JPH1179968A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic capable of synergistically increasing humectant effect, and preventive and improving effects on skin roughing, the loss of the tenseness and springiness of the skin, the darkness of complexion, excessive sebum, etc., and further excellent in usability by compounding a specific phosphoric acid triester and a skin-activating component. SOLUTION: This cosmetic is obtained by compounding (A) a phosphoric acid triester of formula I [R<1> to R<3> are each a 1-4C alkyl; X, Y and Z are each a 2C alkylene or the like; (l), (m) and (n) are each 1-10] [e.g. tris(butoxyethyl) phosphate of the formula II] and (B) a skin-activating component such as a ceramide, an antibacterial agent (preferably, isopropylmethylphenol), a corneum dissolving agent (preferably, salicylic acid or the like), an amino acid (preferably, alginic acid), a plant extract (preferably, a camomile extract or the like), a beautifying agent (preferably, arbutin or the like), an antiinflammatory agent (preferably, glycyrrhetic acid or the like), a singlet oxygen scavenger or an antioxidant (preferably, carotene or the like) or a polysaccharide (preferably, a modified hetero polysaccharide).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to moisturizing the skin, preventing and improving skin roughness, preventing and improving skin flaking, declining elasticity, dullness of complexion, excess sebum, pores caused by bacteria and abnormal keratinization. Prevention and improvement of conspicuousness and acne, prevention of wrinkle formation
The present invention relates to a cosmetic that has an excellent effect of preventing and improving spots and freckles, and also has an excellent usability.

[0002]

2. Description of the Related Art In recent years, maintaining healthy and beautiful skin has become a serious concern for both young and old. However, the skin is delicately affected by aging, temperature, humidity, ultraviolet rays, cosmetics, disease, stress, eating habits, etc. Therefore, various functions of the skin (prevention of loss of moisture etc. from the living body, constant body temperature) Functions that control the maintenance of the body, physical and chemical stimulation from the outside world and the function of protecting the body from various bacteria, the function of maintaining the elasticity of the skin and determining the surface morphology, etc.), the aging of the skin, etc. Trouble occurs.

Further, as described above, skin troubles are caused by changes in the external environment (seasonal changes, ultraviolet rays, etc.), and changes in physiological functions due to aging and diseases, and the functions of skin tissues caused by factors inside and outside the body. In addition to abnormalities, they are caused by skin thickening, parakeratosis, and the like induced by these.

[0004] The main attempts to prevent and improve such skin troubles are to apply a synthetic or natural moisturizing component to prevent drying of the skin and to enhance the moisturizing ability of the skin, and to apply a blood circulation promoter to promote blood circulation. And other methods have been developed.

That is, free amino acids, organic acids, urea,
Prevents the above skin problems by using humectants such as inorganic ions, polysaccharides such as hyaluronic acid, animal and plant extracts, vitamins and their derivatives, peptides, proteins and other medicated skin external preparations and cosmetics. Attempts have been made to improve.

However, even if such a component is applied to the skin, its effect is low and temporary, and it does not essentially prevent or improve the above-mentioned skin troubles.

[0007] On the other hand, wrinkles, which are one of the skin problems, occur due to aging, drying, aging due to ultraviolet rays and the like.
That is, drying, changes in the surface morphology of the epidermis due to external physical and chemical stimuli such as ultraviolet rays and aging, disease, tissue degeneration in the dermis due to stress, etc., especially collagen fibers are greatly lost and dermis degeneration, Aging of the skin, such as due to a decrease in subcutaneous adipose tissue, mainly causes wrinkle relaxation and loss of elasticity.

Conventionally, various compositions and methods have been proposed for suppressing or treating wrinkles due to such an aging effect (JP-A-62-185005,
JP-A-62-502546, JP-A-2-7215
7, JP-A-2-288822, etc.). However, none of these exhibited a satisfactory wrinkle improving effect.

In general, skin spots and freckles are activated by melanocytes due to irritation caused by exposure to ultraviolet rays from sunlight, hormonal abnormalities, or genetic factors. Melanin pigments synthesized there are deposited in the skin. It is thought to be caused by abnormal deposition.

Conventionally, to prevent such skin spots and freckles, L-ascorbic acid and its derivatives,
Hydroquinone, arbutin, kojic acid, cysteine,
BACKGROUND ART Cosmetics containing a melanin inhibitor such as glutathione or a placenta extract that acts on keratinocytes to produce a whitening effect are used. However, these whitening effects are temporary and have not yet been sufficiently satisfactory.

[0011]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a moisturizing effect, a preventive / improving effect for rough skin, a preventive / improving effect for skin peeling, a decrease in elasticity, dullness of complexion, excess sebum, bacteria and the like. Excellent prevention and improvement of pores and acne caused by abnormal keratinization, prevention and improvement of wrinkle formation, prevention and improvement of wrinkle formation, prevention and improvement of spots and freckles, and excellent usability To provide cosmetics.

[0012]

Under these circumstances, the present inventors have conducted intensive studies. As a result, when a specific phosphoric acid triester and a skin active ingredient are used in combination, the phosphoric acid triester is not permeated by the skin active ingredient. Promotes skin moisturizing effect, skin roughening prevention / improvement effect, skin swelling / elasticity decline, skin color dullness prevention / improvement effect, excess sebum, pores caused by bacteria and abnormal keratinization Prevention / improvement effect of conspicuousness and acne, prevention / improvement effect of wrinkle formation, prevention / improvement effect of spots and freckles, prevention / improvement effect of conspicuous pores and acne caused by excess sebum, prevention / improvement effect of wrinkle formation Have been synergistically increased, and furthermore, it has been found that a cosmetic having an excellent feeling in use can be obtained, and the present invention has been completed.

That is, the present invention provides the following components (A) and (B): (A) the general formula (1)

[0014]

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Wherein R ¹ , R ² and R ³ are the same or different and each represent a linear or branched alkyl group having 1 to 4 carbon atoms, and X, Y and Z are the same or different and 2 or 3
And l, m and n are the same or different and represent 1 to 10 numbers. And (B) a skin active ingredient.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION The phosphoric acid triester of the component (A) used in the present invention is represented by the general formula (1). In the general formula (1), as a linear or branched alkyl group having 1 to 4 carbon atoms represented by R ¹ , R ² and R ³ , a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n- Examples thereof include a butyl group, an isobutyl group, a sec-butyl group and a tert-butyl group. Of these, those having an alkyl group having 2 to 4 carbon atoms, particularly an ethyl group and n -Butyl groups are preferred. Further, R ¹ , R ² and R ³ may be the same or different from the viewpoint of performance, but it is preferable that the three are the same in terms of ease of synthesis.

In the general formula (1), examples of the linear or branched alkylene group having 2 to 3 carbon atoms represented by X, Y and Z include an ethylene group, a trimethylene group and a propylene group. However, an ethylene group is preferred. Also,
The numbers 1 to 10 represented by l, m and n are XO,
Shows the average number of added moles of YO and ZO, (XO) _l , (YO) _m and (Z
O) The _n portion may be single or have a distribution. l, m
And n is preferably a number of 1 to 4, especially 2 to 3.

As the phosphoric acid triester of the component (A)
Is a group represented by R in the general formula (1)¹, R ^TwoAnd R^ThreeBut it
Each of which is an alkyl group having 2 to 4 carbon atoms, wherein X, Y and Z are
Is an ethylene group, and l, m and n are each a number of 1 to 4
Are preferred.

According to a known method, phosphoric acid triester (1) can be prepared by adding R ¹ O- (XO) _l -H, R ² O- (YO) _m -H and phosphorus oxyhalide such as phosphorus oxychloride. R ³ O- (ZO) _n -H alcohols (two or one when two or all of the three groups are the same) represented by R ³ O- (ZO) _n -H, directly or in the presence of a base Can be synthesized by reacting all at once or sequentially.

The solvent may not be particularly used, but may be used. In this case, any solvent may be used as long as it is inert to the reaction and can dissolve phosphorus oxyhalide.
Although not particularly limited, for example, ether solvents such as tetrahydrofuran and dioxane, aliphatic hydrocarbons such as hexane, heptane and octane, alicyclic hydrocarbons such as cyclopentane, cyclohexane and methylcyclohexane, benzene, toluene, xylene, ethylbenzene and the like And the like. These solvents can be used alone or in combination of two or more. The amount of the solvent to be used is not particularly limited, but is generally an amount such that the phosphorus oxyhalide concentration is 60% by weight or less, preferably 30% by weight or less.

The base that can be used in this reaction includes:
For example, organic tertiary amines such as triethylamine, tributylamine and pyridine, and alkali metal hydroxides such as sodium hydroxide and potassium hydroxide can be mentioned. These bases can be used alone or in combination of two or more.

Specific examples of the phosphoric acid triester (1) of the component (A) include the following.

[0023]

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The phosphoric acid triester of the component (A) can be used alone or in combination of two or more kinds. It is preferable to mix 1 to 50% by weight in the whole composition, and especially 2 to 25% by weight.
%, More preferably 5 to 20% by weight.

The skin active ingredient of the component (B) used in the present invention refers to any activity on the skin, for example, a moisturizing effect, a skin softening effect, a whitening effect, an anti-inflammatory effect, an antioxidant effect, and a blood circulation promoting effect. It has a sebum secretion inhibitory effect and the like. Such active ingredients are not particularly limited as long as they are various active ingredients used in ordinary cosmetics, quasi-drugs, pharmaceuticals, and the like. For example, ceramides, ceramide-like structural substances, amino acids, plant extracts, and whitening agents And anti-inflammatory agents, singlet oxygen scavengers, antioxidants, polysaccharides, water-soluble thickeners, alcohols, sterols, blood circulation promoters, sebum secretion inhibitors, antibacterial agents, deflocculants and the like.

Among these, ceramides are known compounds represented by the following general formula (2).

[0027]

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[In the formula, R ⁴ and R ⁵ are the same or different and each represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 8 to 26 carbon atoms.]

