JPH1160436A - Cosmetic for improving chapped skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare the subject cosmetic capable improving chapped skin, especially horny formed into a roughened state and rustling state, arranging the texture, achieving a smooth skin, and excellent in safety or the like by including L-alanine, D-alanine or DL-alanine. SOLUTION: This cosmetic contains (A) 1.0-20.0 wt.%, preferably 1.0-10.0 wt.% L-alanine, D-alanine or DL-alanine as an active ingredient, and, if necessary, (B) a powdery component, an oil and fat, a wax, a hydrocarbon, a higher fatty acid, a higher alcohol, esters, a silicone, a surfactant, a moisturizing agent, a water-soluble high molecular compound, a thicknener, a film-forming agent, an ultraviolet absorber, a metal ion-blocking agent, a lower alcohol, a polyhydric alcohol, saccharides, amino acids, organic amines, a synthetic resin emulsion, a pH-adjusting agent, a skin nourishment agent, vitamins, an (assistant) antioxidant, a perfume, water or the like. The formulation may be either one of a solution system, a solubilization system, an emulsion system, an oil liquid system, a gel system, a powder-dispersion system, a water-oil two layer system, water- oil-powder three layer system and the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic for improving skin roughness which has an excellent effect of preventing or improving skin roughness.

[0002]

2. Description of the Related Art Rough skin is caused by external factors such as drying, ultraviolet rays, irritants such as detergents and chemicals, and internal factors such as hormonal imbalance. Reduced barrier function, reduced horny layer water content,
It is accompanied by phenomena such as enhanced epidermal turnover and coarsening of the keratin due to the generation (scaling) of scale. In particular, roughening of the keratin may worsen the makeup paste, which is a cosmetic problem for many women.

Conventionally, for the purpose of improving skin roughness, a method of supplementing the stratum corneum barrier function with an occlusive agent such as petrolatum ointment or a water-in-oil emulsion, a method of supplementing the moisture content of the stratum corneum with a humectant such as sorbitol or glycerin, How to relieve skin inflammation with anti-inflammatory drugs such as glycyrrhetinic acid, vitamins,
A method of activating skin cells by hormones or the like has been used.

[0004]

However, none of the above-mentioned methods known in the prior art has a sufficient skin moisture retention ability, which has a small keratin-reducing effect. It has the drawback of giving it an unpleasant feel, such as being sticky.On the other hand, when a moisturizer is used, it must be blended in a large amount in order to enhance the effect, and as a result, it becomes sticky, slimy, etc. Had the problem of giving an unpleasant feel. Furthermore, when extracts of animal tissues such as the placenta, vitamins, hormones, and the like are used, there are problems in safety related to side effects and the like and stability related to aging. In particular, regarding the roughening of keratin, the situation that exfoliation of keratin was not performed smoothly was being elucidated, but there was no appropriate countermeasure.

The present invention has been made in view of the circumstances of the prior art, and has been proposed to improve rough skin, in particular, roughening and roughening of keratin, improve texture, and realize smooth skin.
Another object of the present invention is to provide a cosmetic for improving skin roughness which is excellent in safety, stability and feel.

[0006]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventor promoted alanine to smoothly exfoliate scales, which are a cause of coarsening of keratin, and to provide an excellent effect of improving rough skin. Have been found, and based on this, the present invention has been completed.

[0007] That is, the present invention is a cosmetic for improving skin roughness characterized by containing L-alanine, D-alanine or DL-alanine as an active ingredient.

Alanine used as an active ingredient in the present invention may be any of L-alanine, D-alanine or DL-alanine (racemic).

In the cosmetic for improving skin roughness according to the present invention, the above compound is present in an amount of 1.0 to 20.0% by weight depending on the physical properties of the compound.
It is preferable to prepare so that If the content is less than 1.0% by weight, the effect of the present invention may not be sufficiently obtained,
If it exceeds 0.0% by weight, it is not preferable in terms of formulation or cost. Moreover, it is preferably 1.0 to 10.0% by weight.

