TW200946141A - Foam-shaped skin liniment - Google Patents

Abstract

The present invention provides a foam-shaped skin liniment, considering safety, maintaining excellent foaming in the aerosol with inner pressure smaller than 0.7 MPa and under low temperature, and making the carbon dioxide act on the skin for long period of time to obtain an adequate blood-circulation promotion effect. The foam-shaped skin liniment is made by filling the mixtures of liquid and gas into the pressure-resistant container so that the inner pressure is less than 0.7 MPa under 25 DEG C. The above-mentioned mixtures of liquid and gas comprises the following ingredients of (A), (B), and (C): (A) carbon dioxide, (B) mixture chosen from hydrocarbon with number of carbon equal to 3 to 5, and the hydrocarbon mixture in the above-mentioned mixtures is 0.1 to 0.3 mass% in the condition of a saturated hydrocarbon content under vapor pressure of above 0.1 MPa and below 0.5 MPa at 35 DEG C equal to 70 to 100 mass%, (C) 0.1 to 25 mass% of surfactant, and a mass ratio (A:B) of (A) and (B) equal to 35:65 to 95:5.

Description

200946141 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to a foamy skin coating agent containing carbon dioxide. [Prior Art] Carbon dioxide (c〇2), if it acts on the skin, promotes the blood circulation of the skin, so the manufacturer has proposed various kinds of cosmetics containing carbon dioxide. For example, it is disclosed that, in a cosmetic material containing carbon dioxide, a saturated concentration of carbon dioxide is temporarily supplied, and a carbon dioxide-saturated solution having a higher concentration is supplied in the presence of ethanol or the like which exhibits a solubility higher than that of water (Patent Document Further Known - A method of maintaining a high viscosity of a sprayed liquid in order to suppress the vaporization of carbon dioxide, or a method of allowing a polyol to coexist at a high concentration in order to maintain a high concentration of carbon dioxide (Patent Documents 2 to 3). In the aerosol, a liquefied petroleum gas containing propane, isobutane and n-butane is used as a jet gas in order to form a foam. However, liquefied petroleum gas ❹ has a problem of strong ignitability and poor foaming at low temperatures. As a technique for solving the problem of the 5 hai, for example, it is known that the water is contained in the same manner as the sputum liquid or the liquefied petroleum gas containing water and the surfactant, and the safety of the fire is high, and the foaming property at a low temperature is also known. A non-degradable aerosol foam composition (patent document 4), in addition to the liquefied gas of 0 to 4% by mass, in addition to the liquefied gas of 0 to 4% by mass, a non-combustible gas is added by a compressed gas such as carbon dioxide. i foam; final product (Patent Document 5). It is also known that: in the stock solution containing the effective liquid water), the composition contains only n-butane and carbon dioxide, and the ignitability is low, and the low temperature foaming compared with liquefied petroleum gas is 139,550. Doc 200946141 A foaming aerosol composition which is excellent in properties and has high temperature and safety (Patent Document 6), but n-butane is expensive. Further, as an aerosol agent for promoting blood circulation using carbon dioxide together with a hydrocarbon oil, it is known to use a specific hydrocarbon such as isopentane or n-pentane in carbon dioxide to improve the foaming property of the foaming agent of the foaming agent. A skin blood circulation promoting agent (Patent Document 7), but does not disclose the effect of foam retention at a low temperature or when reducing the internal pressure of a pressure vessel.

