JPH02209153A - Liquid chemical transporting tube - Google Patents
Liquid chemical transporting tubeInfo
- Publication number
- JPH02209153A JPH02209153A JP1030894A JP3089489A JPH02209153A JP H02209153 A JPH02209153 A JP H02209153A JP 1030894 A JP1030894 A JP 1030894A JP 3089489 A JP3089489 A JP 3089489A JP H02209153 A JPH02209153 A JP H02209153A
- Authority
- JP
- Japan
- Prior art keywords
- ethylene
- layer
- drug solution
- liquid chemical
- transport tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 28
- 239000000126 substance Substances 0.000 title claims abstract description 27
- 229920000915 polyvinyl chloride Polymers 0.000 claims abstract description 22
- 239000004800 polyvinyl chloride Substances 0.000 claims abstract description 22
- 229920001577 copolymer Polymers 0.000 claims abstract description 19
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000005977 Ethylene Substances 0.000 claims abstract description 18
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910002091 carbon monoxide Inorganic materials 0.000 claims abstract description 12
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940117927 ethylene oxide Drugs 0.000 claims abstract description 10
- 229920005989 resin Polymers 0.000 claims abstract description 9
- 239000011347 resin Substances 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims description 51
- 229940079593 drug Drugs 0.000 claims description 50
- 239000010410 layer Substances 0.000 abstract description 23
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract description 21
- 239000012790 adhesive layer Substances 0.000 abstract description 8
- 229920001567 vinyl ester resin Polymers 0.000 abstract description 8
- 150000001336 alkenes Chemical class 0.000 abstract description 7
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 4
- 239000004709 Chlorinated polyethylene Substances 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000010030 laminating Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 42
- 239000005038 ethylene vinyl acetate Substances 0.000 description 19
- 238000007789 sealing Methods 0.000 description 14
- 239000002960 lipid emulsion Substances 0.000 description 9
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 7
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 7
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000004014 plasticizer Substances 0.000 description 7
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 241000156978 Erebia Species 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001038 ethylene copolymer Polymers 0.000 description 1
- -1 ethylene, propylene, vinyl Chemical group 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、医療用として用いられる薬剤容器に連結して
使用され、該薬液容器内の薬液が通流される薬液輸送チ
ューブに関する。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a drug solution transport tube that is used in connection with a drug container used for medical purposes, and through which the drug solution in the drug solution container flows.
（従来の技術）
近時、医療用として、卵黄レシチン、もしくは大豆レシ
チンを含む液剤である脂肪乳剤等の高カロリー輸液を患
者に投与するために、高カロリー輸液バッグが使用され
ている。該高カロリー輸液バッグは、脂肪乳剤等の高カ
ロリー輸液が封入される薬液容器と、該薬液容器に連結
された薬液輸送チューブと、該薬液輸送チューブの先端
に取り付けられる薬液排出部と、必要に応じて薬液排出
部に取り付けられる点滴セットとにより構成される。こ
のような高カロリー輸液バッグでは、高カロリー輸液と
して脂肪乳剤を用いる場合には、脂肪乳剤が封入される
薬液容器として、軟質ｐｖｃに替わり、エチレン・酢酸
ビニル共重合体（ＥＶＡ）を素材とした袋状の容器が使
用されている。(Prior Art) Recently, high-calorie infusion bags have been used for medical purposes to administer high-calorie infusions such as fat emulsions containing egg yolk lecithin or soybean lecithin to patients. The high-calorie infusion bag includes a drug solution container in which a high-calorie infusion such as a fat emulsion is sealed, a drug solution transport tube connected to the drug solution container, a drug solution discharge part attached to the tip of the drug solution transport tube, and a drug solution discharge part attached to the tip of the drug solution transport tube. It consists of a drip set that is attached to the drug solution discharge section according to the requirements. In such a high-calorie infusion bag, when a fat emulsion is used as a high-calorie infusion, the drug solution container in which the fat emulsion is sealed is made of ethylene-vinyl acetate copolymer (EVA) instead of soft PVC. A bag-like container is used.
