JP7012315B2 - 画像生成装置及び画像生成方法 - Google Patents
画像生成装置及び画像生成方法 Download PDFInfo
- Publication number
- JP7012315B2 JP7012315B2 JP2020530281A JP2020530281A JP7012315B2 JP 7012315 B2 JP7012315 B2 JP 7012315B2 JP 2020530281 A JP2020530281 A JP 2020530281A JP 2020530281 A JP2020530281 A JP 2020530281A JP 7012315 B2 JP7012315 B2 JP 7012315B2
- Authority
- JP
- Japan
- Prior art keywords
- image
- sample
- infrared light
- light
- difference
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 25
- 239000000126 substance Substances 0.000 claims description 83
- 230000003287 optical effect Effects 0.000 claims description 70
- 238000010521 absorption reaction Methods 0.000 claims description 58
- 238000009826 distribution Methods 0.000 claims description 44
- 238000001514 detection method Methods 0.000 claims description 31
- 230000001678 irradiating effect Effects 0.000 claims description 18
- 230000010287 polarization Effects 0.000 claims description 13
- 239000000523 sample Substances 0.000 description 242
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 136
- 239000011324 bead Substances 0.000 description 84
- 230000004048 modification Effects 0.000 description 74
- 238000012986 modification Methods 0.000 description 74
- 239000000377 silicon dioxide Substances 0.000 description 67
- 239000011521 glass Substances 0.000 description 54
- 238000012545 processing Methods 0.000 description 53
- 239000013076 target substance Substances 0.000 description 53
- 238000010586 diagram Methods 0.000 description 33
- 230000008859 change Effects 0.000 description 30
- 239000004793 Polystyrene Substances 0.000 description 21
- 229920002223 polystyrene Polymers 0.000 description 21
- 238000003384 imaging method Methods 0.000 description 18
- 239000012472 biological sample Substances 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 238000005259 measurement Methods 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 12
- 230000006870 function Effects 0.000 description 12
- 239000003990 capacitor Substances 0.000 description 11
- 210000003205 muscle Anatomy 0.000 description 11
- 230000005540 biological transmission Effects 0.000 description 10
- 238000000701 chemical imaging Methods 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 10
- 239000000758 substrate Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000007850 fluorescent dye Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000001069 Raman spectroscopy Methods 0.000 description 8
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 8
- 229910001634 calcium fluoride Inorganic materials 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 8
- 238000000862 absorption spectrum Methods 0.000 description 7
- 230000005284 excitation Effects 0.000 description 7
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 6
- 239000011325 microbead Substances 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 5
- 238000012937 correction Methods 0.000 description 5
- 238000002834 transmittance Methods 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 238000010408 sweeping Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000000663 muscle cell Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 229910002808 Si–O–Si Inorganic materials 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 238000005401 electroluminescence Methods 0.000 description 2
- 238000001093 holography Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 229910000530 Gallium indium arsenide Inorganic materials 0.000 description 1
- 229910018557 Si O Inorganic materials 0.000 description 1
- 238000005102 attenuated total reflection Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000003708 edge detection Methods 0.000 description 1
- 230000005274 electronic transitions Effects 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000012632 fluorescent imaging Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000879 optical micrograph Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T5/00—Image enhancement or restoration
- G06T5/50—Image enhancement or restoration using two or more images, e.g. averaging or subtraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4788—Diffraction
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0092—Polarisation microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
- G02B21/08—Condensers
- G02B21/14—Condensers affording illumination for phase-contrast observation
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
