglandin e1 and its preparation

Country Status (1)

Country Link
JP (1) JPS5775968A (en)

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