JPS55147237A - Separation of optically active body and racemic body from partially optically active body of mandelic acid - Google Patents
Separation of optically active body and racemic body from partially optically active body of mandelic acidInfo
- Publication number
- JPS55147237A JPS55147237A JP5532579A JP5532579A JPS55147237A JP S55147237 A JPS55147237 A JP S55147237A JP 5532579 A JP5532579 A JP 5532579A JP 5532579 A JP5532579 A JP 5532579A JP S55147237 A JPS55147237 A JP S55147237A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- mandelic acid
- active body
- racemic
- alkaline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 title abstract 5
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 title abstract 5
- 229960002510 mandelic acid Drugs 0.000 title abstract 5
- 238000000926 separation method Methods 0.000 title abstract 2
- -1 alkaline-earth metal salt Chemical class 0.000 abstract 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 239000001110 calcium chloride Substances 0.000 abstract 2
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001341 alkaline earth metal compounds Chemical class 0.000 abstract 1
- 229910001626 barium chloride Inorganic materials 0.000 abstract 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 abstract 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To carry out the title separation efficiently in high yield and purity, by adding an alkaline-earty metal compound to a solution of a partially optically active body of mandelic acid and selectively precipitating a racemic body of mandelic acid as an alkaline-earth metal salt.
CONSTITUTION: By adding an alkaline-earth metal compound (A) to a solution of a partially optically active body of mandelic acid which contains an optically active body and a racemic body, the racemic body is precipitated as an alkaline-earth metal salt and separated by filtration, to obtain the racemic body of mandelic acid from the precipitate and the optically active body from the filtrate. Although Ca (OH)2, CaCl2, Ba(OH)2, BaCl2, etc. is used as A, Ca(OH)2 and CaCl2 are favorable when water is used as the solvent. The amount of A used is preferably an equivalent to or more than the acemic body.
USE: The optically active body is useful as a raw material of medicines and an optically active agent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5532579A JPS55147237A (en) | 1979-05-08 | 1979-05-08 | Separation of optically active body and racemic body from partially optically active body of mandelic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5532579A JPS55147237A (en) | 1979-05-08 | 1979-05-08 | Separation of optically active body and racemic body from partially optically active body of mandelic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55147237A true JPS55147237A (en) | 1980-11-17 |
Family
ID=12995382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5532579A Pending JPS55147237A (en) | 1979-05-08 | 1979-05-08 | Separation of optically active body and racemic body from partially optically active body of mandelic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55147237A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103450008A (en) * | 2013-09-02 | 2013-12-18 | 江苏宝众宝达药业有限公司 | Method for recovering mandelic acid from waste water |
| CN105037134A (en) * | 2015-05-21 | 2015-11-11 | 启东东岳药业有限公司 | Asymmetric diphenic acid isomeride separation method |
-
1979
- 1979-05-08 JP JP5532579A patent/JPS55147237A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103450008A (en) * | 2013-09-02 | 2013-12-18 | 江苏宝众宝达药业有限公司 | Method for recovering mandelic acid from waste water |
| CN105037134A (en) * | 2015-05-21 | 2015-11-11 | 启东东岳药业有限公司 | Asymmetric diphenic acid isomeride separation method |
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