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JPH01125339A - １，４−ビス（２，２，２−トリフルオロエトキシ）ベンゼンの製造方法 - Google Patents

１，４−ビス（２，２，２−トリフルオロエトキシ）ベンゼンの製造方法

Info

Publication number
JPH01125339A
JPH01125339A JP63135366A JP13536688A JPH01125339A JP H01125339 A JPH01125339 A JP H01125339A JP 63135366 A JP63135366 A JP 63135366A JP 13536688 A JP13536688 A JP 13536688A JP H01125339 A JPH01125339 A JP H01125339A
Authority
JP
Japan
Prior art keywords
bis
reaction
compd
mixture
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63135366A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0372212B2 (nl
Inventor
Charles M Leir
チャールス　エム　リアー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of JPH01125339A publication Critical patent/JPH01125339A/ja
Publication of JPH0372212B2 publication Critical patent/JPH0372212B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63135366A 1979-03-19 1988-06-01 １，４−ビス（２，２，２−トリフルオロエトキシ）ベンゼンの製造方法 Granted JPH01125339A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19
US21331 1979-03-19
US21332 1979-03-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP3467180A Division JPS55143967A (en) 1979-03-19 1980-03-18 Manufacture of 2*55bis*2*2*22trifluoroethoxy** nn*22piperidylmethyl*benzamide

Publications (2)

Publication Number Publication Date
JPH01125339A true JPH01125339A (ja) 1989-05-17
JPH0372212B2 JPH0372212B2 (nl) 1991-11-18

Family

ID=26694559

Family Applications (8)

Application Number Title Priority Date Filing Date
JP63135366A Granted JPH01125339A (ja) 1979-03-19 1988-06-01 １，４−ビス（２，２，２−トリフルオロエトキシ）ベンゼンの製造方法
JP63135363A Granted JPH01104045A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135367A Granted JPH01125341A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）アセトフェノン及びその製造方法
JP63135365A Granted JPH01104044A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２，−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135368A Granted JPH01125342A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−α，α−ジクロロアセトフェノン及びその製造方法
JP63135364A Granted JPH01104043A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135370A Granted JPH01125344A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）安息香酸の製造方法
JP63135369A Granted JPH01125343A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−α，α，α−トリクロロアセトフェノン及びその製造方法

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP63135363A Granted JPH01104045A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135367A Granted JPH01125341A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）アセトフェノン及びその製造方法
JP63135365A Granted JPH01104044A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２，−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135368A Granted JPH01125342A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−α，α−ジクロロアセトフェノン及びその製造方法
JP63135364A Granted JPH01104043A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−ｎ−（２−ピペリジルメチル）ベンザミドの製造方法
JP63135370A Granted JPH01125344A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）安息香酸の製造方法
JP63135369A Granted JPH01125343A (ja) 1979-03-19 1988-06-01 ２，５−ビス（２，２，２−トリフルオロエトキシ）−α，α，α−トリクロロアセトフェノン及びその製造方法

Country Status (14)

Country Link
JP (8) JPH01125339A (nl)
CA (1) CA1137486A (nl)
CH (1) CH643829A5 (nl)
DE (1) DE3010195A1 (nl)
DK (3) DK167062B1 (nl)
ES (1) ES8104227A1 (nl)
FR (7) FR2454438A1 (nl)
GB (2) GB2045760B (nl)
IE (1) IE49558B1 (nl)
IL (1) IL59623A (nl)
IT (1) IT1195262B (nl)
NL (1) NL191486C (nl)
PT (1) PT70967A (nl)
SE (5) SE447992B (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007119424A (ja) * 2005-10-31 2007-05-17 Dainippon Ink & Chem Inc ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519974A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede d'acylation d'halogeno ou trihalogenomethylbenzenes
FR2519975A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylcetones
FR2519980A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de sulfonylation d'halogeno ou trihalogenomethylbenzenes
FR2519979A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylsulfones
FR2525588A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim Procede de preparation de phenylcetones a partir d'halogeno ou trihalogenomethylbenzenes et de composes aliphatiques ou aromatiques trihalogenomethyles
EP0175188A1 (de) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazol-Derivate
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579591B1 (fr) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim Procede de preparation de derives pentafluoroethoxy et pentafluoroethylthiobenzeniques
FR2579594B1 (fr) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim Procede de preparation de trifluoroethoxy ou trifluoroethylthiobenzenes
DE3786037T2 (de) * 1986-04-25 1993-11-25 Abbott Lab Tracer zur Benutzung in immunologischen Fluoreszenz-Polarisationsverfahren zum Nachweis von Flecainid.
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
FR2640262B1 (fr) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie Procede de preparation de cetones aryliques trifluoroethoxylees
IL120715A (en) * 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US6316627B1 (en) * 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS525721A (en) * 1975-06-28 1977-01-17 Fisons Ltd Process for preparing pyrogallol or its salt
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
JPS5331631A (en) * 1976-09-02 1978-03-25 Kawaken Fine Chem Co Ltd Preparation of alkoxyaromatic hydrocarbons

