JPH02227251A - Transfusion bag - Google Patents
Transfusion bagInfo
- Publication number
- JPH02227251A JPH02227251A JP1049219A JP4921989A JPH02227251A JP H02227251 A JPH02227251 A JP H02227251A JP 1049219 A JP1049219 A JP 1049219A JP 4921989 A JP4921989 A JP 4921989A JP H02227251 A JPH02227251 A JP H02227251A
- Authority
- JP
- Japan
- Prior art keywords
- ethylene
- carbon monoxide
- vinyl acetate
- layer
- acetate copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000010410 layer Substances 0.000 claims abstract description 30
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000005977 Ethylene Substances 0.000 claims abstract description 29
- 229920001577 copolymer Polymers 0.000 claims abstract description 28
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002131 composite material Substances 0.000 claims abstract description 13
- 229920005989 resin Polymers 0.000 claims abstract description 13
- 239000011347 resin Substances 0.000 claims abstract description 13
- 239000012790 adhesive layer Substances 0.000 claims abstract description 9
- 229920000098 polyolefin Polymers 0.000 claims abstract description 5
- 239000011342 resin composition Substances 0.000 claims abstract description 3
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 28
- 238000001802 infusion Methods 0.000 claims description 28
- 229940117927 ethylene oxide Drugs 0.000 claims description 20
- -1 polypropylene Polymers 0.000 abstract description 9
- 239000000463 material Substances 0.000 abstract description 8
- 229920000915 polyvinyl chloride Polymers 0.000 abstract description 8
- 239000004800 polyvinyl chloride Substances 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 5
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 239000004743 Polypropylene Substances 0.000 abstract description 4
- 229920000092 linear low density polyethylene Polymers 0.000 abstract description 4
- 239000004707 linear low-density polyethylene Substances 0.000 abstract description 4
- 229920001155 polypropylene Polymers 0.000 abstract description 4
- 229920001684 low density polyethylene Polymers 0.000 abstract description 3
- 239000004702 low-density polyethylene Substances 0.000 abstract description 3
- 239000004014 plasticizer Substances 0.000 abstract description 2
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229920000578 graft copolymer Polymers 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 3
- 229960003529 diazepam Drugs 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 229920001038 ethylene copolymer Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000004709 Chlorinated polyethylene Substances 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
- 229920003314 Elvaloy® Polymers 0.000 description 1
- 241000156978 Erebia Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000012633 leachable Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- WGKLOLBTFWFKOD-UHFFFAOYSA-N tris(2-nonylphenyl) phosphite Chemical compound CCCCCCCCCC1=CC=CC=C1OP(OC=1C(=CC=CC=1)CCCCCCCCC)OC1=CC=CC=C1CCCCCCCCC WGKLOLBTFWFKOD-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Laminated Bodies (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、柔軟性及び透明性に優れ、蒸気滅菌が可能で
あり、溶出物が少ない上に、特に薬剤の吸着の少ない輸
液バッグに関する。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to an infusion bag that has excellent flexibility and transparency, can be steam sterilized, has little eluate, and particularly has little drug adsorption.
（従来の技術）
輸液容器として従来ではガラスが用いられていたが、軽
く、割れ難い等、取り扱いが容易である等の観点から、
プラスチック製の輸液バッグが多く用いられるようにな
ってきた。(Prior art) Glass has traditionally been used as infusion containers, but from the viewpoints of being light, unbreakable, and easy to handle,
Plastic infusion bags have come into widespread use.
ことに、柔軟な輸液バッグは、点滴時に容器の内圧を大
気圧と同等に保つための吸入孔が不要である、いわゆる
クローズドシステムが可能なため、最近では柔軟なプラ
スチック製の輸液バッグが用いられるようになってきた
。In particular, flexible infusion bags do not require a suction hole to keep the internal pressure of the container equal to atmospheric pressure during infusion, making it possible to create a so-called closed system, so recently, flexible plastic infusion bags have been used. It's starting to look like this.
ところで、輸液バッグに必要な条件は、■柔軟であるこ
と、■蒸気滅菌が可能であること、■溶出物のないこと
、■薬剤の吸着が少ないこと、■透明であること、等で
ある。By the way, the conditions necessary for an infusion bag include: 1) being flexible, 2) being steam sterilizable, 2) having no leachables, 2) having little drug adsorption, and 2) being transparent.