In the formula (2), the hydrocarbon groups represented by R ⁴ and R ⁵ are linear or branched having 8 to 26 carbon atoms, and may be saturated or unsaturated. Include, octyl, nonyl, decyl, dodecyl, undecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicodecyl, heneicosyl, docosyl, tricosyl, tetracosyl, pentacosyl, hexacosyl, nonenyl,
Decenyl, dodecenyl, undecenyl, tridecenyl,
Tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl, octadecenyl, nonadecenyl, eicosenyl, heneicosenyl, docosenyl, tricosenyl, tetracosenyl, pentacosenyl, hexacosenyl, nonadienyl, decadienyl, dodecadienyl, pentadienyl, didecadienyl, pentadienyl, didecadienyl, pentadienyl, tridecadienyl , Heptadecadienyl, octadecadienyl, nonadecadiethyl, eicosadienyl, heneicosadenyl, docosadienyl, tricosadienyl, tetracosadenyl, pentacosadenyl, hexacosadenyl, 2-hexyldecyl, 2-octylun Decyl, 2-decyltetradecyl, isostearyl group and the like. These hydrocarbon groups may be substituted by one or more hydroxyl groups.

R ⁴ is preferably a straight-chain alkyl group having 15 to 23 carbon atoms, particularly preferably pentadecyl, heptadecyl and tricosyl groups. R ⁵ is a straight-chain saturated or unsaturated alkyl or alkenyl group having 15 to 23 carbon atoms. The groups are particularly preferably pentadecyl, heptadecyl and pentadecenyl groups. Among the ceramides represented by the general formula (2), a particularly preferred compound is a compound obtained by combining the case where each of R ⁴ and R ⁵ in the general formula (2) is a group in the above particularly preferred range.

Further, examples of the ceramide-like structural substance include those represented by the following general formulas (3) to (7).

[0032]

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[In the formula, R ⁶ represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁷ represents a straight-chain or branched-chain saturated or branched chain having 9 to 25 carbon atoms. Represents an unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, a represents a number of 0 or 1, c represents an integer of 0 to 4, b and d represent 0 to 3 Indicates an integer)

[0034]

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[In the formula, R ⁸ and R ⁹ are the same or different and each represent a linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon group having 1 to 40 carbon atoms;
R ¹⁰ represents a linear or branched alkylene group having 1 to 6 carbon atoms or a single bond, and R ¹¹ represents a hydrogen atom, 1 to 12 carbon atoms.
Represents a linear or branched alkoxy group or a 2,3-dihydroxypropyloxy group. However, when R ¹⁰ is a single bond, R ¹⁸ is a hydrogen atom. ]

[0036]

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[In the formula, R ^8a represents a hydrocarbon group which may be hydroxylated having 4 to 40 carbon atoms, R ^10a represents a linear or branched alkylene group having 3 to 6 carbon atoms,
^11a represents a linear or branched alkoxy group having 1 to 12 carbon atoms. ]

[0038]

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[Wherein R ⁸ , R ⁹ , R ^9a and R ^10a have the same meaning as described above. ]

[0040]

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Wherein R ⁸ , R ⁹ and R ¹⁰ have the same meaning as described above, and R ^11b is a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or 2,3-epoxypropyl. Shows an oxy group. However, when R ¹⁰ is a single bond, R
^11b is a hydrogen atom. ]

These ceramide-like structural substances can be prepared by a known method [for example, Polish Journal of Chemistry (Po. J. Chem.) 52 , 1059 (19)
78); 52 , 1283 (1978);
Nos. 117421, 54-144308, 54-147937, 62-228048, 63-216852, and JP-A-8-3192.
No. 63].

In the general formula (3), the number of carbon atoms represented by R ⁶ is 10
Examples of the linear or branched, saturated or unsaturated hydrocarbon group of to 26, can be mentioned those of the R ⁴ and the carbon number 10 to 26 in R ^5, straight of 9-25 represented by R ⁷ The saturated or unsaturated hydrocarbon group of a chain or a branched chain includes the above-mentioned R
⁴ and those having 10 to 26 carbon atoms in R ⁵ .
R ⁶ is preferably a straight-chain saturated alkyl group having 12 to 18 carbon atoms, particularly preferably tetradecyl, hexadecyl or octadecyl group, and R ⁷ is preferably a straight-chain saturated alkyl group having 9 to 18 carbon atoms, particularly nonyl, Pentadecyl and heptadecyl groups are preferred. Among the ceramide-like structural substances represented by the general formula (3), a particularly preferred compound is a compound obtained by combining the case where each of R ⁶ and R ^{7 in the} general formula (3) is a group in the above particularly preferred range. It is.

In the general formula (4), the linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon groups represented by R ⁸ and R ⁹ having 1 to 40 carbon atoms include: Methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, heenaicosyl, docosyl, nonacosyl, triacontyl, isostearyl, isoheptadecyl , 2
-Ethylhexyl, 1-ethylheptyl, 8-heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 2-heptylundecyl, 9-octadecenyl,
1-hydroxynonyl, 1-hydroxypentadecyl,
2-hydroxypentadecyl, 15-hydroxypentadecyl, 11-hydroxyheptadecyl, 11-hydroxy-8-heptadecenyl and the like.

R ⁸ is preferably a linear or branched alkyl or alkenyl group having 8 to 26 carbon atoms, for example, octyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, triacontyl, isostearyl, 2-ethylhexyl, 2-heptylundecyl and 9-octadecenyl and the like. Particularly preferred hydrocarbon groups as R ⁸ are straight-chain or branched-chain alkyl groups having 12 to 22 carbon atoms, such as dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, and methyl-branched isostearyl groups.

R ⁹ is preferably a straight-chain or branched-chain alkyl or alkenyl group having ^{9 to} 25 carbon atoms, for example, nonyl, undecyl, tridecyl, pentadecyl, heptadecyl, heneicosyl, nonacosyl, isoheptadecyl, 1-ethylheptyl, 8- Heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 1-hydroxynonyl, 1-hydroxypentadecyl, 2-hydroxypentadecyl, 15-hydroxypentadecyl,
11-hydroxyheptadecyl and 11-hydroxy-
8-heptadecenyl and the like. Particularly preferred hydrocarbon groups for R ⁹ are straight-chain and branched-chain alkyl groups having 11 to 21 carbon atoms, such as undecyl, tridecyl,
Pentadecyl, heptadecyl, heneicosyl and methyl-branched isoheptadecyl groups.

R^TenIs a straight or branched chain having 1 to 6 carbon atoms
Represents an alkylene group or a single bond, as an alkylene group
Is, for example, methylene, ethylene, trimethylene, tetrame
Tylene, pentamethylene, hexamethylene, 1-methyl
Ethylene, 1-methyltrimethylene, 2-methyltrime
Tylene, 1,1-dimethylethylene, 1-ethylethylene
, 1-methyltetramethylene, 2-ethyltrimethyle
And the like. R ^TenIs a straight-chain having 1 to 6 carbon atoms
Alkylene groups are preferred, of which methylene, ethylene
And trimethylene are particularly preferred.

R ¹¹ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. Examples of the alkoxy group include methoxy, ethoxy, propoxy, butoxy and hexyloxy. Octyloxy, decyloxy, 1-methylethoxy and 2-ethylhexyloxy.
R ¹¹ is preferably a hydrogen atom, an alkoxy group having 1 to 8 carbon atoms and a 2,3-dihydroxypropyloxy group,
Of these, hydrogen atom, methoxy, ethoxy, propoxy,
Butoxy, 1-methylethoxy, 2-ethylhexyloxy and 2,3-dihydroxypropyloxy groups are particularly preferred.

Among the ceramide-like structural substances (4), particularly preferred compounds are those represented by R ⁸ , R ⁹ and R ^{10 in the} general formula (4).
And a compound in which R ¹¹ is a group in the particularly preferred range described above.

In the general formula (5), the number of carbon atoms represented by R ^8a is 4
Specific examples of the optionally hydroxylated hydrocarbon group of -40 include R ⁸ of ceramide-like structural material (4).
And groups excluding methyl, ethyl and propyl from the above, and the same groups as R ⁸ are preferable. Specific examples of the linear or branched alkylene group having 3 to 6 carbon atoms represented by R ^10a include groups obtained by removing methylene and ethylene from the alkylene groups exemplified in R ¹⁰ of the ceramide-like structural material (4). No. R ^10a is preferably a linear alkylene group having 3 to 6 carbon atoms, and among them, trimethylene is particularly preferable. Examples of the linear or branched alkoxy group having 1 to 12 carbon atoms represented by R ^11a include the same groups as R ^{11 in} the ceramide-like structural substance (4), and the same groups are preferable.

In the general formula (6), R ⁸ , R ⁹ , R
^10a and R ^11a have the same meaning as described above, and the same group is preferable.

In the general formula (7), R ⁸ , R ⁹ and R
¹⁰ shows the same meaning as above, R ^{11 b} is hydrogen, straight-chain or branched alkoxy group or a 2,3-epoxypropyl group having 1 to 12 carbon atoms. R ⁸ , R ⁹
And specifically as R ^10, include the same groups as ceramide-like structure material (4), the same groups are preferred. R
Examples of the straight-chain or branched-chain alkoxy group having 1 to 12 carbon atoms of ^11b include the same groups as R ¹¹ of the ceramide-like structural substance (4), and the same alkoxy group and 2,3 as the hydrogen atom R ^11. -An epoxypropyloxy group is preferred.

These ceramides and ceramide-like structural substances can be used singly or in combination of two or more. Addition of from 20 to 20% by weight, more preferably from 0.1 to 10% by weight, is more preferable in terms of feeling of use, moisturizing effect, prevention and improvement effect of rough skin, prevention and improvement effect of wrinkle formation, and stability.

