JPH0352524Y2 - - Google Patents

Info

Publication number

JPH0352524Y2

JPH0352524Y2 JP12611688U JP12611688U JPH0352524Y2 JP H0352524 Y2 JPH0352524 Y2 JP H0352524Y2 JP 12611688 U JP12611688 U JP 12611688U JP 12611688 U JP12611688 U JP 12611688U JP H0352524 Y2 JPH0352524 Y2 JP H0352524Y2

Authority

JP

Japan

Prior art keywords

storage chamber

water

osmotic pressure

solution

electrolyte

Prior art date

1988-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
• 239000000243 solution Substances 0.000 claims description 46
• 230000003204 osmotic effect Effects 0.000 claims description 44
• 239000003814 drug Substances 0.000 claims description 43
• 229940079593 drug Drugs 0.000 claims description 32
• 239000000411 inducer Substances 0.000 claims description 29
• 239000012528 membrane Substances 0.000 claims description 29
• 239000008151 electrolyte solution Substances 0.000 claims description 21
• 239000003792 electrolyte Substances 0.000 claims description 17
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 239000012466 permeate Substances 0.000 claims description 3
• 230000001939 inductive effect Effects 0.000 claims description 2
• -1 lidocaine) Chemical compound 0.000 description 13
• 239000000126 substance Substances 0.000 description 13
• 239000005667 attractant Substances 0.000 description 12
• 230000031902 chemoattractant activity Effects 0.000 description 12
• 239000007864 aqueous solution Substances 0.000 description 10
• 239000007788 liquid Substances 0.000 description 10
• 239000002202 Polyethylene glycol Substances 0.000 description 8
• 229920001971 elastomer Polymers 0.000 description 8
• 229920001223 polyethylene glycol Polymers 0.000 description 8
• 239000005060 rubber Substances 0.000 description 8
• 229910052783 alkali metal Inorganic materials 0.000 description 6
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 6
• 230000010287 polarization Effects 0.000 description 6
• 229920006395 saturated elastomer Polymers 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 230000007423 decrease Effects 0.000 description 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
• 238000002347 injection Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 238000000520 microinjection Methods 0.000 description 3
• 239000007784 solid electrolyte Substances 0.000 description 3
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
• 102000004877 Insulin Human genes 0.000 description 2
• 108090001061 Insulin Proteins 0.000 description 2
• 229940035676 analgesics Drugs 0.000 description 2
• 239000000730 antalgic agent Substances 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 229940041181 antineoplastic drug Drugs 0.000 description 2
• 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
• 229920002301 cellulose acetate Polymers 0.000 description 2
• 238000009792 diffusion process Methods 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000004744 fabric Substances 0.000 description 2
• 150000004820 halides Chemical class 0.000 description 2
• 229960002897 heparin Drugs 0.000 description 2
• 229920000669 heparin Polymers 0.000 description 2
• 238000009434 installation Methods 0.000 description 2
• 229940125396 insulin Drugs 0.000 description 2
• 239000000463 material Substances 0.000 description 2
• 239000008155 medical solution Substances 0.000 description 2
• 238000000034 method Methods 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 2
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
• 229920003002 synthetic resin Polymers 0.000 description 2
• 239000000057 synthetic resin Substances 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 239000005062 Polybutadiene Substances 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 229910001508 alkali metal halide Inorganic materials 0.000 description 1
• 150000008045 alkali metal halides Chemical class 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000003416 antiarrhythmic agent Substances 0.000 description 1
• 229910052788 barium Inorganic materials 0.000 description 1
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
• MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 238000007599 discharging Methods 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000005484 gravity Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 229960004194 lidocaine Drugs 0.000 description 1
• 229910052744 lithium Inorganic materials 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920002857 polybutadiene Polymers 0.000 description 1
• 239000011148 porous material Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 238000001223 reverse osmosis Methods 0.000 description 1
• 229910052701 rubidium Inorganic materials 0.000 description 1
• IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 229920002379 silicone rubber Polymers 0.000 description 1
• 239000004945 silicone rubber Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 229910052712 strontium Inorganic materials 0.000 description 1
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
• 239000008399 tap water Substances 0.000 description 1
• 235000020679 tap water Nutrition 0.000 description 1
• 229920001169 thermoplastic Polymers 0.000 description 1
• 239000004416 thermosoftening plastic Substances 0.000 description 1
• 239000002699 waste material Substances 0.000 description 1