JPH04169525A - Composition having serum lipid-improving function - Google Patents

Abstract

PURPOSE:To provide the subject composition containing squalene, a fish oil and vitamin E as essential components capable of being ingested as a food or as a component for other foods, exhibiting a blood lipid-improving effect within a short period, and having no adverse action. CONSTITUTION:The composition contains (A) squalene, (B) a fish oil preferably containing eicosapentaenoic acid and docosahexaenoic acid in large amounts, especially >=20wt.% and >=10wt.%, respectively, and (C) vitamin E as essential components. preferably further (D) soybean lecithin and (E) a vegetable oil preferably containing linoleic acid and gamma-linolenic acid in large amounts, especially >=50wt.% and >=7wt.%, respectively, preferably in a ratio comprising A=30-85wt.%, B, D, E=5-50wt.%, respectively, and C=0.1-10wt.%. The composition has a thrombogenesis-preventing action and a thrombosis-treating activity which are useful for preventing and treating cerebral thrombosis and cardiac infarction.

Description

[Detailed description of the invention] <Industrial application field> The present invention relates to a composition having a serum lipid improving function.

<Background of the invention> In recent years, adult diseases such as cancer, heart disease, and stroke have been increasing significantly, and since several years ago, the number of deaths from these three diseases has increased by 3.
As a major cause of death, it ranks in the top three in the total number of deaths each year.

Among these diseases, the main trigger for heart disease and stroke is so-called hyperlipidemia, in which blood cholesterol, phospholipids, triglycerides, etc. greatly exceed the normal range. That is, hyperlipidemia is a major cause of arteriosclerosis, and arteriosclerosis causes serious ischemic disorders in various organs rich in arterioles, including heart disease and stroke. Arteriosclerosis also contributes to high blood pressure, which also increases the risk of developing heart disease and stroke.

The cause of the increase in hyperlipidemia is thought to be mainly due to a change in dietary habits from a conventional diet centered on fish and vegetables to a diet centered on livestock meat such as beef and pork. Beef and pork contain a lot of cholesterol, etc., which penetrates and accumulates under the vascular endothelium, forming aromatic tumors, pushing up the vascular endothelium and narrowing the vascular lumen. In addition, beef and pork contain a large amount of arachidonic acid, which strengthens the aggregation of platelets and promotes the hyperplasia of blood clots. These factors cause thrombosis and embolism, that is, myocardial infarction and cerebral infarction.

<Problem to be solved by the invention> Conventionally, in order to prevent or treat such hyperlipidemia,
Although it is said that it is necessary to improve eating habits and increase the amount of exercise, it is not necessarily easy to continue to do these things in daily life. Furthermore, various preventive and therapeutic agents are known, but they have problems such as insufficient efficacy and large side effects. There were also problems such as the need to take it as a medicine.

Therefore, if a composition with a serum lipid improving effect that can be taken as food or mixed with food without side effects is developed, it would be expected to have a huge impact on a wide range of health. It is desired to develop more such compositions.

The present invention was made in response to such demands, and provides a composition that can be taken as a single food product or mixed with food products, and that exhibits an excellent serum lipid improving effect. The purpose is to

<Summary of the Invention> In order to achieve the above object, the present inventors focused on the effects of various unsaturated fatty acids and unsaturated hydrocarbons in vivo, and targeted various components including α-linolenic acid. As a result of repeated experimental research on the types and ratios of effective compounding materials, we have developed a composition that can be taken as food or mixed with food, and that has an excellent serum lipid improvement effect. I ended up developing it.

That is, the composition having a serum lipid improving effect according to the present invention is basically characterized by containing squalene, fish oil, and vitamin E. In addition to these, it is desirable to contain soybean lecithin and vegetable oil.

Fish oil usually contains eicosapentaenoic acid and docosahexaenoic acid, and since these greatly contribute to the serum lipid improving effect, it is desirable to use a fish oil containing a large amount of eicosapentaenoic acid and docosahexaenoic acid. In addition, some vegetable oils contain linoleic acid and γ-linolenic acid, and these also have the effect of improving serum lipids, so it is desirable to use vegetable oils that contain a large amount of linoleic acid and γ-linolenic acid. Evening primrose oil contains large amounts of linoleic acid and γ-linolenic acid.

According to research by the present inventors, the content ratios of each of the above components are squalene: 30 wt% or more and 85 wt% or less, and fish oil: 5 wt% or more and 50 wt% or less.

Soybean lecithin: 5wt% or more and 50wt% or less, vegetable oil: 5wt% or more and 50wt% or less, vitamin E: 0.1w
The serum lipid improving effect was highest when the content was t% or more and 10 wt% or less.

Further, it is desirable that the fish oil contains 20 wt% or more of eicosapentaenoic acid and 10 wt% or more of docosahexaenoic acid from the viewpoint of serum lipid improving effect.