従来、輸液バッグに用いられていた素材としては、ポリ
プロピレン、ポリエチレン、エチレン酢酸ビニル共重合
体、軟質ポリ塩化ビニル等がある。Conventionally, materials used for infusion bags include polypropylene, polyethylene, ethylene vinyl acetate copolymer, and soft polyvinyl chloride.
（発明が解決しようとする課題）
とコロが、ポリプロピレンを素材として輸液バッグを作
製した場合には柔軟性に劣り、ポリエチレンを素材とし
た場合には蒸気滅菌性及び透明性に劣り、エチレン酢酸
ビニル共重合体を素材とした場合には薬剤の吸着量が多
く、軟質ポリ塩化ビニルを素材とした場合には溶出物が
多く、また薬剤の吸着量も多いといった欠点があった。(Problems to be Solved by the Invention) When an infusion bag is made of polypropylene, it has poor flexibility, and when made of polyethylene, it has poor steam sterilization and transparency; When a copolymer is used as a material, a large amount of drug is adsorbed, and when a soft polyvinyl chloride material is used, there is a large amount of eluate and a large amount of drug adsorbed.
そこで、本発明者らはポリエチレンと軟質ポリ塩化ビニ
ルとを積層した複合フィルムにて輸液バッグを作製する
ことを検討したが、このものは蒸気滅菌によって層間剥
離を生じるので、輸液バッグの素材に適用できなかった
。Therefore, the present inventors considered making an infusion bag using a composite film made by laminating polyethylene and soft polyvinyl chloride, but this material causes delamination during steam sterilization, so it is not suitable for use as a material for infusion bags. could not.
本発明は、上記の欠点を解決したものであり、その目的
とするところは、輸液バッグの素材として必要とされる
上記各項目を満足した複合フィルムを用いて作製した輸
液バッグを提供することにある。The present invention has solved the above-mentioned drawbacks, and its purpose is to provide an infusion bag made using a composite film that satisfies each of the above requirements as a material for an infusion bag. be.
（課題を解決するための手段）
本発明の輸液バッグは、ポリオレフィンにて形成される
内面層と、接着剤層と、塩化ビニル系樹脂とエチレン・
一酸化炭素・酢酸ビニル共重合体とを含有し、エチレン
・一酸化炭素・酢酸ビニル共重合体の含有量が３５〜６
５重量％である樹脂組成物にて形成される外面層と、が
この順で積層された複合フィルムにて形成されており、
そのことにより上記目的が達成される。(Means for Solving the Problems) The infusion bag of the present invention includes an inner layer formed of polyolefin, an adhesive layer, vinyl chloride resin, and ethylene.
Contains carbon monoxide/vinyl acetate copolymer, and the content of ethylene/carbon monoxide/vinyl acetate copolymer is 35 to 6.
an outer layer formed of a resin composition of 5% by weight, and a composite film laminated in this order,
This achieves the above objective.
本発明の輸液バッグの素材として用いられる複合フィル
ムＡは、第１図に示すように、内面層１と接着剤層２と
外面層３がこの順で積層された３層構造となっている。As shown in FIG. 1, the composite film A used as the material for the infusion bag of the present invention has a three-layer structure in which an inner layer 1, an adhesive layer 2, and an outer layer 3 are laminated in this order.
上記内面層２は、直鎖状の低密度ポリエチレン（ＬＬＤ
ＰＥ） 、低密度ポリエチレン、ポリプロピレン等のポ
リオレフィンにて形成することができる。The inner layer 2 is made of linear low density polyethylene (LLD).
PE), low density polyethylene, polypropylene, and other polyolefins.
上記接着剤層２は次の接着剤の中から選ばれた１種また
は２Ｆ！以上の混合物にて形成することができる。The adhesive layer 2 is one type selected from the following adhesives or 2F! It can be formed from a mixture of the above.
■酢酸ビニル・エチレン共重合体（酢酸ビニル含有ｆｆ
１３５〜８０重量％、メルトフローレイト（ＭＦＲ、Ａ
ＳＴＭ Ｄ １２３８） １ ｄｇ／分以上）。■Vinyl acetate/ethylene copolymer (vinyl acetate containing ff
135-80% by weight, melt flow rate (MFR, A
STM D 1238) 1 dg/min or higher).
