JP3816999B2 - Bioactive glass-containing oral coating - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an oral coating agent for forming a hydroxyapatite film on a tooth surface.
[0002]
[Prior art]
Some glass and ceramics naturally bond with biological tissues, and these are called bioactive materials. Bioactive glass having bioactive ability is one type, and has already been used as an artificial bone or an artificial tooth root.
These bioactive glasses can be broadly classified into bioactive crystallized glass containing crystals such as apatite and wollastonite in the glass and ordinary bioactive glasses not containing such crystals. For example, Japanese Examined Patent Publication No. 62-10939 discloses a crystallized glass for artificial bone containing apatite and wollastonite crystals and a method for producing the same. The crystallized glass is excellent in biocompatibility and directly with bone. It describes that it forms a chemical bond and is excellent in mechanical strength.
In JP-A-6-30984, an artificial bone made of glass or crystallized glass mainly composed of CaO and SiO ₂ is used to adjust the elution amount of Ca ²⁺ ions by binding hydrophobic groups to the glass surface. Thus, a technique for preventing the strength deterioration of the glass is disclosed.
Japanese Patent Application Laid-Open No. 5-31166 discloses a technique in which a metal such as titanium is coated with bioactive glass and used as a bone grafting material.
Furthermore, in Japanese Patent Laid-Open No. 2-255515, bioactive glass is used for living body such as bone repair material, implantable medical device, medical supplies, artificial organ, regardless of inorganic material, metal material, and organic material. A method for forming a bioactive apatite film similar to bone in vivo on the surface of all materials used therein is disclosed.
On the other hand, in the field of oral preparations, film forming agents are known, and a technique for forming a film using a silicon derivative to suppress stains and caries (Japanese Patent Laid-Open No. Hei 2-209805), fluoroalkyl phosphate ester A technique for coating the tooth surface and suppressing plaque and stain (Japanese Patent Laid-Open No. 3-38517), and a technique for forming a thin film on the tooth surface using higher alkyl betaine to inhibit plaque formation (Japanese Patent Laid-open No. Hei 4). -134025) and the like. In addition, antibacterial agents are blended into a varnish base consisting of natural resin and ethanol, and technologies related to antibacterial preparations with long-term activity (Japanese Patent Publication No. 5-508383), sustained-release acrylic polymers, drugs, release control Technology for polymer preparations that provide a sustained release of drugs (Japanese Patent Laid-Open No. 3-128316), dental primer varnish in which a chelating coupling agent is dissolved in a volatile solvent has good adhesion to the tooth surface A technique for applying force (Japanese Patent Laid-Open No. 50-100952) is disclosed. However, there is no disclosure of a technique for retaining bioactive glass on the tooth surface and forming hydroxyapatite on the tooth surface.
[0003]
[Problems to be solved by the invention]
An object of the present invention is to make bioactive glass stay on the tooth surface and form hydroxyapatite on the tooth surface.
[0004]
[Means for Solving the Problems]
As a result of intensive studies to solve the above problems, the present inventor has made bioactive glass stay on the tooth surface for a long time by blending bioactive glass, a film-forming substance, and an organic solvent, and uniform hydroxyapatite. The inventors have found that a film can be formed and have completed the present invention.
That is, the present invention provides an oral coating composition comprising a bioactive glass, a film-forming agent, and an organic solvent.
According to the present invention, bioactive glass can be retained on the tooth surface, hydroxyapatite can be effectively formed on the tooth surface, and an excellent effect in preventing caries can be exhibited.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
The bioactive glass used in the present invention is not limited as long as it is a glass material that naturally binds to the tooth surface, and bioactive crystallized glass containing crystals in the glass, or does not contain such crystals. Any of normal bioactive glass may be used. The composition of the bioactive glass is preferably 20 to 70% by weight of SiO ₂ and 10 to 60% by weight of CaO with respect to the whole glass, particularly 30 to 60% by weight of SiO ₂ and 10 to 50% of CaO. It is preferable to contain 0 to 30% by weight of Na ₂ O. If the SiO ₂ content in the glass is less than 20% by weight, the affinity with the tooth surface is lowered. On the other hand, if it exceeds 70% by weight, vitrification becomes difficult. On the other hand, if the CaO content in the glass is less than 10% by weight, the affinity with the tooth surface is lowered. On the other hand, if it exceeds 50% by weight, vitrification becomes difficult. Na ₂ O is a TeiTorusei the glass, but not preferred to lower the affinity exceeds the tooth surface 30 wt%.
