JPS5663961A - Novel isoindoline derivative and its preparation - Google Patents
Novel isoindoline derivative and its preparationInfo
- Publication number
- JPS5663961A JPS5663961A JP12799079A JP12799079A JPS5663961A JP S5663961 A JPS5663961 A JP S5663961A JP 12799079 A JP12799079 A JP 12799079A JP 12799079 A JP12799079 A JP 12799079A JP S5663961 A JPS5663961 A JP S5663961A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- isoindoline derivative
- compound
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:An isoindoline derivative expressed by formula I (R1 and R2 are Hs or halogens; R3 and R4 are lower alkyls, or together with N may form pyrrolidine , piperidine or morpholine; ring A is formula II, III or IV).
EXAMPLE: 2-[ 4-( β-pyrrolidinoethoxy )phenyl ]-4,5,6,7-tetrahydroisoindolin-1-one.
USE: An analgesic agent.
PROCESS: A compound expressed by formula VI or a salt thereof, e.g. sodium salt, is refluxed with a compound expressed by formula VII (X is halogen) in water or an organic solvent, e.g. acetone, preferably in the presence of a base, e.g. NaOH, under heating to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12799079A JPS5663961A (en) | 1979-10-05 | 1979-10-05 | Novel isoindoline derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12799079A JPS5663961A (en) | 1979-10-05 | 1979-10-05 | Novel isoindoline derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5663961A true JPS5663961A (en) | 1981-05-30 |
Family
ID=14973717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12799079A Pending JPS5663961A (en) | 1979-10-05 | 1979-10-05 | Novel isoindoline derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5663961A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0644655U (en) * | 1992-11-26 | 1994-06-14 | 隆 松下 | Seat belt fixing device |
| WO2004089897A1 (en) * | 2003-04-07 | 2004-10-21 | Glaxo Group Limited | Compounds having activity at 5ht2c receptor and uses thereof |
| EP1467979A4 (en) * | 2001-12-19 | 2006-03-15 | Bristol Myers Squibb Co | Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function |
-
1979
- 1979-10-05 JP JP12799079A patent/JPS5663961A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0644655U (en) * | 1992-11-26 | 1994-06-14 | 隆 松下 | Seat belt fixing device |
| EP1467979A4 (en) * | 2001-12-19 | 2006-03-15 | Bristol Myers Squibb Co | Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function |
| WO2004089897A1 (en) * | 2003-04-07 | 2004-10-21 | Glaxo Group Limited | Compounds having activity at 5ht2c receptor and uses thereof |
| JP2006522065A (en) * | 2003-04-07 | 2006-09-28 | グラクソ グループ リミテッド | Compounds having 5-HT2C receptor activity and uses thereof |
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