脂肪乳剤が封入される薬液容器の素材として、軟質ｐｖ
ｃ （ポリ塩化ビニル）を用いると、封入された脂肪乳
剤と軟質ＰＶＣに可塑剤として含まれるＤＯＰ（フタル
酸ジオクチル）とが親和性が高いために、該ＤＯＰが脂
肪乳剤中に多量に溶出するが、ＥＶＡではこのようなお
それがない。該袋状の薬剤容器は、一対のＥＶＡ製シー
トの周縁部を高周波シールすることにより、 ５００〜
３０００＊１の容量の袋状に製造されている。該ＥＶＡ
を素材とした薬液容器は薬液が収容された状態でも破損
しないように、ＥＶＡ内の酢酸ビニル（ＶＡｃ） 量は
、通常、５〜３０重量％とされる。Soft PV is used as a material for drug solution containers in which fat emulsions are sealed.
When c (polyvinyl chloride) is used, the encapsulated fat emulsion and DOP (dioctyl phthalate) contained as a plasticizer in the soft PVC have a high affinity, so a large amount of DOP is eluted into the fat emulsion. However, with EVA, there is no such fear. The bag-like drug container is manufactured by high-frequency sealing the peripheral edges of a pair of EVA sheets.
It is manufactured in the form of a bag with a capacity of 3000*1. The EVA
The amount of vinyl acetate (VAc) in EVA is usually 5 to 30% by weight so that chemical liquid containers made of EVA will not be damaged even when the chemical liquid is contained therein.
これに対し、薬液輸送チューブおよび点滴セットには、
可撓性、可塑性にすぐれた軟質ＰｖＣが使用される。On the other hand, drug delivery tubes and IV sets have
Soft PvC with excellent flexibility and plasticity is used.
薬液輸送チューブは、薬液容器と連結され該薬液容器内
の脂肪乳剤が該薬液輸送チューブ内へ流入して通流する
。しかし、ＥｖＡを素材とした薬液容器と、ＤＯＰを可
塑剤として含有する軟質ＰｖＣを素材とした薬液輸送チ
ューブとは、高周波シールおよびヒートシールにより接
着させることができず、しかも、有機溶剤による接着も
できない。このため、このような素材の薬液容器と薬液
輸送チューブとは、例えば、第２図に示すように、薬液
容器３０に設けられた管状に突出する連結部３１内と、
薬液輸送チューブ４０の一端部内とに、管状の連結部材
５０の各端部をそれぞれ嵌合させることにより、あるい
は、第３図に示すように、該薬液輸送チューブ４０の一
端部を、テトラヒドロフラン（ＴＨＦ）等の有機溶剤に
て溶融状態にして連結部３１内に嵌合させ、両者を接着
している。The drug solution transport tube is connected to the drug solution container, and the fat emulsion in the drug solution container flows into the drug solution transport tube. However, a chemical liquid container made of EvA and a chemical liquid transport tube made of soft PvC containing DOP as a plasticizer cannot be bonded together by high frequency sealing or heat sealing, and furthermore, it is not possible to bond them using organic solvents. Can not. Therefore, the drug solution container and drug solution transport tube made of such materials are, for example, as shown in FIG.
By fitting each end of the tubular connecting member 50 into one end of the drug solution transport tube 40, or as shown in FIG. ) is melted with an organic solvent such as ) and fitted into the connecting portion 31 to bond the two together.
（発明が解決しようとする課題）
このような方法で薬液容器と薬液輸送チューブとを連結
した場合には、両者の接合力が弱（、しかも、両者の連
結状態が不安定であるため、使用中に薬液輸送チューブ
が薬液容器から抜けるおそれがある。薬液容器を、ＤＯ
Ｐを含有する軟質ＰｖＣにて製造すれば、軟質ＰｖＣ製
の薬液輸送チューブとは、高周波シールやヒートシール
により強固に接着し得るが、前述したように、軟質Ｐｖ
Ｃに可塑剤として含まれるＤＯＰが脂肪乳剤中に多量に
溶出するという問題がある。(Problem to be Solved by the Invention) When the chemical liquid container and the chemical liquid transport tube are connected in this way, the bonding force between the two is weak (and the state of connection between the two is unstable, making it difficult to use). There is a risk that the drug solution transport tube may come off from the drug solution container.