■塩素化ポリエチレン（塩素含有量２０〜４０重１％）
■エチレン・一酸化炭素・酢酸ビニル共重合体（一酸化
炭素含有ｆｆ１３〜２０重量％、酢酸ビニル含有量１０
〜４０重量％）
■エチレン・一酸化炭素・ （メタ）アクリル酸アル牛
ルエステル（一酸化炭素含有量５〜３０重量％、（メタ
）アクリル酸アルキルエステル含有ｍｉｓ〜４０重量％
）
上記外面層３は無可塑剤軟質ポリ塩化ビニルにて形成さ
れている。この無可塑剤軟質ポリ塩化ビニルは、塩化ビ
ニル系樹脂と、エチレン・一酸化炭素・酢酸ビニル共重
合体とを含有する組成物であって、エチレン・一酸化炭
素・酢酸ビニル共重合体が３５〜６５重量％含有された
ものである。■Chlorinated polyethylene (chlorine content 20-40% by weight)
■Ethylene/carbon monoxide/vinyl acetate copolymer (carbon monoxide content ff13-20% by weight, vinyl acetate content 10%)
~40% by weight) Ethylene/carbon monoxide/(meth)acrylic acid alkyl ester (carbon monoxide content 5-30% by weight, (meth)acrylic acid alkyl ester content mis~40% by weight)
) The outer layer 3 is made of plasticizer-free soft polyvinyl chloride. This plasticizer-free soft polyvinyl chloride is a composition containing a vinyl chloride resin and an ethylene/carbon monoxide/vinyl acetate copolymer, and the ethylene/carbon monoxide/vinyl acetate copolymer contains 35% of the ethylene/carbon monoxide/vinyl acetate copolymer. The content was 65% by weight.
上記エチレン・一酸化炭素・酢酸ビニル共重合体の含有
量が３５重量％未満であると、柔軟性及び透明性に劣る
ので好ましくない。エチレン・一酸化炭素・酢酸ビニル
共重合体の含有量が６５重量％を超えると、蒸気滅菌時
にベタツキを生じ、外面層がブロッキングし易くなるた
め好ましくない。If the content of the ethylene/carbon monoxide/vinyl acetate copolymer is less than 35% by weight, flexibility and transparency will be poor, which is not preferable. If the content of the ethylene/carbon monoxide/vinyl acetate copolymer exceeds 65% by weight, it is not preferable because it becomes sticky during steam sterilization and the outer layer tends to block.
無可塑剤軟質塩化ビニル樹脂は、一般には塩化ビニル系
樹脂とエチレン・一酸化炭素・酢酸ビニル共重合体とを
溶融混合して得られるが、以下のようにして得られたも
のも使用することができる。Plasticizer-free soft vinyl chloride resin is generally obtained by melt-mixing vinyl chloride resin and ethylene/carbon monoxide/vinyl acetate copolymer, but those obtained as follows can also be used. Can be done.
■エチレン・一酸化炭素・酢酸ビニル共重合体の存在下
に塩化ビニル単独、あるいは塩化ビニルと共重合しうる
単量体をラジカル重合させて得られる、いわゆるエチレ
ン・一酸化炭素・酢酸ビニル共重合体の塩化ビニル系グ
ラフト重合体。■So-called ethylene/carbon monoxide/vinyl acetate copolymer obtained by radical polymerization of vinyl chloride alone or a monomer that can be copolymerized with vinyl chloride in the presence of ethylene/carbon monoxide/vinyl acetate copolymer. Polymerized vinyl chloride graft polymer.
この塩化ビニル系グラフト重合体は、特公昭３９−２７
８７６号公報、特開昭５５−１３９５１８号公報に記載
された方法に準じて製造することができる。This vinyl chloride graft polymer was
It can be produced according to the method described in JP-A-876 and JP-A-55-139518.
■上記エチレン・一酸化炭素・酢酸ビニル共重合体の塩
化ビニル系グラフト重合体に、可塑剤としてエチレン・
一酸化炭素・酢酸ビニル共重合体を配合したものでもよ
く、あるいは前記塩化ビニル系グラフト重合体と塩化ビ
ニル系重合体の混合物であってもよい。■Add ethylene/carbon monoxide/vinyl acetate as a plasticizer to the vinyl chloride graft polymer of the ethylene/carbon monoxide/vinyl acetate copolymer.
It may be a mixture of carbon monoxide/vinyl acetate copolymer, or a mixture of the vinyl chloride graft polymer and the vinyl chloride polymer.
