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JPH01502750A - ６―オキソプロスタグランジン―ｅ―誘導体、その製造法およびその医薬用途 - Google Patents

６―オキソプロスタグランジン―ｅ―誘導体、その製造法およびその医薬用途

Info

Publication number
JPH01502750A
JPH01502750A JP63502393A JP50239388A JPH01502750A JP H01502750 A JPH01502750 A JP H01502750A JP 63502393 A JP63502393 A JP 63502393A JP 50239388 A JP50239388 A JP 50239388A JP H01502750 A JPH01502750 A JP H01502750A
Authority
JP
Japan
Prior art keywords
group
formula
free
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63502393A
Other languages
English (en)
Japanese (ja)
Inventor
クラール，ウルリツヒ
スクバラ，ヴエルナー
フオアブリユツゲン，ヘルムート
シユテユルツエベヒヤー，クラウス―シユテフエン
テイーラウフ，カール―ハインツ
シリンガー，エツケハルト
Original Assignee
シエーリング　アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シエーリング　アクチエンゲゼルシヤフト filed Critical シエーリング　アクチエンゲゼルシヤフト
Publication of JPH01502750A publication Critical patent/JPH01502750A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
JP63502393A 1987-03-13 1988-03-11 ６―オキソプロスタグランジン―ｅ―誘導体、その製造法およびその医薬用途 Pending JPH01502750A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873708537 DE3708537A1 (de) 1987-03-13 1987-03-13 6-oxoprostaglandin-e-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE3708537.9 1987-03-13

Publications (1)

Publication Number Publication Date
JPH01502750A true JPH01502750A (ja) 1989-09-21

Family

ID=6323216

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63502393A Pending JPH01502750A (ja) 1987-03-13 1988-03-11 ６―オキソプロスタグランジン―ｅ―誘導体、その製造法およびその医薬用途

Country Status (16)

Country Link
US (1) US5023273A (de)
EP (1) EP0284547B1 (de)
JP (1) JPH01502750A (de)
AT (1) ATE99677T1 (de)
AU (1) AU620543B2 (de)
CA (1) CA1326022C (de)
DE (2) DE3708537A1 (de)
DK (1) DK160871C (de)
ES (1) ES2061715T3 (de)
FI (1) FI90661C (de)
HU (1) HU206342B (de)
IE (1) IE62469B1 (de)
IL (1) IL85711A (de)
NZ (1) NZ223858A (de)
WO (1) WO1988007037A1 (de)
ZA (1) ZA881777B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019085413A (ja) * 2017-11-08 2019-06-06 Ａｇｃ株式会社 新規なプロスタグランジン誘導体を有効成分として含有する医薬

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831222A1 (de) * 1988-09-09 1990-03-22 Schering Ag 6-oxo-9-fluor-prostaglandin-derivate verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4010339A1 (de) * 1990-03-29 1991-10-02 Schering Ag Neues verfahren zur synthese von propargylalkoholen und dessen anwendung zur herstellung von prostaglandinvorstufen
DE19828881A1 (de) * 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5384942A (en) * 1976-12-30 1978-07-26 Upjohn Co Prostaglandin analogue
JPS5444639A (en) * 1977-09-16 1979-04-09 Ono Pharmaceut Co Ltd Prostaglandin analog and its preparation
JPS55141465A (en) * 1979-04-06 1980-11-05 Hoechst Ag Novel prostaglandin derivative
JPS5675473A (en) * 1979-11-15 1981-06-22 Upjohn Co Prostacycline analogues
JPS58203911A (ja) * 1982-05-25 1983-11-28 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤
JPS5973522A (ja) * 1982-10-20 1984-04-25 Dainippon Pharmaceut Co Ltd 脳神経細胞の酸素欠乏性疾患治療剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4205178A (en) * 1976-12-30 1980-05-27 The Upjohn Company 6-Keto prostaglandin E-type compounds
DE2729960A1 (de) * 1977-06-30 1979-01-18 Schering Ag Neue acetylenprostaglandine und verfahren zu ihrer herstellung
DE2907118A1 (de) * 1979-02-20 1980-09-04 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
DE3125271A1 (de) * 1981-06-24 1983-01-13 Schering Ag, 1000 Berlin Und 4619 Bergkamen (delta)(pfeil hoch)8(pfeil hoch),(pfeil hoch)9(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4403100A (en) * 1981-10-30 1983-09-06 The Upjohn Company (11R)-11-Deoxy-11-alkyl-6-oxo-prostaglandins
AU565905B2 (en) * 1984-02-29 1987-10-01 John Deks Australia Pty. Ltd. Improvements relating to flashing for buildings
US4540993A (en) * 1984-07-23 1985-09-10 Sanders Associates, Inc. Plotter pen
JPS62277352A (ja) * 1986-01-30 1987-12-02 Ono Pharmaceut Co Ltd 新規な６−ケト−プロスタグランジンｅ１誘導体、それらの製造方法およびそれらを有効成分として含有する細胞障害治療剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5384942A (en) * 1976-12-30 1978-07-26 Upjohn Co Prostaglandin analogue
JPS5444639A (en) * 1977-09-16 1979-04-09 Ono Pharmaceut Co Ltd Prostaglandin analog and its preparation
JPS55141465A (en) * 1979-04-06 1980-11-05 Hoechst Ag Novel prostaglandin derivative
JPS5675473A (en) * 1979-11-15 1981-06-22 Upjohn Co Prostacycline analogues
JPS58203911A (ja) * 1982-05-25 1983-11-28 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤
JPS5973522A (ja) * 1982-10-20 1984-04-25 Dainippon Pharmaceut Co Ltd 脳神経細胞の酸素欠乏性疾患治療剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019085413A (ja) * 2017-11-08 2019-06-06 Ａｇｃ株式会社 新規なプロスタグランジン誘導体を有効成分として含有する医薬

Also Published As

Publication number Publication date
IL85711A (en) 1993-06-10
DK160871C (da) 1991-10-14
AU1423788A (en) 1988-10-10
DK632588A (da) 1988-11-11
IL85711A0 (en) 1988-08-31
ES2061715T3 (es) 1994-12-16
IE62469B1 (en) 1995-02-08
US5023273A (en) 1991-06-11
DE3708537A1 (de) 1988-09-22
FI885219A0 (fi) 1988-11-11
EP0284547B1 (de) 1994-01-05
FI90661B (fi) 1993-11-30
ZA881777B (en) 1988-09-09
DK160871B (da) 1991-04-29
IE880737L (en) 1988-09-13
FI90661C (fi) 1994-03-10
HU206342B (en) 1992-10-28
AU620543B2 (en) 1992-02-20
FI885219A (fi) 1988-11-11
ATE99677T1 (de) 1994-01-15
CA1326022C (en) 1994-01-11
HUT49118A (en) 1989-08-28
NZ223858A (en) 1990-11-27
WO1988007037A1 (fr) 1988-09-22
DK632588D0 (da) 1988-11-11
EP0284547A1 (de) 1988-09-28
DE3886798D1 (de) 1994-02-17

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