The cosmetic for improving skin roughness according to the present invention includes, in addition to the above essential components, other components usually used in cosmetics, such as powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, Fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants,
Amphoteric surfactants, nonionic surfactants, humectants, water-soluble polymer compounds, thickeners, coating agents, ultraviolet absorbers, sequestering agents, lower alcohols, polyhydric alcohols, sugars,
Amino acids, organic amines, synthetic resin emulsion, p
An H adjuster, a skin nutrient, a vitamin, an antioxidant, an antioxidant aid, a fragrance, water and the like can be appropriately compounded as needed. Hereinafter, specific examples of components that can be blended are listed. The cosmetic for improving skin roughness of the present invention can be produced by a conventional method by blending any one or more of these components with the above essential components. it can.

The powder components include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, mica, biotite, lithia mica, vermiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcium gypsum), calcium phosphate, Fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powders, organic resin powders such as copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, and inorganic white such as titanium dioxide and zinc oxide Fee, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, inorganic yellow pigments such as yellow iron oxide and loess, and inorganic black pigments such as black iron oxide, carbon black and lower titanium oxide , Inorganic violet pigments such as chromium oxide, chromium hydroxide, cobalt titanate, etc., inorganic blue pigments such as ultramarine blue, navy blue, etc., titanium oxide coated mica, titanium oxide coated oxychloride Bismuth, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red 220
No., Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401
No. 3, organic pigments such as Blue No. 404, Red No. 3, Red No. 10
No. 4, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4,
Organic pigments such as zirconium, barium or aluminum lakes such as Yellow No. 5, Yellow 202, Yellow 203, Green No. 3, and Blue No. 1, and natural pigments such as chlorophyll and β-carotene. However, the powder may be any powder that can be applied to general cosmetics, and is not limited to the above components.

Examples of liquid fats and oils include avocado oil,
Camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Glycerin trioctanoate, glycerin triisopalmitate and the like can be mentioned.

Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef tallow, mokuro kernel oil, hardened kernel oil Oil, beef tallow, mokuro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin,
Sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, hydrogenated lanolin alcohol ether of POE and the like. Can be

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid. Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

Examples of the higher alcohol include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol. And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol and octyldodecanol.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl octanoate, Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neodicaprate Pentyl glycol, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylol tri-2-ethylhexylate Bread, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristate Glycerin, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2-
Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of silicones include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane. Examples include a cyclic polysiloxane, a silicone resin forming a three-dimensional network structure, and silicone rubber.

Examples of the anionic surfactant include soap base materials, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and lauryl sulfate K,
Alkyl ether sulfates such as POE lauryl sulfate triethanolamine and POE sodium lauryl sulfate; N-acyl sarcosine acids such as sodium lauroyl sarcosine; N-myristoyl-N-methyltaurine sodium; coconut oil fatty acid methyltauride sodium;
Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride; phosphate salts such as POE oleyl ether sodium phosphate and POE stearyl ether phosphoric acid; sodium di-2-ethylhexyl sulfosuccinate; monolauroyl monoethanolamide polyoxyethylene Sulfosuccinates such as sodium sulfosuccinate and sodium lauryl polypropylene glycol sodium sulfosuccinate; alkylbenzene sulfonates such as sodium linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonate triethanolamine and linear dodecylbenzenesulfonate; monosodium N-lauroylglutamate , N-stearoyl disodium glutamate, N-myristoyl-L-monosodium glutamate Acyl glutamate, higher fatty acid ester sulfate such as hydrogenated coconut oil fatty acid glycerin sodium sulfate, sulfated oil such as funnel oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher grade Fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate,
Sodium lauroyl monoethanolamidosuccinate,
N-palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium chloride, and poly (N, N'-dimethyl-3, Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imitazolinium hydroxide-1-carboxy. Imidazoline amphoteric surfactants such as ethyloxy disodium salt, 2-heptadecyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetate betaine, alkyl betaine,
Betaine surfactants such as amidobetaine and sulfobetaine are exemplified.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as diglycerol sorbitan penta-2-ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate, glycerin mono-cottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as α'-oleic acid glyceryl pyroglutamate and glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and POE-sorbitan. Sorbit Monolaurate, POE-Sorbit Monooleate, POE
POE sorbitol fatty acid esters such as sorbit pentaoleate, POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin triisostearate; POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, and POE octyl. POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, and POE dinonyl phenyl ether; pluronic type such as pluronic;
POE / POP alkyl ethers such as POP cetyl ether, POE / POP2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate, P
POE castor oil triisostearate, POE hardened castor oil monopyroglutamic acid monoisostearate diester, POE hardened castor oil Maleic acid, etc. POE castor oil hardened castor oil derivative, POE bee wax lanolin derivative such as POE sorbitol beeswax, coconut oil Alkanolamides such as fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide,
POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate,
Examples thereof include alkylethoxydimethylamine oxide and trioleyl phosphoric acid.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-
Butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, carolinic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen , Diglycerin (EO) PO adduct, Izayobara extract, Achillea millefolium extract, melilot extract and the like.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymer (Carbopol);
Polyoxyethylene polymers such as 000, 4,000 and 6,000, copolymer polymers such as polyoxyethylene polyoxypropylene copolymer, acrylic polymers such as sodium polyacrylate, polyethyl acrylate and polyacrylamide, polyethylene Examples include imines and cationic polymers.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (Vegum), laponite, hectorite, silicic anhydride and the like.