The bioactive glass used in the present invention is selected from the group consisting of P ₂ O ₅ , K ₂ O, Li ₂ O, TiO ₂ , Al ₂ O ₃ , MgO, B ₂ O ₃ , ZrO ₂ and F. 1 type, or 2 or more types of inorganic compounds can be contained. Of these inorganic compounds, P ₂ O ₅ stabilizes the glass, K ₂ O, Li ₂ O, and B ₂ O ₃ render the glass low fusible, TiO ₂ , Al ₂ O ₃ , MgO, ZrO ₂ and F acts to adjust the coating speed of the apatite. These inorganic compounds can be contained in an amount of 0 to 30% by weight based on the entire bioactive glass.
In the coating agent of this invention, 0.001-10 weight% can be mix | blended with respect to the coating agent whole quantity combining 1 type, or 2 or more types of these bioactive glass. If the blending amount is less than 0.001% by weight, no apatite is formed on the tooth surface. On the other hand, if the blending amount exceeds 10% by weight, no further effect can be expected.
The bioactive glass used in the present invention has a spherical shape, a bead shape, a granular shape, a granular shape, or the like, and can be manufactured based on, for example, a method disclosed in JP-A-60-239341. In addition, as the bioactive glass, glass having a mesh size of less than 32 mesh is preferably used, and 65 mesh pass is particularly preferable. When the size is 32 mesh or more, the feeling of use of the coating agent is impaired, which is not preferable.
[0006]
As the film-forming substance used in the present invention, known substances for film formation can be used, for example, natural resins such as shellac resin, rosin, sandalac, alkyd resin, copalite, and sumatra benzoic resin, polyvinyl alcohol, polyvinyl pyrrolidone, polyurethane , Nonionic polymers such as polystyrene, polymethyl methacrylate, polyvinyl acetate, polyvinyl chloride, polyacrylonitrile, vinyl pyrrolidone / vinyl acetate polymer, vinyl pyrrolidone / dimethylaminoethyl methacrylate copolymer, carboxy vinyl polymer, methyl vinyl ether / maleic ester Copolymer, anionic polymer such as acrylate / methacrylate copolymer, vinyl acetate / crotonic acid copolymer, dimethylallyl ammonium chloride , Hydroxyethylcellulose / dimethylallylammonium chloride copolymer, cationic polymer such as vinylpyrrolidone quaternized dialkylaminoalkyl acrylate polymer, higher alkylbetaine, monochloroacetic acid amphoteric product of dialkylaminoethyl methacrylate polymer, octylacrylamide / butylaminoethyl methacrylate / Amphoteric polymers such as acrylic acid ester copolymers, fluororesins such as fluoroalkyl phosphates, silicon derivatives such as dimethylsiloxane, etc., which are dissolved or dispersed in organic solvents.
These film-forming substances may be used alone or in combination of two or more, and the blending amount is 0.01 to 15% by weight with respect to the total amount of the coating agent. When the blending amount is less than 0.01% by weight, the film forming ability is poor, and when the blending amount exceeds 15% by weight, the activity ability of the bioactive glass is impaired, which is not preferable.
[0007]
Examples of the organic solvent used in the present invention are volatile organic solvents such as ethyl acetate, dichloromethane, chloroform, alcohol, dioxane, siloxane, hexane, cyclohexane, hexane, acetone, ether, petroleum ether, and propylene carbonate, and these are also used alone. Alternatively, two or more kinds may be combined, and the blending amount is 10 to 90% by weight, preferably 20 to 70% by weight, based on the total amount of the coating agent.