[Patent Document 1] Japanese Patent Laid-Open Publication No. Hei. No. Hei. No. Hei. No. Hei. [Patent Document 5] Japanese Patent Laid-Open Publication No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. Content] [The problem that the invention wants to solve]

An object of the present invention is to provide a foam-like skin coating which has a low internal pressure in a container and which maintains a good foam at a low service and allows carbon dioxide to act on the skin for a long period of time to obtain a sufficient blood circulation promoting effect. Dressing. [Technical means for solving the problem] The inventor of the present invention has been able to obtain a coating agent for promoting the circulation of blood in Liangye, in order to obtain a coating agent for promoting the circulation of carbon dioxide for a long time on the skin. It was found that it was contained by 35. (: The vapor pressure below is 0.1 139550.doc •4·200946141 MPa or more and less than 〇5 MPa of saturated hydrocarbons as the main component of the hydrocarbon mixture having a carbon number of 3 to 5', and it is possible to dissolve carbon dioxide at a high concentration. When sprayed onto the skin, the foam containing a high concentration of carbon dioxide will remain on the skin for a long period of time, and a good foam can be formed at a low temperature, thereby having a good blood circulation promoting foamy skin coating agent. Provided is a foam-like skin coating agent which is prepared by filling a composition of a liquid and a gas into a pressure-resistant container so that the internal pressure is less than 7 MPa at 2 yc. The composition of the above liquid and gas includes the following Component (A), (A) Carbon dioxide (B) is selected from the group consisting of a hydrocarbon having a carbon number of 3 to 5, and the vapor pressure at 35 ° C in the above mixture is 〇.1 MPa or more and less than .5 MPa. a hydrocarbon mixture having a saturated hydrocarbon content of 70 to 100% by mass 〇.1 to 3% by mass (C) a surfactant 〇1 to 25% by mass, and a mass ratio of (A) to (B) (A: B) ) is 35 : 65 to 95 : 5. _ [Effect of the invention] Foamy skin coating of the present invention By the internal pressure of the container being a low pressure of less than 7 MPa, and the foam containing high concentration of carbon dioxide when sprayed onto the skin can be kept on the skin for a long time 'and the foam spreads on the skin,' thereby obtaining the skin The blood circulation promoting effect is excellent. Further, the sprayed foam is also stable at a low temperature. Therefore, it is easy to massage or the like on the skin. [Embodiment] The foamy skin coating agent of the present invention will contain the above ingredients. (B> 139550.doc 200946141 and (c) The composition of the liquid and gas is filled into a financial pressure vessel. The carbon dioxide of the component (A) is a foamed material of the present invention filled in a gas pressure form into a pressure resistant container. The active ingredient of the skin coating agent, which is also a component which functions as a propellant, is partially dissolved in the liquid in the pressure-resistant container, and is foamed when applied to the skin. Also, on the skin. The gaseous carbon dioxide in the foam and the carbon dioxide dissolved in the liquid portion have the effect of promoting blood circulation of the skin. Therefore, it is preferred to emulsify carbon in the container. The undulation is present in the above-mentioned liquid. The amount of carbon dioxide dissolved in the liquid in the above-mentioned pressure-pressure container is preferably 5 〇〇 to 25,000 ppm in terms of sufficient effect when applied to the skin. More preferably, it is 1,000 to 20,000 ppm, particularly preferably 5, 〇〇〇 18 18 〇〇〇 ppm. As for the hydrocarbon mixture of the component (B), the foamy skin coating agent of the present invention is applied to the skin. In the case of foaming together with carbon dioxide, it has a function of forming a foam containing carbon dioxide at a time. In order to press the coating agent of the present invention at 25 in a pressure resistant container. (: Under the maintenance of less than 7 MPa, and good foaming and blood circulation promoting effect when spraying, it is more important that the steam pressure of the above-mentioned hydrocarbon mixture is above Q1 Mpa and the saturation of the lower grade 5 chest The hydrocarbon is 70 to 100% by mass, and particularly preferably 80 to 100% by mass, more preferably 9 to 1% by mass, in terms of improving the effect at the time of use. 100% by mass. As the saturated hydrocarbon having a vapor pressure of 0.1 MPa or more and less than 0.5 MPa, the number of carbon atoms is 4 (4006 MPa), and the number of turns is 0.33 MPa. It is 5 new simmered (〇·23 MPa), isoprene (〇.13 dog, etc. Among them, the bubble at low temperature is good, f is preferable, if isobutane or n-butane is considered J39550.doc 200946141 In order to be economical, special use is to combine n-butane with iso-alkane. In: It is a hydrocarbon with a number of rabbits of 5, preferably isoprene.