- G01N2021/1725—Modulation of properties by light, e.g. photoreflectance
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10048—Infrared image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10056—Microscopic image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10141—Special mode during image acquisition
- G06T2207/10152—Varying illumination
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
- G06T2207/20212—Image combination
- G06T2207/20224—Image subtraction
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Multimedia (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Theoretical Computer Science (AREA)
- Signal Processing (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
- Image Processing (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018133711 | 2018-07-13 | ||
JP2018133711 | 2018-07-13 | ||
PCT/JP2019/027754 WO2020013325A1 (fr) | 2018-07-13 | 2019-07-12 | Dispositif de génération d'images et procédé de génération d'images |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2020013325A1 JPWO2020013325A1 (ja) | 2021-08-26 |
JP7012315B2 true JP7012315B2 (ja) | 2022-01-28 |
Family
ID=69142711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020530281A Active JP7012315B2 (ja) | 2018-07-13 | 2019-07-12 | 画像生成装置及び画像生成方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20230010572A1 (fr) |
EP (1) | EP3822685A4 (fr) |
JP (1) | JP7012315B2 (fr) |
CN (1) | CN112771432A (fr) |
WO (1) | WO2020013325A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3502695A1 (fr) * | 2017-12-22 | 2019-06-26 | IMEC vzw | Procédé et dispositif pour examiner et évaluer le cardiomyocyte |
WO2021155363A1 (fr) | 2020-01-31 | 2021-08-05 | Photothermal Spectroscopy Corp. | Procédé et appareil pour spectroscopie et imagerie infrarouge photothermique à large champ haute performance |
JP7588150B2 (ja) | 2020-09-11 | 2024-11-21 | 浜松ホトニクス株式会社 | 観察装置および観察方法 |
WO2022195731A1 (fr) * | 2021-03-16 | 2022-09-22 | 株式会社エビデント | Dispositif d'estimation, système d'estimation, procédé d'estimation et support d'enregistrement |
JP7600365B2 (ja) | 2021-03-17 | 2024-12-16 | 株式会社エビデント | 推定装置、推定システム、推定方法、及び記録媒体 |
JP7524119B2 (ja) * | 2021-03-22 | 2024-07-29 | 株式会社東芝 | 光学装置、光学検査方法及び光学検査プログラム |
JP2023079437A (ja) * | 2021-11-29 | 2023-06-08 | 浜松ホトニクス株式会社 | 観察装置および観察方法 |
US20250052678A1 (en) * | 2021-11-29 | 2025-02-13 | Hamamatsu Photonics K.K. | Evaluation method, evaluation device, and information processing program |
JP2023079440A (ja) * | 2021-11-29 | 2023-06-08 | 浜松ホトニクス株式会社 | 観察装置および観察方法 |
JP7390423B2 (ja) * | 2022-03-22 | 2023-12-01 | 浜松ホトニクス株式会社 | 細胞評価方法および細胞評価装置 |
JP7554860B2 (ja) | 2023-02-17 | 2024-09-20 | 浜松ホトニクス株式会社 | 観察装置および観察方法 |
JP7554859B2 (ja) * | 2023-02-17 | 2024-09-20 | 浜松ホトニクス株式会社 | 観察装置および観察方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005195801A (ja) | 2004-01-06 | 2005-07-21 | Shimadzu Corp | 赤外顕微鏡 |
WO2006085606A1 (fr) | 2005-02-10 | 2006-08-17 | Kanagawa Academy Of Science And Technology | Microscope a lentille thermique dichroique circulaire |
JP5241078B2 (ja) | 2006-03-31 | 2013-07-17 | Ntn株式会社 | 固定式等速自在継手 |
JP2013183108A (ja) | 2012-03-02 | 2013-09-12 | Sony Corp | 照明光学系、分光測定用光照射装置及び分光測定装置 |
US20150036145A1 (en) | 2011-07-13 | 2015-02-05 | Universität Leipzig | Twin-focus photothermal correlation spectroscopy method and device for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05241078A (ja) | 1992-02-28 | 1993-09-21 | Shimadzu Corp | 赤外線顕微鏡 |
WO2002054046A1 (fr) * | 2000-12-28 | 2002-07-11 | Dmitri Olegovich Lapotko | Procede et dispositif d'examen phototermique d'irregularites microscopique |
JP6283104B2 (ja) * | 2014-05-26 | 2018-02-21 | 株式会社日立製作所 | 光学分析装置 |
EP2998776A1 (fr) * | 2014-09-22 | 2016-03-23 | Nanolive SA | Microscopie tomographique de phase |
CN106331442B (zh) * | 2015-07-02 | 2021-01-15 | 松下知识产权经营株式会社 | 摄像装置 |
EP3338075B1 (fr) * | 2015-08-20 | 2020-06-10 | Massachusetts Institute of Technology | Dispositif et procédé de détection de cibles à l'aide de détection de chatoiement photothérmique |
US10677722B2 (en) * | 2016-04-05 | 2020-06-09 | University Of Notre Dame Du Lac | Photothermal imaging device and system |
US10033910B2 (en) * | 2016-04-15 | 2018-07-24 | General Electric Company | Synchronous sampling methods for infrared cameras |
WO2018102467A1 (fr) * | 2016-11-29 | 2018-06-07 | Anasys Instruments Corporation | Procédé et appareil d'imagerie et de spectroscopie photothermiques améliorées |
US11879837B2 (en) * | 2018-06-01 | 2024-01-23 | Photothermal Spectroscopy Corp. | Wide area optical photothermal infrared spectroscopy |