Among the skin active ingredients of the component (B) used in the present invention, antibacterial agents include, for example, sulfur, triclosan, trichlorocarbanilide, chlorhexine hydrochloride, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride , Benzalkonium alkylphosphate, isopropylmethylphenol, benzoic acid, photosensitive element 201 and resorcinol. Of these,
Particularly, isopropylmethylphenol is preferable. When these antibacterial agents are blended, 0.0001 in the total composition
-5% by weight, especially 0.001-2% by weight, further 0.01%
It is preferable to mix it by 1% by weight.

Among the skin active ingredients of the component (B) used in the present invention, examples of the deflocculant include salicylic acid, N-acetylcysteine, lactic acid, citric acid, succinic acid, malic acid and alkylamine oxide. And benzoyl peroxide. Of these, salicylic acid and citric acid are particularly preferred. When these deflocculants are blended, 0.01 to 10% by weight, especially 0.1% by weight in the total composition.
It is preferable to mix it by 1% by weight.

Among the skin active ingredients of component (B) used in the present invention, amino acids or salts thereof include, for example, ornithine, tryptophan, lysine, arginine,
Histidine, canavanine, glutamic acid, aspartic acid, serine, alanine, glycine, leucine, isoleucine, proline, threonine, valine, methionine, cystine, cysteine, hydroxyproline, phenylalanine, tyrosine, hydroxylysine, trimethylglycine, sodium aspartate, aspartic acid Potassium, magnesium aspartate, calcium aspartate, sodium glutamate, potassium glutamate, magnesium glutamate, calcium glutamate, glutamate hydrochloride, cysteine hydrochloride, histidine hydrochloride, histidine acetate, histidine phosphate,
Lysine hydrochloride, lysine acetate, ornithine hydrochloride, ornithine acetate, tryptophan hydrochloride, arginine-glutamate, ornithine-glutamate, lysine
Glutamate, lysine-aspartate, ornithine-aspartate, ε-aminocaproic acid and the like can be mentioned. Of these, arginine, lysine, hydroxylysine, and histidine are preferred, and arginine is particularly preferred.

These amino acids or salts thereof can be used singly or in combination of two or more. It is preferable to add 0.0001 to 15% by weight in the whole composition, and particularly 0.001 to 10% by weight. %, More preferably 0.01 to 8% by weight, because they are more excellent in moisturizing effect, prevention and improvement effect of wrinkle formation, prevention and improvement effect of rough skin, feeling of use and stability.

Among the skin active ingredients of the ingredient (B) used in the present invention, plant extracts include, for example, ashitaba, adzuki bean, asenyaku, avocado, amacha, amachatull, altea, alteca, arnica, almond, aloe, Apricot, nettle, iris, fennel, turmeric,
Ages, ogre, oak, orange, barley,
Okra, Hypericum perforatum, Odorikosou, Ononis, Dutch mustard, oyster, cuckoo, valerian, birch,
Cattail, chamomile, chamomile, oats, liquorice, raspberry, kiwi, kina, cucumbers, kyounin,
Kukui nuts, gardenia, kumazasa, walnuts, cauliflower,
Mulberry, Gunjou, Gentian, Gennoshoko, Lubbish, Ginseng, Burdock, Sesame, Wheat, Comfrey, Rice, Sasanqua, Saffron, Hawthorn, Sansho, Shiitake, Jio, Shikon, Shiso, Shinanoki, Shimotake, Peony, Show Ginger, ginger, ginger, birch, watermelon, horsetail, stevia, vegetative,
Hawthorn, elderberry, albino,
Achillea millefolium, St. John's wort, Sage, Common mallow, Senkyu, Assemblage, Mulberry bark, Soybean, Daisou, Thyme, Cha, Butterfly, Chimney, Evening primrose, Camellia, Camellia, Teuchigurumi, Touki, Tonenkin, Tonin, Spruce, Corn , Tomato, carrot, garlic, wild rose, balsam, mushy winter, parsley, naked stalk, adlay, peppermint, papaya, hamamelis, rose, cypress, sunflower, loquat, coltsfoot, grape, placenta, hazelnut, loofah, safflower, bodaiju, button , Hops, macadamia nuts, pine, matsukasa, marronnier, melissa, melilot, peach, bean sprouts, cornflower, palm, eucalyptus, yukinoshita, lily, yokunin, mugwort, rye, peanut, lavender, apple Litchi, lettuce, lemon, Rengesou, rosemary, funnel, Roman chamomile, ShitoneChin蒿, agrimony, catalpa, dolabrata, Horutosou, cause, date, Senkishi, chickweed, duckweed,
Sagebrush, ginkgo, ginkgo, chrysanthemum, kumazasa,
Examples include extracts obtained from mud sorghum, forsythia, and the like.

These plant extracts are dried or pulverized without drying the whole plant of each plant or one or more portions thereof (hereinafter referred to as the “base material”) such as leaves, bark, roots and branches. After that, it can be obtained by extraction with a solvent at room temperature or under heating, or by using an extraction device such as a Soxhlet extractor. Here, the solvent used is not particularly limited, for example, water; primary alcohols such as methyl alcohol and ethyl alcohol; propylene glycol;
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Liquid fatty acid lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; known solvents such as ethyl ether and acetone; these solvents may be used alone or in combination of two or more. it can. Among them, the extraction solvent is ethyl alcohol,
1,3-butylene glycol is preferred.

As a specific example of a preferred extraction method from the drug substance, 100 g of the dried and pulverized product is added with 1000 ml of 50 v / v% ethanol, and extraction is performed at room temperature for 3 days with occasional stirring. The obtained extract is filtered, the filtrate is left at 5 ° C. for 3 days, and then filtered again to obtain a supernatant. The plant extract obtained under the above conditions may be used as it is as an extracted solution. However, if necessary, a plant extract that has been subjected to treatments such as concentration and filtration can be used.

These plant extracts can be used alone or in combination of two or more. It is preferable to add 0.0001 to 20% by weight in the total composition in terms of dry solid content. 0.0001 to 10% by weight, further 0.000
1-5% by weight, moisturizing effect, prevention of wrinkle formation
It is preferable because it has the effect of improving, preventing and improving rough skin, preventing and improving skin swelling, declining elasticity, dullness of complexion, and preventing and improving spots and freckles, and is excellent in use feeling and stability. .

Among these plant extracts, in particular, chamomile, tea, cucumber, clove, liquorice, loquat, spruce, ginseng, peonies, hawthorn, barley winter, ginger, matsukasa, mulberry bark, balsam, incin Using one or two or more plant extracts selected from the extracts of hako, asenyaku, yellow gon, aloe, altea, spiraea, Dutch mustard, kina, comfrey, rosemary and funnel, synergic whitening The effect is enhanced, and it is possible to effectively prevent and improve spots and freckles, as well as to moisturize and prevent rough skin.
The improvement effect can also be significantly increased.

Among these, the chamomile extract is a chamomile [Matricaria chamomilla]
L. (Compositee)] can be obtained as an extract by extracting the flower with water or a hydrophilic organic solvent such as methanol, ethanol, propanol, propylene glycol, 1,3-butylene glycol or a mixture thereof. The extract can be dried and obtained in the form of a dry powder. Extraction with a hydrophilic organic solvent such as castor oil, persic oil, liquid paraffin, soybean oil, isopropyl myristate, lower fatty acid triglyceride, medium fatty acid triglyceride, sunflower oil, neopentyl glycol dicaprate, squalane, or a mixed solvent thereof. Can be obtained. In the present invention, one of the thus obtained chamomile extract
Species or a combination of two or more can be used.

The extract of chamomile generally contains azulene, camazulene, umbelliferone, 7-methoxycoumarin, matricin, matricalin, taraxasterol, lupeol, apiin, chroman, spiroether and the like. Here, a preferable method for extracting chamomile includes, for example, the following method.

The chamomile flowers are dried and minced. After adding squalane thereto and immersing it from room temperature to 50 ° C. with occasional stirring, the extract is separated by pressing to obtain an extract. This extract is filtered to obtain a chamomile extract.

In the case of using these plant extracts, it is preferable to add 0.00001 to 5% by weight in terms of dry solid content in the whole composition from the viewpoint of whitening effect and stability. 0005-3% by weight, 0.001-2
It is preferable that the compounding by weight is sufficient because a sufficient whitening effect, moisturizing effect, skin roughening prevention / improvement effect can be obtained, and excellent feeling in use and stability can be obtained.

[0067] Among the plant extracts, horsetail, gentian, hamamelis, button, cornflower, catalpa,
When one or two or more selected from extracts of asunaro, orthodox, cypress and pheasant are used, synergistically,
Skin aging prevention effect is enhanced, effectively preventing wrinkle formation
In addition to being able to improve, the moisturizing effect and the effect of preventing and improving rough skin can be significantly enhanced.

When these plant extracts are used, they are converted to dry solids and contained in the total composition in an amount of 0.00001 to 20%.
%, Preferably 0.0001 to 10% by weight.
% By weight, and further 0.0001 to 5% by weight, the effect of preventing and improving sufficient wrinkle formation, skin sticking, weakening of elasticity,
It is preferable because it has effects of preventing and improving dullness of the complexion, moisturizing effect, and preventing and improving rough skin, and is more excellent in use feeling and stability.

Among the component (B) used in the present invention, the whitening agent is not particularly limited as long as it is one used in ordinary cosmetics. Examples thereof include L-ascorbic acid and its derivatives, hydroquinone derivatives, Kojic acid and its derivatives, placental extracts, and the like.

Of these, ascorbic acid and its derivatives are not particularly limited.
L which is a monovalent metal salt of ascorbic acid phosphate
-Ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, divalent metal salt L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt,
L-ascorbic acid phosphate aluminum salt which is a trivalent metal salt, L-ascorbic acid sulfate sodium salt and L-ascorbic acid potassium salt potassium salt which are monovalent metal salts of L-ascorbic acid sulfate L-ascorbic acid sulfate potassium magnesium salt, L-ascorbic acid sulfate calcium salt, trivalent metal salt L-ascorbic acid sulfate aluminum salt, L-ascorbic acid monovalent metal salt L-ascorbic acid -Ascorbic acid sodium salt, L
-Ascorbic acid potassium salt, divalent metal salt L-ascorbate magnesium salt, L-ascorbate calcium salt, trivalent metal salt L-ascorbate aluminum salt and the like can be preferably mentioned.