In addition, it is desirable that the vegetable oil contains 50 wt % or more of linoleic acid and 7 wt % or more of γ-linolenic acid from the viewpoint of improving the serum lipid improving effect. Furthermore, it is desirable that vitamin E contains 60 wt% or more as total tocopherol.

The above composition can be used as it is as a liquid food material, but it may also be used by blending it with other food materials such as salad oil.

<Example> The effectiveness of the above composition was confirmed through clinical trials.

An example thereof will be described below.

Example 1: Regarding 10 people who had already been diagnosed with hyperlipidemia,
The following clinical trials were attempted. That is, 900 mg of the composition according to the present invention having the following ingredients was ingested as food at each meal three times a day. Continued intake for 4 months,
Blood total cholesterol, phospholipid, triglyceride, β-riboprotein, free cholesterol, and HDL cholesterol values were tested every month. The result is 1
Figure 1 shows the average value for 0 people.

The range of normal values or reference values for each test item is: total cholesterol: 120 mg or more, 250 mg
/ dl or less, phospholipid: 150mg or more 280mg
/di or less, neutral fat: 40 mg or more 170 mg
/di or less, β-lipoprotein: 200mg or more 550mg
/dl or less, free cholesterol: 30 mg or more 60
mg/dl or less, and HDL nylsterol is 40 mg or more and 70 mg/dl or less for men and 45 mg or more and 75 mg/dl or less for women.

(Composition) Squalene: 55.56wt% Fish oil:
16.67wt% soybean lecithin: 12.22wt% evening primrose oil: 13.33wt% vitamin E oil;
2.22wt% The composition of each component is as follows.

Squalene: 99.9% purity Fish oil: 23.0 wt% eicosapentaenoic acid and 12.0 wt% docosahexaenoic acid. ．． 0wt% plus 1 vitamin E
．． Contains 2% Soybean lecithin: 60.0% as acetone insoluble matter Evening primrose oil: Contains 60.0wt% linoleic acid and 7.5wt% γ-linolenic acid Vitamin E: Contains 70.0% as total tocopherol Figure 1 As can be seen from the clinical test results, the composition according to the present invention already showed sufficient effects at the time of testing one month after the start of intake, and had a well-balanced effect on all types of blood lipids. It has been obtained. Moreover, no side effects were observed.

Example 2: The same composition as in Example 1 was administered at 2700 mg/day to 4500 mg/day to 28 people who had conventionally high blood lipid levels and were concerned about their progression and who wished to sample the composition according to the present invention. After administering the drug for 6 consecutive months, I experienced chronic headaches and a feeling of headache that I had been suffering from for a long time.

Stiffness in the neck and shoulders completely disappeared within the second half of the second or third day after starting the intake, and within about five days at the latest. Furthermore, no side effects or other abnormalities were observed.

Example 3: The same composition as in Example 1 was orally administered to 20 rats at 8 g/kg daily for one month continuously.

Further, 42 g/kg of the composition was orally administered to 20 mice every day for one month. After that, the condition was observed for 10 days, but there was no death, and there was no toxicity at all.

That is, acute toxicity is LD. It was confirmed that the weight was 35 g/kg or more.

As shown in the above examples, the composition of the present invention can be ingested as a food product or mixed into a food product, and has an extremely excellent serum lipid improving effect.

<Effects of the Invention> As explained above, the composition of the present invention can be ingested as a food product or mixed with other food products, and has the effect of improving blood lipids in a short period of time. No side effects.

Therefore, it has antithrombotic and thrombotic treatment effects.
It can be used for the prevention and treatment of cerebral infarction and myocardial infarction.

[Brief explanation of drawings]

FIG. 1 is a graph showing changes in the amount of serum lipids such as cholesterol in Example 1. Patent applicant Nissei Marine Industry Co., Ltd. Agent
Patent attorney Kiyoshi Takahashi

Claims (1)

[Scope of Claims] 1) A composition containing squalene, fish oil, and vitamin E and having a serum lipid improving function. 2) A composition containing squalene, fish oil, soybean lecithin, vegetable oil, and vitamin E and having a serum lipid improving function. 3) Squalene, fish oil rich in eicosapentaenoic acid and docosahexaenoic acid, soybean lecithin, vegetable oil rich in linoleic acid and gamma-linolenic acid, and vitamin E.
A composition having a serum lipid improving function. 4) Squalene: 30wt% or more and 85wt% or less, Fish oil: 5wt% or more and 50wt% or less, Soybean lecithin: 5wt
% or more and 50wt% or less, vegetable oil: 5wt% or more and 50wt
% or less, and vitamin E: 0.1 wt% or more and 10 wt% or less. 5) The composition having a serum lipid improving function according to claim 4, wherein the fish oil contains 20 wt% or more of eicosapentaenoic acid and 10 wt% or more of docosahexaenoic acid. 6) The composition having a serum lipid improving function according to claim 4, wherein the vegetable oil contains 50 wt% or more of linoleic acid and 7 wt% or more of γ-linolenic acid.