JPH0597653A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic excellent in the skin-whitening activity and in the prevention of the skin roughness and fine wrinkles and guaranteed at the point of safety. CONSTITUTION:A cosmetic contains the solvent extract of Rheum in a dry amount of 0.00001-5wt.%, preferably 0.0001-2wt.%. The Rheum is extracted with a hydrophilic organic solvent such as a lower alcohol, a polyhydric alcohol or acetone and water, or the mixed solvents, preferably ethanol, water or the mixture as an extraction solvent. The extracted solution or its dry powder obtained by a lyophilization method, etc., is mixed with other raw materials (e.g. a liquid oil, a solid oil, various active agents, a humectant, various chemicals) and subsequently prepared into the cosmetics having various preparation shapes.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect, smoothing the skin and keeping youthful skin.

Rhubarb is widely used as a medicine.
The purpose is to treat colonic laxatives and anti-inflammatory stomachic agents as a drug to eliminate toxic type poisoning in Chinese herbs, promote profitability, and cure chest fullness, lodging, abdominal pain due to constipation, and purulent swelling. Although it is a raw material described in the Japanese Pharmacopoeia, there is no precedent for using it in cosmetics.

[0003]

DISCLOSURE OF THE INVENTION The object of the present invention is to have a high whitening effect, to make the skin smooth, to keep youthful skin,
Another object of the present invention is to provide a cosmetic product that is highly safe and has a raw material that is easily available.

[0004]

[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have conducted diligent research and, regarding the raw materials that have been used as internal medicines in Kampo for a long time and whose safety has been confirmed, As a result of investigating the effect as a cosmetic, it was found that it has an excellent whitening effect, and the present invention was completed.

That is, the present invention is a cosmetic product containing a solvent extract of Rhubarb. Daihaku has long been used as an internal medicine, and made of water or ethanol extract, and its safety has been sufficiently confirmed. Various types of plants are used for rhubarb. Rheu
m Palmatum Linne), Tangut rhubarb (Rheum tang
uticum Maximowicz), Rheum officinale B
aillon), Korean rhubarb (Rheum coreanum Naka
i) or their interspecific hybrids such as Shinshu Daihoku. The rhizome of these plants is rhubarb.

As a solvent for extracting the rhubarb, lower alcohols such as methanol and ethanol, polyhydric alcohols such as glycerin, propylene glycol and 1,3 butylene glycol, hydrophilic organic solvents such as acetone, and water,
Alternatively, extraction is performed using a mixed solvent of two or more kinds selected from these solvent groups. However, ethanol, water, or a mixture thereof is most suitable for extracting cosmetic raw materials. The extraction time is selected according to the method of chopping the rhubarb, the temperature, and the stirring conditions.

The extract or a dry powder obtained by freeze-drying the extract without decomposing the active ingredient is used as another cosmetic raw material, for example, liquid oil such as squalane and jojoba.
Cosmetics of various dosage forms can be prepared by adding solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol, and various agents. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose.

The effect of the compound of this extract varies depending on the dosage form to be compounded, the purpose of the product, the presence or absence of coexisting agents, the origin and type of rhubarb, etc. 0.00001 to 5% by weight,
It is preferably 0.0001 to 2% by weight.

[0009]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. First, the method for producing the solvent extract used in the examples will be described.

(Production Example 1) Rheum officinale Bai
llon) 50g methanol 50ml methanol 500ml 3
It was heated with a reflux condenser for an hour. After cooling, filtration and freeze-drying were performed.

(Production Example 2) Rheum officinale Bai
Llon) (50 g) was added with methanol (500 ml), and the mixture was heated for 3 hours with a reflux condenser attached. After cooling, filtration and freeze-drying were performed.

(Production Example 3) Rheum officinale Bai
Llon) (50 g) was added with purified water (500 ml) and heated at 80 ° C. for 3 hours. After cooling, filtration and freeze-drying were performed.

(Production Example 4) 500 g of 50% ethanol was added to 50 g of Daihaku (commercially available in Japan) and left at room temperature for 5 days. After filtration, it was freeze-dried.

(Production Example 5) 50 g of 50% ethanol was added to 50 g of Shinshu Daio and left at room temperature for 5 days. After filtration, it was freeze-dried.

(Production Example 6) 50% in 50 g of Daio (Nishikimon)
After adding 500 ml of ethanol, the mixture was left at room temperature for 5 days. After filtration, it was freeze-dried.

