ES2061715T3 - Derivados de 6-oxo-prostaglandina-e, procedimiento para su produccion y su aplicacion farmaceutica. - Google Patents
Derivados de 6-oxo-prostaglandina-e, procedimiento para su produccion y su aplicacion farmaceutica.Info
- Publication number
- ES2061715T3 ES2061715T3 ES88730060T ES88730060T ES2061715T3 ES 2061715 T3 ES2061715 T3 ES 2061715T3 ES 88730060 T ES88730060 T ES 88730060T ES 88730060 T ES88730060 T ES 88730060T ES 2061715 T3 ES2061715 T3 ES 2061715T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- pct
- cycloalkyl
- alkyl
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- ROUDCKODIMKLNO-CTBSXBMHSA-N 6-oxoprostaglandin E1 Chemical class CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(O)=O ROUDCKODIMKLNO-CTBSXBMHSA-N 0.000 abstract 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 abstract 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxymethylene group Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION SE REFIERE A DERIVADOS DE 6-OXOPROSTAGLANDINA-E1 DE FORMULA (I), DONDE R1 ES UN RESTO COOR2 CON R2 COMO ATOMO DE HIDROGENO, UN GRUPO C1-10 ALQUILO, UN CICLOALQUILO C5-C6 O UN GRUPO ARILO C6-C10 O UN RESTO HETEROCICLICO, O UN RESTO HETEROCICLICO, O L RESTO CONHSO2R5 COMO C1-10 ALQUILO, C5-6 CICLOALQUILO O C6-10 ARILO; A ES UN GRUPO CH=CH CONFIGURADO E O UN GRUPO -C=C-, W ES UN GRUPO HIDROXIMETILENO LIBRE O FUNCIONAL O UN GRUPO (II) LIBRE O FUNCIONAL, DONDE LOS GRUPOS OH PUEDEN SER ALFA- O BETA-, D ES UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA CON 1-5 ATOMOS DE C, E ES UN GRUPO -C=C- O UN GRUPO C2-C4-ALQUENILENO, R3 ES UN GRUPO C1-C10 ALQUILO, C3-C10 CICLOALQUILO O UN GRUPO ARILO C6-C10 SUSTITUIDO SI ES CASO O UN GRUPO HETEROCICLICO, R4 ES UN GRUPO HIDROXI LIBRE O FUNCIONAL Y R2 TIENE EL SIGNIFICADO DE UN ATOMO DE HIDROGENO, CUYAS SALES SIGNIFICAN BASES FISIOLOGICAMENTE ACEPTABLES, ASI COMO LOS ALFAY BETA- O GAMMA-CICLODEXTRINCLARATOS DE LOS COMPUESTOS DE FORMULA (I), PROCEDIMIENTO PARA SU OBTENCION Y SU APLICACION FARMACEUTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873708537 DE3708537A1 (de) | 1987-03-13 | 1987-03-13 | 6-oxoprostaglandin-e-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2061715T3 true ES2061715T3 (es) | 1994-12-16 |
Family
ID=6323216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88730060T Expired - Lifetime ES2061715T3 (es) | 1987-03-13 | 1988-03-11 | Derivados de 6-oxo-prostaglandina-e, procedimiento para su produccion y su aplicacion farmaceutica. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5023273A (es) |
| EP (1) | EP0284547B1 (es) |
| JP (1) | JPH01502750A (es) |
| AT (1) | ATE99677T1 (es) |
| AU (1) | AU620543B2 (es) |
| CA (1) | CA1326022C (es) |
| DE (2) | DE3708537A1 (es) |
| DK (1) | DK160871C (es) |
| ES (1) | ES2061715T3 (es) |
| FI (1) | FI90661C (es) |
| HU (1) | HU206342B (es) |
| IE (1) | IE62469B1 (es) |
| IL (1) | IL85711A (es) |
| NZ (1) | NZ223858A (es) |
| WO (1) | WO1988007037A1 (es) |
| ZA (1) | ZA881777B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3831222A1 (de) * | 1988-09-09 | 1990-03-22 | Schering Ag | 6-oxo-9-fluor-prostaglandin-derivate verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| DE4010339A1 (de) * | 1990-03-29 | 1991-10-02 | Schering Ag | Neues verfahren zur synthese von propargylalkoholen und dessen anwendung zur herstellung von prostaglandinvorstufen |
| DE19828881A1 (de) * | 1998-06-22 | 1999-12-23 | Schering Ag | Oxidationsinhibitor bei Prostan-Derivaten |
| JP6705974B2 (ja) * | 2017-11-08 | 2020-06-03 | Ａｇｃ株式会社 | 新規なプロスタグランジン誘導体を有効成分として含有する医薬 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU511711B2 (en) * | 1976-12-30 | 1980-09-04 | Upjohn Company, The | 6-Oxo and 5, 6-Dihalo prostaglandin analogues |