In order to reduce the vapor pressure of the hydrocarbon mixture in order to reduce the vapor pressure of the carbon monoxide in the pressure vessel, in addition to the carbon number of 4: n-butane, it is preferred to use isopentane. In all the compositions in the pressure-resistant container, decyl isopentane having isopentane is 1.8% by mass in terms of the blood circulation promoting effect, and more preferably 12% by mass, particularly preferably 0.1 to 0.9% by mass. As the saturated hydrocarbon having a vapor pressure of more than 0.5 MPa at 35 C, an alkylate (1·25 MPa) or the like can be listed. Normally, liquefied petroleum gas (LPG) is a mixture of C: and butane' and is prepared to be grasped by adjusting the ratio of the mixed gas according to the purpose. In the present invention, in order to obtain a foam which is made to have a high pressure in a pressure-resistant container and which contains carbon dioxide at a high concentration and can be kept on the skin for a long period of time, it is preferred that the vapor pressure at a high pressure of 35t is relatively low. . It is preferred that the propane is not substantially formulated, but in view of industrial availability, the n-butane and/or isobutane:propane (mass ratio) contained in the LPG is preferably 70 to 100: 〇~30 , better is 90~99.9: 0.1~10, especially good is 97~99.5: 0_5~3. In a preferred embodiment of the hydrocarbon mixture having 3 to 5 carbon atoms, the hydrocarbon having a carbon number of $ is B1, the hydrocarbon having 4 carbon atoms is B2, and the hydrocarbon having 3 carbon atoms is B3. : B2 : B3 (mass ratio) is better 〇 ~ 75 : 15~100 : 〇 ~ 30 composition, better is 0~75 : 20~99 : 0.1~3 composition, especially good is 0~ 50 : 49 to 99 : a hydrocarbon mixture of 0.5-1. Further, the content of B2 is preferably 〇. 1 to 3 mass%, more preferably 139550.doc 200946141 is Ο.1 to 2 mass ° / in all compositions in the pressure vessel. Especially good is 0.3~1.5 mass 0/〇. In the present invention, the content of the component (B) is 0.1 to 3% by mass in all the compositions in the pressure-resistant container, but it is preferable in terms of satisfying both good foaming and blood circulation promoting effects. It is 0.2 to 25% by mass, and particularly preferably 0.5 to 2% by mass. /〇. Further, as for the mass ratio (A: B) of the components (A) to (B) filled in the pressure-resistant container, it is important to satisfy both the good foam and the blood circulation promoting effect. : 65~95: 5, in terms of blood circulation promoting effect, it is 45: 55~95: 5, especially good W: 45~90 · 1〇, especially good 6〇: 4 〇~85: 15. The component (B) is dispersed or emulsified, and the foamy skin coating agent of the present invention should be

Examples of the nonionic surfactant include a propylene glycol fatty acid ester, a montreal fatty acid ester, and a sorbitan fat. In the present invention, the surfactant of the component (C) is contained in a liquid. And

139550.doc 200946141 Acid s曰' polyoxyethylene sorbitol needle fatty acid cool, polyoxyethylene sorbitan oligosaccharide S 曰 polyglycol fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, Pentaerythritol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether 'polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene - alcohol, polyoxyethylene sesame oil, polyoxyethylene Dilute hardening sesame oil, polyoxyethylene alkyl amine, polyoxyethylene fatty acid amine, hospital base alcohol amine, hospital based glycerin mystery, glucosamine, alkyl polyglucoside, amino acid vinegar, polyether A modified anthrone or a modified alkyl ketone or the like, an alkylpolysaccharide or the like. Examples of the anionic surfactant include a burnt-based sulfate, a polyoxyethylene burnt-sulfate, a polyoxyethylene alkyl phthalate, an N-glycosyl acid salt, an alkyl phosphate, and a poly Oxyethylene alkyl ether phosphate, fatty acid salt, fluorenyl sulfonate, alkyl sulfonate, alkyl sulfoacetate, alkyl sulfosuccinate, polyoxyethylene alkyl sulfosuccinate Salt and so on. Examples of the salt include an alkali metal salt such as sodium, potassium or lithium; an alkanolamine salt such as triethanolamine, diethanolamine