The hydroquinone derivative is not particularly limited, and examples thereof include a condensate of hydroquinone and a sugar, and a condensate of an alkyl hydroquinone and a sugar obtained by introducing one alkyl group having 1 to 4 carbon atoms into hydroquinone. Among these, preferred are, for example, arbutin and the like.

The kojic acid and its derivatives are not particularly restricted but include, for example, kojic acid, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamo. Preferred examples include monoesters such as acetate and kojic acid monobenzoate, and diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, and kojic acid dioleate.

As the placenta extract, those which are generally marketed as a water-soluble placenta extract and used as cosmetic raw materials can be used. For example, the placenta of mammals such as cows, pigs or humans can be washed, blood removed, After extraction of water-soluble components through steps such as crushing and freezing, those obtained by further removing impurities can be mentioned.

Among these whitening agents, arbutin,
Kojic acid and a water-soluble placenta extract are preferred.

These whitening agents can be used singly or in combination of two or more. From the viewpoint of whitening effect, emulsion stability and feeling of use, 0.01 to 30% by weight is blended in the whole composition. It is preferable to mix 0.01 to 10% by weight, more preferably 0.01 to 5% by weight, because not only a sufficient whitening effect can be obtained, but also the use feeling and the stability are excellent.

Among the skin active ingredients of the component (B) used in the present invention, examples of anti-inflammatory agents include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, isopropylaminocaproic acid and its salts, allantoin, chloride Examples include lysozyme, guaiazulene, methyl salicylate, and γ-oryzanol. Of these, glycyrrhetinic acid, stearyl glycyrrhetinate, and epsilon aminocaproic acid are preferred.

These anti-inflammatory agents can be used alone or in combination of two or more.
% By weight, particularly 0.01 to 2% by weight, more preferably 0.01 to 1% by weight, from which a high effect of preventing and improving wrinkle formation can be obtained, and it is also preferable in terms of usability and stability.

Among the active ingredients of the component (B) used in the present invention, examples of the singlet oxygen scavenger or antioxidant include α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin Carotenoids such as isoseaxanthin, rhodoxanthin, capsanthin, crocetin; 1,4-diazacyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, histidine, tryptophan, methionine, alanine or an alkyl ester thereof; dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, tannic acid,
Examples thereof include tannins such as epicatechin, epicarocatechin, epicatechin gallate, epicarocatechin gallate, and flavonoids such as rutin. Of these, carotene, tocopherol, ascorbic acid, tannic acid,
Epicatechin gallate and epicarocatechin gallate are preferred.

These singlet oxygen scavengers or antioxidants can be used alone or in combination of two or more. It is preferable that the singlet oxygen scavenger or antioxidant be incorporated in the total composition in an amount of 0.001 to 5% by weight, particularly 0.1 to 5% by weight. When added in an amount of from 0.01 to 2% by weight, more preferably from 0.01 to 1% by weight, a high effect of preventing and improving the formation of wrinkles is obtained, and it is preferable in terms of feeling of use and stability.

Of the skin active ingredients of the component (B) used in the present invention, the polysaccharide is preferably an acidic polysaccharide. For example, according to the method described in Japanese Patent Application Laid-Open No. Sho 64-10997, the polysaccharides belong to the genus Polyantes. The callus derived from the plant belonging to it can be cultured and collected from the resulting culture. Plants belonging to the genus Polyantes include tuberose (Polianthes tuberosa).
L. ) Is a preferred example, and as the acidic polysaccharide, it is particularly preferable to use a modified heteropolysaccharide derived from tuberous callus.

As a method for collecting the acidic polysaccharide, for example, in the case of tuberose, it can be performed according to the following tissue culture method. That is, ^10-5 M of auxin and 10 ^-6 M of cytokinin are added as plant hormones to a base medium of Linsamaier-skool as explants of a part of tuberose flowers and the like, and 3% sucrose is further added as a carbon source. After the callus is induced using the added medium, subculture is performed, followed by shaking culture using a liquid medium containing the same components as the above callus culture medium.
Thereafter, the cells are removed from the culture solution by centrifugation or filtration, and the culture solution is concentrated using a rotary evaporator or the like, and the concentrated solution is precipitated by adding a solvent such as ethanol or acetone, and the precipitate is freeze-dried. Thus, the acidic polysaccharide can be separated and obtained.

The acidic polysaccharide thus obtained is preferably incorporated in the entire composition in an amount of 0.0001 to 30% by weight, particularly 0.001 to 20% by weight, and more preferably 0.01 to 15% by weight.
When blended by weight, a high moisturizing effect, an effect of preventing and improving rough skin, and an effect of preventing and improving spots and freckles are obtained, and are also preferable in terms of feeling of use and stability.

Among the skin active ingredients of the component (B) used in the present invention, examples of the water-soluble thickener include acrylic acid polymers and water-soluble polymers. Among these, the acrylic acid-based polymer forms a gel by neutralization with an alkaline agent. Accordingly, the acrylic acid polymer is not particularly limited as long as it forms a gel by neutralizing with an alkali agent, and a polymer generally called a water-soluble alkali thickening polymer is used. Such acrylic acid-based polymers include:
For example, B. F. Goodrich (BFGoodrich Compan
y) Carbopol 90 commercially available from
7, 910, 934, 934-P, 940, 941, 9
54, 980, 981, 1342, ETD2020, E
TD2050, 1382, 2984, 5984, etc .; Pemulen TR-1, TR-2, etc .;
o Hypan commercially available from Chemicals Inc.
m) SA-100H, SR-150H, SS-201,
AQUPEC HV-501, HV-504, HV-5 commercially available from Sumitomo Seika Co., Ltd. such as QT-100
And Sepigel (SEPIGEL) 305, 501 commercially available from Seppic. Inc. Of these, particularly preferred acrylic acid polymers include Carbopol 941, 981, 940, 98
0, 1342, 1382; Pemran TR-1, TR-
2. Sepigel 305.

These acrylic acid-based polymers can be used alone or in combination of two or more. The amount of the acrylic acid-based polymer varies depending on the type of the polymer and may be appropriately determined.
It is preferable to mix 0.1 to 20% by weight in the whole composition,
In particular, it is preferable to add 0.1 to 10% by weight, more preferably 0.15 to 5% by weight, because it is excellent in moisturizing effect, feeling in use and stability.

Examples of the alkaline agent for neutralizing and gelling the acrylic acid polymer include inorganic bases such as sodium hydroxide, potassium hydroxide and ammonium hydroxide and organic acids such as triethanolamine and L-arginine. Salts. These alkaline agents are used in an amount of 0.1 to 3 parts by weight, especially 0.1 to 3 parts by weight, based on 1 part by weight of the acrylic acid polymer.
It is preferable to use 5 to 2 parts by weight.

The water-soluble polymer is not particularly limited as long as it is used in ordinary cosmetics and the like. Examples thereof include guar gum, quince seed, carrageenan, locust bean gum, gum arabic, tragacanth, pectin, mannan, and the like. Starch, sodium alginate, sodium hyaluronate, xanthan gum, pullulan dextran, curdlan, collagen, keratin, casein, albumin, gelatin, chondroitin sulfate, chitin, cationized cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, Hydroxypropyltrimethylammonium chloride ether, carboxymethylcellulose, dextran sulfate, carboxymethyl Emissions, soluble starch, carboxymethyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, sodium polyacrylate, polyvinyl methyl ether, and the like. Among these, xanthan gum, sodium hyaluronate, hydroxyethyl cellulose and the like are particularly preferred.

These water-soluble polymers can be used alone or in combination of two or more.
It is preferable to mix 5.0% by weight, especially 0.05 to
It is preferable to add 3.0% by weight, more preferably 0.05 to 0.3% by weight, because it is excellent in moisturizing effect, feeling in use and stability.

Among the skin active ingredients of the component (B) used in the present invention, examples of the alcohols include higher alcohols and polyhydric alcohols. Examples of the higher alcohol include benzyl alcohol, isocetyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, phenylethyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, and 2-hexyldecanol. And particularly preferred are cetanol and stearyl alcohol.

These higher alcohols can be used alone or in combination of two or more.
-20% by weight, especially 0.05-1% by weight.
Addition of 0% by weight, more preferably 0.1 to 5% by weight, increases the moisturizing effect, the effect of preventing / improving rough skin, and the effect of preventing / improving wrinkle formation, and is more excellent in use feeling and stability.

The polyhydric alcohol is not particularly restricted but includes, for example, polyglycerin such as glycerin, diglycerin, triglycerin and tetraglycerin, ethylene glycol, 1,3-propanediol, glucose, maltose, maltitol and the like. Sucrose, fructose, xylitol, sorbitol, maltotriose,
Examples include threitol, erythritol, amylolytic sugar-reducing alcohol, sorbitol, and polyoxyalkylene alkyl glycosides. Of these, glycerin and 1,3-propanediol are particularly preferred.

These polyhydric alcohols can be used alone or in combination of two or more.
It is preferable that the content is 0.01 to 50% by weight.
When added in an amount of from 30 to 30% by weight, and more preferably from 0.1 to 20% by weight, the moisturizing effect, the effect of preventing and improving rough skin and the effect of preventing and improving wrinkle formation are enhanced, and the feeling and stability are more excellent.

