JPH1149630A - Bleaching preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation excellent in skin bleaching effects, by including serine as an active ingredient. SOLUTION: This preparation contains preferably 0.001-20.0 wt.% of based on the whole amount of the cosmetic of serine (a kind of an amino acid, an α-aminohydroacrylic acid, L-serine, D-serine, DL-serine are known). The cosmetic can be formulated, for example, with a powdery component, liquid oils and fats, solid oils and fats, a wax, a hydrocarbon, a higher fatty acid, a hither alcohol, an ester, a silicone, an anionic surfactant, a cationic surfactant, an amphoteric surfactant, a nonionic surfactant, a moisturizing agent, a water-soluble polymer compound, etc., besides the active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel whitening cosmetic for the purpose of skin whitening.

[0002]

2. Description of the Related Art Although there are some unclear factors about the mechanism of skin spots, freckles, and pigmentation on skin after sunburn, there are some unknown factors, but in general, hormonal abnormalities and irritation of ultraviolet rays from sunlight cause the problem. It is considered that melanin pigment is formed, and this is abnormally deposited in the skin.

[0003] In order to treat such spots, freckles, pigmentation on the skin after tanning, etc., a substance that suppresses the production of melanin, for example, a method of administering a large amount of vitamin C, or glutathione is injected. In addition, a method of applying kojic acid, cysteine, or the like to an ointment, a cream, a lotion, or the like, and applying the composition locally is used.

[0004] In Europe and the United States, hydroquinone preparations are used as pharmaceuticals. In addition, various skin external preparations for the purpose of whitening, for example, alkyl catechol glycosides (JP-A-4-59718), taxioside (JP-A-5-310747), curcumin, capsaicin, 4- Hydroxy-3-methoxycinnamaldehyde (JP-A-6-227959), tetraacetylguaiacol β-D-glucoside (JP-A-6-2)
No. 56138) is known.

[0005]

However, these compounds, except for hydroquinone, exhibit very slow effects, so that the whitening effect is not sufficient. On the other hand, although the effects of hydroquinone have been recognized, However, this also has a problem in the safety (irritation and sensitization) of the substance itself, so that its use is generally restricted.

[0006] In view of the above circumstances, the present inventors have conducted intensive studies on substances having a whitening effect, and as a result, have found that serine exhibits an excellent whitening effect, thereby completing the present invention.

[0007] An object of the present invention is to provide a whitening cosmetic in which serine is blended as an active ingredient having a whitening effect.

[0008]

That is, the present invention provides a skin-whitening cosmetic characterized by containing serine.

Further, the present invention provides the above-mentioned whitening cosmetic, wherein the content of the serine is 0.001 to 20.0% by weight based on the total amount of the whitening cosmetic. is there.

Further, the present invention provides the above-mentioned whitening cosmetic, wherein the content of the serine is 0.1 to 10.0% by weight based on the total amount of the whitening cosmetic. is there.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The serine used in the present invention is α-aminohydroacrylic acid which is a kind of amino acid, and three kinds of L-serine, D-serine and DL-serine are known. Although it is a known compound as a cosmetic raw material, it has never been used in a whitening cosmetic as a whitening agent.

In the present invention, the amount of serine is 0.001 to 20.0% by weight, preferably 0.1 to 10.0% by weight, based on the total amount of the whitening cosmetic. 0.001% by weight
When the amount is less than the above, the skin whitening effect is poor, and even when the amount exceeds 20.0% by weight, an increase in the whitening effect cannot be expected.

The whitening cosmetic of the present invention contains, in addition to the above-mentioned essential components, other components usually used in cosmetics,
For example, powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, humectants , Water-soluble polymer compounds, thickeners, film agents, ultraviolet absorbers, sequestering agents, lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, synthetic resin emulsions, pH adjusters, skin nutrition , Vitamins, antioxidants, antioxidant aids, fragrances, water and the like can be added as needed. Specific examples of components that can be blended are listed below. The whitening cosmetic of the present invention can be produced by a conventional method by blending any one or more of these components with the above essential components.