As the thickener, for example, gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N- Dimethyl PABA methyl ester, N,
Benzoic acid-based UV absorbers such as N-dimethyl PABA ethyl ester and N, N-dimethylbutyl ester, anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, Salicylic acid type ultraviolet absorbers such as octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-
Diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl- p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate,
Cinnamic acid ultraviolet absorbers such as 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate,
2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone,
2,2′4,4′-tetrahydroxybenzophenone,
2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5
Benzophenone-based ultraviolet rays such as sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone; Absorbent, 3-
(4′-methylbenzylidene) -d, l-camphor;
3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-
Methylbenzoxazole, 2,2'-hydroxy-5
Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzarazin, dianisylmethane, 4-methoxy- 4'-t-butyldibenzoylmethane, 5- (3,3'dimethyl-2-norbornylidene) -3-pentan-2-one, etc. These ultraviolet absorbers and various plant extracts having an ultraviolet absorption action are exemplified. By adding various UV-absorbing substances such as substances, it is possible to obtain a cosmetic for improving rough skin having an effect of preventing and preventing sunburn.

Examples of the sequestering agent include 1-hydroxyethane-1,1 diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and edetate tetraacid. Examples include sodium, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and the like.

The lower alcohol includes, for example, methanol, ethanol, propanol, isopropanol,
Isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-
Butylene glycol, pentamethylene glycol, 2-
Dihydric alcohols such as butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol; and tetrahydric alcohols such as pentaerythritol Pentahydric alcohols such as xylitol, sorbitol, hexahydric alcohols such as mannitol,
Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, Ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, D Dihydric alcohol alkyl ethers such as lenglycol dibutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene Glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether Dihydric alcohol alkyl ethers such as dipropylene glycol butyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, Dihydric alcohol ethers such as diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc. Glycerin monoalkyl ethers such as ter, xyl alcohol, serachyl alcohol, and batyl alcohol, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitolose,
Sugar alcohols such as starch-decomposed sugar-reducing alcohol, glysolid, tetrahydrofurfuryl alcohol, PO
E Tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphoric acid, POP
POE pentane erythritol ether and the like.

The monosaccharides include, for example, tricarbonates such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbons such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose, D-xylose, Pentoses such as L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, D-glucose, D-talose, D-
Bucose, D-galactose, D-fructose, L
-Hexoses such as galactose, L-mannose, D-tagatose, heptose such as aldoheptose and hebutulose;
Octanose such as octulose, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-
Deoxy sugars such as L-mannose, D-glucosamine, D
-Amino sugars such as galactosamine, sialic acid, aminouronic acid and muramic acid, and uronic acids such as D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid and L-iduronic acid.

Examples of the oligosaccharide include sucrose, guntianose, umbelliferose, lactose, planteose, isorikunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bean gum, succinoglucan, caronic acid and the like.

Examples of the amino acids include neutral amino acids such as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tryptophan, cystine, cysteine, methionine, proline and hydroxyproline, aspartic acid, glutamic acid, asparagine and glutamine. Examples include acidic amino acids and basic amino acids such as arginine, histidine, lysine, hydroxylysine and the like. Examples of amino acid derivatives include acyl sarcosine sodium (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

As the organic amine, for example, monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1 -Propanol and the like.

