JPS5473771A - Substituted indoline-2,3-dione and its preparation - Google Patents
Substituted indoline-2,3-dione and its preparationInfo
- Publication number
- JPS5473771A JPS5473771A JP13691677A JP13691677A JPS5473771A JP S5473771 A JPS5473771 A JP S5473771A JP 13691677 A JP13691677 A JP 13691677A JP 13691677 A JP13691677 A JP 13691677A JP S5473771 A JPS5473771 A JP S5473771A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- dichloro
- dione
- compound
- inert solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title abstract 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- BIXZHMJUSMUDOQ-UHFFFAOYSA-N dichloran Chemical compound NC1=C(Cl)C=C([N+]([O-])=O)C=C1Cl BIXZHMJUSMUDOQ-UHFFFAOYSA-N 0.000 abstract 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:1-(2,6-Dichloro-4-mitrophenyl)indoline-2,3-dione of formula I.
USE: Intermediate for 2-(2,6-dichloroanilino) phenylacetic acid usable as a raw material of pharmaceuticals for pair, inflammation, chronic arthrorheumatism, arthritis deformans, etc.
PROCESS: 2,6-Dichloro-4-nitrodiphenylamine is reacted with oxalyl chloride, preferably in the presence of an inert solvent at 20W100°C to form a compound of formula III, which is subjected to the Friedel-Crafts reaction in the presence of a catalyst, e.g. aluminum chloride, or an inert solvent to give the comopound of formula I. The starting compound of formula II can be obtained from 2, 6-dichloro-4-nitroaniline, anintermediate for inexpensive azo dispense dyes via a compound of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13691677A JPS5473771A (en) | 1977-11-15 | 1977-11-15 | Substituted indoline-2,3-dione and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13691677A JPS5473771A (en) | 1977-11-15 | 1977-11-15 | Substituted indoline-2,3-dione and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5473771A true JPS5473771A (en) | 1979-06-13 |
Family
ID=15186563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13691677A Pending JPS5473771A (en) | 1977-11-15 | 1977-11-15 | Substituted indoline-2,3-dione and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5473771A (en) |
-
1977
- 1977-11-15 JP JP13691677A patent/JPS5473771A/en active Pending
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