| US4205178A (en) * | 1976-12-30 | 1980-05-27 | The Upjohn Company | 6-Keto prostaglandin E-type compounds |
| DE2729960A1 (de) * | 1977-06-30 | 1979-01-18 | Schering Ag | Neue acetylenprostaglandine und verfahren zu ihrer herstellung |
| JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| DE2907118A1 (de) * | 1979-02-20 | 1980-09-04 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| DE2913856A1 (de) * | 1979-04-06 | 1980-10-23 | Hoechst Ag | Neue prostaglandinderivate in der 6-keto-pge tief 1 -reihe |
| ZA805820B (en) * | 1979-11-15 | 1981-09-30 | Upjohn Co | Prostacyclin analogues |
| DE3125271A1 (de) * | 1981-06-24 | 1983-01-13 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | (delta)(pfeil hoch)8(pfeil hoch),(pfeil hoch)9(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4403100A (en) * | 1981-10-30 | 1983-09-06 | The Upjohn Company | (11R)-11-Deoxy-11-alkyl-6-oxo-prostaglandins |
| JPS5973522A (ja) * | 1982-10-20 | 1984-04-25 | Dainippon Pharmaceut Co Ltd | 脳神経細胞の酸素欠乏性疾患治療剤 |
| JPS58203911A (ja) * | 1982-05-25 | 1983-11-28 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤 |
| AU565905B2 (en) * | 1984-02-29 | 1987-10-01 | John Deks Australia Pty. Ltd. | Improvements relating to flashing for buildings |
| US4540993A (en) * | 1984-07-23 | 1985-09-10 | Sanders Associates, Inc. | Plotter pen |
| JPS62277352A (ja) * | 1986-01-30 | 1987-12-02 | Ono Pharmaceut Co Ltd | 新規な６−ケト−プロスタグランジンｅ１誘導体、それらの製造方法およびそれらを有効成分として含有する細胞障害治療剤 |
-
1987
- 1987-03-13 DE DE19873708537 patent/DE3708537A1/de not_active Ceased
-
1988
- 1988-03-11 HU HU881863A patent/HU206342B/hu not_active IP Right Cessation
- 1988-03-11 ZA ZA881777A patent/ZA881777B/xx unknown
- 1988-03-11 AU AU14237/88A patent/AU620543B2/en not_active Ceased
- 1988-03-11 CA CA000561283A patent/CA1326022C/en not_active Expired - Fee Related
- 1988-03-11 DE DE88730060T patent/DE3886798D1/de not_active Expired - Fee Related
- 1988-03-11 US US07/276,502 patent/US5023273A/en not_active Expired - Fee Related
- 1988-03-11 NZ NZ223858A patent/NZ223858A/en unknown
- 1988-03-11 JP JP63502393A patent/JPH01502750A/ja active Pending
- 1988-03-11 EP EP88730060A patent/EP0284547B1/de not_active Expired - Lifetime
- 1988-03-11 ES ES88730060T patent/ES2061715T3/es not_active Expired - Lifetime
- 1988-03-11 IL IL85711A patent/IL85711A/xx not_active IP Right Cessation
- 1988-03-11 WO PCT/DE1988/000151 patent/WO1988007037A1/de active IP Right Grant
- 1988-03-11 AT AT88730060T patent/ATE99677T1/de active
- 1988-03-14 IE IE73788A patent/IE62469B1/en not_active IP Right Cessation
- 1988-11-11 DK DK632588A patent/DK160871C/da not_active IP Right Cessation
- 1988-11-11 FI FI885219A patent/FI90661C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL85711A (en) | 1993-06-10 |
| DK160871C (da) | 1991-10-14 |
| AU1423788A (en) | 1988-10-10 |
| DK632588A (da) | 1988-11-11 |
| IL85711A0 (en) | 1988-08-31 |
| IE62469B1 (en) | 1995-02-08 |
| JPH01502750A (ja) | 1989-09-21 |
| US5023273A (en) | 1991-06-11 |
| DE3708537A1 (de) | 1988-09-22 |
| FI885219A0 (fi) | 1988-11-11 |
| EP0284547B1 (de) | 1994-01-05 |
| FI90661B (fi) | 1993-11-30 |
| ZA881777B (en) | 1988-09-09 |
| DK160871B (da) | 1991-04-29 |
| IE880737L (en) | 1988-09-13 |
| FI90661C (fi) | 1994-03-10 |
| HU206342B (en) | 1992-10-28 |
| AU620543B2 (en) | 1992-02-20 |
| FI885219A (fi) | 1988-11-11 |
| ATE99677T1 (de) | 1994-01-15 |
| CA1326022C (en) | 1994-01-11 |
| HUT49118A (en) | 1989-08-28 |
| NZ223858A (en) | 1990-11-27 |
| WO1988007037A1 (fr) | 1988-09-22 |
| DK632588D0 (da) | 1988-11-11 |
| EP0284547A1 (de) | 1988-09-28 |
| DE3886798D1 (de) | 1994-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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