上記塩化ビニル系樹脂しては、ポリ塩化ビニル単独の重
合体、または塩化ビニルとエチレン、プロピレン、酢酸
ビニル、（メタ）アクリル酸エステル等の１種または２
種以上の共重合体があげられる。The vinyl chloride resin mentioned above is a polymer of polyvinyl chloride alone, or one or two of vinyl chloride and ethylene, propylene, vinyl acetate, (meth)acrylic acid ester, etc.
Examples include copolymers of more than one species.
ｉ上記エチレン・一酸化炭素・酢酸ビニル共重合体は、
エチレンと一酸化炭素と酢酸ビニルとの共重合体である
。このエチレン・一酸化炭素・酢酸ヒニル共重合体では
、エチレンは４０〜８０重量％、好ましくは６０〜７０
重量％の量で、一酸化炭素は５〜３０重量％、好ましく
は５〜２０重量％の量で、酢酸ビニルは１０〜６０重量
％、好ましくは１０〜４０重量％の量で含まれているこ
とが望ましく、必要に応じてさらに他の単量体を共重合
させることも可能である。このようなエチレン・一酸化
炭素・酢酸ビニル共重合体を製造するには、単量体であ
るエチレン、一酸化炭素、酢酸ビニルのそれぞれを、触
媒とともに所定の割合で高速攪拌反応容器中に供給して
混合し、高温、高圧下に高速で攪拌することによって単
量体を共重合すればよい。このエチレン・一酸化炭素・
酢酸ビニル共重合体は、メルトフローレイト（ＭＦＲ，
ＡＳＴＭ Ｄ １２３８）が１〜５００ｇ／ｌＧ分、好
ましくは１０〜５０ｇ／ｉｏ分であることが望ましい。iThe above ethylene/carbon monoxide/vinyl acetate copolymer is
It is a copolymer of ethylene, carbon monoxide, and vinyl acetate. In this ethylene/carbon monoxide/hinyl acetate copolymer, ethylene is 40 to 80% by weight, preferably 60 to 70% by weight.
Carbon monoxide is present in an amount of 5-30%, preferably 5-20% by weight, and vinyl acetate is included in an amount of 10-60%, preferably 10-40% by weight. This is desirable, and it is also possible to further copolymerize other monomers as necessary. To produce such an ethylene/carbon monoxide/vinyl acetate copolymer, the monomers ethylene, carbon monoxide, and vinyl acetate are each fed at a predetermined ratio together with a catalyst into a high-speed stirring reaction vessel. The monomers may be copolymerized by stirring at high speed under high temperature and high pressure. This ethylene, carbon monoxide,
Vinyl acetate copolymer is melt flow rate (MFR,
ASTM D 1238) is preferably 1 to 500 g/lG min, preferably 10 to 50 g/io min.
上記無可塑剤軟質塩化ビニル樹脂には、上記のような塩
化ビニル系樹脂及びエチレン・一酸化炭素・酢酸ビニル
共重合体に加えて、医療器材用途に用いられている従来
より公知の無毒添加剤、例えばステアリン酸カルシウム
、ステアリン酸亜鉛、エポキシ化大豆油、ジ−ｎ−オク
チルスズ化合物、トリス（ノニルフェニル）ホスファイ
トなどを含有することができる。In addition to the above-mentioned vinyl chloride resin and ethylene/carbon monoxide/vinyl acetate copolymer, the above-mentioned plasticizer-free soft vinyl chloride resin contains conventionally known non-toxic additives used for medical device applications. , for example, calcium stearate, zinc stearate, epoxidized soybean oil, di-n-octyltin compound, tris(nonylphenyl)phosphite, and the like.
この無可塑剤軟質塩化ビニル樹脂は、上記した塩化ビニ
ル系樹脂と、エチレン・一酸化炭素・酢酸ビニル共重合
体と、必要に応じて安定剤、滑剤などの添加剤とを、ロ
ール、バンバリーミキサ−などのバッチ式混練機あるい
は二軸押出機などの連続混練機を用いて、溶融混合（メ
ルトブレンド）することにより得られる。This plasticizer-free soft vinyl chloride resin is produced by mixing the above-mentioned vinyl chloride resin, ethylene/carbon monoxide/vinyl acetate copolymer, and additives such as stabilizers and lubricants as necessary with a roll or Banbury mixer. It can be obtained by melt-blending using a batch kneader such as - or a continuous kneader such as a twin-screw extruder.
