JPH0141609B2 - - Google Patents

Info

Publication number: JPH0141609B2
Authority: JP; Japan
Prior art keywords: tylosin; apramycin; combination; physiologically acceptable; antibiotic
Prior art date: 1979-12-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP55183671A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5699417A (en

Inventor

Enu Haru Robaato

Esu Gorudeii Robaato

Ii Ose Aaru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-12-26

Filing date

1980-12-23

Publication date

1989-09-06

1980-12-23 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1981-08-10 Publication of JPS5699417A publication Critical patent/JPS5699417A/ja

1989-09-06 Publication of JPH0141609B2 publication Critical patent/JPH0141609B2/ja

Status Granted legal-status Critical Current

Links

229950006334 apramycin Drugs 0.000 claims description 53
229930194936 Tylosin Natural products 0.000 claims description 42
235000019375 tylosin Nutrition 0.000 claims description 42
239000004182 Tylosin Substances 0.000 claims description 41
229960004059 tylosin Drugs 0.000 claims description 41
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 claims description 41
XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 claims description 37
241000204031 Mycoplasma Species 0.000 claims description 33
241000282887 Suidae Species 0.000 claims description 33
229960000707 tobramycin Drugs 0.000 claims description 31
150000003839 salts Chemical class 0.000 claims description 29
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 25
238000000034 method Methods 0.000 claims description 17
239000000203 mixture Substances 0.000 claims description 16
239000003120 macrolide antibiotic agent Substances 0.000 claims description 15
239000002647 aminoglycoside antibiotic agent Substances 0.000 claims description 14
229960002518 gentamicin Drugs 0.000 claims description 10
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 9
229930182566 Gentamicin Natural products 0.000 claims description 9
229940126574 aminoglycoside antibiotic Drugs 0.000 claims description 9
IEMDOFXTVAPVLX-YWQHLDGFSA-N Leucomycin A1 Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 IEMDOFXTVAPVLX-YWQHLDGFSA-N 0.000 claims description 8
230000000844 anti-bacterial effect Effects 0.000 claims description 8
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FQVHOULQCKDUCY-OGHXVOSASA-N [(2s,3s,4r,6s)-6-[(2r,3s,4r,5r,6s)-6-[[(1s,3r,7r,8s,9s,10r,12r,14e,16s)-7-acetyloxy-8-methoxy-3,12-dimethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimeth Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@H]1[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@@H]2O[C@H]2C[C@@H](C)OC(=O)C[C@H]([C@@H]1OC)OC(C)=O)[C@H]1C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O1 FQVHOULQCKDUCY-OGHXVOSASA-N 0.000 claims description 7
229960004927 neomycin Drugs 0.000 claims description 7
239000004104 Oleandomycin Substances 0.000 claims description 6
RZPAKFUAFGMUPI-UHFFFAOYSA-N Oleandomycin Natural products O1C(C)C(O)C(OC)CC1OC1C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C2(OC2)CC(C)C(OC2C(C(CC(C)O2)N(C)C)O)C1C RZPAKFUAFGMUPI-UHFFFAOYSA-N 0.000 claims description 6
RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 claims description 6
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NBOODGNJLRRJNA-IAGPQMRQSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl Chemical compound OP(O)(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 NBOODGNJLRRJNA-IAGPQMRQSA-N 0.000 claims description 4
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SKKLOUVUUNMCJE-FQSMHNGLSA-N kanamycin B Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SKKLOUVUUNMCJE-FQSMHNGLSA-N 0.000 claims description 3
229930182824 kanamycin B Natural products 0.000 claims description 3
WGLYHYWDYPSNPF-RQFIXDHTSA-N Apramycin sulfate Chemical compound OS(O)(=O)=O.O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O WGLYHYWDYPSNPF-RQFIXDHTSA-N 0.000 claims description 2
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UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
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VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
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FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
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ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 description 1
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229940127126 plasminogen activator Drugs 0.000 description 1
239000013641 positive control Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000001902 propagating effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000004044 response Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
238000010972 statistical evaluation Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000004448 titration Methods 0.000 description 1
229960004477 tobramycin sulfate Drugs 0.000 description 1
229960001717 tylosin tartrate Drugs 0.000 description 1
239000000273 veterinary drug Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Polymers & Plastics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Zoology (AREA)
Animal Husbandry (AREA)
Oncology (AREA)
Epidemiology (AREA)
Food Science & Technology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Feed For Specific Animals (AREA)
Fodder In General (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

JP18367180A 1979-12-26 1980-12-23 Antibiotic blend Granted JPS5699417A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10723979A	1979-12-26	1979-12-26

Publications (2)

Publication Number	Publication Date
JPS5699417A JPS5699417A (en)	1981-08-10
JPH0141609B2 true JPH0141609B2 (it)	1989-09-06

Family

ID=22315603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP18367180A Granted JPS5699417A (en)	1979-12-26	1980-12-23	Antibiotic blend

Country Status (5)