or monoethanolamine; and an alkali amino acid salt such as aminic acid or arginine. Examples of the cationic surfactant include an alkyltrimethylammonium salt, a calcinyl monomethyl I* salt, a succinylpropyltrimethylammonium salt, and a pyridyl dimethylammonium salt. Ammonium or amine salt. By adding these components, in addition to the foaming property, a bactericidal action, a care effect, an antistatic effect, and the like can be obtained. As an amphoteric surfactant, in order to enhance the foaming power, etc., an alkyl dimethyl amine oxide, an alkyl dimethyl amino acetic acid betaine, an alkyl amidopyl propyl betaine, an alkyl sulfo group may be added as needed. Betaine, alkyl hydroxy sulfobeet 139550.doc 200946141 Alkali-dishylmethyl group by base ethyl imipenem beet test. The towel and the ampoules are selected from the group consisting of a nonionic surfactant and an anionic surfactant, or two or more kinds thereof. As the nonionic surfactant, glycerin fatty acid vinegar, polyoxyethylene glycerin fatty acid vinegar, sorbitan fatty acid ester, polyoxyethylene sorbitol liver fatty acid vinegar, poly (ethylene sorbitan fatty acid) are preferred. Stuffed, polyethylene glycol fatty acid ester, polyglycerin fatty acid vinegar, sucrose fatty acid sputum, polyoxyethylene sulphur scream, polyoxyethylene hard stalk sesame oil $ oxyethylene alkylamine, polyoxyethylene fatty acid amine , the base of the alcohol-burning amine 16-based glycerin, burnt-based polyglucose, amino acid vinegar and the like. Further, as the anionic surfactant, a polyoxyethylene ketone sulfate, a polyoxyethylene ketone acetate, a ruthenium sulfhydryl acid salt, a ketone sulfonate, a fatty acid salt or the like is preferable. Among these surfactants, those having an alkyl chain having a carbon number of 8 to 16 are preferred in terms of stability of the blistering on the skin. Among these surfactants, the above-mentioned nonionic surfactant and polyoxyethylene alkyl ether sulfate are particularly preferable in terms of foaming property, foam stability on the skin, and foam touch. A polyoxyethylene alkyl ether acetate, a fluorenyl-mercapto-amino acid salt or an alkyl phosphate is used in combination. In terms of the stability of the blister on the skin and the sensation of the blister, it is preferable that the amount of the surfactant is large, and on the other hand, in terms of skin irritation and the like, due to a large amount of The use causes irritation and the like, and therefore the surfactant is preferably in the range of 0.1 to 25% by mass in the total amount of all the compositions in the container. In particular, in the rinsing agent such as a detergent or a massage agent, it is preferably 2 to 20% by mass, more preferably 4 to 16% by mass. Further, 139550.doc 200946141 In a system in which an emulsion or a lotion directly remains on the skin, it is preferred that (M~1〇% by mass is more preferably 2 to 6% by mass, particularly preferably 〇 .3~3 = quantity %. As for carbon dioxide, it does not form carbon dioxide in an experimental environment, but forms a carbonate, so it does not produce a blood circulation promoting effect. Therefore, carbon dioxide is dissolved at a high concentration to obtain excellent results. In terms of the effect of the blood circulation promoting effect, the pH of the above composition is preferably from 2. 5 to 7, particularly preferably from ❹ 4·5 to 6·5. When the enthalpy is adjusted to the ranges As the pH adjusting agent, for example, an organic acid such as citric acid, malic acid or tartaric acid or a salt thereof or a dish acid or a salt thereof can be used. In the case of the skin-like skin of the present invention, in order to stably maintain the above The viscosity of the liquid filled in the pressure-resistant container is preferably 1〇〇~5 in the dispersed or emulsified state of the component (Β) and in order to maintain a good blood circulation promoting effect in order to maintain a carbon oxide in the foam applied to the skin. 