上記３層構造の複合フィルムＡは押出成形等によって、
連続して製造することができ、この複合フィルムＡを製
袋することにより、輸液バッグが作製される。輸液バッ
グを作製するには、例えば、−対の複合フィルムＡをそ
の内面層ｌを内側にした状態で２枚重ね合わせ、接続部
分をヒートシールすることにより、内面層１．ｌ同志を
融着させて製袋する。The above three-layer composite film A is made by extrusion molding etc.
It can be manufactured continuously, and by bag-making this composite film A, an infusion bag is manufactured. To produce an infusion bag, for example, two pairs of composite films A are placed one on top of the other with the inner surface layer 1 facing inside, and the connected portions are heat-sealed to form inner layer 1. A bag is made by fusing the two pieces together.
本発明の輸液バッグにおいては、上記した内面層１の厚
さは２０〜１００μ腸が好ましい。内面層１の厚さが１
００μ−を超える場合には、透明性が劣るばかりでなく
、蒸気滅菌（１２１”ＣＸ ２Ｇ分）に耐えることがで
きず、輸液バッグにシワがよったり、変形するおそれが
ある。また、上記複合フィルムＡの厚さは柔軟性を確保
するために、２００〜５ｏｏμ論が好ましい。In the infusion bag of the present invention, the thickness of the inner layer 1 described above is preferably 20 to 100 μm. The thickness of inner layer 1 is 1
If it exceeds 00 μ-, not only will the transparency deteriorate, but it will not be able to withstand steam sterilization (121”CX 2G), and the infusion bag may wrinkle or deform. The thickness of the film A is preferably 200 to 5 ooμ in order to ensure flexibility.
（実施例） 以下、本発明を実施例に基づいて詳細に説明する。(Example) Hereinafter, the present invention will be explained in detail based on examples.
友ＪｌｆＬＬ
エチレン含有量が４重量％で平均重合度が１．３００
（ＪＩＳ Ｋ ６７２１により測定）の塩化ビニル・エ
チレン共重合体１００重量部、エチレン・一酸化炭素・
酢酸ビニル共重合体（デュポン社製、エルバロイ７４１
） １００重量部、エポキシ化大豆油１０重量部、Ｃａ
−Ｚｎ系安定剤（アデカアーガス社製マーク３７） ２
重ｆｉ部を２本ロールにより１７０℃で５分間混練して
無可更剤塩化ビニル樹脂を得た。Tomo JlfLL Ethylene content is 4% by weight and average degree of polymerization is 1.300
100 parts by weight of vinyl chloride/ethylene copolymer (measured according to JIS K 6721), ethylene/carbon monoxide/
Vinyl acetate copolymer (manufactured by DuPont, Elvaloy 741
) 100 parts by weight, 10 parts by weight of epoxidized soybean oil, Ca
-Zn stabilizer (Mark 37 manufactured by Adeka Argus) 2
The heavy fi part was kneaded using two rolls at 170°C for 5 minutes to obtain a softener-free vinyl chloride resin.
これを裁断し角ベレ−／ トとした後、押出機を用いて
外面層を押し出すと同時に、エチレン・酢酸ビニル共重
合体（酢酸ビニル含有量４５重量％）にて形成される接
着剤層及び直鎖状の低密度ポリエチレン（三井石油化学
製、ウルトゼックス１０３０Ｌ）にて形成される内面層
を押し出し、各層を積層−体化して複合フィルムを得た
。After cutting this into square berets, the outer layer is extruded using an extruder, and at the same time an adhesive layer formed of ethylene/vinyl acetate copolymer (vinyl acetate content: 45% by weight) is extruded. The inner layer formed of linear low-density polyethylene (Mitsui Petrochemical Co., Ltd., Ultzex 1030L) was extruded, and each layer was laminated to obtain a composite film.
得られた複合フィルムの厚さは３００μ諷であり、各層
の厚みは、内面層３０μＩ、接着剤層２０μｍ、外面層
２５０μｌであった。The thickness of the obtained composite film was 300 μm, and the thickness of each layer was 30 μl for the inner layer, 20 μm for the adhesive layer, and 250 μl for the outer layer.
この複合フィルムをヒートシールにてｇ Ｍ５ ｏ ｏ
ｍｌの輸液バッグを作製した。得られた輸液バッグは
柔軟であり、また透明性も良好であった。Heat seal this composite film to g M5 o o
A ml infusion bag was prepared. The obtained infusion bag was flexible and had good transparency.