Examples of the powder components include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite,
Synthetic mica, biotite, biotite, lithia mica, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite , Barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder ( Nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulo Organic powders scan powder such as titanium dioxide, inorganic white pigments such as zinc oxide, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as loess black iron oxide, carbon black, inorganic black pigments such as lower titanium oxide, Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine blue and dark blue; titanium oxide coated mica; titanium oxide coated bismuth oxychloride , Titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red 220
No. Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401
No. 3, and organic pigments such as Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No. Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
Organic pigments such as zirconium, barium or aluminum lakes such as No. 1 and Blue No. 1, and natural pigments such as chlorophyll and β-carotene. However, the powder may be any powder that can be applied to general cosmetics, and is not limited to the above components.

Examples of liquid fats and oils include avocado oil,
Camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Glycerin trioctanoate, glycerin triisopalmitate and the like can be mentioned.

Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef bone oil, mokuro kernel oil, hardened kernel oil Oil, beef tallow, mocro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin,
Sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like. Can be

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (beheninic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid. Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

The higher alcohols include, for example, linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol. And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol, and the like.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neodicaprate Pentyl glycol, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylol tri-2-ethylhexylate Bread, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristate Glycerin, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2-
Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. Examples include polysiloxane, silicone resin and silicone rubber forming a three-dimensional network structure.

Examples of the anionic surfactant include a soap base, a fatty acid soap such as sodium laurate and sodium palmitate, a higher alkyl sulfate such as sodium lauryl sulfate and lauryl sulfate K,
POE lauryl sulfate triethanolamine, alkyl ether sulfates such as POE lauryl sodium sulfate, N-acyl sarcosine acids such as lauroyl sarcosine sodium, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltauride sodium,
Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride, POE oleyl ether sodium phosphate, phosphate ester salts such as POE stearyl ether phosphoric acid, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene Sulfosuccinates such as sodium sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonate triethanolamine and linear dodecylbenzenesulfonate; monosodium N-lauroylglutamate , N-stearoyl disodium glutamate, N-myristoyl-L-monosodium glutamate and the like. Acyl glutamate, higher fatty acid ester sulfate such as hydrogenated coconut oil fatty acid glycerin sodium sulfate, sulfated oil such as funnel oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher grade Fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate,
Sodium lauroyl monoethanolamidosuccinate,
N-palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium salt, and poly (N, N'-dimethyl-3, Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline amphoteric surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetate betaine, alkyl betaine,
Betaine-based surfactants such as amidobetaine and sulfobetaine are exemplified.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as glycerin α'-oleate pyroglutamate and glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and POE-sorbitan. Sorbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbitol fatty acid esters such as sorbit pentaoleate and POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate; POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether and POE dinonyl phenyl ether; pluronic type such as bruronic;
POE / POP alkyl ethers such as POP cetyl ether, POE / POP2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate, P
OE hardened castor oil triisostearate, POE hardened castor oil monopyroglutamic acid monoisostearate diester, POE hardened castor oil, maleic acid, etc. POE castor oil hardened castor oil derivative, POE sorbitol bee wax, etc. POE beeswax lanolin derivative, coconut oil Alkanolamides such as fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide,
POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate,
Examples thereof include alkylethoxydimethylamine oxide and trioleyl phosphoric acid.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3
-Butylene glycol, xylitol, sorbitol,
Maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO Examples include an adduct, a primrose extract, a Yarrow extract, and a melilot extract.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone and carboxyvinyl polymer (Carbopol), polyethylene glycol 20,000, 4,000,000, Polyoxyethylene polymer such as 600,000, polyoxyethylene polyoxypropylene copolymer copolymer polymer, acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethyleneimine, cationic polymer And the like.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (veegum), laponite, hectorite, silicic anhydride and the like.

As the thickener, for example, gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

As the ultraviolet absorber, for example, para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA Ethyl ester, N, N
Benzoic acid ultraviolet absorbers such as -dimethyl PABA butyl ester and N, N-dimethyl PABA tyl ester; anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate; menthyl salicylate; homomenthyl salicylate; octyl Salicylic acid type ultraviolet absorbers such as salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate,
Ethyl-4-isopropylcinnamate, methyl-2,
5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, Octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, Cinnamic acid ultraviolet absorbers such as 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, 2,4-dihydroxybenzophenone, 2,2′-
Dihydroxy-4-methoxybenzophenone, 2,2 ′
-Dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone,
-Ethylhexyl-4'-phenyl-benzophenone-
Benzophenone-based ultraviolet absorbers such as 2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone;
3- (4′-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5
-Methylbenzoxazole, 2,2'-hydroxy-5
-Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzarazine, dianisoylmethane, 4-methoxy -4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, etc. These ultraviolet absorbers and various plants having an ultraviolet absorption action By adding various UV-absorbing substances such as extracts, it is also possible to obtain a whitening cosmetic having an effect of preventing and preventing sunburn.