Among the skin active ingredients of the ingredient (B) used in the present invention, sterols include, for example, cholesterol, cholesteryl isostearate, provitamin D ₃ , cambesterol, stegmasteranol, stegmasterol, 5-dihydro Cholesterol, α-
Spinasterol, palisterol, clionasterol, gamma-sitosterol, stegmasterol, salgastellol, apenasterol, ergostanol, sitosterol, corbisterol, chondrilosterol, polyferasterol, haliclonasterol, neosvongosterol, fucosterol , Aptostanol, ergostadienol, ergosterol, 22
-Dihydroergosterol, brassicasterol, 2
4-methylene cholesterol, 5-dihydroergosterol, dehydroergosterol, fungisterol, cholestanol, coprostanol, dimosterol, 7-heterocholesterol, latosterol, 22-
Dehydrocholesterol, β-sitosterol, cholestatrien-3β-ol, coprostanol, cholestanol, ergosterol, 7-dehydrocholesterol, 24-dehydrocholestazan-3β-ol,
Equilenin, equilin, estrone, 17β-estradiol, androst-4-en-3β, 17β-diol, dehydroebiandrosterone, cholesterol alkenyl succinate (Japanese Patent Application Laid-Open No. H5-294989) and the like. Of these, cholesterol, cholesteryl isostearate and cholesteryl alkenyl succinate are particularly preferred.

These sterols can be used alone or in combination of two or more.
５０50% by weight, preferably 0.005 to
When added in an amount of 30% by weight, more preferably 0.01 to 20% by weight, the moisturizing effect, the effect of preventing / improving rough skin, the effect of preventing / improving wrinkle formation are enhanced, and the feeling and stability are more excellent.

[0094] Of the skin active components of component (B) used in the present invention, blood circulation promoters include, for example, cosmetics,
Agents used in quasi-drugs, pharmaceuticals and the like can be used as they are. In particular, as the compound,
-87506, an esterified product of vitamin E which is a vasodilator, nicotinic acid ester or orotic acid ester, and vitamin E which is a peripheral circulation promoting agent described in Japanese Patent Application Laid-Open No. 62-195316. And acetic acid esters or succinic acid esters. In addition, nicotinamide, methyl nicotinate and the like are used.

[0095] Examples of plant extracts having a blood circulation promoting effect include extracts specified in the fragrance journal extra edition No. 6 published in 1986 and the fragrance journal extra edition No. 1 published in 1979, for example. Arnica, hawthorn, kina, salvia, bodaiju, panax ginseng, ginger, mannenrow, hypericum, ginkgo, melissa, ononis, malonier, assembly, garlic, chamomile, saim, mint, nettle,
Pepper, ginger, hops, horse chestnut, lavender, carrot, mustard, kei, pine, senkyu,
Elderberry, yamaseri, hasiridokoro, button, bayberry, dokudami, kohone, shibugaki, tokinsenka,
Plant extracts such as gavidinsou, gentian, grape, Hamabofu, Daidai, Yuzu, Shobu, Natsumikan, Hamamelis, Merryloth, Fennel, Sansho, Peonies, Eucalyptus, Artemisia, Emmeiso, Rice, Clara, Shokyo, Clove, etc. are used. Can be

[0096] These plant extracts are obtained, for example, by extracting leaves, roots, stems, flowers, etc. of these plants with water and / or a hydrophilic organic solvent to obtain an extract; And a method for obtaining a powder by freeze-drying, spray-drying, distillation under reduced pressure and the like. As the hydrophilic organic solvent,
For example, methanol, ethanol and the like can be mentioned, and ethanol is particularly preferable. These solvents may be used alone or in combination of two or more, or may be used by mixing water and these hydrophilic organic solvents. The use amount of these extraction solvents is not particularly limited, and the obtained extract can be used as it is or after further concentration and purification.
Also, commercially available products of these plant extracts can be suitably used.

Among these, the compounds are preferably tocopherol nicotinate, tocopherol acetate, and nicotinamide, and the plant extracts are preferably plant extracts, hypericum extract, ginkgo extract, arnica extract, kina extract, hamamelis extract, and calendula extract. , Marronnier extract, Emperor extract, Salvia extract, Hamabo extract, Sansho extract, rice germ oil, bodaiju extract, ginger tincture, and clove extract are preferred.

These blood circulation enhancers can be used singly or in combination of two or more. Usually, as an active ingredient (in the case of a plant extract, as a dry solid content), 0.001 to 10% %, Preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight. Prevention / improvement effect of skin swelling, decrease in elasticity, dullness of complexion, moisturizing effect, rough skin. In addition to the effects of preventing and improving the effect of preventing and improving wrinkle formation and preventing and improving the effect of preventing wrinkles and freckles, it is preferable because it is superior in use feeling and stability.

Among the skin active ingredients of the component (B) used in the present invention, examples of the sebum secretion inhibitor include “Fragrance Journal No. 10 (1994).
), And commonly used as sebum secretion inhibitors, anti-androgenic agents, crude drug extracts, astringents, and other components.

Specifically, as the anti-androgen,
Examples include oxendrone, 17-α-methyl-β-nortestosterone, chromadinone acetate, cyproterone acetate, spironolactone, hydroxyflutamide, estradiol, ethinylestradiol, and the like.

Examples of crude drug extracts include walnut leaves,
Oregon, sage, hop, rosemary, hypericum, peppermint, chamomile, pheasant bird, yellow ream, yellow bamboo, yellow rye, heavy medicine, Chen skin, carrot, peonies, toshishi, propolis,
Extracts such as taxia, tannin, hamamelis, button, birch tar, royal jelly, and extract of Kobo are mentioned.

Examples of the astringent include zinc sulfocarbonate, zinc oxide, aluminum hydroxychloride and allantoindihydroxyaluminum.
In addition, vitamin B ₆ , 13-cis-retinoic acid, vitamin E, glycyrrhetinic acid, salicylic acid, nicotinic acid, calcium pantothenate, dipotassium azelate, 10-hydroxyundecanoic acid, 12-hydroxystearic acid, etc. are also sebum secretion inhibitors. Can be used.

Of these, estradiol, zinc sulfocarbonate, zinc oxide, royal jelly, 10-hydroxyundecanoic acid and 12-hydroxystearic acid are particularly preferred.

When these sebum secretion inhibitors are blended, 0.01 to 10% by weight, especially 0.1 to 5% by weight in the total composition.
% By weight (in the case of a crude drug extract, as dry solids).

As the skin active ingredient of the component (B), the above-mentioned various ingredients can be used alone or in combination of two or more kinds.
The total amount is 5 to 60% by weight in the total composition, especially 10 to 4%.
It is preferably 0% by weight.

Further, the cosmetic of the present invention may contain various optional components usually used in cosmetics, quasi-drugs, pharmaceuticals, etc., in addition to the above essential components, as long as the effects of the present invention are not impaired. They can be appropriately blended. Such optional components include, for example, purified water, ethanol, surfactants, oily components, silicones, fluorinated oils, UV protection agents, powders, oil gelling agents, film forming agents, softeners, pH adjusters And the like.

Specifically, the surfactant is not particularly limited, and may be a nonionic surfactant, an anionic surfactant,
Any of the amphoteric surfactants and the like can be suitably used. Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, fatty acid monoglyceride, and polyoxyethylene sorbitol fatty acid ester. Oxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil alkyl sulfate, polyoxyethylene castor oil, polyoxyethylene alkyl sulfate, polyglycerin fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, alkyl phosphate ester, polyoxy Examples include ethylene alkyl phosphate, fatty acid alkali metal salts, and alkyl glyceryl ether.

Examples of the anionic surfactant include a linear or branched alkylbenzene sulfonate, a linear or branched alkyl or alkenyl ether sulfate, an alkyl or alkenyl sulfate having an alkyl or alkenyl group, and an olefin. Sulfonate, alkane sulfonate, unsaturated fatty acid salt, alkyl or alkenyl ether carboxylate, α-sulfofatty acid salt or ester having alkyl or alkenyl group, N-acyl having acyl group and free carboxylic acid residue Examples of the surfactant include amino acid surfactants and mono- or diester phosphate surfactants having an alkyl group or an alkenyl group.

Examples of the amphoteric surfactant include an imidazoline-based amphoteric surfactant having an alkyl group, an alkenyl group or an acyl group, a carbobetaine-based, an amidobetaine-based, a sulfobetaine-based, a hydroxysulfobetaine-based or an amidosulfobetaine-based amphoteric surfactant. Surfactants and the like. Further, a polyether-modified silicone,
It is also possible to use a silicone-containing surfactant such as a siloxane derivative described in JP-A-087995, a surfactant having a perfluoroalkyl group, and the like.

When these surfactants are blended,
It is preferable to add 0.01 to 20% by weight, especially 0.1 to 5% by weight in the whole composition.

The oil component is not particularly limited and may be volatile or non-volatile. For example, hydrocarbons such as solid or liquid paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene, etc. Eucalyptus oil, peppermint oil, camellia oil, macadamia nut oil, avocado oil, tallow, lard,
Horse fat, egg yolk, olive oil, carnauba wax, lanolin, jojoba oil; glycerin monostearate,
Glycerin distearate, glycerin monooleate, isopropyl palmitate, isopropyl stearate, butyl stearate, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, myristyl lactate ,
Diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoyl glycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, di-2-ethylhexanoate Neopentyl glycol, octyldodecyl oleate, glycerol triisostearate, di-paramethoxycinnamic acid
Ester oils such as glyceryl mono-2-ethylhexanoate; higher fatty acids such as stearic acid, palmitic acid and oleic acid. When these oily components are blended, 0.001 to 50% by weight, particularly 0.1% by weight in the total composition.
It is preferable to mix 005 to 30% by weight.

The silicones are not particularly limited as long as they are usually compounded in cosmetics. For example, octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methyl In addition to phenylpolysiloxane, methylpolycyclosiloxane such as octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane, trimethylsiloxysilicic acid, alkyl-modified silicone, polyether / alkyl-modified silicone, alkylglyceryl ether-modified silicone, Kaihei 6-72
And modified silicones such as the modified organopolysiloxane described in JP-A-851. When these silicones are blended, it is preferable to blend 0.001 to 50% by weight, particularly 0.005 to 30% by weight in the total composition.