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US3900481A (en) 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
DE2616478C2 (de) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Fluoracylresorcine enthaltende Arzneimittel, Biocide und Kosmetika
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS525721A (en) * 1975-06-28 1977-01-17 Fisons Ltd Process for preparing pyrogallol or its salt
JPS5331631A (en) * 1976-09-02 1978-03-25 Kawaken Fine Chem Co Ltd Preparation of alkoxyaromatic hydrocarbons
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007119424A (ja) * 2005-10-31 2007-05-17 Dainippon Ink & Chem Inc ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Also Published As

Publication number Publication date
JPH0339498B2 (nl) 1991-06-14
GB2097000A (en) 1982-10-27
CA1137486A (en) 1982-12-14
FR2454438A1 (fr) 1980-11-14
JPH01125344A (ja) 1989-05-17
DK79891D0 (da) 1991-04-30
DK112180A (da) 1980-09-20
SE8901533D0 (sv) 1989-04-27
JPH0251907B2 (nl) 1990-11-08
SE8002003L (sv) 1980-09-20
JPH0251906B2 (nl) 1990-11-08
JPH0251908B2 (nl) 1990-11-08
IT8020746A0 (it) 1980-03-18
SE8401554D0 (sv) 1984-03-21
JPH0149695B2 (nl) 1989-10-25
SE463419B (sv) 1990-11-19
IE49558B1 (en) 1985-10-30
FR2468576B1 (nl) 1983-01-21
SE8901532D0 (sv) 1989-04-27
SE8401555D0 (sv) 1984-03-21
JPH022870B2 (nl) 1990-01-19
SE447993B (sv) 1987-01-12
SE8901533L (sv) 1989-04-27
DE3010195A1 (de) 1980-10-02
IL59623A0 (en) 1980-06-30
SE463418B (sv) 1990-11-19
JPH01104043A (ja) 1989-04-21
JPH0372212B2 (nl) 1991-11-18
DK164857C (da) 1993-01-18
ES489629A0 (es) 1981-04-01
SE463260B (sv) 1990-10-29
JPH01125342A (ja) 1989-05-17
IT1195262B (it) 1988-10-12
ES8104227A1 (es) 1981-04-01
FR2454438B1 (nl) 1982-07-23
NL191486C (nl) 1995-08-04
JPH01125343A (ja) 1989-05-17
FR2468591A1 (fr) 1981-05-08
NL8001551A (nl) 1980-09-23
DE3010195C2 (nl) 1990-10-25
JPH01125341A (ja) 1989-05-17
SE8401554L (sv) 1984-03-21
JPH022869B2 (nl) 1990-01-19
IL59623A (en) 1983-07-31
FR2468590B1 (nl) 1983-09-23
FR2468570A1 (fr) 1981-05-08
FR2468576A1 (fr) 1981-05-08
NL191486B (nl) 1995-04-03
DK122290A (da) 1990-05-17
IE800549L (en) 1980-09-19
DK164857B (da) 1992-08-31
SE447992B (sv) 1987-01-12
FR2468570B1 (nl) 1983-03-11
GB2045760B (en) 1983-05-11
PT70967A (en) 1980-04-01
DK79891A (da) 1991-04-30
FR2468569A1 (fr) 1981-05-08
FR2468569B1 (nl) 1983-03-11
GB2097000B (en) 1983-11-30
FR2468591B1 (nl) 1983-07-22
JPH01104044A (ja) 1989-04-21
JPH01104045A (ja) 1989-04-21
FR2468590A1 (fr) 1981-05-08
FR2468571A1 (fr) 1981-05-08
FR2468571B1 (nl) 1983-03-11
DK122290D0 (da) 1990-05-17
SE8401555L (sv) 1984-03-21
DK167062B1 (da) 1993-08-23
CH643829A5 (de) 1984-06-29
GB2045760A (en) 1980-11-05
SE8901532L (sv) 1989-04-27

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