If manufactured with soft PvC containing P, it can be firmly bonded to a soft PvC chemical transport tube by high frequency sealing or heat sealing.
There is a problem that a large amount of DOP contained in C as a plasticizer is eluted into the fat emulsion.
、本発明は上記従来の問題を解決するものであり、その
目的は、脂肪乳剤等が収容されるＥＶＡ製の薬液容器に
、高周波シールやヒートシール、さらには接着剤等によ
り強固に接合し得る薬液輸送チューブを提供することに
ある。The present invention solves the above-mentioned conventional problems, and its purpose is to firmly bond it to an EVA drug solution container containing fat emulsion etc. by high frequency sealing, heat sealing, adhesive, etc. The purpose of the present invention is to provide a drug solution transport tube.
（課題を解決するための手段）
本発明の薬液輸送チューブは、薬液容器に連結されて、
該薬液容器内の薬液が通流される薬液輸送チューブであ
って、塩化ビニル系樹脂とエチレン・一酸化炭素・ （
メタ）アクリル酸アルキルエステル共重合体とを含有す
る無可塑剤軟質ポリ塩化ビニル層を有してなり、そのこ
とにより上記問題が解決される。(Means for Solving the Problems) The drug solution transport tube of the present invention is connected to a drug solution container,
A chemical liquid transport tube through which the chemical liquid in the chemical liquid container flows, and is made of vinyl chloride resin, ethylene, carbon monoxide, (
The above problem is solved by having a plasticizer-free soft polyvinyl chloride layer containing a meth)acrylic acid alkyl ester copolymer.
（実施例） 以下に本発明を実施例について説明する。(Example) The present invention will be described below with reference to Examples.
本発明の薬液輸送チューブは、第１図に示すように、無
可塑剤軟質ＰＶＣ（ポリ塩化ビニル）層に接着剤層１２
を介して、オレフィン・ビニルエステル共重合体層１３
が積層されている。As shown in FIG. 1, the drug solution transport tube of the present invention has an adhesive layer 12 on a non-plasticized soft PVC (polyvinyl chloride) layer.
Through the olefin/vinyl ester copolymer layer 13
are layered.
ＤＯＰ等の可塑剤が含有された軟質ＰｖＣでは、その表
面に可塑剤がブリードするため、該表面にＥＶＡ （エ
チレン・酢酸共重合体）を積層することは困難である。With soft PvC containing a plasticizer such as DOP, the plasticizer bleeds onto the surface, making it difficult to laminate EVA (ethylene/acetic acid copolymer) on the surface.
これに対し、本発明の薬液輸送チューブに使用される可
塑剤が添加されていない無可塑剤軟質ＰｖＣは、塩化ビ
ニル系樹脂と、エチレン・一酸化炭素・ （メタ）アク
リル酸アルキルエステル共重合体とにより構成されてお
り、その共重合体の含有量によっては、ＥＶＡとはヒー
トシールや高周波シールにより容易に接着することがで
き、また、適当な接着剤によっても、容易に接着し得る
。On the other hand, the plasticizer-free soft PvC to which no plasticizer is added and which is used in the chemical liquid transport tube of the present invention is made of a vinyl chloride resin and an ethylene/carbon monoxide/(meth)acrylic acid alkyl ester copolymer. Depending on the content of the copolymer, it can be easily adhered to EVA by heat sealing or high frequency sealing, or by a suitable adhesive.