〇〇〇〇〇mb s, better is 200 to 200,000 mPa.s, particularly preferably 3〇〇~5〇〇〇〇© mPa'S. In particular, in order to prevent separation of the above component (B) in the pressure-resistant container, a good foam cannot be obtained, preferably 100 mPa. On the other hand, in consideration of the spout property or the bubble state, and the industrially stable production, when the pressure vessel is a single-chamber structure spray container, it is preferable that ^^'00 〇mPa's, in the above-mentioned pressure vessel is a double-structured aerosol container, it is preferably 1, 〇〇〇~50,000 mPa.s. In order to adjust the viscosity of the liquid filled into the pressure vessel, it is better. (D) Viscosity modifier is used. As the viscosity modifier, any of the synthetic or semi-synthetic natural molecules can be used as a synthetic system, and examples thereof include carboxy 139550.doc 200946141-based ethylene polymer, propylene Examples of the acid-saturated ester copolymer, the acrylic acid-acrylic acid ester copolymer, the acrylic acid-alkyl acrylate copolymer, and the acrylic acid-based polymer of polyacrylic acid include polyvinyl alcohol and polyvinylpyrrolidone. Synthetic high scores such as polyethylene glycol and polymer fluorenone Further, in the semi-synthetic system or the natural system, a polysaccharide-based polymer, specifically microcrystalline cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, may be mentioned. , cellulose polymer such as hydroxypropyl decyl cellulose, carboxy mercapto cellulose, cationized cellulose; sinosaur, hydroxypropyl sinica, sulphate powder, cyclodextrin, poly Microbial polymers such as dextran, curdlan, and amber sterol; starch, soluble starch, carboxylated starch, methyl starch, starch vinegar, etc.; guar gum (guar gum), cationized guar gum hydroxypropylated guar gum and other guar gum polymers; alginic acid polymers such as propylene glycol alginate and sodium alginate; carrageenan, agar , qUinee seed gum, mannan, dextrin, dextrin fatty acid ester, L〇cust bean gum, Arabian Gum, yellow f gum (tragacanth) Gum), pectine, chitin (c) Hitin) and so on. As for the total amount of all the compositions of the viscosity adjusting agent containing 1' in the granule, it is preferably 〇1 〇 1 〇 1% by weight, particularly preferably 0.05 to 5% by weight. In the case of the stability of the carbon dioxide, it is preferred to contain an acrylic polymer, and it is preferred to use a polysaccharide-based polymer in combination. The content of the acrylic polymer is preferably 〇0.05 to 3% by weight based on the total amount of all the components in the container, and particularly preferably 139,550.doc • 12 to 200946141 0_05 to 2% by weight. Further, when a polysaccharide-based polymer is used in combination with the acrylic polymer, the polysaccharide is preferably a high molecular weight of 0.01 to 5% by weight based on the total amount of all the components in the container, and particularly preferably 〇.〇5~ 3 wt%. For example, the foamy skin coating agent of the present invention is in the form of a detergent, and a polyoxyethylene alkyl ether sulfate, a polyoxyethylene alkyl ether acetate, a hydrazine-based amino acid salt, an alkyl phosphate, or the like is used. When the anionic surfactant is used as the surfactant, it is preferred to use one or two or more kinds of the polysaccharide-based polymer alone or in combination with the polysaccharide-based polymer. More specifically, it is preferred to use at least one or more of an acrylic polymer and a polysaccharide polymer in the alkyl phosphate in combination with the acrylic polymer and the fluorenyl amino acid salt. It is preferred to use an acrylic polymer and a cellulose-based two molecules in one or more selected from the group consisting of polyoxyethylene alkyl ether sulfates and polyoxyethylene alkyl ether acetates. Further, the foamy skin coating agent of the present invention may further contain water, alcohols, oils, humectants, perfumes, plant extracts, bactericides, preservatives, chelating agents and the like. The foamy skin coating agent of the present invention is produced by filling the above components (A), (B), (C) and other components into a pressure-resistant container. For example, after filling the pressure-containing container with the liquid containing the component (C), the component (A) carbon dioxide and the component (B) hydrocarbon mixture are further filled. At this time, other injection gases may be filled as needed. As the pressure-resistant bar, it is preferable that the content liquid can be ejected in a foam form. For example, a can of a single-chamber structure made of a metal such as aluminum or tinplate can be used, and as a container material, if it is under pressure In the limit, 139550.doc 13 200946141 A synthetic resin container such as an acetal resin or a polycarbonate resin, or glass may be used. In particular, it is preferable to adjust the impact material of the wall thickness of the container when the high-pressure carbon dioxide is filled in the industry. Further, depending on the viscosity of the stock solution, a double container having an inner bag in the pressure resistant container can also be used. In the case of a double container, the spray composition of the present invention is filled into the inner bag to fill other jet gases between the pressure resistant container and the inner bag. The injection gas can be used if it is a gas used for usual spraying. The pressure in the pressure-resistant bar is less than 7 Mpa at 25 ° C. In terms of obtaining good foam, it is preferably 〇 4 MPa or more and less than 7 MPa, more preferably 〇. 45 MPa or more and less than 7 Mpa, particularly preferably 0.5 to 0.65 MPa. It is preferred to apply the foamy skin coating agent of the present invention to the skin to spread the generated foam on the skin. Here, as a method applied to the skin, it can be directly sprayed onto the desired skin and formed into a foam at the portion; it can also be sprayed onto the hand to form a foam, and then coated/coated. On the skin of hope. The foam formed by the foam coating agent of the present invention can be kept stable for a long period of time, and even if it is subjected to an operation for diffusing it on the skin, a gentle massage or the like is stable, a high concentration of carbon dioxide acts on the skin for a long time, and is produced. Excellent blood circulation promoting effect. Therefore, the foamy skin coating agent of the present invention can be used as a cosmetic or external preparation for skin, and can be used as a detergent for skin, a hair wash, a makeup remover, a massage agent, a pack mask agent. , cream, lotion, lotion, beauty lotion, skin care agent, hair conditioner, makeup, aroma, deodorant, decolorizer, hair removal, hair removal, hair growth. 139550. Doc -14- 200946141 Hair care, as well as acne, etc.: Anti-seven.M ^ ^ sb therapeutic coating agent. Wipe, anti-edema or edema prevention or treatment can be adjusted to be effective. , wipes, etc. According to the knives, for example, for cosmetics (including washing materials), in addition to the above humectant, an anti-caries agent (υν·Α and/or an absorbent/reflectant), a whitening agent, and a body lotion may be used. , deodorant, antiperspirant (antip (1) Pirant), shrinking agent 1 cooling agent, various synthetic vitamins of wrinkle aging inhibitors, derivatives of strontium and its derivatives, amino acids and derivatives thereof. As an active ingredient of the hair growth and hair growth material, various blood flow promoters, plant extracts, and the like can be used. As the massage or rubbing agent, various anti-inflammatory agents or local anesthetics, anti-inflammatory analgesics, antihistamines, bactericides and the like can be added. [Examples] Examples 1 to 8 and Comparative Examples 1 to 4 According to the conditions described in Table 1, the components other than A and B were mixed to prepare a stock solution (liquid component), and after filling into a pressure-resistant container, the hydrocarbons were sequentially filled. The aerosol composition was obtained by mixing _ (B) and carbon dioxide (A). The resulting aerosol composition was at 25. (: After 1 week of storage, 'evaluation of foam stability and skin blood flow. At this time', in all the compositions, the pH is less than 7. The viscosity is BM' type viscometer (Dongji Industry Co., Ltd.), The measurement temperature was set to 25 ° C, and the measurement was performed by the measurement conditions of the rotor Ν ο 2, 30 r / min, and 1 minute. Further, the amount of the fragrance in the table was 0.03% by mass. 139550.doc 15· 200946141 Ιί ΙΌ ϊ·° 0Ί 8·€ S01 SS ^_ loels.o sc ¥¥~ ΓΟ ·0 •I 6Τ •ι •ι 6·Ζ SI 5 ΙΟ ι·0 Οϊ ·{: i ^_ -4 meals^ ◎ νό —0811— 08121 0ΓΙ ΤΙΤε1961 ¥i~ S Γ0 ·0 οτ 9Ί 0 ΙΌ ·0 s •e ε5 om Τ9·0 ο: οοι W~ S Γ0 Γ0 ◎ 08Τ ^_ ^ο.ϊ ^_ 6Γ0 ^_

