[go: up one dir, main page]

JPS57120524A - Manufacture of blood coagulation factor medicine - Google Patents

Manufacture of blood coagulation factor medicine

Info

Publication number
JPS57120524A
JPS57120524A JP56189354A JP18935481A JPS57120524A JP S57120524 A JPS57120524 A JP S57120524A JP 56189354 A JP56189354 A JP 56189354A JP 18935481 A JP18935481 A JP 18935481A JP S57120524 A JPS57120524 A JP S57120524A
Authority
JP
Japan
Prior art keywords
manufacture
blood coagulation
coagulation factor
factor medicine
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56189354A
Other languages
English (en)
Other versions
JPH0348171B2 (ja
Inventor
Shiyubuin Horusuto
Haimuburugaa Noruberuto
Kiyumupe Geruharuto
Buorumuzubekuseru Buirufuriito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of JPS57120524A publication Critical patent/JPS57120524A/ja
Publication of JPH0348171B2 publication Critical patent/JPH0348171B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP56189354A 1980-11-29 1981-11-27 Manufacture of blood coagulation factor medicine Granted JPS57120524A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803045153 DE3045153A1 (de) 1980-11-29 1980-11-29 Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x

Publications (2)

Publication Number Publication Date
JPS57120524A true JPS57120524A (en) 1982-07-27
JPH0348171B2 JPH0348171B2 (ja) 1991-07-23

Family

ID=6117972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56189354A Granted JPS57120524A (en) 1980-11-29 1981-11-27 Manufacture of blood coagulation factor medicine

Country Status (10)

Country Link
US (1) US4405603A (ja)
EP (1) EP0053338B1 (ja)
JP (1) JPS57120524A (ja)
AT (1) ATE11640T1 (ja)
AU (1) AU544157B2 (ja)
CA (1) CA1182047A (ja)
DE (2) DE3045153A1 (ja)
ES (1) ES8206975A1 (ja)
IL (1) IL64396A (ja)
MX (1) MX6947E (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953428A (ja) * 1982-08-19 1984-03-28 ベ−リングヴエルケ・アクチエンゲゼルシヤフト 低温殺菌されたヒト−フイブリノ−ゲンおよびその製法
JPS5988427A (ja) * 1982-10-09 1984-05-22 ベ−リングヴエルケ・アクチエンゲゼルシヤフト 低温殺菌された抗血友病性寒冷沈降物の製造方法
JPS6094917A (ja) * 1983-10-28 1985-05-28 Green Cross Corp:The Ｂ型肝炎感染予防用ワクチンの製造方法
JPH09506256A (ja) * 1993-12-10 1997-06-24 オクタファルマ・アクチェン・ゲゼルシャフト メンブレンクロマトグラフィーによるビタミンｋ依存性蛋白の精製
JP2006219500A (ja) * 1994-04-26 2006-08-24 Genetics Inst Llc 因子ｉｘ用処方