As the sequestering agent, for example, 1-
Hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, metaphosphoric acid Examples include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.

As the lower alcohol, for example, methanol, ethanol, propanol, isopropanol,
Isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, and 2,3-butyl glycol.
Butylene glycol, pentamethylene glycol, 2-
Dihydric alcohols such as butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol; and tetrahydric alcohols such as pentaerythritol Pentahydric alcohols such as xylitol, sorbitol, hexahydric alcohols such as mannitol,
Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, ethylene glycol monomethyl ether, ethylene glycol monoethyl Ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl Ether, d Dihydric alcohol alkyl ethers such as lenglycol dibutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene Glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether Dihydric alcohol alkyl ethers such as dipropylene glycol butyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadibate, ethylene glycol disuccinate Dihydric alcohol ethers such as diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc. Glycerin monoalkyl ethers such as ter, xyl alcohol, serachyl alcohol, and batyl alcohol, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitolose,
Sugar alcohols such as starch-decomposed sugar-reducing alcohol, glysolid, tetrahydrofurfuryl alcohol, PO
E Tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphoric acid, POP
POE pentane erythritol ether and the like.

Examples of the monosaccharide include tricarbonates such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbons such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose, D-xylose, and the like. Pentoses such as L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, D-glucose, D-talose, D-
Bucose, D-galactose, D-fructose, L
-Hexoses such as galactose, L-mannose, D-tagatose, heptose such as aldoheptose and heppulose;
Octanose such as octulose, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-
Deoxy sugars such as L-mannose, D-glucosamine, D
-Amino sugars such as galactosamine, sialic acid, aminouronic acid and muramic acid, and uronic acids such as D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid and L-iduronic acid.

Examples of the oligosaccharide include sucrose, guntianose, umbelliferose, lactose, planteose, isorikunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Examples of polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bean gum, succinoglucan, caronic acid and the like. As amino acids, for example, glycine, valine, leucine, isoleucine, serine, threonine, tryptophan, cystine, cysteine, neutral amino acids such as methionine, proline, hydroxyproline, aspartic acid, glutamic acid, asparagine, acidic amino acids such as glutamine, and arginine , Histidine, lysine,
Basic amino acids such as hydroxylysine are exemplified. Examples of amino acid derivatives include acyl sarcosine sodium (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

As the organic amine, for example, monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1 -Propanol and the like.

Examples of the synthetic resin emulsion include:
An acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and the like are included.

Examples of the pH adjuster include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Examples of the vitamins include vitamins A, B1, B2, B6, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

The formulation of the whitening cosmetic of the present invention is arbitrary, and may be any of a solution type, a solubilizing type, an emulsifying type, an oil-liquid type, a gel type, a powder dispersing type, a water-oil two-layer type, and a water-oil-type. By mixing one or more of the above optional components such as a three-layer powder system and the essential components of the present invention, a wide range of dosage forms can be obtained by a conventional method according to the target product.

The whitening cosmetic of the present invention means a cosmetic applied to the outer skin for the purpose of whitening, and may have any product form as long as it has a whitening effect. , Creams, packs, foundations and other whitening cosmetics.

[0050]

Next, the present invention will be described in more detail by way of examples. The present invention is not limited by this.

“Examples 1 to 12, Comparative Example 1: Whitening lotion” 95% ethyl alcohol 5.0% by weight Carboxyvinyl polymer 0.3 Polyoxyethylene (15 mol) oleyl ether 0.8 Glycerin 5.0 1,3-butylene glycol 5.0 Whitening agent (described in Table 1) Amount shown in Table 1 Methylparaben 0.1 Perfume Appropriate amount Ion-exchanged water residue (Preparation method) Each component is stirred.

[0052]

[Table 1]

"(1) Whitening effect test 1" (Test method) 70 subjects who were exposed to sunlight in summer for 4 hours (2 hours a day for 2 days) were exposed to the sunlight on the upper arm inner skin. Each sample was applied once a day in the morning and evening for 5 weeks after 5 days on the day. The panel was divided into 10 groups and divided into 7 groups, and the samples of Examples 1 to 12 and Comparative Example 1 were tested.