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形成. Forming the beads and keeping them for 2 minutes △: Although foam is formed, it collapses. X does not form foam. (3) Skin blood flows to the front wrist to spray the beads to 3 _, (4) 2 minutes after wiping off the foam, visual Observe the state of the skin (skin redness). ◎: a clear red tide was observed 〇: a red tide was observed Δ: a slight red tide X: no red tide was observed As a result, in the examples 丨8 of the present invention, carbon dioxide was dissolved at a high concentration, and 25 was further obtained. (The foam underneath is good, and the skin redness is seen. In addition, regarding the blood flow of the skin, in the same way as (3), the beads are sprayed on the front wrist and wiped off. After 5 seconds, the blood is used immediately. The flow imaging device FLPI (manufactured by M〇or Instruments, m〇〇rFLpi) measures the blood flow of the skin tissue and compares it with the blood flow when the skin is not applied. The result is that the skin is 139550.doc 200946141 The flow rate is increased. In the table, when the ratio of the component (A) is 30% by mass or less (Comparative Example 1), no red tide is observed, and blood flow promoting effect is hardly observed. Further, the ratio of the component (4) When the mass is % and the material contains the component (b) (Comparative Example 2), the red tide of the skin can be clearly seen, and the blood flow promoting effect is also remarkably increased, but the foam collapses and the stability of the foam is poor. Further, if the component W is used, The hydrocarbon mixture under the pit and the ratio of saturated hydrocarbons above MPa and less than 5 MPa to less than 7 Qf of the hydrocarbon mixture (comparative) results in an internal pressure exceeding 〇.7 MPa. Further, the viscosity is lower. The composition liquid of Comparative Example 4 was separated, because This was not evaluated. Examples 9 to 14 and Comparative Example 5 According to Table 2, components other than AAB were kneaded to prepare a stock solution. The raw liquid, carbon dioxide, and hydrocarbon mixed gas were sealed to a pressure-resistant container to obtain a spray. The composition was evaluated for the stability of the material and the blood flow of the skin after the week. At this time, in the composition, the pH was less than 7. i * . The blending amount of the medium is 〇μ mass%. 苟υ·苟υ3 139550.doc 200946141 _ i ¥1 ~~ ro 10 0·ϊ 3 SI 8Tf 10 10 1.0 0.1 6·£ Sεζ/ϊ SS 1.0 01 5 SI 10 10 Γ0 0.1 6·ε SOI SO.Iε.ι #Η Γ0 10 0.1 S 9.1 8ΤΤ το ϊο 10 0·ι 6Ύ 696.0 6960 5.1 #妹ΓΟϊοο.ίο.ε 9.Ϊ 6., 10 ϊο ϊοΟΙ 3 S 9Ssso εε.Ι 09ε

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*# Avoid fr-镏S-蚪澈葙(%09)镏资-^94 澈镏镏镏J-^is-IP 鮏ue 镏鍩-B-fs-M #龄沭塯域装装fiB--key 袈¢ 铋 铋 to to to to to to ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( 8<s: u=^«: Yue Bu Mi: Domain hlr ϊ * 139550.doc -19- 200946141 , ·-. As is apparent, in Examples 9 to 14 of the present invention, carbon dioxide was dissolved at a high concentration, and the foam stability at 25 C was good, and a red tide of the skin was observed. In Comparative Example 5 using only isodecane as the component (B), the foam at a low temperature (5 ° C) was liable to collapse. Examples 15 and 16 The foamy moisturizing liquid (Example 丨 5) and the foamy cosmetic liquid (Example 16) shown in Table 3 were prepared and stored at 25t for a week after foam stability and skin blood machine. Comment. Also, measuring each stock solution? ] ^ value (25 it), together with = table 3. Further, in the measurement of the pH value, a positive meter (F-52, which is θ-formed by Horiba, Ltd.) was used. The stability of the foam is good, and the effect of skin blood flow is also seen. Further, the amount of the fragrance in the table was 0.03 mass 〇 / 〇. I39550.doc 20· 