Examples of the fluorinated oil include perfluoropolyether, which is a liquid perfluoro organic compound at normal temperature,
Fluorine-modified silicones are preferred. For example, perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, perfluorononane, perfluoropentane, perfluorodecane, perfluorododecane, fluorine-modified silicone, a compound represented by the general formula (8) )

[0114]

Embedded image

(Wherein R ¹² , R ¹⁴ , R ¹⁵ and R ¹⁶ may be the same or different and each represents a fluorine atom, a perfluoroalkyl group or a perfluoroalkyloxy group, and R ¹³ represents a fluorine atom or a perfluoroalkyloxy group). A ₁ , b ₁ and c ₁ have a molecular weight of 500 to 100,0
Indicates a number equal to or greater than 0 that is 00. Where a ₁ = b ₁ = c
₁ = 0 never occurs. And the like. Here, the perfluoro groups shown in parentheses need not be arranged in this order, and may be random polymerization or block polymerization. As the perfluoropolyether, a liquid having a viscosity of 5 to 5,000 cs (centistokes) is particularly preferable. For example, the following general formula (9)

[0116]

Embedded image

(Wherein d ₁ and e _{1 each} have a molecular weight of 500 to 500)
The number is 10,000, and d ₁ / e ₁ is 0.2 to 2
It is. ) Represented by FOMBLIN HC-04 (average molecular weight 1,500) and HC-25 (3,200)
And the same HC-R (6,600) (produced by Montefloss) and the following general formula (10)

[0118]

Embedded image

(Where f ₁ represents a number of 4 to 500)
Demnum S-20 (weight average molecular weight 25.0
00), S-65 (4,500), S-100
(5,600) and S-200 (8,400)
Commercially available products (such as those manufactured by Daikin Industries, Ltd.) can be used.

Examples of the fluorine-modified silicone include those having at least one of structural units represented by the following general formulas (11) to (14) and a structural unit represented by the following general formula (15). Can be mentioned.

[0121]

Embedded image

[Wherein, Rf and Rf ′ may be the same or different and each is a linear or branched perfluoroalkyl group having 1 to 20 carbon atoms or the following formula: H (CF ₂ ) _g1- (g
₁ shows the omega-H- perfluoroalkyl group represented by an integer of 1~20); R ^17, R ²⁰ and R ^21, which may be identical or different, straight-C20 A chain or branched chain aliphatic hydrocarbon group or an alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms; R ¹⁸ is a hydrogen atom, a linear or branched aliphatic chain having 1 to 20 carbon atoms; hydrocarbon group, alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms, a perfluoroalkyl group or the formula 1 to 20 carbon _{atoms: H (CF 2) g1 -} (g 1 is an integer from 1 to 20 Indicates)
An ω-H-perfluoroalkyl group represented by the formula:
¹⁹ represents a divalent hydrocarbon group having 2 to 6 carbon atoms; X ² and Y ² is a single bond, -CO- or a divalent hydrocarbon group having 1 to 6 carbon atoms; i ₁ is indicates the number of 2 to 16, j ₁ and k ₁ each represents the number of 1 to 16, h ₁ is 20
Indicates the number of 0, w ₁ represents a number of 0~20, v ₁ is 0
Show the number of 200]

In the structural units represented by the general formulas (11) to (15), as the perfluoroalkyl group represented by Rf and Rf ', any of a linear or branched chain can be used. , CF _3- , C ₂ F _5- , C ₄ F
_{9 -, C 6 F 13 -} , C 8 F 17 -, C 10 F 21 -, H (CF 2)
_{2 -, H (CF 2)} 4 -, H (CF 2) 6 -, H (CF 2) 8
—, (C ₃ F ₇ ) C (CF ₃ ) ₂ — and the like. Further, _{g in} H (CF ₂ ) _g − is 6 to 2
An integer of 0 is preferred. Examples of the hydrocarbon group represented by R ¹⁷ , R ²⁰ and R ²¹ include straight-chain groups such as methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, and decyl groups. Branched alkyl group such as isopropyl group, s-butyl group, t-butyl group, neopentyl group, 1-ethylpropyl group and 2-ethylhexyl group; cyclic alkyl group such as cyclopentyl group and cyclohexyl group; phenylnaphthyl And an aromatic hydrocarbon group such as a group. As the divalent hydrocarbon group represented by R ¹⁹ , a linear or branched alkylene group having 2 to 4 carbon atoms is preferable, and an ethylene group and a propylene group are particularly preferable.

As the fluorine-modified silicone having such a structural unit, for example, the following general formula (16)

[0125]

Embedded image

[In the formula, at least one of Z ² and Z ³ represents a structural unit selected from the general formulas (11) to (14), the remainder represents a single bond, and v ₁ , R ²⁰ and R ²¹ represent the same as above. Having the same meaning as described above) or the following general formula (1
7)

[0127]

Embedded image

[Wherein, Z^FourAre represented by the general formulas (11) to (1)
4) represents a structural unit selected from^{twenty two}Is carbon number 1-2
0 linear or branched aliphatic hydrocarbon group or carbon number
Represents 5 to 10 alicyclic or aromatic hydrocarbon groups,
p₁Represents a number from 0 to 200; ₁, R²⁰And R^{twenty one}Is before
The meaning is the same as
Wear.

The structural units represented by the general formulas (11) to (15) and the group in each formula in the fluorine-modified silicone represented by the general formulas (16) and (17) are used to prevent makeup loss and improve usability. In consideration of the following, the following are preferable. Rf and Rf 'each represent a linear or branched perfluoroalkyl group having 6 to 20 carbon atoms or the following formula;
_{(CF 2) q1 - (q} 1 is an integer of 6-20) preferably omega-H- perfluoroalkyl group represented by.
R ¹⁷ , R ²⁰ and R ²¹ may be the same or different, and are preferably a linear or branched aliphatic hydrocarbon group having 1 to 4 carbon atoms. R ¹⁸ is a hydrogen atom, a carbon number of 6 to 2;
A perfluoroalkyl group of 0 or the following formula: H (CF ₂ ) _q1
- ω-H- (q ₁ is an integer of 6-20) represented by
Perfluoroalkyl groups are preferred. R ¹⁹ is preferably a divalent hydrocarbon group having 2 to 4 carbon atoms. X ² and Y
² is preferably a single bond, -CO- or a divalent hydrocarbon group having 1 to 4 carbon atoms, i ₁ is preferably a number of 2 to 10, especially 2 to 5, and j ₁ and k ₁ are each 2 -10, especially 1
And the number h1 is preferably ₁ to 100, particularly 1 to 10
Preferably the number of, w ₁ is 0 to 20, particularly preferably the number of 0 to 5, v ₁ is 0 to 100, in particular the number of 0 preferred. The arrangement of the structural units of the fluorine-modified silicone represented by the general formula (17) may be alternate, block, or random.

Further, as a preferred example of the fluorine-modified silicone, a polymerization degree of from 2 to 200 described in JP-A-5-247214, having structural units represented by the general formulas (12) and (15), is preferable. Of fluorine-modified silicone,
Japanese Unexamined Patent Application Publication No.
No. 184312, a fluorine-modified silicone having a polymerization degree of 2 to 200, a commercially available FSL manufactured by Asahi Glass Co., Ltd.
-300, Shin-Etsu Chemical's X-22-819, X-
22-820, X-22-821, X-22-822 and FL-100, FS-1265 manufactured by Dow Corning Toray Silicone Co., Ltd., and the like.

When these fluorine-based oils are blended, it is preferable to blend them in an amount of from 2 to 98% by weight, especially from 5 to 60% by weight in the whole composition, since the feeling in use becomes good.

The ultraviolet protective agent is not particularly limited, and any of commonly used ultraviolet scattering agents, oil-soluble ultraviolet absorbing agents, and water-soluble ultraviolet absorbing agents can be suitably used. Among these, as the ultraviolet scattering agent, for example, titanium oxide and fine particle titanium oxide (Japanese Patent Application Laid-Open No. 57-67)
681), zinc oxide, fine zinc white (Japanese Patent Laid-Open No. Sho 62-62).
228006), flaky zinc oxide (Japanese Unexamined Patent Publication No.
No. 75921), iron oxide, fine-particle iron oxide, cerium oxide, zirconium oxide and the like. These may be those which have been surface-treated with silicone, metal soap, N-acylglutamic acid, perfluoroalkyl phosphate or the like. Good. Their shape, size and form are not particularly limited, and they may be used in the form of a sol or the like.

As the oil-soluble ultraviolet absorber, benzoic acid-based ones include para-aminobenzoic acid (hereinafter referred to as PA).
BA), glyceryl PABA, ethyl dihydroxypropyl PABA, N-ethoxylate PABA ethyl ester, N-dimethyl PABA ethyl ester, N
-Dimethyl PABA butyl ester, N-dimethyl PA
BA amyl ester, octyl dimethyl PABA and the like;
Anthranilic acid-based homomenthyl-N
-Acetylanthranilate and the like; salicylic acid-based ones, such as amyl salicylate, menthyl salicylate,
Homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc .; cinnamic acid-based octyl cinnamate, ethyl-4-isopropyl cinnamate, Ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-
Methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α -Cyano-β-phenylcinnamate, glycerylmono-2-ethylhexanoyldiparamethoxycinnamate and the like; 2,4-dihydroxybenzophenone as a benzophenone type;
2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone and the like But also: 3- (4'-methylbenzylidene) -dl-camphor, 3-benzylidene-dl-camphor, urocanic acid ethyl ester,
-Phenyl-5-methylbenzoxazole, 2,2'-
Hydroxy-5-methylphenylbenzotriazole,
2- (2'-hydroxy-5-t-octylphenyl)
Benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbonylidene)
-3-pentan-2-one, a benzene bis-1,3-diketone derivative described in JP-A-2-212579,
And benzoylpinacone derivatives described in JP-A-3-220153.

Examples of the water-soluble ultraviolet absorber include diethanolamine p-methoxycinnamate, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, tetrahydroxybenzophenone, methylherperidine, and 3-hydroxy-4-methoxycinnamate Sodium acid, sodium ferulate, urocanic acid and the like, and extracts of animals and plants such as yarrow, aloe, below mallow, burdock, salvia and the like, which have an ultraviolet absorbing effect, are exemplified.