[0008]
The oral coating of the present invention can be in the form of aerosol, mist, foam, varnish, etc. by a conventional method, such as a method of spraying directly on the tooth surface, a method of using a tray, or a method of applying with a brush, etc. Is applied to the tooth surface.
In addition to the above essential components, the oral coating agent of the present invention includes base materials such as surfactants, flavoring agents, sweeteners, pH adjusters, wetting agents, and other medicinal components as appropriate. It can mix | blend in the range which is not impaired.
[0009]
Examples of the surfactant include a nonionic surfactant, an anionic surfactant, and an amphoteric surfactant. Examples of the nonionic surfactant include sucrose fatty acid ester, maltose fatty acid ester, and maltitol fatty acid ester. , Maltotriitol fatty acid ester, maltotetritole fatty acid ester, maltopentylitol fatty acid ester, maltohexaitol fatty acid ester, maltoheptytitol fatty acid ester, sorbitan fatty acid ester, lactose fatty acid ester, lactinose fatty acid ester, polyoxyethylene Polyoxyethylene sorbitan fatty acid esters such as polyoxypropylene glycol ether, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene Emissions hardened castor oil, polyoxyethylene fatty acid esters, fatty acid monoglyceride, polyoxyethylene higher alcohol ethers, polyoxyethylene polyoxypropylene fatty acid esters.
Examples of the anionic surfactant include water-soluble salts of higher alkyl sulfates having 8 to 18 carbon atoms in the alkyl group, such as sodium lauryl sulfate and sodium myristyl sulfate, polyoxyethylene alkyl sulfate, alkyl sulfo Examples include acetates, α-olefin sulfonates, alkylsulfosuccinic acid derivatives, higher fatty acid sodium monoglyceride monosulfates, N-methyl-N-palmitoyl tauride salts, N-long chain acyl basic amino acid salts, and the like.
Examples of the amphoteric surfactant include betaine type, imidazolium type, imidazolium betaine type, amino acid type, carboxylic acid type such as amine oxide type, and the like.
These surfactants may be used alone or in combination of two or more thereof, and the amount thereof is usually 0.001 to 5% by weight based on the total amount of the coating agent.
[0010]
As a flavoring agent, for example, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineol, linalool, ethyl linalool, Examples include crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla oil, winter green oil, clove oil, eucalyptus oil, etc. These 1 or more types are 0.1 to 3 weight% with respect to the coating agent whole quantity.
Examples of the sweetening agent include saccharin sodium, acetyl farm potassium, stevioside, neohespolydyl dihydrochalcone, glycyrrhizin, perilartine, thaumatin, asparatylphenylalanine methyl ester, p-methoxycinnamic aldehyde, xylit, malt, lactit and the like.
Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, and the like.
In addition, wetting agents such as sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and polypropylene glycol may be used alone or in combination of two or more.
Also, bactericides such as chlorhexidine gluconate, cetylpyridinium chloride, triclosan, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme), sodium monofluorophosphate, potassium monofluorophosphate, etc. Alkali metal monofluorophosphate, fluorides such as sodium fluoride, stannous fluoride, vitamin derivatives, tranexamic acid and epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, Medicinal ingredients such as sodium chloride, caropeptide and water-soluble inorganic phosphate compounds can also be blended.
[0011]
【Example】
EXAMPLES Next, the present invention will be described more specifically with reference to examples and comparative examples, but the present invention is not limited to these examples. Unless otherwise specified, “%” indicates wt%.
Example 1
Component Blending amount (%)
Ethanol 30.0
Glycerin 10.0
Polyoxyethylene hydrogenated castor oil 1.0
Acrylic acid copolymer 1.0
Bioactive glass 10.0
(SiO ₂ / CaO: 50/50)
Water 48.0
Total 100.0
These components were mixed by a conventional method to produce an oral coating.