このような構成の薬液輸送チューブは、外径が３〜２０
ｍ、内径が２〜１６ ｍ 、全体の肉厚が０．５〜４ｍ
ｍとされる。無可塑剤軟質ＰＶＣ層１１の肉厚は、全体
の肉厚の３０〜７０％−１接着剤層１２の肉厚は全体の
肉厚の５〜３０％、オレフィン・ビニルエステル共重合
体層１３の肉厚は、全体の肉厚の０〜６５％とされるの
がよい。A chemical liquid transport tube with such a configuration has an outer diameter of 3 to 20 mm.
m, inner diameter 2-16 m, total wall thickness 0.5-4 m
It is assumed that m. The thickness of the plasticizer-free soft PVC layer 11 is 30 to 70% of the total thickness. The thickness of the adhesive layer 12 is 5 to 30% of the total thickness. The olefin vinyl ester copolymer layer 13 is It is preferable that the wall thickness is 0 to 65% of the total wall thickness.
無可塑剤軟質ｐｖｃ層１１は、塩化ビニル系樹脂（ポリ
塩化ビニルまたは塩化ビニルと、エチレン、プロピレン
、酢酸ビニル、（メタ）アクリル酸エステル等との一種
または二種以上の共重合体）が３５〜７５重量％、エチ
レン・一酸化炭素・ （メタ）アクリル酸アルキルエス
テル共重合体（一酸化炭素含有ｊ！５〜３０重量％、（
メタ）アクリル酸アルキルエステル含有ｔｔｓ〜６０重
量％）が２５〜６５重量％でなる組成物である。単なる
混合物である必要はなく、グラフト共重合体、安定剤と
してエポキシ化大豆油やＣａ−Ｚｎ系安定剤等を含有し
ていてもよい。The plasticizer-free soft PVC layer 11 is made of vinyl chloride resin (one or more copolymers of polyvinyl chloride or vinyl chloride and ethylene, propylene, vinyl acetate, (meth)acrylic acid ester, etc.). ~75% by weight, ethylene/carbon monoxide/(meth)acrylic acid alkyl ester copolymer (carbon monoxide content j! 5~30% by weight, (
The composition contains 25 to 65% by weight of meth)acrylic acid alkyl ester (tts to 60% by weight). It does not need to be a simple mixture, and may contain a graft copolymer and a stabilizer such as epoxidized soybean oil or a Ca-Zn stabilizer.
接着剤層１２は、エチレン・酢酸ビニル共重合体（酢酸
ビニル含有量３０〜６０１１量％）、塩素化ポリエチレ
ン（塩素含有量２０〜４０重量％）、エチレン・一酸化
炭素・ （メタ）アクリル酸アルキルエステル共重合体
（一酸化炭素含有ｊ１５〜３０重量％、（メタ）アクリ
ル酸アルキルエステル含有ｆｉｔ５〜６０重量％）のう
ちのいずれか一種または二種以上の混合物で構成される
。The adhesive layer 12 is made of ethylene/vinyl acetate copolymer (vinyl acetate content: 30-6011% by weight), chlorinated polyethylene (chlorine content: 20-40% by weight), ethylene/carbon monoxide/(meth)acrylic acid. It is composed of any one type or a mixture of two or more of alkyl ester copolymers (carbon monoxide content: 15 to 30% by weight, (meth)acrylic acid alkyl ester content: 5 to 60% by weight).
オレフィン・ビニルエステル共重合体層１３は、例えば
、エチレン・酢酸ビニル共重合体（酢酸ビニル含有ｆｆ
１５〜３０重量％）で構成される。The olefin/vinyl ester copolymer layer 13 is made of, for example, ethylene/vinyl acetate copolymer (vinyl acetate containing ff
15-30% by weight).
本発明の薬液輸送チューブの具体例を以下に説明する。Specific examples of the drug solution transport tube of the present invention will be described below.
無可塑軟質ＰＶＣ層１１として、次の組成物を用いた。The following composition was used as the non-plastic soft PVC layer 11.