As the synthetic resin emulsion, for example,
An acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and the like are included.

Examples of the pH adjuster include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

The vitamins include, for example, vitamins A, B1, B2, B6, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

The formulation of the cosmetic for improving skin roughness of the present invention is arbitrary, and may be any of a solution type, a solubilizing type, an emulsifying type, an oil-liquid type, a gel type,
One or more of the above optional components, such as a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, etc., and the essential components of the present invention are blended with the essential components of the present invention, and the desired product is produced in a conventional manner A wide range of dosage forms can be used depending on the drug.

[0046]

Next, the present invention will be described in more detail with reference to examples. The present invention is not limited by these. The compounding amount is% by weight.

Example 1 Ethanol 5.0% by weight Carboxyvinyl polymer 0.3 POE (15) oleyl ether 0.8 Glycerin 5.0 1,3-butylene glycol 5.0 DL-alanine 5.0 Methyl paraben 0.1 Purified water residue

Example 2 Ethanol 5.0% by weight Carboxyvinyl polymer 0.3 POE (15) oleyl ether 0.8 Glycerin 5.0 1,3-butylene glycol 5.0 DL-alanine 1.0 Methyl paraben 0.1 Purified water residue

Comparative Example 1 Ethanol 5.0% by weight Carboxyvinyl polymer 0.3 POE (15) oleyl ether 0.8 Glycerin 5.0 1,3-butylene glycol 5.0 Methyl paraben 0.1 Purified water Residue

(1) Skin roughness improvement effect test The skin roughness improvement effect of the above-mentioned Examples 1 and 2 and Comparative Example 1 was carried out as follows.

Improvement of rough skin The subjects were women in their 20s and 50s who suffer from rough skin.
By the name, the lotion of the example or the comparative example was continuously applied to the cheek of the face for two weeks. The effect of improving skin roughness was evaluated by the subject's own report. The evaluation was carried out according to the following evaluation criteria in four steps: significant, effective, somewhat effective, and no effect, and indicated by a ratio (effective rate) indicating significant, effective, or somewhat effective. Table 1 shows the evaluation results. In addition, a replica of the skin surface morphology was collected, observed with a microscope (17 times), and the skin roughness was evaluated according to the criteria shown in Table 2. Table 3 shows the results. <Evaluation Criteria> Significant effect: Skin roughness was completely eliminated, and a smooth feel was obtained. Effective: Skin roughness was reduced and smooth feeling increased. Somewhat effective: Skin swelling decreased. No effect: There was no change or deterioration in skin roughness.

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Table 1 Example 1 Example 2 Comparative Example 1著 Excellent 7 5 0 Effective 9 7 1 Slightly effective 7 8 11 No effect 7 10 18 ──────────有効 Effectiveness of skin roughness improvement 77 67 40 ──────────────────────── ─────

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[Table 2] 点 Scores Standards for scores ───────────── ──────────────── 1 Skin groove, skin ridge disappearance, turning over of wide area of horny layer 2 Skin groove, skin hill is unclear, turning of horny layer 3 Skin groove, skin hill 4 is flat, but the skin and ridge are sharp. 5 The skin and ridge are clear and well-aligned. ─────

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[Table 3] Replica score Example 1 Example 2 Comparative example 1 １ 1 0 0 0 2 1 4 11 3 12 16 15 4 9 8 4 5 8 2 0 ─────── ──────────────────────

Improvement of razor losing The men in their 20s and 50s suffering from razor losing, and 20 people in each group were asked to apply the lotion of Example or Comparative Example to the cheeks of the face for 2 weeks. The effect of improving skin roughness was evaluated by the visual evaluation by the subject himself. The evaluation was carried out according to the following evaluation criteria in four steps: significant, effective, somewhat effective, and no effect, and indicated by a ratio (effective rate) indicating significant, effective, or somewhat effective. Table 4 shows the results. <Evaluation Criteria> Significant effect: Lost razor. Effective: Razor loser weakened. Somewhat effective: Razor losing slightly weakened. No effect: no change in razor loss.

