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JPS57200391A - 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine - Google Patents

1-(5-oxo-2-hexenyl)3,7-dimethylxanthine

Info

Publication number
JPS57200391A
JPS57200391A JP8478381A JP8478381A JPS57200391A JP S57200391 A JPS57200391 A JP S57200391A JP 8478381 A JP8478381 A JP 8478381A JP 8478381 A JP8478381 A JP 8478381A JP S57200391 A JPS57200391 A JP S57200391A
Authority
JP
Japan
Prior art keywords
compound shown
formula
dimethylxanthine
formulai
lewis acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8478381A
Other languages
Japanese (ja)
Inventor
Takumi Matsumura
Tatsuo Shinohara
Yasuhiro Koyagi
Hiroshi Kawahara
Akihiro Yashiro
Akira Yokozuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daitou Koueki Kk
Daito Koeki KK
Original Assignee
Daitou Koueki Kk
Daito Koeki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daitou Koueki Kk, Daito Koeki KK filed Critical Daitou Koueki Kk
Priority to JP8478381A priority Critical patent/JPS57200391A/en
Publication of JPS57200391A publication Critical patent/JPS57200391A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formulaI.
USE: An intermediate for preparing 1-(5-oxohexyl)-3,7-dimethyl-xanthine useful as a remedy for circulatory organs having a vasodilating action or a medicament for circulatory organs having a promoting action on the deformation state of erythrocyte.
PROCESS: A compound shown by the formula II is acetylated with acetyl chloride in the presence of a Lewis acid (e.g., AlCl3, etc.) in a solvent such as dichloromethane, etc. at -10W40°C, to give a compound shown by the formulaI. The amount of the Lewis acid used is 6W10 equivalents, preferably 7W8 equivalents based on the compound shown by the formula II. The amount of acetyl chloride used is preferably equivalent W1.5 equivalent based on the compound shown by the formula II. The compound shown by the formula II is obtained by reacting 3-bromo-1-butene with an alkali metal salt of 3,7-dimethylxanthine easily in high yield.
COPYRIGHT: (C)1982,JPO&Japio
JP8478381A 1981-06-02 1981-06-02 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine Pending JPS57200391A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8478381A JPS57200391A (en) 1981-06-02 1981-06-02 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8478381A JPS57200391A (en) 1981-06-02 1981-06-02 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine

Publications (1)

Publication Number Publication Date
JPS57200391A true JPS57200391A (en) 1982-12-08

Family

ID=13840289

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8478381A Pending JPS57200391A (en) 1981-06-02 1981-06-02 1-(5-oxo-2-hexenyl)3,7-dimethylxanthine

Country Status (1)

Country Link
JP (1) JPS57200391A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3199203A1 (en) 2008-02-29 2017-08-02 Concert Pharmaceuticals Inc. Substitued xanthine derivatives
WO2011028835A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2963040A1 (en) 2009-09-02 2016-01-06 Concert Pharmaceuticals Inc. Substituted xanthine derivatives
WO2013155465A1 (en) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives

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