塩化ビニル・エチレン共重合体（エチレン含有量４重量
％、平均重合度１３００） １００１１［置部
エチレン・一酸化炭素・アクリル酸ｎブチル共重合体（
一酸化炭素１０重量％、アクリル酸ｎブチル３０重量％
）１００重量部
エポキシ化大豆油（アデカアーガス社製、商品名ｒｏ−
１３０ｐＪ） １０重量部Ｃａ−Ｚｎ
系安定剤（アデカアーガス社製、商品名「マーク３７Ｊ
１．５重量部滑剤（三井石
油化学社製、商品名「ハイワックス４２０２ＥＪ）
１重量部接着剤層１２として、酢
酸ビニル含有量が４５重量％のエチレン・酢酸ビニル共
重合体く三井石油化学社製、商品名［エバフレックス４
５ＬＸＪ）を用いた。Vinyl chloride/ethylene copolymer (ethylene content 4% by weight, average degree of polymerization 1300) 10011
Carbon monoxide 10% by weight, n-butyl acrylate 30% by weight
) 100 parts by weight epoxidized soybean oil (manufactured by Adeka Argus, trade name ro-
130pJ) 10 parts by weight Ca-Zn
System stabilizer (manufactured by Adeka Argus, product name “Mark 37J”)
1.5 parts by weight lubricant (manufactured by Mitsui Petrochemical Co., Ltd., trade name "Hiwax 4202EJ")
1 part by weight As the adhesive layer 12, an ethylene/vinyl acetate copolymer having a vinyl acetate content of 45% by weight was used, manufactured by Mitsui Petrochemicals Co., Ltd. under the trade name [Evaflex 4].
5LXJ) was used.
オレフィン・ビニルエステル共重合体！ｔ３トして、酢
酸ビニル含有量が１５％、Ｍ＋＝ １．８ｇｒ／ １０
ｍ１ｎのエチレン・酢酸ビニル共重合体（東ソー社製、
商品名「ウルトラセン６３０ＦＪ ）を用いた。Olefin/vinyl ester copolymer! t3, vinyl acetate content is 15%, M+= 1.8gr/10
m1n ethylene/vinyl acetate copolymer (manufactured by Tosoh Corporation,
The product name "Ultrasen 630FJ" was used.
これらの材料を共押出しにより、外径７ｆｆｉＩｍ、内
径４■、従って、肉厚１．５ｍの薬液輸送チューブを製
造した。無可塑剤軟質ＰＶＣ層１１の厚さは０．６−１
接着剤層１２の厚さは０．２圓、オレフィン・ビニルエ
ステル共重合体層１３の厚さは０．７ｍｍであった。By coextruding these materials, a liquid drug transport tube having an outer diameter of 7ffilm, an inner diameter of 4 mm, and a wall thickness of 1.5 m was manufactured. The thickness of the plasticizer-free soft PVC layer 11 is 0.6-1
The thickness of the adhesive layer 12 was 0.2 mm, and the thickness of the olefin/vinyl ester copolymer layer 13 was 0.7 mm.
この薬液輸送チューブをディスポーザブル輸血セ；、ト
および輸液セット基準（昭和４５年８月、厚生省告示第
３０１号）に基づき試験したところ、表１の結果が得ら
れた。When this drug solution transport tube was tested based on disposable blood transfusion set standards (Ministry of Health and Welfare Notification No. 301, August 1970), the results shown in Table 1 were obtained.
表 １
次に、ＥＶＡ （東ソー社製、商品名「ウルトラセン６
３０ＦＪ （酢酸ビニル含有量１５％））を用い、厚さ
３５０μｌ、折径１２０μ馬にインフレ押出し成形した
ＥＶＡシートを一辺が２００ｍにカットして、一対のＥ
ＶＡシート間に、上述した構成の薬液輸送チューブを５
０＋ｍにカットして、そのＬｏｗにわたってはさみ、３
．５ｋｗの出力を有する高周波ウェルダーにて、３秒間
にわたって高周波シールすることにより、両者を接着し
た。その後に、ＥＶＡシートの底部と両側縁部を高周波
シールにより接着し、袋状の薬液容器とした。Table 1 Next, EVA (manufactured by Tosoh Corporation, product name “Ultrasen 6”)
30FJ (vinyl acetate content 15%)), an EVA sheet with a thickness of 350 μl and a fold diameter of 120 μl was cut into a length of 200 m on a side, and a pair of EVA sheets were cut.
Between the VA sheets, 5 drug solution transport tubes with the above-mentioned configuration are installed.
