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JPS5539712A - Production of 6-aminopenicillanic acid by fixed enzyme method - Google Patents

Production of 6-aminopenicillanic acid by fixed enzyme method

Info

Publication number
JPS5539712A
JPS5539712A JP11144378A JP11144378A JPS5539712A JP S5539712 A JPS5539712 A JP S5539712A JP 11144378 A JP11144378 A JP 11144378A JP 11144378 A JP11144378 A JP 11144378A JP S5539712 A JPS5539712 A JP S5539712A
Authority
JP
Japan
Prior art keywords
aminopenicillanic acid
penicillin
fixed
water
acylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11144378A
Other languages
Japanese (ja)
Other versions
JPS6022920B2 (en
Inventor
Kunio Matsumoto
Hideji Seijiyou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP11144378A priority Critical patent/JPS6022920B2/en
Publication of JPS5539712A publication Critical patent/JPS5539712A/en
Publication of JPS6022920B2 publication Critical patent/JPS6022920B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: Penicillin acylase is fixed on a water-insoluble aminated polyacrylo-nitrile polymer, thereby producing high-purity 6-aminopenicillanic acid in high yield.
CONSTITUTION: Penicillin acylase collected from cells of a bacterium producing penicilline acylase or the culture filtrate is fixed on a water-insoluble aminated acrylonitrile polymer that is made into fiber, membrane or hollow fiber and has porous structure with 100W200 micron pore diameter by physical adsorption or covalent bonds. The fixed enzyme is filled in a column and the pH is adjusted to 6.5W9.5 and an aqeuous solution of penicillin or its water-soluble salt of 3W 12W/V% concentration whose pH is adjusted to 6.5W9.5 is passed at 15W40°C and a low rate of 100W300 bed volume/hr for 1W10hr until more than 90% of penicillin is converted into 6-aminopenicillanic acid. Then the 6-aminopenicillanic acid is isolated and purified.
COPYRIGHT: (C)1980,JPO&Japio
JP11144378A 1978-09-11 1978-09-11 Production method of 6-aminopenicillanic acid by immobilized enzyme method Expired JPS6022920B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11144378A JPS6022920B2 (en) 1978-09-11 1978-09-11 Production method of 6-aminopenicillanic acid by immobilized enzyme method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11144378A JPS6022920B2 (en) 1978-09-11 1978-09-11 Production method of 6-aminopenicillanic acid by immobilized enzyme method

Publications (2)

Publication Number Publication Date
JPS5539712A true JPS5539712A (en) 1980-03-19
JPS6022920B2 JPS6022920B2 (en) 1985-06-04

Family

ID=14561319

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11144378A Expired JPS6022920B2 (en) 1978-09-11 1978-09-11 Production method of 6-aminopenicillanic acid by immobilized enzyme method

Country Status (1)

Country Link
JP (1) JPS6022920B2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0668519U (en) * 1993-03-11 1994-09-27 鐘紡株式会社 Insole for school bag
JPH08332A (en) * 1994-06-23 1996-01-09 Sankyo Sogyo:Kk Knapsack

Also Published As

Publication number Publication date
JPS6022920B2 (en) 1985-06-04

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