JPH04282311A - Aerosol-type foamable wound-disinfectant - Google Patents

Abstract

PURPOSE:To provide an aerosol-type foamable wound-disinfectant capable of surely disinfecting the wound to give easy feeling because the application of the disinfectant to the wound can be confirmed with eye and applicable without loss and the staining of clothes because the disinfectant is free from dripping tendency. CONSTITUTION:The objective disinfectant contains (a) a wound-disinfectant such as iodine, (b) an aqueous medium such as water or a waterethanol solution, (c) a foaming agent such as anionic and/or nonionic surfactant and (d) a conventional propellant for aerosol products as essential components and preferably further contains (e) a collagen compound such as collagen hydrochloride and/or (f) a film-forming agent such as a foamable agent containing a water-soluble polymer (e.g. polyvinyl alcohol). The components are filled in an aerosol container to obtain the aerosol-type foamable wound-disinfectant covering the wound with foam. The wound-disinfectant exhibits, in addition to the above effects, a hemostatic effect and a skin-regeneration effect when the disinfectant contains the component (e) and a wound-protecting effect to form a thin film on the wound when it contains the component (f).

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aerosol-type foaming wound disinfectant that covers wounds in the form of foam.

0002

2. Description of the Related Art Simple wound disinfectants are used mainly at home. This is an aqueous disinfectant that is applied to the wound or sprayed into a mist using a pump.

[0003] However, since this wound disinfectant is a liquid, it may drip down after application and the effect may not last long.
May stain clothes, etc. In addition, because it runs off and is transparent, there are many cases where users become anxious because they cannot confirm whether it has been applied properly to the wound and is effective, and they may end up applying more than necessary or feeling anxious. It may not be possible to wipe it completely. Furthermore, when the dermis is exposed or blood is visibly seeping out, anyone feels anxious and it is not a pleasant experience.

0004

SUMMARY OF THE INVENTION It is an object of the present invention to provide a wound disinfectant that can be seen at a glance that the disinfectant has been applied to the wound without fail, and that is highly effective and provides a sense of security.

[0005]

[Means for Solving the Problems] The aerosol-type foaming wound disinfectant of the present invention is characterized in that an aerosol container is filled with a foam-forming agent containing a wound disinfectant, an aqueous medium, a foaming agent, and a propellant. shall be.

[0006]

[Action] The wound disinfectant is applied to the affected area (wound) from the aerosol container.
When squirted, it foams to form bubbles that cover the entire wound. This foam lasts for a while, and eventually disappears by pressing with gauze or the like.

[0007]

[Example] Fig. 1 is a sectional view showing an example of the aerosol type foaming wound disinfectant of the present invention.
A foam-forming agent 21 is filled inside. 13 indicates a dip tube.

Foam-forming agents 21 include wound disinfectants, aqueous media, foaming agents, and propellants. When the actuator 17 is pushed to open the valve 15, the foam-forming agent 21 is taken out from the spout 19. At this time, the shock at the time of ejection (
By stirring) and gasifying the propellant, the aqueous medium containing the foaming agent foams, and the foam-forming agent 21 turns into a mass of fine white foam and covers the wound on the limb or the like. Therefore, it can be confirmed that the medicine 21 has been reliably applied to the wound. In addition, the wound is covered with white foam and becomes invisible, giving a sense of security. Furthermore, unlike ordinary liquids, there is no dripping, so there is no waste and there is no chance of staining clothes, etc.

[0009] By defoaming or breaking the foam, the wound disinfectant can be applied to the wound and a disinfecting effect can be obtained. You can leave it as is until the foam naturally disappears, or you can break the foam by lightly pressing gauze, etc. from above, absorb the excess ingredients into gauze, etc., and fix it with a bandage from above. .

[0010] The fineness of the foam and the foam maintenance time can be adjusted by the type and amount of the foaming agent, and if necessary, a thickener (foaming agent) can be added to the foam-forming agent. . moreover,
Collagens and film-forming agents can also be added to the foam-forming agent.

[0011] When collagens are included in the composition, the above treatment can promote hemostasis and skin regeneration effects. Furthermore, when a film forming agent is included in the composition, a thin film is formed on the wound after defoaming to protect the wound.