Cut to 0+m and use scissors across the Low part, 3
．． The two were bonded together by high frequency sealing for 3 seconds using a high frequency welder with an output of 5 kW. Thereafter, the bottom and both side edges of the EVA sheet were adhered using high-frequency sealing to form a bag-shaped drug solution container.
得られた薬液容器と薬液輸送チューブとをエチレンオキ
サイドガス（ガス濃度７００■／ハ、６０℃、６時間）
にて滅菌した。そして、両者の接合強度を引っ張り試験
機（引っ張り速度２００ ｍ ／分）にて測定した。こ
のような試験を３回行った。その結果を表２に高周波融
着の実施例として示す。The obtained chemical liquid container and chemical liquid transport tube were heated with ethylene oxide gas (gas concentration 700 cm/c, 60°C, 6 hours).
It was sterilized. Then, the bonding strength between the two was measured using a tensile tester (pulling speed: 200 m/min). Such a test was conducted three times. The results are shown in Table 2 as an example of high frequency fusion.
また、上述した薬液輸送チューブの組成物である無可塑
剤軟質ＰＶＣのみを用いて、外径４■、内径３ｍ、長さ
１ｍの薬液輸送チューブを製造して、該チューブの端部
１０ｍｎを、上述した薬液容器と同様の組成であって薬
液輸送チューブを内嵌し得る管状の連結部を有する薬液
容器の該管状連結部に、Ｔ）（Ｆ （テトラヒドロフラ
ン）により接合した。In addition, a drug solution transport tube with an outer diameter of 4 cm, an inner diameter of 3 m, and a length of 1 m was manufactured using only the plasticizer-free soft PVC, which is the composition of the drug solution transport tube described above, and the end portion of the tube was 10 mm long. It was joined by T)(F (tetrahydrofuran) to the tubular connecting portion of a chemical liquid container having the same composition as the chemical liquid container described above and having a tubular connecting portion into which a chemical liquid transport tube could be fitted.
そして、その接合部を上記引っ張り試験機にて試験した
。このような試験を３回行った。その結果を表２にＴＨ
Ｆ接着の実施例として併記する。Then, the joint was tested using the above-mentioned tensile tester. Such a test was conducted three times. The results are shown in Table 2.
It is also described as an example of F adhesion.
比較のために、塩化ビニル系樹脂１００重量部に対して
、可塑剤としてＤＯＰを５５重量部含有する軟質ｐｖｃ
により、外径４■、内径３■の薬液輸送チューブを製造
し、前述した薬液容器と同様の薬液容器に、長さｌＯｍ
にわたり、３．５ｋｖの出力を有する高周波ウェルダー
にて４秒間、高周波シールした。このような試験を３回
行った。その結果を表２に高周波融着の比較例として併
記する。両者はほとんど融着しなかった。また、該薬液
輸送チューブを、上記薬液容器と同様の組成（東ソー社
製、商品名「ウルトラセン６３０ＦＪ ）のＥＶＡにて
外径７！ｗ１内径４ｍに製造されたチューブ内に嵌合さ
せて、ＴＨＦにて接着した。そして、前述したエチレン
オキサイドガスによる滅菌と同様の滅菌を行った後に、
上記引っ張り試験機により試験した。このような試験を
３回行った。結果を表２にＴＨＦ接着の比較例として併
記する。For comparison, a soft PVC containing 55 parts by weight of DOP as a plasticizer per 100 parts by weight of vinyl chloride resin was used.
A chemical solution transport tube with an outer diameter of 4 mm and an inner diameter of 3 mm was manufactured using
High frequency sealing was performed for 4 seconds using a high frequency welder with an output of 3.5 kV. Such a test was conducted three times. The results are also listed in Table 2 as a comparative example of high frequency fusion. The two were hardly fused together. In addition, the drug solution transport tube was fitted into a tube made of EVA having the same composition as the drug solution container (manufactured by Tosoh Corporation, product name "Ultrasen 630FJ") with an outer diameter of 7!w1 and an inner diameter of 4 m, It was adhered with THF.Then, after being sterilized in the same way as the ethylene oxide gas described above,
It was tested using the above-mentioned tensile tester. Such a test was conducted three times. The results are also listed in Table 2 as a comparative example of THF adhesion.