(Evaluation Method) The lightening effect after use was determined based on the following criteria. (Judgment criteria) Significant effect: Pigmentation became almost inconspicuous. Effective: Pigmentation was very light. Somewhat effective: Pigmentation became light. Invalid: No change. (Judgment) ：: 80% or more of the test subjects showed excellent and effective. ：: The proportion of the test subjects showing excellent and effective was 50% or more and less than 80%. Δ: The proportion of the test subjects showing significant effect and effectiveness was 30% or more and less than 50%. ×: Less than 30% of the test subjects showed significant effect and effectiveness.

[0055]

[Table 2] ---------------------------------------------- ---------------------- Example Comparative example ------------------------ -------------------------------------------- 1 2 3 4 5 6 7 8 9 10 11 12 1 ------------------------------------------- ------------------------- Whitening effect: ◎ ◎ ◎ ○ ◎ ◎ ◎ ○ ◎ ◎ ◎ ○ × --------- -------------------------------------------------- ---------

As is clear from Table 2, the whitening effect after exposure to sunlight was less in the example than in the comparative example, the deposition of excess melanin pigment was prevented, and the whitening effect was prevented. This indicates that the whitening cosmetic of the present invention has an excellent whitening effect.

"(2) Whitening effect test 2" (Test method) Subject 70 suffering from darkness, spots, freckles, etc.
Each sample was applied to the face once a day in the morning and evening for three months. The panel was divided into 10 groups and divided into 7 groups, and the samples of Examples 1 to 12 and Comparative Example 1 were tested.

(Evaluation Method) The lightening effect after three months was determined based on the following criteria. (Judgment criteria) Significant effect: Pigmentation became almost inconspicuous. Effective: Pigmentation was very light. Somewhat effective: Pigmentation became light. Invalid: No change. (Judgment) ：: 80% or more of the test subjects showed excellent and effective. ：: The proportion of the test subjects showing excellent and effective was 50% or more and less than 80%. Δ: The proportion of the test subjects showing significant effect and effectiveness was 30% or more and less than 50%. ×: Less than 30% of the test subjects showed significant effect and effectiveness.

[0059]

[Table 3] ---------------------------------------------- ---------------------- Example Comparative example ------------------------ -------------------------------------------- 1 2 3 4 5 6 7 8 9 10 11 12 1 ------------------------------------------- ------------------------- Whitening effect: ◎ ◎ ◎ ○ ◎ ◎ ◎ ○ ◎ ◎ ◎ ○ × --------- -------------------------------------------------- ---------

As is evident from Table 3, the whitening effect of the examples was recognized to be superior to that of the comparative example for the whitening effect on blacks, spots, freckles, and the like. It can be seen that it has an excellent whitening effect.

Hereinafter, other examples of the whitening cosmetic composition of the present invention will be described.

Example 13 Whitening Cream Stearic Acid 5.0% by Weight Stearyl Alcohol 4.0 Isopropyl Myristate 18.0 Glycerin Monostearate 3.0 Propylene Glycol 10.0 L-Serine 20.0 Caustic Potassium 0.2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchanged water residue (Preparation method) Add propylene glycol and caustic potash to ion-exchanged water, heat and maintain at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture was uniformly emulsified with a homomixer, cooled to 30 ° C. with good stirring, and manufactured.

Example 14: Whitening Cream Stearic Acid 6.0% by Weight Sorbitan Monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan Monostearate 1.5 Propylene Glycol 10.0 D-Serine 7.0 Glycerin trioctanoate 10.0 Squalene 5.0 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchanged water residue (Aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. while stirring well to produce.

Example 15 Whitening Cream Stearyl Alcohol 7.0% by Weight Stearic Acid 2.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodecyl Alcohol 6.0 Polyoxyethylene (25 mol) Cetyl Alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 DL-serine 0.001 Fragrance Appropriate amount Sodium bisulfite 0.03 Ethyl paraben 0.3 Ion exchange water Residue (Production method) Propylene glycol for ion exchange water And heat to maintain 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase was added to the water phase, pre-emulsified, homogenized uniformly with a homomixer, and cooled to 30 ° C. with good stirring to produce.