Country	Link
JP (1)	JPS5699417A (it)
BE (1)	BE886765A (it)
CA (1)	CA1160569A (it)
PH (1)	PH16876A (it)
ZA (1)	ZA808001B (it)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009501023A (ja) *	2005-07-14	2009-01-15	プリナミルズ，エルエルシー	ゲルベースの家畜用飼料、製造方法および使用
JP2012130355A (ja) *	2012-04-05	2012-07-12	Purina Mills Llc	ゲルベースの家畜用飼料、製造方法および使用
US9918487B2 (en)	2003-12-02	2018-03-20	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201013207D0 (en) *	2010-08-05	2010-09-22	Helperby Therapeutics Ltd	Novel combination

1980
- 1980-12-19 BE BE1/10083A patent/BE886765A/fr not_active IP Right Cessation
- 1980-12-22 ZA ZA00808001A patent/ZA808001B/xx unknown
- 1980-12-22 CA CA000367383A patent/CA1160569A/en not_active Expired
- 1980-12-23 PH PH25029A patent/PH16876A/en unknown
- 1980-12-23 JP JP18367180A patent/JPS5699417A/ja active Granted

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9918487B2 (en)	2003-12-02	2018-03-20	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use
US10085466B2 (en)	2003-12-02	2018-10-02	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use
US10231473B2 (en)	2003-12-02	2019-03-19	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use
US10383346B2 (en)	2003-12-02	2019-08-20	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use
US10653167B2 (en)	2003-12-02	2020-05-19	Purina Mills Llc	Gel based livestock feed, method of manufacture and use
US11051533B2 (en)	2003-12-02	2021-07-06	Purina Mills, Llc	Gel based livestock feed, method of manufacture and use
JP2009501023A (ja) *	2005-07-14	2009-01-15	プリナミルズ，エルエルシー	ゲルベースの家畜用飼料、製造方法および使用
JP2012130355A (ja) *	2012-04-05	2012-07-12	Purina Mills Llc	ゲルベースの家畜用飼料、製造方法および使用

Also Published As

Publication number	Publication date
CA1160569A (en)	1984-01-17
ZA808001B (en)	1982-07-28
BE886765A (fr)	1981-06-19
JPS5699417A (en)	1981-08-10
PH16876A (en)	1984-04-02

Publication	Publication Date	Title
JP2008297316A (ja)	2008-12-11	ブタ及び家禽類の疾患及び感染症の治療及び予防
Smith et al.	1945	The influence of streptomycin and streptothricin on the intestinal flora of mice
RU2197237C2 (ru)	2003-01-27	Способ лечения заболеваний животных, вызванных бактериями (варианты), и способ изготовления лекарственного средства
EP0032304B1 (en)	1984-08-15	Antibiotic compositions
JPH0141609B2 (it)	1989-09-06
GB2159409A (en)	1985-12-04	Synergistic antibiotic composition and process for its preparation
US4379781A (en)	1983-04-12	Antibiotic compositions
US20060166905A1 (en)	2006-07-27	Aivlosin for the treatment of disease due to brachyspira pilosicoli or ornithobacterium rhinotracheale
US4283388A (en)	1981-08-11	Method for treating colibacillosis in pigs with tylosin apramycin compositions
US4871722A (en)	1989-10-03	Synergistic veterinary composition and/or fodder premix and process for preparing same
KR100516418B1 (ko)	2005-12-20	플루로뮤틸린유도체의수의학적용도
KR102199186B1 (ko)	2021-01-06	병원성 세균에 의한 질병의 예방 및 치료용 수의학적 조성물
KR950009945B1 (ko)	1995-09-04	음료수 또는 동물사료에 첨가제로서 겐타마이신과 린코마이신의 항생제 혼합물을 함유하는 수의제제 및 이의 돼지사육에 대한 용도
US3185573A (en)	1965-05-25	Animal feed composition and method of using same
EP0517394A1 (en)	1992-12-09	A prophylactic/therapeutic composition for swine pleuropneumonia
Bletner et al.	1957	Control of Infectious Synovitis: 3. The Efficacy of Chlortetracycline with Relation to Time of Experimental Infection
TW410221B (en)	2000-11-01	A pharmaceutical composition for the use in the therapy of a veterinary disease complex caused by increasing stocking density
SE467445B (sv)	1992-07-20	Nya laekemedelskompositioner med antimikrobiell aktivitet och foerfarande foer deras framstaellning
Ishimura et al.	1975	Effects of gentamicin on the intestinal bacterial flora of rats
Stuart et al.	1966	The Enhancement of Chlortetracycline Activity Against Pasteurella multocida with Sodium Sulfate
Hare	1960	Antibiotic potentiation—a review
Hoge et al.	1939	The effect of sulfanilamide therapy upon bovine mastitis as indicated by laboratory tests
HU201668B (en)	1990-12-28	Method for producing veterinary preparation and fodder premixture of synergetic effect serving for making more economical breeding of animals
JPS60227641A (ja)	1985-11-12	家畜用の相乗作用の成長促進飼料添加組成物
JPS61165332A (ja)	1986-07-26	家畜マイコプラズマ症と豚赤痢の予防または治療剤