JPS56161369A - Novel vitamin d derivative - Google Patents
Novel vitamin d derivativeInfo
- Publication number
- JPS56161369A JPS56161369A JP6404080A JP6404080A JPS56161369A JP S56161369 A JPS56161369 A JP S56161369A JP 6404080 A JP6404080 A JP 6404080A JP 6404080 A JP6404080 A JP 6404080A JP S56161369 A JPS56161369 A JP S56161369A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyvitamin
- formula
- vitamin
- chromatography
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 2
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003643 water by type Substances 0.000 abstract 2
- 239000004039 25-hydroxy-24-oxo-cholecalciferol Substances 0.000 abstract 1
- DDZHNKIBJQESJA-AHMPPUFCSA-N 25-hydroxy-24-oxocalciol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCC(=O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C DDZHNKIBJQESJA-AHMPPUFCSA-N 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007792 gaseous phase Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:25-Hydroxy-24-oxocholecalciferol of the formula.
USE: A medicine having a physiological activity like that of vitamin D.
PROCESS: 25-Hydroxyvitamin D3 is incubated in a homogenate of a kidney obtained from a chicken of a domestic fowl to which vitamin D3 is administered, and the resultant homogenate is subjected to a means, e.g. chromatography, to give the titled compound of the formula. 25-Hydroxyvitamin D3 contains 1μg [26, 27-3H]- 25-hydroxyvitamin D3. The incubation is carried out in the gaseous phase of oxygen at 37°C for 30min, and the chromatography is the high speed liquid chromatography, e.g. Waters model 204 (manufactured by Waters Associates, Inc.).The compound of the formula is separated from the 25-hydroxyvitamin D3.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6404080A JPS56161369A (en) | 1980-05-16 | 1980-05-16 | Novel vitamin d derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6404080A JPS56161369A (en) | 1980-05-16 | 1980-05-16 | Novel vitamin d derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56161369A true JPS56161369A (en) | 1981-12-11 |
Family
ID=13246599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6404080A Pending JPS56161369A (en) | 1980-05-16 | 1980-05-16 | Novel vitamin d derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56161369A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60172960A (en) * | 1984-02-17 | 1985-09-06 | Chugai Pharmaceut Co Ltd | Novel vitamin d3 derivative |
-
1980
- 1980-05-16 JP JP6404080A patent/JPS56161369A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60172960A (en) * | 1984-02-17 | 1985-09-06 | Chugai Pharmaceut Co Ltd | Novel vitamin d3 derivative |
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