Example 16 Whitening Emulsion Stearic Acid 2.5% by Weight Cetyl Alcohol 1.5 Vaseline 5.0 Liquid Paraffin 10.0 Polyoxyethylene (10 mol) Monooleate 2.0 Polyethylene Glyco- 1500 3.0 Triethanolamine 1.0 L-Serine 10.0 Sodium bisulfite 0.01 Ethylparaben 0.3 Carboxyvinyl polymer 0.05 Perfume Appropriate amount Ion-exchanged water residue (Preparation method) Carboxy in a small amount of ion-exchanged water Dissolve the vinyl polymer (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and maintained at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase was added to the water phase, preliminarily emulsified, the phase A was added, and the mixture was uniformly emulsified with a homomixer.

Example 17 Whitening Emulsion (Oil Phase) Stearyl Alcohol 1.5% by Weight Squalene 2.0 Vaseline 2.5 Deodorized Liquid Lanolin 1.5 Evening Primrose Oil 2.0 Isopropyl myristate 5.0 Glycerin Monooleate 2.0 Polyoxyethylene (60 mol) hydrogenated castor oil 2.0 Tocopherol acetate 0.05 Ethyl paraben 0.2 Butyl paraben 0.1 L-Serine 1.0 D-Serine 1.0 Perfume Appropriate amount (aqueous phase Part) Sodium bisulfite 0.01% by weight Glycerin 5.0 Sodium hyaluronate 0.01 Carboxyvinyl polymer 0.2 Potassium hydroxide 0.2 Purified water Residue (Preparation method) The oil phase is dissolved at 70 ° C. 70 ° C in the aqueous phase
, And the oil phase was mixed with the aqueous phase, emulsified by an emulsifier, and then cooled to 30 ° C. by a heat exchanger to produce.

Example 18: Whitening jelly 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 caustic soda 0.15 L-arginine 0.1 DL-serine 1.0 methyl paraben 0.2 perfume Appropriate amount ion-exchanged water residue (Preparation method) The carboxyvinyl polymer is uniformly dissolved in ion-exchanged water, while DL-serine is dissolved in 95% ethanol.
Dissolve the polyoxyethylene (50 mol) oleyl alcohol ether and add to the aqueous phase. Next, after adding other components, the mixture was neutralized with caustic soda and L-arginine to increase the viscosity, and thus produced.

Example 19: Whitening Essence (Phase A) Ethanol (95%) 10.0% by weight Polyoxyethylene (20 mol) octyldodecanol 1.0 Methyl paraben 0.15 Pantothenyl ethyl ether 1 L-serine 0.05 (B phase) Potassium hydroxide 0.1 (C phase) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 Purified water Residue (Preparation method) A Phase and phase C are uniformly dissolved, and
Add phases and solubilize. Next, after the phase B was added, the mixture was filled and produced.

Example 20: Whitening Pack (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) L-serine 1.0 Olive oil 0 Tocophenol acetate 0.2 Ethyl paraben 0.2 Fragrance 0.2 (Phase C) Sodium bisulfite 0.03 Polyvinyl alcohol (degree of saponification, degree of polymerization 2000) 13.0 Ethanol 7.0 Purified water residue (Production method) ) A phase, B phase and C phase are each dissolved uniformly,
Add phase B to phase and solubilize. Subsequently, this was added to the phase C and then filled to produce.

Example 21 Whitening Ointment Polyoxyethylene (30 mol) Cetyl Ether 2.0% by Weight Glycerin Monostearate 10.0 Liquid Paraffin 10.0 Vaseline 40.0 Cetanol 6.0 Methyl Paraben 0.1 Butylparaben 0.1 Glycerin monostearate 2.0 L-serine 5.0 Propylene glycol 10.0 Ion exchange water Residual perfume Appropriate amount (Production method) Propylene glycol is added to ion exchange water,
Dissolve and heat to maintain 70 ° C. (aqueous phase). 70 other ingredients
Mix and dissolve at ℃ (oil phase). The oil phase was added to the aqueous phase, uniformly emulsified by a homomixer, cooled, and filled to produce a product.

The whitening cosmetics obtained in Examples 13 to 21 were all effective in the same whitening effect test as in Examples 1 to 12.

[0072]

According to the present invention, a whitening cosmetic having an excellent skin whitening effect can be provided.

Claims (3)

[Claims] 1. A whitening cosmetic comprising serine. 2. The whitening cosmetic according to claim 1, wherein the content of the serine is 0.001 to 20.0% by weight based on the total amount of the whitening cosmetic. 3. The whitening cosmetic according to claim 1, wherein the content of the serine is 0.1 to 10.0% by weight based on the total amount of the whitening cosmetic.