(Example 1) Lotion part by weight Extract of Production Example 1 1.0 Purified water 94.0 Glycerin 4.9 Methyl paraoxybenzoate 0.1

(Example 2) Cream A 2 parts by weight Squalane 20.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 B Parts by weight Purified water 54.9 Polyoxyethylene (20E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 glycerin 5.0 methyl paraoxybenzoate 0.1 Extraction of Production Example 2 Material 2.0 A and B were weighed and heated to 70 ° C., A was gradually added to B with stirring and then cooled to 30 ° C. with slow stirring.

Example 3 The extract of Production Example 1 of Example 1 was replaced with the extract of Production Example 3.

Example 4 The extract of Production Example 2 of Example 2 was replaced with the extract of Production Example 4.

Example 5 The extract of Production Example 1 of Example 1 was replaced with the extract of Production Example 5.

Example 6 The extract of Production Example 2 of Example 2 was replaced with the extract of Production Example 6.

Comparative Example 1 The extract of Production Example 1 of Example 1 was replaced with purified water.

(Comparative Example 2) The extract of Production Example 2 of Example 2 was replaced with purified water.

(Measurement of Tyrosinase Activity Inhibition Rate) (Test Method) Mcllvaln Buffer Solution 0.9
ml, 1.66 mM Tyrosine solution 1.0 ml, the sample (dry product) was dissolved in ethanol, water was added, and ethanol was removed by an evaporator, and then 0.1 weight (dry product) / volume Sample liquid adjusted to a specified concentration of 1.
0 ml was placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. 0.1 ml of tyrosinase solution (manufactured by Sigma, mushroom-derived, 914 units / ml) was added, and the mixture was kept warm in a constant temperature water bath at 37 ° C., and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution, and the same measurement was performed.

(Calculation formula) A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 The measurement results are shown in Table 1.

[0026]

[Table 1]

(Active oxygen production inhibition test) 21 in the atmosphere
There is% oxygen, without which no organisms (other than anaerobics) can exist. However, oxygen becomes active oxygen under the influence of ultraviolet rays and enzymes. Active oxygen oxidizes fatty acids and produces peroxides. It also oxidizes and damages the phospholipids of biological membranes in the body. Moreover, it is said that the generated peroxide and active oxygen damage DNA and accelerate aging. It also influences the mechanism of melanin production from tyrosine and is involved in skin darkening. Suppressing this active oxygen is one of the important factors required for the skin, in other words, for cosmetics.

(Measurement method) Measuring the effect of suppressing active oxygen
There are various methods to do this, but in the present invention, the following method is used.
Was measured. pH 7.8 50 mM potassium phosphate buffer (containing 1,3 mM DETAPAC) 133 ml 40 unit / ml Catalase above potassium phosphate buffer 5 ml 2 mM nitroblue tetrazolium above potassium phosphate buffer 5 ml17 ml of the above potassium phosphate buffer solution containing 1.8 mM xanthine  160 ml 2.4 ml of the mixture of the above reagents and the sample (the above sample solution)
Add 0.3 ml of xanthine oxynase
When performing an experiment, the absorbance is about 0.02 per minute or more
Adjust with the above potassium phosphate buffer so that it rises.
(3) Add 0.3 ml of the solution and immediately measure the absorbance (560 nm).
Set. (Measurement is performed for 2 minutes to confirm linearity) Calculation formula Inhibition rate = (A−B) / A × 100 A: Change in absorbance per minute when the sample is water B: 1 minute of sample Change in absorbance per hit

The results are shown in Table 2.

[Table 2]

(Use test) 15 women are divided into 3 groups,
For each of 5 persons, the face was divided into left and right sides, one of which was used as an example and the other was used as a comparative example, and the following samples were used once or more daily as shown in Table 3, and a questionnaire was conducted after 3 months.

[Table 3]

The judgment criteria are as follows, and the results of the questionnaire are summarized in Table 4. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is slightly good -1 Comparative example is quite good -2 Comparative example Is very good -3

[0032]

[Table 4]

[0033]

[Effects of the Invention] As is clear from the examples, the extract of Rhubarb is useful for whitening, preventing rough skin, and preventing wrinkles, and its safety has been used and guaranteed as a herbal medicine for many years. It is the best one.

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[Procedure amendment]

[Submission date] December 10, 1991

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0026

[Correction method] Change

[Correction content]

[0026]

[Table 1]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] 0029

[Correction method] Change

[Correction content]

The results are shown in Table 2.

[Table 2]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakamura Masami 6-32 Ikegami Town, Toba City, Mie Prefecture

Claims (1)

[Claims] 1. A cosmetic product containing a solvent extract of Rhubarb.