Among these ultraviolet protective agents, zinc oxide, titanium oxide, fine titanium oxide, fine zinc white, flaky zinc oxide, fine iron oxide, octyldimethyl PAB
A, 2-ethylhexyl-p-methoxycinnamate,
4-methoxy-4'-t-butyldibenzoylmethane,
1- (3,4-Dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione is preferred.

When these ultraviolet protective agents are blended, 0.1 to 40% by weight, especially 0.1 to 30% by weight in the total composition.
%, More preferably 1 to 20%.

Examples of the powder include extenders such as mica, talc, sericite, kaolin, nylon powder and polymethylsilsesquioxane; inorganic pigments such as pearl;
Organic pigments such as Red No. 202, Red No. 226, Yellow No. 4, and aluminum lake are exemplified. These powders are subjected to a surface treatment such as a silicon treatment, a metal soap treatment, an amino acid treatment, a fatty acid treatment, an alkyl phosphate ester treatment, an N-acylglutamic acid treatment, a fluorine treatment by a perfluoroalkyl phosphate ester treatment, or the like. May be used.

When these powders are blended, they are preferably blended in an amount of 0.001 to 50% by weight, especially 0.005 to 30% by weight in the whole composition.

Examples of the oil gelling agent include dextrin fatty acid esters such as dextrin palmitate and dextrin stearate. When these oil gelling agents are blended, 0.001 to 20
% By weight, particularly preferably 0.01 to 5% by weight.

Examples of the softener include, but are not particularly limited to, α-hydroxy-isobutyric acid, α-hydroxy-isocaproic acid, α-hydroxy-n-caproic acid, α-hydroxy-isocaprylic acid, and α-hydroxy-isocaprylic acid. Hydroxy-n-caprylic acid, α-hydroxy-n-capric acid,
Α-hydroxy acids such as lactic acid, α-hydroxystearic acid, citric acid, and glycolic acid; and amines such as ε-aminocaproic acid, urea, and 2-hydroxyguanidine-2- (2-hydroxyethoxy) ethylguanidine;
JP-A-62-99315 and JP-A-2-17820.
No. 7 peptides, JP-A-6-29
No. 3625, for example, trimethylglycine and the like. When these softeners are blended, 0.05 to 10% by weight, especially 0.2 to 5% by weight in the total composition
It is preferable to mix them.

Examples of the pH adjuster include metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, and the like.
Organic acids such as diisopropanolamine, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogenphosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid, etc .; betaines such as glycine betaine and lysine betaine; No. The cosmetic of the present invention can be prepared by using these pH adjusters and the like to adjust the pH to 2 to 11, particularly to the pH of 3.
It is preferable to set the region to 10 to 10.

Further, other components include, for example, inorganic salts such as magnesium sulfate, potassium sulfate, sodium sulfate, magnesium chloride and sodium chloride; preservatives such as paraben, dehydroacetic acid and its salts; edetic acid and its salts; Sequestering agents such as acids and salts thereof; 6-
Hydroxyhexanoic acid, 8-hydroxyundecanoic acid,
Hydroxy acids such as 9-hydroxyundecanoic acid, 10-hydroxyundecanoic acid and ethyl 11-hydroxyundecanoate and salts thereof; pigments, medicinal ingredients, fragrances and the like.

The cosmetic of the present invention can be produced according to a conventional method. Further, the cosmetic of the present invention is not limited to general skin cosmetics, but encompasses quasi-drugs, topical medicines, etc., and the dosage form may be arbitrarily selected according to the purpose. Cream, ointment, emulsion, lotion, solution, gel, pack, powder, stick, etc.

The cosmetics of the present invention may be in various forms, for example, water / oil type emulsified cosmetics, oil / water type emulsified cosmetics, creams, cosmetic emulsions, lotions, oily cosmetics, packs, lipsticks,
It can be used as a cosmetic such as a foundation, a skin cleanser, a hair tonic, a hair styling agent, a hair restorer, a hair restorer and the like.

[0145]

The cosmetic composition of the present invention has a synergistic moisturizing effect and a preventive / improving effect of rough skin by using the phosphoric acid triester of the component (A) in combination with the skin active component of the component (B). , Prevention of skin swelling, loss of elasticity, dullness of complexion, etc.
Improvement effect, prevention and improvement effect of excess sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention and improvement effect of wrinkle formation, and prevention and improvement effect of spots and freckles are enhanced. It has excellent stability.

[0146]

EXAMPLES The present invention will be described below in more detail with reference to examples, but the present invention is not limited to these examples. still,
Unless otherwise specified,% in the examples is based on weight, and the amount of the plant extract is represented by a value converted into a dry solid content.

Example 1 Cosmetics having the compositions shown in Tables 1 to 6 were produced by a conventional method.
Using the obtained cosmetic, moisturizing effect on the skin when using it, preventing / improving skin roughness, preventing / improving effects such as weakness of skin, weakening of elasticity, dullness of complexion, excess sebum, bacteria and keratinization Prevention of pores and acne caused by abnormalities
The improvement effect, the prevention and improvement effect of wrinkle formation, the prevention and improvement effect of spots and freckles, and the feeling of use were evaluated. Table 1 shows the results.
It is shown in Table 6. In addition, the compounding quantity of the plant extract was shown by the value as dry solid content.

(Evaluation Method) The moisturizing effect of the skin, the effect of preventing and improving the roughness of the skin,
Prevention / improvement effect of decreased elasticity / dullness of complexion, prevention / improvement effect of excessive sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement effect of wrinkle formation, prevention of spots and freckles・ Improvement effect and usability: Professional panelists 20
The names were used for each of the cosmetics for two months, and the sensory evaluation was performed according to the following criteria. ◎: Out of 20 persons, 16 or more persons were judged to be good. ：: Out of the 20 persons, 11 to 15 persons were judged to be good. Δ: Out of the 20 persons, 6 to 10 persons were judged to be good. ×: Out of 20 persons, 5 or less persons were judged to be good.

[0149]

[Table 1]

[0150]

[Table 2]

[0151]

[Table 3]

[0152]

[Table 4]

[0153]

[Table 5]

[0154]

[Table 6]

1) In the general formula (2), R ⁴ = C ₁₅ H
₃₁ , R ⁵ ＣＨCH ₃ (CH ₂ ) ₁₆ ＣＨCH 2) In the general formula (3), R ⁶ ＣC ₁₆ H ₃₃ , R ⁷ ＣC
₁₅ H ₃₁ , a = b = d = 0, c = 1 3) In the general formula (4), R ⁸ = C ₁₆ H ₃₃ , R ⁹ = C
₁₃ H ₂₇ , R ¹⁰ = C ₃ H ₆ , R ¹¹ = OCH ₃ 4) Hamamelis Liquid (Ichimaru Falcos) 5) Falco Rex Buttonpi E (Ichimaru Falcos) 6) Asnaro Extract (Ichimaru Falcos) 7) Extract of chamomile (manufactured by Maruzen Pharmaceutical Co., Ltd.) 8) Green tea liquid (manufactured by Ichimaru Falcos Co., Ltd.) 9) Acidic heteropoly derived from callus of tuberose produced according to Example 1 of JP-A-64-10997 Sugars 10) Maronier extract BG (Maruzen Pharmaceutical)

As is clear from the results shown in Tables 1 to 6, all of the cosmetics of the present invention have a moisturizing effect, a preventive / improving effect of rough skin, and a better skin elasticity and elasticity than conventional cosmetics. Prevention / improvement effect of deterioration / dullness, dullness, etc., prevention / improvement effect of excess sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement effect of wrinkle formation and prevention / improvement of spots and freckles The effect was synergistically enhanced, and good results were also obtained in the feeling of use.

Example 2 An emulsion having the following composition was produced according to a conventional method. The obtained emulsion has a moisturizing effect, a preventive and ameliorating effect on rough skin, a preventive and ameliorating effect on skin swelling, loss of elasticity, dullness of complexion, excess sebum,
Prevention / improvement effect of conspicuous pores and acne caused by bacteria and abnormal keratinization, prevention / improvement effect of wrinkle formation, and prevention / improvement effect of spots and freckles are synergistically enhanced, and furthermore, good feeling in use. The results are shown.

[0158]

[Table 7] (Components) (% by weight) Tris (butoxyethyl) phosphate 5.0 Cetanol 1.0 Squalane 2.0 Ceramide-like structural substance ²⁾ 3.0 Hamamelis extract (Hamamelis liquid: manufactured by Ichimaru Falcos) 0.5 Acrylic acid polymer (Pemran TR-2: manufactured by BF Goodrich) 0.1 Acrylic acid polymer (Carbopol 981: manufactured by BF Goodrich) 0.1 Xanthan gum 0.1 Sodium hyaluronate 0.1 Arbutin 2.0 Rosemary extract (Phyterene EG-009 (BG): manufactured by Ichimaru Falcos) 0.5 Polyoxyethylene (40) hydrogenated castor oil 1.0 Acidic heteropolysaccharide ⁹⁾ 0 .1 ethanol 5.0 glycerin 2.0 nicotinic acid-dl-α-tocopherol 2.0 estradiol 0.5 succinic acid 0.1 L -Arginine 0.2 Perfume 0.1 Purified water Balance

Example 3 A cream having the following composition was produced according to a conventional method. The resulting cream has a moisturizing effect, a preventive / improving effect on rough skin, a preventive / improving effect on skin swelling / elasticity, dullness of complexion, excess sebum, conspicuous pores due to bacteria and abnormal keratinization, etc. And synergistic effects of preventing and improving wrinkle formation and preventing and improving wrinkles and freckles, and also showed good results in use feeling.

[0160]

(Ingredient) (% by weight) Tris (butoxyethoxyethyl) phosphate 5.0 Stearic acid 0.6 Cetanol 0.4 Cholesterol 1.0 Squalane 4.0 Ceramide-like structural substance ³⁾ 1.0 Asnaro extraction Product (Asnalo extract: Ichimaru Falcos) 0.5 Acrylic acid polymer (Pemran TR-1: BF Goodrich) 0.2 Acrylic acid polymer (Carbopol 980: BF Good) Rich Co., Ltd.) 0.2 Xanthan gum 0.1 Sodium hyaluronate 0.1 L-ascorbic acid magnesium phosphate 2.0 Polyoxyethylene (60) hydrogenated castor oil 1.0 Acidic heteropolysaccharide ⁹⁾ 0.1 Acetic acid -Dl-α-tocopherol 2.0 sulfonite zinc carbonate 0.5 salicylic acid 0.1 ethanol 5.0 glycerin .0 L-Arginine 0.4 Perfume 0.1 Purified water balance

Example 4 A pack having the following composition was produced according to a conventional method. The resulting pack has a moisturizing effect, a preventive and ameliorating effect on rough skin, a preventive and ameliorating effect on skin swelling, reduced elasticity, dullness of complexion, excess sebum, conspicuous pores due to bacteria and abnormal keratinization, and acne. And the effects of preventing and improving wrinkles and the effect of preventing and improving spots and freckles were also synergistically improved.

[0162]

Table 9 (Components) (% by weight) Tris (butoxyethoxyethoxyethyl) phosphate 5.0 Dipropylene glycol 3.0 Ceramide ¹⁾ 1.0 Polyethylene glycol 3.0 1,3-butylene glycol 1.0 Acrylic Acid-based polymer (Sepigel 305; manufactured by Sepic) 3.0 Polyvinyl alcohol 12.0 Lactic acid 0.5 Aloe extract (Aloe extract: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.1 Beef placenta extract (Biofalco CP-12: Ichimaru) Falcos) 1.0 Artear extract (Falco Rex Artair: Ichimaru Falcos) 0.2 Polyoxyethylene (40) hydrogenated castor oil 1.0 Acidic heteropolysaccharide ⁹⁾ 0.1 Sodium citrate 1.0 Glycerin 0.5 Hypericum extract (Hypericum extract: Maruzen Pharmaceutical Co., Ltd.) 0.5 Royal jelly 0.5 Salici Acid 0.1 L-arginine 0.2 Ethanol 5.0 Perfume 0.1 Purified water balance

Example 5 An essence having the following composition was produced according to a conventional method. The resulting essence has a moisturizing effect, a preventive and ameliorating effect on rough skin, a preventive and ameliorating effect on skin swelling, reduced elasticity, dullness of complexion, excess sebum, conspicuous pores and acne caused by bacteria and abnormal keratinization, etc. And synergistic effects of preventing and improving wrinkle formation and preventing and improving wrinkles and freckles, and also showed good results in use feeling.

[0164]

[Table 10] (Components) (% by weight) Tris (ethoxyethoxyethyl) phosphate 10.0 Horsetail extract (Sugar extract BG: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Acrylic acid polymer (Pemran TR-2: B) 0.2 Acrylic acid polymer (Carbopol 981: BF Goodrich) 0.2 Xanthan gum 0.1 Sodium hyaluronate 0.1 Arbutin 2.0 Citric acid 0. 2 Sodium citrate 1.0 Acidic heteropolysaccharide ⁹⁾ 0.1 Ginkgo extract (Ginkgo biloba extract BG: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 10-Hydroxyundecanoic acid 0.5 Ethanol 5.0 1,3- Butylene glycol 2.0 L-arginine 0.4 Perfume 0.1 Purified water Balance

Example 6 A lotion having the following composition was produced according to a conventional method. The obtained lotion has a moisturizing effect, a preventive / improving effect on rough skin, a preventive / improving effect on skin swelling / elasticity / dullness of complexion, excessive sebum, conspicuous pores due to bacteria and abnormal keratinization, etc. And synergistic effects of preventing and improving wrinkle formation and preventing and improving wrinkles and freckles, and also showed good results in use feeling.

[0166]

Table 11 (Ingredients) (% by weight) Tris (ethoxyethoxyethoxyethyl) phosphate 10.0 Hamamelis extract ⁴⁾ 0.5 Sodium hyaluronate 0.1 Beef placenta extract (Biofalco CP-12: Ichimaru Falcos) 1.0 Althea extract (Falco Rex Artair: Ichimaru Falcos) 0.2 Polyoxyethylene (60) hydrogenated castor oil 1.0 Acidic heteropolysaccharide ⁹⁾ 0.1 Sodium citrate 1.0 Ethanol 5 0.0 glycerin 0.5 assembly extract (assembly extraction liquid: manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 12-hydroxystearic acid 0.5 isopropylmethylphenol 0.1 L-arginine 0.2 potassium hydroxide 0.2 perfume 0 .1 Purified water balance

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 K X W Y U

Claims (14)

[Claims] 1. The following components (A) and (B): (A) General formula (1) [Wherein, R ¹ , R ² and R ³ are the same or different and each represent a linear or branched alkyl group having 1 to 4 carbon atoms, and X, Y and Z are the same or different and each have 2 or 3 carbon atoms. And l, m and n are the same or different and represent 1 to 10 numbers. ] A phosphoric acid triester represented by the formula: (B) a skin active ingredient. 2. The phosphoric acid triester of the component (A) is a compound represented by the general formula (1), wherein R ¹ , R ² and R ³ are each an alkyl group having 2 to 4 carbon atoms, and X, Y and Z are The cosmetic according to claim 1, wherein the cosmetic is an ethylene group, and each of l, m and n is a number of 1 to 4. 3. Component (B) is a ceramide, a ceramide-like structural substance, an amino acid, a plant extract, a whitening agent, an anti-inflammatory agent, a singlet oxygen scavenger, an antioxidant, a polysaccharide, and a water-soluble thickener. 1 selected from the group consisting of agents, alcohols, sterols, blood circulation promoters, sebum secretion inhibitors, antibacterial agents and deflocculants
The cosmetic according to claim 1, wherein the cosmetic is a kind or two or more kinds. 4. Component (B) is represented by the following general formula (2):
(7) [Wherein, R ⁴ and R ⁵ are the same or different and each have 8 to
26 straight-chain or branched-chain saturated or unsaturated hydrocarbon groups.] [In the formula, R ⁶ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁷ represents 9 to 2 carbon atoms.
5 represents a linear or branched saturated or unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, and a represents 0
Or 1 represents a number, c represents an integer of 0 to 4, b and d
Represents an integer of 0 to 3]. Wherein R ⁸ and R ⁹ are the same or different and have 1 to 1 carbon atoms.
A linear or branched saturated or unsaturated hydrocarbon group which may be hydroxylated, and R ¹⁰ has 1 carbon atom
And R ¹¹ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. However, when R ¹⁰ is a single bond, R ¹¹ is a hydrogen atom. [Chemical formula 5] [Wherein, R ^8a represents a hydrocarbon group which may be hydroxylated having 4 to 40 carbon atoms, R ^10a represents a linear or branched alkylene group having 3 to 6 carbon atoms, and R ^11a represents a carbon atom. It represents a straight-chain or branched-chain alkoxy group of the formulas 1 to 12. [Formula 6] Wherein R ⁸ , R ⁹ , R ^10a and R ^11a have the same meaning as described above. [Formula 7] [Wherein, R ⁸ , R ⁹ and R ¹⁰ have the same meanings as described above;
R ^11b represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-epoxypropyloxy group. However, when R ¹⁰ is a single bond, R ^11b is a hydrogen atom. The cosmetic according to any one of claims 1 to 3, wherein the cosmetic is at least one selected from the group consisting of ceramides and ceramide-like substances. 5. The component (B) is one or more selected from the group consisting of amino acids and salts thereof.
4. The cosmetic according to any one of items 3 to 5. 6. The component (B) is at least one member selected from the group consisting of L-ascorbic acid and its derivatives, hydroquinone derivatives, kojic acid and its derivatives, and placental extracts. The cosmetic according to any one of the preceding claims. 7. The cosmetic according to claim 1, wherein the component (B) is one or more selected from plant extracts. 8. The plant extract may include chamomile, cha, cucumber, butterflies, liquorice, loquat, spruce, ginseng, peonies, hawthorn, mushy winter, ginger, matsukasa, mulberry bark, magnolia, innchiko, The cosmetic according to claim 3 or 7, wherein the cosmetic is one or more selected from the group consisting of extracts of Asenyaku, Ougon, Aloe, Altea, Spiraea, Dutch mustard, kina, comfrey, rosemary and funnel. 9. The plant extract according to claim 3, wherein the plant extract is one or more selected from the group consisting of horsetail, gentian, hamamelis, button, cornflower, catalpa, asunaro, holtsou, cypress, and pheasant.
The cosmetic described. 10. The component according to claim 1, wherein the component (B) is one or more selected from the group consisting of carotene, tocopherol, ascorbic acid, tannic acid, epicatechin gallate and epicarocatechin gallate. Or 1
Cosmetics described in the item. 11. The ingredient (B) comprising: tocopherol nicotinate, nicotinamide, tocopherol acetate, assembly extract, hypericum extract, ginkgo extract, arnica extract, kina extract, hamamelis extract, calendula extract, malonie extract, emmeiso extract,
One or two selected from the group consisting of Salvia extract, Hamabou extract, Sansho extract, rice germ oil, Bodaiju extract, Ginger tincture and Clove extract
The cosmetic according to any one of claims 1 to 3, which is at least one kind. 12. The cosmetic according to claim 1, wherein the component (B) is one or more selected from the group consisting of an antiandrogen, a crude drug extract, a hydroxy fatty acid and an astringent. Fees. 13. The composition according to claim 1, wherein the component (B) is selected from the group consisting of antibacterial agents.
Or the cosmetics of any one of Claims 1-3 which are two or more types. 14. Component (B) is selected from the group consisting of deflocculants.
The cosmetic according to any one of claims 1 to 3, wherein the cosmetic is a kind or two or more kinds.