200946141 [Table 3] Ingredient (% by mass) Example 15 Example 16 (A) Carbon dioxide 1.22 1.22 (B) Liquefied petroleum gas (0.15 MPa, 20 ° C) Wood 1 0.405 0.405 (B) Isopren Alkane 0.405 0.405 (C) Polyoxyethylene hardened castor oil (60E.O.) 0.3 (C) Polyoxyethylene isocetyl ether (20E.O.) 0.2 - (C) dimethyloxoxime-methyl ( Undecylglycerol mystery copolymer 0.1 - acrylic acid-alkyl methacrylate copolymer 0.3 0.3 squalane - 0.5 dipentyl neodecyl glycol ester - 2.9 dl-α-tocopherol acetate 0.01 0.01 Ascorbate dipalmitate 0.01 ubiquinone - 0.01 decyl polyoxane (2CS) 0.1 0.2 glycerol (86%) 7.8 7.8 13-butanediol 2 2 polyethylene glycol 1540 2 2 dipropylene glycol 2.9 D-pan Alcohol 0.1 Ethanol - 6.3 Potassium Hydroxide Solution (48%) 0.2 0.2 Tea Extract 0.1 Eucalyptus Extract 0.2 Pomelo Extract - 0.1 Methylparaben 0.2 0.3 Good amount of appropriate amount of ion exchange water remaining rest Α Α : : ΒΙ 60 : 40 60 : 40 pH of the stock solution (25 ° C) 6.0 6.4 Internal pressure i25 ° C) iMPa) 0.64 0.64 Viscosity i25 ° C) imPa-s) 27200 14600 Bubble stability 〇 skin red tide ◎ ◎

Wood 1 n-butane: isobutane: propane burning = 71 : 28 : 1 mass. / 〇 Examples 17 to 22 The foamy skin coating agents described in Table 4 were prepared, and after one week of storage at 25 ° C, foam stability and skin blood flow were evaluated. Further, the pH value (25 ° C) of each stock solution was described in Table 4. The stability of the foam is good, and the effect of blood flow to the skin is also seen. 139550.doc -21 - 200946141 I I βί^τ _ ss^ - si^ _ (%¥輙) 喊 [inch^]

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Claims (1)

200946141 VII. Patent application scope: - a foamy skin coating agent which is filled with a composition containing a liquid and a gas into a pressure-resistant container so that the internal pressure becomes less than 〇 at 7 ° C, 7 MPa The above liquid and gas containing composition comprises the following components (A), (B) and (C): (A) carbon dioxide (B) 0.1 to 3% by mass of a hydrocarbon mixture 'the hydrocarbon mixture is selected from the number of breaks a mixture of hydrocarbons of 3 to 5 in which the vapor pressure at 35 ° C is more than 0.1 MPa and the saturated smoke content of less than 0.5 MPa is 7 〇 〜1 〇〇 mass % (C) surfactant 0.1 ～25 mass%, and the mass ratio of (A) to (B) (A: B) is 35: 65 to 95: 5. 2. The foamy skin coating agent of claim 1, wherein the amount of carbon dioxide dissolved in the liquid in the pressure resistant container is 500 to 25, 〇〇〇 ppm. 3. The foamy skin coating agent of claim 1, wherein the (B) hydrocarbon mixture comprises n-butane having a carbon number of 4 and isobutane. 4. The foamy skin coating agent of claim 1, wherein the (B) hydrocarbon mixture comprises a hydrocarbon having a carbon number of 4 and a hydrocarbon having a carbon number of 5, and a hydrocarbon having a carbon number of 5 is contained in the above-mentioned resistant container The composition in the above composition is 〜1 to 18% by mass. The foamy skin coating agent according to any one of claims 1 to 4, wherein the liquid in the above composition has a pH of 2.5 to 7. The foamy skin coating agent according to any one of claims 1 to 4, wherein the viscosity of the liquid in the pressure resistant container is from 1 500 to 500,000 mPa·s. The foamy skin coating agent according to any one of claims 1 to 4, wherein the above-mentioned 139550.doc 200946141 8. 9. 10. The pressure-resistant container is a single-chambered aerosol container. The foamy skin coating agent according to any one of claims 1 to 4, wherein the pressure resistant container is a double-structured aerosol container. The foamy skin coating agent according to any one of claims 1 to 4, wherein the foam formed by ejecting the pressure vessel from the pressure vessel spreads on the skin to promote blood circulation of the skin. The foamy skin coating agent of any one of claims 1 to 4 which spreads on the skin by foaming the foam formed by ejecting the pressure vessel from above to press the skin. 139550.doc 4 ' 200946141 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best display invention. Chemical formula of the feature: (none) 139550.doc