JPS56144091A - Separation of coenzyme q homologue - Google Patents
Separation of coenzyme q homologueInfo
- Publication number
- JPS56144091A JPS56144091A JP4524480A JP4524480A JPS56144091A JP S56144091 A JPS56144091 A JP S56144091A JP 4524480 A JP4524480 A JP 4524480A JP 4524480 A JP4524480 A JP 4524480A JP S56144091 A JPS56144091 A JP S56144091A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- homologue
- mixture
- substances
- separated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005515 coenzyme Substances 0.000 title abstract 2
- 238000000926 separation method Methods 0.000 title 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 abstract 4
- 235000017471 coenzyme Q10 Nutrition 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- NWAKMJSLSDJISV-JVLSEPFISA-N 2-[(2e,6e,10e,14e,18e,22e,26e,30e,34e,38e,42e)-3,7,11,15,19,23,27,31,35,39,43,47-dodecamethyloctatetraconta-2,6,10,14,18,22,26,30,34,38,42,46-dodecaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O NWAKMJSLSDJISV-JVLSEPFISA-N 0.000 abstract 1
- XGCJRRDNIMSYNC-INVBOZNNSA-N Coenzyme Q4 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O XGCJRRDNIMSYNC-INVBOZNNSA-N 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To separate two or more titled substances easily and industrially, by dissolving a mixture comprising two or more titled substances in a hydrophilic solvent at a specific temperature, followed by cooling the solution gradually so that the coenzyme having a higher molecular weight is crystallized first, separated and collected.
CONSTITUTION: A mixture comprising two or more coenzyme Q homologue from coenzyme Q4 to coenzyme Q12 is purified conventionally, and substances other than the coenzyme Q homologue are removed. The mixture of coenzyme Q homologue is dissolved in a hydrophilic solvent, e.g., acetonitrile, acetone, etc. at about 40W60°C. The solution is cooled first at a rate 1W3°C per hour, and when crystal separtes out, the cooling rate is made ≤1°C/hr, and the final temperature is made about 10W20°C. In possible, crystals are separated and collected, and the coenzyme Q homologue is separated easily each other and industrially.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4524480A JPS56144091A (en) | 1980-04-08 | 1980-04-08 | Separation of coenzyme q homologue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4524480A JPS56144091A (en) | 1980-04-08 | 1980-04-08 | Separation of coenzyme q homologue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56144091A true JPS56144091A (en) | 1981-11-10 |
Family
ID=12713838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4524480A Pending JPS56144091A (en) | 1980-04-08 | 1980-04-08 | Separation of coenzyme q homologue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56144091A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1415970A4 (en) * | 2001-07-13 | 2006-02-01 | Kaneka Corp | Method of producing reduced coenzyme q10 crystals with excellent handling properties |
-
1980
- 1980-04-08 JP JP4524480A patent/JPS56144091A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1415970A4 (en) * | 2001-07-13 | 2006-02-01 | Kaneka Corp | Method of producing reduced coenzyme q10 crystals with excellent handling properties |
| KR100876756B1 (en) * | 2001-07-13 | 2009-01-07 | 가부시키가이샤 가네카 | Method for preparing reduced coenzyme Ｑ10 crystals with excellent operability |
| JP2009046495A (en) * | 2001-07-13 | 2009-03-05 | Kaneka Corp | Method for producing reduced coenzyme q10 crystal with excellent handling property |
| US8003828B2 (en) | 2001-07-13 | 2011-08-23 | Kaneka Corporation | Method of producing reduced coenzyme Q10 crystals with excellent handling properties |
| US8853464B2 (en) | 2001-07-13 | 2014-10-07 | Kaneka Corporation | Method of producing reduced coenzyme Q10 crystals with excellent handling properties |
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