表 ２
（発明の効果）
本発明の薬液輸送チューブは、このように、塩化ビニル
系樹脂とエチレン・一酸化炭素・ （メタ）アクリル酸
アルキルエステル共重合体とを含有する無可塑剤軟質２
７０層を有しているため、脂肪乳剤等が封入されるＥＶ
Ａ製の薬液容器と該無可塑剤軟質ｐｖｃ層とが、適当な
接着剤により、直接、強固に接着させることができる。Table 2 (Effects of the Invention) As described above, the chemical liquid transport tube of the present invention is a plasticizer-free soft 2 containing a vinyl chloride resin and an ethylene/carbon monoxide/(meth)acrylic acid alkyl ester copolymer.
Since it has 70 layers, it is an EV in which fat emulsion etc. can be encapsulated.
The chemical solution container manufactured by A and the plasticizer-free soft PVC layer can be directly and firmly bonded to each other using a suitable adhesive.
また、無可塑剤軟質２７０層にＥＶＡ層を適当な接着剤
により強固に積層し得るため、その積層されたＥＶＡ層
と上記ＥＶＡ製の薬液容器とを、高周波シールやヒート
シール、あるいは適当な接着剤により強固に接着し得る
。その結果、本発明の薬液輸送チューブは、ＥＶＡ製の
薬液容器とは強固に連結され、該薬液容器内の薬液を通
流させている際に、該薬液容器から抜けるおそれがない
。In addition, since the EVA layer can be strongly laminated on the non-plasticized soft 270 layer using a suitable adhesive, the laminated EVA layer and the above-mentioned EVA drug container can be bonded by high frequency sealing, heat sealing, or suitable adhesive. Can be strongly bonded with adhesive. As a result, the drug solution transport tube of the present invention is firmly connected to the EVA drug solution container, and there is no risk of it coming off from the drug solution container when the drug solution is flowing through the drug solution container.
４、 の、 な号１
第１図は本発明の薬液輸送チューブの一例を示す断面図
、第２図および第３図はそれぞれ従来の薬液輸送チュー
ブと薬液容器との連結状態を示す断面図である。4. No. 1 Fig. 1 is a cross-sectional view showing an example of the liquid drug transport tube of the present invention, and Figs. 2 and 3 are cross-sectional views showing the connected state of a conventional liquid drug transport tube and a liquid medicine container, respectively. be.
１１・・・無可塑剤ｐｖｃ層、１２・・・接着剤層、１
３・・−オレフィン・ビニルエステル共重合体１１以上11...Plasticizer-free PVC layer, 12...Adhesive layer, 1
3...-Olefin/vinyl ester copolymer 11 or more
Claims (1)
される薬液輸送チューブであって、塩化ビニル系樹脂と
エチレン・一酸化炭素・（メタ）アクリル酸アルキルエ
ステル共重合体とを含有する無可塑剤軟質ポリ塩化ビニ
ル層を有してなる薬液輸送チューブ。1. A drug solution transport tube connected to a drug solution container and through which the drug solution in the drug solution container flows, which contains a vinyl chloride resin and an ethylene/carbon monoxide/(meth)acrylic acid alkyl ester copolymer. A chemical liquid transport tube comprising a plasticizer-free soft polyvinyl chloride layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1030894A JPH02209153A (en) | 1989-02-08 | 1989-02-08 | Liquid chemical transporting tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1030894A JPH02209153A (en) | 1989-02-08 | 1989-02-08 | Liquid chemical transporting tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02209153A true JPH02209153A (en) | 1990-08-20 |
Family
ID=12316435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1030894A Pending JPH02209153A (en) | 1989-02-08 | 1989-02-08 | Liquid chemical transporting tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02209153A (en) |
-
1989
- 1989-02-08 JP JP1030894A patent/JPH02209153A/en active Pending
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