US10845248B1 (en) * | 2019-05-01 | 2020-11-24 | Trustees Of Boston University | Systems and methods for bond-selective transient phase imaging |
WO2021155363A1 (fr) * | 2020-01-31 | 2021-08-05 | Photothermal Spectroscopy Corp. | Procédé et appareil pour spectroscopie et imagerie infrarouge photothermique à large champ haute performance |
-
2019
- 2019-07-12 US US17/260,185 patent/US20230010572A1/en active Pending
- 2019-07-12 WO PCT/JP2019/027754 patent/WO2020013325A1/fr unknown
- 2019-07-12 CN CN201980046780.4A patent/CN112771432A/zh active Pending
- 2019-07-12 EP EP19835002.7A patent/EP3822685A4/fr active Pending
- 2019-07-12 JP JP2020530281A patent/JP7012315B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005195801A (ja) | 2004-01-06 | 2005-07-21 | Shimadzu Corp | 赤外顕微鏡 |
WO2006085606A1 (fr) | 2005-02-10 | 2006-08-17 | Kanagawa Academy Of Science And Technology | Microscope a lentille thermique dichroique circulaire |
JP5241078B2 (ja) | 2006-03-31 | 2013-07-17 | Ntn株式会社 | 固定式等速自在継手 |
US20150036145A1 (en) | 2011-07-13 | 2015-02-05 | Universität Leipzig | Twin-focus photothermal correlation spectroscopy method and device for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers |
JP2013183108A (ja) | 2012-03-02 | 2013-09-12 | Sony Corp | 照明光学系、分光測定用光照射装置及び分光測定装置 |
Non-Patent Citations (3)
Title |
---|
MIYAZAKI Jun, KAWASUMI Koshi, KOBAYASHI Takayoshi,Resolution improvement in laser diode-based pump-probe microscopy with an annular pupil filter,OPTICS LETTERS,Vol.39, No.14,米国,2014年07月15日,4219-4222 |
MIYAZAKI Jun, TSURUI Hiromichi, HAYASHI-TAKAGI Akiko, KASAI Haruo, KOBAYASHI Takayoshi,Sub-diffraction resolution pump-probe microscopy with shot-noise limited sensitivity using laser diodes,OPTICS EXPRESS,Vol.22, No.8,米国,2014年04月07日,9024-9032 |
MIYAZAKI Jun, TSURUI Hiromichi, KAWASUMI Koshi, KOBAYASHI Takayoshi,Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues,OPTICS EXPRESS,Vol.22, No.16,米国,2014年07月28日,18833-18842 |
Also Published As
Publication number | Publication date |
---|---|
US20230010572A1 (en) | 2023-01-12 |
JPWO2020013325A1 (ja) | 2021-08-26 |
CN112771432A (zh) | 2021-05-07 |
EP3822685A4 (fr) | 2022-03-23 |
WO2020013325A1 (fr) | 2020-01-16 |
EP3822685A1 (fr) | 2021-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7012315B2 (ja) | 画像生成装置及び画像生成方法 | |
US10845248B1 (en) | Systems and methods for bond-selective transient phase imaging | |
US8817255B2 (en) | Apparatus and method for irradiating a scattering medium | |
US11885745B2 (en) | Fluorescence enhanced photothermal infrared spectroscopy and confocal fluorescence imaging | |
JP5329449B2 (ja) | 顕微鏡イメージングを実行する方法 | |
US9500846B2 (en) | Rapid adaptive optical microscopy over large multicellular volumes | |
JP7170342B2 (ja) | ホログラフィック3次元マルチスポット光刺激装置及び方法 | |
CN103256983B (zh) | 光学装置 | |
US20220381695A1 (en) | Focus scan type imaging device for imaging target object in sample that induces aberration | |
US11879837B2 (en) | Wide area optical photothermal infrared spectroscopy | |
US11982621B2 (en) | Autofluorescence photothermal characterization systems and methods | |
JP5106369B2 (ja) | 光学装置 | |
JP5489620B2 (ja) | 観察装置 | |
JP5344344B2 (ja) | 観察装置 | |
JPH10281876A (ja) | 偏光性イメージング装置 | |
US20220390895A1 (en) | Incoherent color holography lattice light-sheet (ichlls) | |
EP3855252B1 (fr) | Procédé et appareil pour la récupération de phase et la reconstruction d'imagerie volumétrique | |
JP2013195203A (ja) | 観察方法および観察装置 | |
JPH0815155A (ja) | 光学的検査方法および光学的検査装置 | |
WO2025009401A1 (fr) | Dispositif de spectrométrie et procédé de spectrométrie | |
JP5325697B2 (ja) | 観察方法および観察装置 | |
JP2016170054A (ja) | 撮影装置及び撮像システム | |
CN119522389A (zh) | 用于使用自参考定量相位成像来放大信号的装置 | |
Müllenbroich | Sensorless adaptive optics in advanced microscopy techniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210113 |
|
A80 | Written request to apply exceptions to lack of novelty of invention |
Free format text: JAPANESE INTERMEDIATE CODE: A801 Effective date: 20210212 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20210113 |
|
A80 | Written request to apply exceptions to lack of novelty of invention |
Free format text: JAPANESE INTERMEDIATE CODE: A80 Effective date: 20210212 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211214 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220107 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7012315 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |