JPS56160992A - Enzymic pharmaceutical of sustained release type - Google Patents
Enzymic pharmaceutical of sustained release typeInfo
- Publication number
- JPS56160992A JPS56160992A JP6582580A JP6582580A JPS56160992A JP S56160992 A JPS56160992 A JP S56160992A JP 6582580 A JP6582580 A JP 6582580A JP 6582580 A JP6582580 A JP 6582580A JP S56160992 A JPS56160992 A JP S56160992A
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- gel
- monomer
- acrylate
- enzymic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 6
- 108090000790 Enzymes Proteins 0.000 abstract 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 3
- 239000000178 monomer Substances 0.000 abstract 3
- 239000003431 cross linking reagent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920002401 polyacrylamide Polymers 0.000 abstract 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000001420 bacteriolytic effect Effects 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003505 polymerization initiator Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
Landscapes
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To develop a pharamaceutical capable of releasing an enzyme slowly, by immobilizing the enzyme in a polymeric gel, e.g. polyacrylamide gel or polyhydroxylethyl acrylate gel, by the entrapping method.
CONSTITUTION: Acrylamide monomer or hydroxyethyl (meth)acrylate monomer, an enzyme and N,N'-methylenebisacrylamide which is a crosslinking agent are dissolved in a buffer solution, and a polymerization accelerator and a a polymerization initiator are added to polymerize and crosslink the monomer. Thus, the enzyme is immobilized in the resultant polyacrylamide gel or polyhydroxyethyl (meth)acrylate gel by the entrapping method. The microporous diameter of the polymeric gel is controlled by adjusting the concentration of the monomer or crosslinking agent. Protease or bacteriolytic enzyme or both are used as the enzyme.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6582580A JPS56160992A (en) | 1980-05-17 | 1980-05-17 | Enzymic pharmaceutical of sustained release type |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6582580A JPS56160992A (en) | 1980-05-17 | 1980-05-17 | Enzymic pharmaceutical of sustained release type |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56160992A true JPS56160992A (en) | 1981-12-11 |
Family
ID=13298184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6582580A Pending JPS56160992A (en) | 1980-05-17 | 1980-05-17 | Enzymic pharmaceutical of sustained release type |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56160992A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6110514A (en) * | 1984-06-26 | 1986-01-18 | Toyo Tire & Rubber Co Ltd | Medicines that release physiologically active substances in vivo |
| JPS61282313A (en) * | 1985-06-06 | 1986-12-12 | Nitto Electric Ind Co Ltd | Enzyme-containing plaster |
| KR100316212B1 (en) * | 1994-08-10 | 2002-06-20 | 흐레비니크 미콜라 미콜라요비치 | Biocompatible hydrogel |
-
1980
- 1980-05-17 JP JP6582580A patent/JPS56160992A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6110514A (en) * | 1984-06-26 | 1986-01-18 | Toyo Tire & Rubber Co Ltd | Medicines that release physiologically active substances in vivo |
| JPH0324445B2 (en) * | 1984-06-26 | 1991-04-03 | Toyo Gomu Kogyo Kk | |
| JPS61282313A (en) * | 1985-06-06 | 1986-12-12 | Nitto Electric Ind Co Ltd | Enzyme-containing plaster |
| KR100316212B1 (en) * | 1994-08-10 | 2002-06-20 | 흐레비니크 미콜라 미콜라요비치 | Biocompatible hydrogel |
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