JPH01305020A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a composition for oral cavity containing calcium tertiary phosphate, apatite fluoride, etc., and forming a film on the surface of tooth and repairing unevenness of the surface of tooth and having beautifying effects of tooth and effective to prevention and repair of dental caries and strengthening of dental quality. CONSTITUTION:The composition for oral cavity containing at least one kind selected from a group consisting of mixture of calcium tertiary phosphate [Ca3(PO4)2], calcium quaternary phosphate [Ca4(PO4)2], octa calcium phosphate [Ca8H2(PO4)6.5H2O], apatite fluoride [Ca10(PO4)6F2], apatite carbonate [Ca10(PO4)6CO3] or calcium secondary phosphate [CaHPO4.2H2O] and calcium carbonate and mixture of anhydrous calcium secondary phosphate [CaHPO4.2H2 O] and calcium carbonate and anhydrous calcium secondary phosphate and calcium carbonate. Powder of the above-mentioned active ingredient, liquid or paste like drug obtained by dispersing the powder into a non-aqueous solvent or water soluble film-forming material is dissolved in a solvent and an active ingredient is added thereto and the mixture is kneaded and molded into sheet form and then solvent is evaporated to used in form of sheet.

Description

Detailed Description of the Invention [Field of Industrial Application] The present invention relates to an oral cavity composition, in particular, a composition that forms a film on the tooth surface, repairs irregularities on the tooth surface, and has a tooth whitening effect.
The present invention relates to an oral composition effective for preventing and restoring dental caries and strengthening tooth structure.

[Conventional technology]

Toothpaste has conventionally been used as a preparation for whitening teeth. However, the main purpose of tooth brushing is basically to remove foreign substances from the tooth surface, and the teeth whitening effect is not sufficient. In contrast, so-called tooth make-up preparations have recently been commercially available that actively form a film on the tooth surface to increase the whitening effect. This method uses a solvent or the like to extract resin from the tooth surface, but it is difficult to use and requires skill, and there are also problems with the safety of the material.

On the other hand, it prevents and repairs tooth decay by strengthening the tooth structure and promoting remineralization (Hydroxyabatai).
Toothpaste containing (HAP) powder has also been proposed (Japanese Patent Application Laid-open Nos. 55-57514, 56-73014 and 5
No. 6-73015).

This toothpaste uses the side layer action of HAP powder to remove foreign substances from the tooth surface, or uses NaCβ, KCj! .

MgCj! This method attempts to coat the teeth by dissolving a portion of HAP in the coexistence of HAP and depositing HAP crystals on the tooth surface. However, since HAP is extremely poorly soluble in water, its coating effect cannot be said to be sufficient.

[Problem to be solved by the invention]

Therefore, the purpose of the present invention is to form a film on the tooth surface,
An object of the present invention is to provide an oral composition that has a tooth whitening effect and is also useful as a preparation for preventing and restoring dental caries.

[Means to solve the problem]

The object of the present invention is to use tricalcium phosphate (TCP;
a, (PO4) 2), Quaternary calcium phosphate (T
eCP;[:a4(PO4) 20) , octacalcium phosphate (OCP;CaJ2(p[1,) s'5H2
0), 7-/element apatite (FAP; ca+o(Po
4) gF2), carbonate apatite (C to CO88P
a+o(PO<)scOi), dicalcium phosphate (
A mixture of DcPD; CaHPO, 2) 120) and calcium carbonate, and anhydrous dicalcium phosphate (DCPA)
This is achieved by an oral composition characterized by containing at least one selected from the group consisting of a mixture of CaHPO<) and calcium carbonate.

The oral composition of the present invention comprises at least one of the above active ingredients.
A powder consisting of seeds, or a liquid or paste preparation in which the powder is dispersed in a non-aqueous solvent (e.g., glycerin, ethanol), or methanol, ethanol,
A water-soluble film-forming material such as polyvinylpyrrolidone (PVP) is dissolved in a solvent such as methyl ethyl ketone or impropatul, and the active ingredient and other sub-components are added thereto, kneaded, and formed into a sheet. After that, it is preferable to evaporate the solvent to form a sheet with a thickness of about 20 to 100 μm. The size of the active ingredient particles is suitably 100 μm or less, preferably 2 to 20 μm.

