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IKEDA MOHANDO CO
IKEDA MOHANDOU KK
Original Assignee
IKEDA MOHANDO CO
IKEDA MOHANDOU KK
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Filing date
Publication date
Application filed by IKEDA MOHANDO CO, IKEDA MOHANDOU KKfiledCriticalIKEDA MOHANDO CO
Priority to JP15343478ApriorityCriticalpatent/JPS5579352A/en
Publication of JPS5579352ApublicationCriticalpatent/JPS5579352A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
NEW MATERIAL:Compound of formula I (R1,2 are lower alyl).
EXAMPLE: N,N-Dimethyl-o-iodophenylacetamide.
USE: Intermediate of diclofenac which is a non-steroidal analgesic antiinflammatory agent.
PROCESS: 1W10moles of thionyl chloride is reacted to 1mol of o-iodophenylacetic acid, to form an acid chloride, and the unreacted thionyl chloride is removed from a reaction product under reduced pressure. Then, said acid chloride is reacted with an amine compound, to obtain a compound of formula I. Diclofenac can be prepared from the compound of formula I, by carrying out the ulmann reaction with 2,6- dichloroaniline and hydrolyzing the resulting N,N-di-lower-alkyl-(2,6-dichloroanilino)-phenylacetamide.
A new compound with analgesic, antiinflammatory and antipyretic activity, process for the preparation thereof and pharmaceutical compositions therefrom.