[0012] As the wound disinfectant, iodine, pompidone iodine, acrinol, acrinoflavin, nitrofurazone, benzalkonium chloride, benzethonium chloride, chlorhexidine, etc. are used.

Collagen hydrochloride, which is a type of collagen, absorbs water when it comes into contact with blood, causing platelet adhesion and aggregation. In addition, positively charged rich collagen obtained by esterifying the -COOH group of collagen causes stronger platelet adhesion than the original unmodified collagen, and is expected to have a more hemostatic effect than ordinary disinfectants. Furthermore, by adding collagen fibers, the collagen fibers absorb water and swell under acidic conditions, increasing adhesiveness and improving adhesion to wound areas and skin moldability due to changes in the properties of the stock solution.

[0014] Collagen is desirably blended in an amount of 0.1 to 3.0% by weight in the stock solution (composition obtained by removing the propellant from the foam-forming agent). The aqueous medium is water or water-
A substance that is safe for the human body, such as an ethanol solution, is used.

[0015] As the foaming agent, surfactants are typical, and anionic surfactants, nonionic surfactants, etc. are used. When using a nonionic surfactant, in order to solubilize other components of the wound disinfectant, a highly oily nonionic surfactant (for example, HLB = 2 to 3) and a highly hydrophilic surfactant ( For example, HLB=10-12) can be used in combination at an appropriate ratio. Specific examples of the former include higher fatty acid esters of sorbitan (span 20,
Specific examples of the latter include ethylene oxide adducts of sorbitan partial higher fatty acid esters (Tween 20, manufactured by Kao Atlas, etc.). Furthermore, HLB can also be controlled by adjusting the number of moles of ethylene oxide added to polyoxyethylene higher alkyl ether or the like.

[0016] As the thickener, carboxymethylcellulose, carboxyvinyl polymer, etc. are used.

Film forming agents include polyvinyl alcohol, polyvinyl acetate, polyvinyl acetate partial hydrolyzate,
Water-soluble polymers such as polyvinylpyrrolidone or vinylpyrrolidone-vinyl acetate copolymer are mainly used. These also act as thickeners, and some of the above thickeners act as film-forming agents. The film-forming agent is preferably blended in an amount of 3 to 20% by weight in the stock solution.

As the propellant, those used in aerosol products are generally used, such as dimethyl ether, liquefied petroleum gas, chlorofluorocarbons, carbon dioxide gas, and the like. Mixing 5 to 25 parts by weight of propellant and 75 to 95 parts by weight of stock solution,
It is generally filled into an aerosol container.

85 parts by weight of the stock solution of the formulation in Table 1 below and a propellant (
A wound disinfectant of the present invention was prepared by filling an aerosol container with 15 parts by weight of a mixture of dimethyl ether and LP gas. Note that the iodine content is an 8% ethanol solution of iodine.

[0020]

[Table 1] Iodity degree

10 wt% polyvinylpyrrolidone
15 wt% polyoxyethylene (9 mol) lauryl ether
0.5wt% polyoxyethylene (15 mol) lauryl ether
1.0wt% ethanol

12wt
% collagen

1.5wt% purified water

balance


100 wt%

When this wound disinfectant was squirted onto the wound, fine, slightly colored white bubbles covered the surface of the wound.

[0022]

[Effects of the Invention] According to the present invention, by filling an aerosol container with a wound disinfectant as a foaming composition, it is possible to visually confirm that the disinfectant covers the wound, ensuring disinfection and providing a high sense of security. . Also, unlike regular liquids, it does not drip and stain clothes.

[0023] Furthermore, when collagens are contained, their hemostatic and skin regenerating effects can be utilized.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing an embodiment of the aerosol-type foaming wound disinfectant of the present invention.

[Explanation of symbols]

11 Aerosol container 13 Dip tube 15 Valve 17 Actuator 19 Spout 21 Foam-forming agents

Claims (3)

[Claims] 1. An aerosol-type foaming wound disinfectant, characterized in that an aerosol container is filled with a foam-forming agent containing a wound disinfectant, an aqueous medium, a foaming agent, and a propellant. 2. The aerosol-type foaming wound disinfectant according to claim 1, wherein the foam-forming agent further contains collagen. 3. The aerosol-type foaming wound disinfectant according to claim 1, wherein the foam-forming agent further comprises a film-forming agent.