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JPS5716881A - 5-fluorouracil derivative - Google Patents

5-fluorouracil derivative

Info

Publication number
JPS5716881A
JPS5716881A JP9207980A JP9207980A JPS5716881A JP S5716881 A JPS5716881 A JP S5716881A JP 9207980 A JP9207980 A JP 9207980A JP 9207980 A JP9207980 A JP 9207980A JP S5716881 A JPS5716881 A JP S5716881A
Authority
JP
Japan
Prior art keywords
formula
fluorouracil
cyano
compound
necessary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9207980A
Other languages
Japanese (ja)
Other versions
JPS6157832B2 (en
Inventor
Wataru Nagata
Susumu Kamata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP9207980A priority Critical patent/JPS5716881A/en
Publication of JPS5716881A publication Critical patent/JPS5716881A/en
Publication of JPS6157832B2 publication Critical patent/JPS6157832B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:5-Fluorouracil derivatives of formula I [R<1>, R<2> are H, formula H, III (R<3>, R<4> are H, hydroxyl, trialkylsilyloxy, alkoxy, amino, alkoxycarbonylamino, haloalkoxycarbonylamino, nitro, cyano, carboxy, carboxyalkyl; R<5>, R<6> are alkyl); wherein the case where R<1> and R<2> are H at the same time is excluded]. EXAMPLE:1-(3-Oxo-6-cyano-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil. USE:Antitumor agent: they have high safety and relatively wide range of effective dose, therefore, the dose can be readily increased or decreased and they can be administrered orally or parenterally. PREPARATION:Equimolar amounts or excessive amounts of compounds of formula V and VI (theoretically two equivalent amount is necessary) is made to act on a compound of formula IV, when necessary, hydrolyzed to give the compound of formula I.
JP9207980A 1980-07-04 1980-07-04 5-fluorouracil derivative Granted JPS5716881A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9207980A JPS5716881A (en) 1980-07-04 1980-07-04 5-fluorouracil derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9207980A JPS5716881A (en) 1980-07-04 1980-07-04 5-fluorouracil derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP8925482A Division JPS5823623A (en) 1982-05-25 1982-05-25 Antitumor agent containing 5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
JPS5716881A true JPS5716881A (en) 1982-01-28
JPS6157832B2 JPS6157832B2 (en) 1986-12-09

Family

ID=14044435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9207980A Granted JPS5716881A (en) 1980-07-04 1980-07-04 5-fluorouracil derivative

Country Status (1)

Country Link
JP (1) JPS5716881A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5767578A (en) * 1980-10-09 1982-04-24 Grelan Pharmaceut Co Ltd N-phthtalidy-5-fluorouracil derivative
EP0112067A2 (en) * 1982-11-18 1984-06-27 Shionogi & Co., Ltd. Phthalidylammonium compounds and their production, and their use in the production of 1-phthalidyl-5-fluorouracil derivatives and formulations containing such derivatives
JPH0398001U (en) * 1990-01-23 1991-10-09

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5078304A (en) * 1973-11-08 1975-06-26
JPS5393224U (en) * 1976-12-28 1978-07-29
JPS54140543A (en) * 1978-04-23 1979-10-31 Canon Inc Monitor for zerographic apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5078304A (en) * 1973-11-08 1975-06-26
JPS5393224U (en) * 1976-12-28 1978-07-29
JPS54140543A (en) * 1978-04-23 1979-10-31 Canon Inc Monitor for zerographic apparatus

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5767578A (en) * 1980-10-09 1982-04-24 Grelan Pharmaceut Co Ltd N-phthtalidy-5-fluorouracil derivative
US4528372A (en) * 1980-10-09 1985-07-09 Grelan Pharmaceutical Co., Ltd. N-Phthalidyl-5-fluorouracils
JPS6348273B2 (en) * 1980-10-09 1988-09-28 Grelan Pharmaceutical Co
EP0112067A2 (en) * 1982-11-18 1984-06-27 Shionogi & Co., Ltd. Phthalidylammonium compounds and their production, and their use in the production of 1-phthalidyl-5-fluorouracil derivatives and formulations containing such derivatives
US4605738A (en) * 1982-11-18 1986-08-12 Shionogi & Co., Ltd. Production of 1-phthalidyl-5-fluorouracil derivatives
JPH0398001U (en) * 1990-01-23 1991-10-09

Also Published As

Publication number Publication date
JPS6157832B2 (en) 1986-12-09

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