In addition, FAP and Co
, and those containing AP as a main component are preferred.

In addition to the active ingredients, the oral composition of the present invention may optionally contain a diluent such as silicic anhydride, calcium birophosphate, alumina, aluminum hydroxide, titanium oxide, etc.
); Water-soluble thickeners such as carboxymethylcellulose sodium salt and methylcellulose carrageenan (0-5%)
: Adsorption accelerator for malic acid, glycolic acid, succinic acid, fumaric acid, lactic acid, pyruvic acid, etc. (0-25%); Fragrance (0
~3%).

The content of the active ingredient in the oral composition of the present invention is suitably 50 to 100% for powder preparations, 20 to 50% for paste and liquid preparations, and 10 to 50% for sheet preparations.

Powder, paste and liquid formulations of the present invention can be prepared from 10 to
After dispersing 20 g in 40-50 rnl of water, swish it in your mouth and keep it in your mouth for 5-10 minutes, then rinse with water, or disperse 1.0-20 g of the preparation in 10 rnl of water, then apply it to your teeth. Simply apply an appropriate amount to the surface, leave it for 3 to 5 minutes, and then rinse with water. Thereby, a uniform film can be formed on the tooth surface.

On the other hand, a sheet-like preparation may be wetted with water, applied to the desired tooth surface, left as it is for 5 to 10 minutes, and then rinsed with water. As a result, water-soluble components such as PVP are eluted, and the active ingredients form a hardened film on the tooth surface.

〔Effect of the invention〕

The oral composition of the present invention can form a film on the tooth surface very easily and safely by appropriately selecting its active ingredients.

〔Example〕

Various formulations were prepared by mixing the components shown in Table 1. As the active ingredient, one having a particle size of 5 to 20 μm was used.

10 g each of the preparations thus obtained (Nα1-10) were added to 4 ml of water.
0 m1', and 3 extracted teeth were placed in this dispersion.
After being immersed for 30 minutes at 7°C, it was taken out and the amount of film formed (adsorption amount) per tooth was measured. The results are shown in Table 2.

Table 2 For DCPO (-lucium phosphate used in boat fishing toothpaste), the adsorption amount was below the measurement limit.

It can be seen that the system using TeCP is relatively easy to form a film.

In addition, in formulation Nα1, the particle size of the active ingredient TeCP was changed as shown in Table 3, and 10 g of each was added to 40 ml of water.
3 extracted teeth were placed in this dispersion at 37℃ for 3 hours.
After immersion for 0 minutes, it was taken out and the amount of film formed (adsorption amount) per tooth was measured. The results are shown in Table 3.

The results shown in Table 3 indicate that the particle size of the active ingredient of the present invention is 10.
This indicates that 0 μm or less, particularly 2 to 20 μm, is preferable.

Furthermore, in formulation N011, the active ingredient TeC
P with a particle size of 10 to 50 μm was used, and the formulation Log
The amount of water used was changed as shown in Table 4, and three extracted teeth were immersed in this dispersion at 37° C. for 30 minutes, then taken out, and the amount of adsorption per tooth was measured. The results are shown in Table 4.

Table 4 When the concentration of the preparation was 40% or more (the amount of water was 15 g or less), it did not become a suspension but became linear, making it impossible to measure. It can be seen that a formulation concentration range of 5 to 29% (water amount of 25 to 190 g) is preferable. However, considering that 29% is somewhat difficult to use, 10-20% (amount of water 40-90g)
) is preferred.

Moreover, it is more effective to apply the coating at 40% or more.

Claims (1)

[Claims] Contains at least one member selected from the group consisting of tricalcium phosphate, quaternary calcium phosphate, octacalcium phosphate, fluoroapatite, carbonate apatite, a mixture of dibasic calcium phosphate and calcium carbonate, and a mixture of anhydrous dibasic calcium phosphate and calcium carbonate. An oral composition characterized by: