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JPS55113723A - Drug composition to be absorbed in digestive canal - Google Patents

Drug composition to be absorbed in digestive canal

Info

Publication number
JPS55113723A
JPS55113723A JP2244679A JP2244679A JPS55113723A JP S55113723 A JPS55113723 A JP S55113723A JP 2244679 A JP2244679 A JP 2244679A JP 2244679 A JP2244679 A JP 2244679A JP S55113723 A JPS55113723 A JP S55113723A
Authority
JP
Japan
Prior art keywords
drug
absorbed
digestive
composition
diketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2244679A
Other languages
Japanese (ja)
Inventor
Ko Kamata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Sawai Pharmaceutical Co Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Sawai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd, Sawai Pharmaceutical Co Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Priority to JP2244679A priority Critical patent/JPS55113723A/en
Priority to FR8003909A priority patent/FR2449447A1/en
Priority to GB8006355A priority patent/GB2046091A/en
Publication of JPS55113723A publication Critical patent/JPS55113723A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: A drug composition to be absorbed in digestive canals for use as a substance capable of increasing usefully the concentration in the flood of a drug having difficulty in being absorbed, comprising a specific β-diketone composition as an absorbing auxiliary as well as curing active ingredients.
CONSTITUTION: An absorbing auxiliary consisting of one or more of β-diketone compounds (e.g., glycerol-1,3-diacetacetate, etc.) shown by the formula (R is alkyl, aralkyl, aryl, heterocyclic group etc.; Y is O, S, etc.; R' is alkyl) is belended with a main or base drug which is a curing active ingredient, an excipent, and an auxiliary, e.g., a diluent to give a drug composition to be absorbed in digestive canals. The amount of the β-diketone compound shown by the formula is 0.5W 85wt% based on the total drug. A drug for a nervous system, antibacterial agent, a drug for a digestive canal may be cited as the main drug.
COPYRIGHT: (C)1980,JPO&Japio
JP2244679A 1979-02-26 1979-02-26 Drug composition to be absorbed in digestive canal Pending JPS55113723A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2244679A JPS55113723A (en) 1979-02-26 1979-02-26 Drug composition to be absorbed in digestive canal
FR8003909A FR2449447A1 (en) 1979-02-26 1980-02-22 ADDITIVE TO PROMOTE THE ABSORPTION OF THERAPEUTICALLY ACTIVE SUBSTANCES IN THE DIGESTIVE APPARATUS
GB8006355A GB2046091A (en) 1979-02-26 1980-02-26 Pharmaceutical compositions containing beta-diketones for promoting the enteric absorption of pharmacologically active substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2244679A JPS55113723A (en) 1979-02-26 1979-02-26 Drug composition to be absorbed in digestive canal

Publications (1)

Publication Number Publication Date
JPS55113723A true JPS55113723A (en) 1980-09-02

Family

ID=12082929

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2244679A Pending JPS55113723A (en) 1979-02-26 1979-02-26 Drug composition to be absorbed in digestive canal

Country Status (3)

Country Link
JP (1) JPS55113723A (en)
FR (1) FR2449447A1 (en)
GB (1) GB2046091A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6212746A (en) * 1985-07-11 1987-01-21 Hoechst Gosei Kk Production of acetoacetylated oligomer

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037943B1 (en) * 1980-03-31 1985-08-14 Teijin Limited Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom
US4582820A (en) * 1982-12-23 1986-04-15 Research Corporation Orally administered biologically active peptides and proteins
WO1995009144A1 (en) * 1993-09-30 1995-04-06 Eastman Chemical Company Nutritive water soluble glycerol esters of hydroxy butyric acid
US5420335A (en) * 1993-09-30 1995-05-30 Birkhahn; Ronald H. Parenteral nutrients based on watersoluble glycerol bisacetoacetates
WO1995009145A1 (en) * 1993-09-30 1995-04-06 Eastman Chemical Company NUTRITIVE GLYCEROL ESTERS OF β-ACYLOXY BUTYRATES
EP0881253A1 (en) * 1997-05-27 1998-12-02 Akcros Chemicals B-ketoesters for use as polymer stabilisers
JP7546828B2 (en) * 2019-06-12 2024-09-09 ケトリピックス セラポーティクス ゲーエムベーハー Method for producing polyol-based esters of ketocarboxylic acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277465A (en) * 1978-08-26 1981-07-07 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6212746A (en) * 1985-07-11 1987-01-21 Hoechst Gosei Kk Production of acetoacetylated oligomer
JPH0513142B2 (en) * 1985-07-11 1993-02-19 Hoechst Gosei Kk

Also Published As

Publication number Publication date
GB2046091A (en) 1980-11-12
FR2449447A1 (en) 1980-09-19

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