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
ATE36457T1 (de) * 1983-05-02 1988-09-15 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen krankheitserregern.
US4764369A (en) * 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
DE3330770A1 (de) * 1983-08-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von humanplasma
US4615886A (en) * 1983-08-31 1986-10-07 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Utilizing a halohydrocarbon containing dissolved water to inactivate a lipid virus
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
US4490361A (en) * 1983-12-02 1984-12-25 Alpha Therapeutic Corporation Virus inactivating heat treatment of plasma fractions
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US5171569A (en) * 1985-03-15 1992-12-15 National Research Development Corporation Factor IX preparations uncontaminated by plasma components or pox virus
AT390560B (de) * 1986-05-30 1990-05-25 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
IL86417A (en) * 1987-05-22 1992-09-06 Armour Pharma Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers
WO1989005652A1 (en) * 1987-12-21 1989-06-29 American National Red Cross Pure factor ix product
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix
FR2664165B1 (fr) * 1990-07-03 1992-10-16 Lille Transfusion Sanguine Composition pour stabiliser le plasma sanguin en cours de pasteurisation.
ES2150914T3 (es) * 1991-03-01 2000-12-16 Rhone Poulenc Rorer Int Preparacion de factor ix.
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
FR2687317B1 (fr) * 1992-02-13 1995-06-23 Aetsrn Composition pour stabiliser le plasma sanguin en cour de pasteurisation et solution plasmatique pasteurisee a usage therapeutique.
AT399818B (de) * 1992-04-24 1995-07-25 Immuno Ag Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation
EP0674531A1 (de) * 1992-12-16 1995-10-04 IMMUNO Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
EP1010852A1 (en) 1998-12-15 2000-06-21 Schlegel BVBA Sealing gasket and method of making and inserting the same
GB0521139D0 (en) 2005-10-18 2005-11-23 Univ Sheffield Therapeutic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081432A (en) * 1977-07-25 1978-03-28 Monsanto Company Method of separating a Factor IX preparation from plasma using ethylene-maleic anhydride polymers
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
JPS56135418A (en) * 1980-03-27 1981-10-22 Green Cross Corp:The Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953428A (ja) * 1982-08-19 1984-03-28 ベ−リングヴエルケ・アクチエンゲゼルシヤフト 低温殺菌されたヒト−フイブリノ−ゲンおよびその製法
JPS5988427A (ja) * 1982-10-09 1984-05-22 ベ−リングヴエルケ・アクチエンゲゼルシヤフト 低温殺菌された抗血友病性寒冷沈降物の製造方法
JPS6094917A (ja) * 1983-10-28 1985-05-28 Green Cross Corp:The Ｂ型肝炎感染予防用ワクチンの製造方法
JPH09506256A (ja) * 1993-12-10 1997-06-24 オクタファルマ・アクチェン・ゲゼルシャフト メンブレンクロマトグラフィーによるビタミンｋ依存性蛋白の精製
JP2006219500A (ja) * 1994-04-26 2006-08-24 Genetics Inst Llc 因子ｉｘ用処方
JP2010077148A (ja) * 1994-04-26 2010-04-08 Genetics Inst Llc 因子ｉｘ用処方

Also Published As

Publication number Publication date
CA1182047A (en) 1985-02-05
AU544157B2 (en) 1985-05-16
DE3045153A1 (de) 1982-07-08
EP0053338B1 (de) 1985-02-06
DE3168834D1 (en) 1985-03-21
IL64396A (en) 1985-02-28
JPH0348171B2 (ja) 1991-07-23
US4405603A (en) 1983-09-20
ES507400A0 (es) 1982-09-01
EP0053338A3 (en) 1982-08-04
ATE11640T1 (de) 1985-02-15
EP0053338A2 (de) 1982-06-09
MX6947E (es) 1986-12-19
IL64396A0 (en) 1982-02-28
ES8206975A1 (es) 1982-09-01
AU7795081A (en) 1982-06-10

Similar Documents

Publication Publication Date Title
JPS57120524A (en) Manufacture of blood coagulation factor medicine
JPS57116018A (en) Production of blood coagulation factor
DE3162578D1 (en) Process for heat treatment of aqueous solution containing human blood coagulation factor xiii
AU537668B2 (en) Non-stirring measurement of blood coagulation time
ATE21046T1 (de) Verfahren zur absorption von schwefeldioxid.
ATE24658T1 (de) Verfahren zur herstellung eines molkeproduktes.
SE7707992L (sv) Forfarande for framstellning av en blodkoagulationsbefremjande preparation av humanblodplasma
GEP20084347B (en) New derivatives of diphosphonic acid, method for their preparation and medicamentous form containing them
EP0376251A3 (en) An anticoagulant substance obtained from urine
DE2963117D1 (en) Ubiquitary tissue protein pp8 and process for its preparation
ES2042532T3 (es) Procedimiento para preparar un agente destinado a la terapia o profilaxis de trastornos hemostaticos.
AU527089B2 (en) Absorbant facing for medical purposes and process for making same
EP0044343A4 (en) PROTHROMBIN-CONTAINING THERAPEUTIC COMPOSITIONS AND METHOD FOR THE PRODUCTION OF ENZYMATICALLY ACTIVE BLOOD-COUTTERING FACTORS FROM PROTHROMBIN-CONTAINING BLOOD FRACTIONS.
AU4704579A (en) Mechanical treatment of blood in surgery
FI883450A0 (fi) Menetelmä istukan kudosproteiinin PP4 puhdistamiseksi
ZA894945B (en) Strontium salt,process for the preparation thereof and pharmaceutical compositions containing it
SU1113093A1 (ru) Способ лечени остеомиелита
JPS56104672A (en) Method of sterilizing blood purifier
JPS5735521A (en) Fractionation of plasma protein
AU7077881A (en) Disposable surgical face mask and the method of producing it
JPS5485598A (en) Blood dialyser and method of dialyzing same