[0012]
Comparative Example 1
Component Blending amount (%)
Ethanol 30.0
Glycerin 10.0
Polyoxyethylene hydrogenated castor oil 1.0
Bioactive glass 10.0
(SiO ₂ / CaO: 50/50)
Water 49.0
Total 100.0
These components were mixed by a conventional method to produce an oral coating.
Example 1 and Comparative Example 1 were each applied to an acrylic plate in an amount of 0.1 g, and immersed in artificial saliva for 24 hours. After 24 hours, it was confirmed by induction crystal plasma emission analysis that hydroxyapatite was formed on the coating of Example 1.
[0013]
Example 2
Component Blending amount (%)
Ethanol 50.0
Sandalak 2.0
Bioactive glass 10.0
(SiO ₂ / CaO / Na ₂ O: 50:25:25)
Water 38.0
Total 100.0
These components were mixed by a conventional method to produce an oral coating.
[0014]
Comparative Example 2
Component Blending amount (%)
Ethanol 50.0
Bioactive glass 10.0
(SiO ₂ / CaO / Na ₂ O: 50:25:25)
Water 40.0
Total 100.0
These components were mixed by a conventional method to produce an oral coating.
[0015]
Example 3
Component Blending amount (%)
Ethyl acetate 85.0
Polyurethane 5.0
Bioactive glass 10.0
(SiO ₂ / CaO / Na ₂ O / P ₂ O ₅ : 45: 25: 25: 5)
Total 100.0
These components were mixed by a conventional method to produce an oral coating.
[0016]
It applied to the adult permanent tooth enamel which extracted the coating agent of Example 2 and Example 3 with a brush. This adult permanent tooth was immersed in whole saliva for 1 week. In Examples 2 and 3, a film was formed on the adult permanent tooth after 1 week, and hydroxyapatite was detected from the compound extracted from the film. On the other hand, when Comparative Example 2 was similarly applied to adult permanent teeth and immersed in whole saliva, no film remained after one week.
From these results, it was confirmed that the composition for oral cavity of the present invention forms a film on the tooth surface and uniformly forms a hydroxyapatite film on the tooth surface.
[0017]
【The invention's effect】
According to the present invention, a uniform hydroxyapatite film can be formed on the tooth surface, repairing defects such as secondary caries, root caries and wedge-shaped defects, reducing hypersensitivity, and aesthetic coating on the tooth surface. An effective oral application agent can be provided.

Claims (8)

  An oral application agent for repairing a tooth surface defect comprising a bioactive glass, a film-forming substance, and an organic solvent. A bioactive glass, a film-forming material is characterized by being obtained by blending an organic solvent, secondary caries, Nemen caries, oral coating agent for repairing the wedge Joketsu loss.   The oral application agent according to claim 1 or 2, wherein the bioactive glass is less than 32 mesh pass. The oral application agent according to any one of claims 1 to 3, wherein the bioactive glass contains 20 to 70% by weight of SiO ₂ and 10 to 60% by weight of CaO.   The oral application agent according to any one of claims 1 to 4, comprising 0.001 to 10% by weight of bioactive glass based on the total amount of the application agent. Bioactive glass, 30 to 60 wt% of _SiO 2, applied orally according to claim 1 containing 10 to 50 wt% of CaO and from 0 to 30% by weight of Na ₂ O Agent. The bioactive glass is further one or two selected from the group consisting of P ₂ O ₅ , K ₂ O, Li ₂ O, TiO ₂ , Al ₂ O ₃ , MgO, B ₂ O ₃ , ZrO ₂ and F. The coating agent for oral cavity of any one of Claims 1-6 containing the above inorganic compound.   The film-forming substance is dissolved or dispersed in an organic solvent, and the blending amount is 0.01 to 15% by weight with respect to the total amount of the coating agent. Oral coating agent.