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[Table 4] Example 1 Example 2 Comparative Example 1有効 Razor loss improvement effective rate 65 40 25 ───────────────────── ────────

As is clear from Tables 1, 3 and 4, the cosmetics for improving skin roughness according to the present invention exhibited an excellent effect of improving skin roughness and losing razors.

Example 3 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 DL-alanine 0.01 Caustic potash 0.0 2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchange water residue (Production method) Propylene glycol and DL-
Add and dissolve alanine and caustic potash and heat to maintain at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 4 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 L-alanine 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) ,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. with good stirring.

Example 5 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 D-alanine 0.1 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Preparation method) Add soap powder and borax to ion-exchange water and heat and dissolve And maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

Example 6 Emulsion (Formulation) 2.5% by weight of stearic acid Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Product name: Carbopol 941, BFGoodrich Chemical company) DL-alanine 0.05 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water residue (Production method ) The carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsification is performed, the phase A is added, and the mixture is uniformly emulsified with a homomixer.

Example 7 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 L-alanine 10.0 Sodium bisulfite 0.01 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Production method)
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 8 Jelly (Formulation) 95% ethyl alcohol 10.0% by weight Dipropylene glycol 15.0 Polyoxyethylene (50 mol) oleyl alcohol ether 2.0 Carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 D-alanine 7.0 Sodium 2-hydroxy-4-methoxybenzophenonesulfonate 0.05 Ethylenediaminetetraacetate trisodium.2 water 0.05 Methylparaben 0 .2 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) Carbopol 940 and D-
Alanine is uniformly dissolved, while polyoxyethylene (50 mol) oleyl alcohol ether is dissolved in 95% ethanol and added to the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 9 Essence (Formulation) (A phase) Ethyl alcohol (95%) 10.0% by weight Polyoxyethylene (20 mol) octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 Methyl paraben 0.15 (B phase) Potassium hydroxide 0.1 (C phase) DL-alanine 1.5 Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (Product name: Carbopol 940, BFGoodrich Chemical company) Purified water residue (Preparation method) Dissolve A phase and C phase uniformly, and add A to C phase
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 10 Pack (Formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Fragrance 0.2 (Phase C) L-alanine 0.01 Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, Degree of polymerization 2,000) Ethanol 7.0 Purified water residue (Production method) A phase, B phase, and C phase are each dissolved uniformly,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 11 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 0.0 Isostearic acid 4.0 POE sorbitan monooleate 3.0 Isocetyl octoate 2.0 D-alanine 1.0 Preservatives Appropriate amount Fragrance Appropriate amount (Production method) Thorough mixing of talc-black iron oxide powder components with a blender, The oily components of squalane to isocetyl octanoate, D-alanine, preservatives, and flavors are added to the mixture, kneaded well, and the mixture is filled into a container and molded.

Example 12 Emulsified Foundation (Cream Type) (Prescription) (Powder Part) Titanium Dioxide 10.3% by Weight Sericite 5.4 Kaolin 3.0 Yellow Iron Oxide 0.8 Bengala 0.3 Black Iron Oxide 0.2 (oil phase) decamethylcyclopentasiloxane 11.5 liquid paraffin 4.5 polyoxyethylene-modified dimethylpolysiloxane 4.0 (aqueous phase) purified water 50.0 1,3-butylene glycol 4.5 DL -Alanine 1.5 Sorbitan sesquioleate 3.0 Preservatives Appropriate amount Flavors Appropriate amount (Preparation method) After heating and stirring the aqueous phase, a well-mixed and pulverized powder portion is added, followed by homomixer treatment. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

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As described above, the cosmetic for improving skin roughness according to the present invention is excellent in the effect of improving skin roughness, and has excellent effects in improving and preventing various skin diseases, skin roughness, roughness and the like. It is also excellent in safety.

Claims (2)

[Claims] 1. L-alanine, D-alanine or DL
-A cosmetic for improving skin roughness characterized by containing alanine as an active ingredient. 2. A cosmetic composition for improving skin roughness, comprising the active ingredient according to claim 1 in a total amount of 1.0 to 20.0% by weight based on the total amount of the cosmetic composition.