次に、この輸液バッグに生理食塩水約４００ｍ１を封入
し、このものを１２１℃・２０分間蒸気滅菌した。Next, about 400 ml of physiological saline was sealed in this infusion bag, and this bag was steam sterilized at 121° C. for 20 minutes.
その結果、輸液バッグのの融着や、破袋及び液の漏れを
ひき起こす欠損部は見あたらなかった。As a result, no defects were found that would cause fusion of the infusion bag, bag breakage, or fluid leakage.
これに、さらにジアゼパムをｌＯμｇ／ｇ＋１となるよ
溶解して２５°Ｃで２４時間放置した。放置後のジアゼ
パムの残存率を測定すると９５％であり、良好な結果を
示した。Diazepam was further dissolved in the solution to a concentration of 10 μg/g+1, and the solution was left at 25° C. for 24 hours. The residual rate of diazepam after standing was 95%, indicating a good result.
匡未匹
軟質塩化ビニル樹脂のフィルム（ポリ塩化ビニル（平均
重合度１４００）１００重量部とジオクチルフタレート
５５重量部を主成分とするフィルム）にて輸液バッグを
作製し、この輸液バッグについて、実施例１と同様に行
ってジアゼパムの残存率を測定したところ６７％であっ
た。An infusion bag was prepared from a soft vinyl chloride resin film (a film whose main components are 100 parts by weight of polyvinyl chloride (average degree of polymerization 1400) and 55 parts by weight of dioctyl phthalate), and the following examples were prepared for this infusion bag. The residual rate of diazepam was measured in the same manner as in 1 and found to be 67%.
（発明の効果）
本発明の輸液バッグの構成は上述の通りであり、透明で
、かつ柔軟であり、蒸気滅菌が可能であり、溶出物がな
い上に、さらに加えて薬剤の吸着が少ない利点がある。(Effects of the Invention) The configuration of the infusion bag of the present invention is as described above; it is transparent, flexible, can be steam sterilized, has no eluate, and has the additional advantage of less adsorption of drugs. There is.
４ の な雷日 第１図は本発明一実施例の輸液バッグの断面図である。4 thunderstorms FIG. 1 is a sectional view of an infusion bag according to an embodiment of the present invention.
１・・・内面層、２・・・接着剤層、３・・・外面層。1... Inner layer, 2... Adhesive layer, 3... Outer layer.
以上that's all
Claims (1)
と、塩化ビニル系樹脂とエチレン・一酸化炭素・酢酸ビ
ニル共重合体とを含有し、エチレン・一酸化炭素・酢酸
ビニル共重合体の含有量が３５〜６５重量％である樹脂
組成物にて形成される外面層と、がこの順で積層された
複合フィルムにて形成されている輸液バッグ。1. Contains an inner layer formed of polyolefin, an adhesive layer, a vinyl chloride resin, and an ethylene/carbon monoxide/vinyl acetate copolymer. An infusion bag made of a composite film laminated in this order, including an outer layer made of a resin composition having a content of 35 to 65% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1049219A JPH02227251A (en) | 1989-02-28 | 1989-02-28 | Transfusion bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1049219A JPH02227251A (en) | 1989-02-28 | 1989-02-28 | Transfusion bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02227251A true JPH02227251A (en) | 1990-09-10 |
Family
ID=12824835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1049219A Pending JPH02227251A (en) | 1989-02-28 | 1989-02-28 | Transfusion bag |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02227251A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007224205A (en) * | 2006-02-24 | 2007-09-06 | Mitsubishi Plastics Ind Ltd | Vinyl chloride resin composition and stretch film |
| JP2013014127A (en) * | 2011-04-15 | 2013-01-24 | Mitsubishi Chemicals Corp | Laminate and medical container |
| CN113787793A (en) * | 2021-09-15 | 2021-12-14 | 科顺防水科技股份有限公司 | Pre-laid self-adhesive film coiled material composite waterproof sheet and preparation method and application thereof |
-
1989
- 1989-02-28 JP JP1049219A patent/JPH02227251A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007224205A (en) * | 2006-02-24 | 2007-09-06 | Mitsubishi Plastics Ind Ltd | Vinyl chloride resin composition and stretch film |
| JP2013014127A (en) * | 2011-04-15 | 2013-01-24 | Mitsubishi Chemicals Corp | Laminate and medical container |
| CN113787793A (en) * | 2021-09-15 | 2021-12-14 | 科顺防水科技股份有限公司 | Pre-laid self-adhesive film coiled material composite waterproof sheet and preparation method and application thereof |
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