JP6431251B2 - Teeth whitening agent and whitening method - Google Patents

Description

  The present invention relates to a tooth whitening agent and a method for whitening teeth using the same.

  In recent years, in order to improve the impression of appearance, the demand for whitening teeth, that is, tooth whitening, is increasing regardless of gender and age. Needs are also becoming increasingly sophisticated and diversified, especially with regard to safety, low prices, and expectations for time savings.

  The method of whitening teeth is mainly a bleaching method using a bleaching agent, and peroxides such as hydrogen peroxide and urea peroxide are mainly used as the bleaching agent used for bleaching. As such a method and a bleaching agent, for example, a bleaching agent in which a hydrogen peroxide solution and orthophosphoric acid are mixed has been reported (Patent Document 1). For example, a mixture of about 35% hydrogen peroxide and about 85% orthophosphoric acid is mixed at a mixing ratio of 8: 2 and applied to the teeth to simultaneously etch and bleach the teeth. It is.

  However, hydrogen peroxide and urea peroxide are irritating. In particular, when high concentration of hydrogen peroxide of about 35% is used, measures are taken to avoid the irritation and ensure safety. In addition, there is a problem that the bleaching apparatus used for the process is enlarged or complicated.

As a method of using a low concentration of hydrogen peroxide, a method of using titanium oxide having a photocatalytic action in combination with a low concentration hydrogen peroxide solution of about 3.5% (Patent Document 2) is disclosed. However, even in such a low concentration, it is essentially the same as the conventional agent in that it is necessary to prevent the bleach from coming into contact with the gingiva in order to ensure safety.
On the other hand, a method using visible light type titanium oxide, light irradiation, and hydrogen carbonate or carbonate (Patent Document 3) has been reported without using hydrogen peroxide. Although there are certain achievements in terms of avoidance, it is essential to use visible light type titanium oxide, which is an expensive component. In addition, when ordinary titanium oxide is used, a device such as a light irradiator is separately required for irradiating strong light, and thus is not suitable for home use.

JP-A-8-143436 JP 2005-343813 A JP 2006-316204 A JP 2009-126819 A

  In light of the above-mentioned problems in the prior art, the present inventors have searched for a new material as a whitening agent that does not require stimulating hydrogen peroxide, expensive visible light titanium oxide, light irradiation, etc. When a whitening method using ozone-dissolved glycerin (Patent Document 4) was developed, this was expected as an unprecedented type of whitening, but the whitening ability is still not sufficient by the subsequent studies by the present inventors. In addition, practical problems such as the possibility of decalcifying teeth were pointed out.

  That is, the present inventors have realized that the conventional technology is not sufficient to provide a whitening agent and a whitening method that are safe and easy to use, low in cost, and have sufficient whitening ability. It was. Accordingly, an object of the present invention is to provide a whitening agent and a whitening method that solves the problems in the prior art, can respond appropriately to sophisticated and diversified needs, is safe and easy to use, has low cost, and has sufficient whitening ability. It is to provide.

  Surprisingly, the inventors of the present invention have made extensive studies in order to solve the above-mentioned problems. Surprisingly, carbonates such as sodium carbonate, which have been widely used in conventional detergents, have been found to contain components such as hydrogen peroxide and titanium oxide. The present invention was completed as a result of obtaining a completely new knowledge that the tooth whitening effect was sufficiently exhibited without requiring a light irradiation step, and further research.

That is, the present invention relates to the following [1] to [13].
[1] A whitening agent for teeth, which contains carbonate as a whitening component.
[2] The whitening agent according to [1], wherein the carbonate is sodium carbonate.
[3] The whitening agent according to [1] or [2], which does not contain titanium oxide.
[4] The whitening agent according to any one of [1] to [3], further comprising a bicarbonate.
[5] The whitening agent according to [4], wherein the bicarbonate is sodium bicarbonate.
[6] The whitening agent according to [4] or [5], wherein the blending ratio of carbonate to bicarbonate is 10: 1 to 1:10.
[7] The whitening agent according to any one of [1] to [6], wherein the whitening component is sodium sesquicarbonate.
[8] The whitening agent according to any one of [1] to [7], further comprising an ozone-dissolved glycerin solution.
[9] The whitening agent according to any one of [1] to [7], further comprising a mixture of an ozone-dissolved glycerin solution and polyethylene glycol.
[10] The whitening agent according to any one of [1] to [9], further comprising an additional whitening component selected from the group consisting of hydrogen peroxide, urea peroxide and sodium percarbonate at a final concentration of 3% or less.
[11] A method for whitening a tooth, comprising applying the whitening agent according to any one of [1] to [10] to a tooth surface.
[12] A kit for whitening teeth, comprising carbonate, bicarbonate, ozone-dissolved glycerin solution, and hydrogen peroxide.
[13] A method for whitening teeth, which is applied to the tooth surface in combination with one or more selected from the group consisting of sesquicarbonate, ozone-dissolved glycerin solution, hydrogen peroxide and light irradiation, The above-mentioned method comprising adjusting one or two or more selected from the group consisting of a pH value in the oral cavity, an application time, and a measured value of tooth color by a shade guide.

  According to the tooth whitening agent of the present invention, it is safe even without using highly irritating hydrogen peroxide, expensive visible light type titanium oxide, or light irradiation which has been indispensable in many conventional bleaching agents. Simple and low-cost whitening can be realized. The advantage of not containing hydrogen peroxide is particularly significant in home use whitening where dentist monitoring is not always in sight.

  By further adding a weak alkaline bicarbonate to the whitening agent containing an alkaline carbonate, it becomes easy to adjust to a pH suitable for oral application, and at the same time, a higher whitening effect can be exerted on the teeth.

Since the present inventors have found that the ozone-dissolved glycerin solution is an acidic solution having a pH of about 2, by including the ozone-dissolved glycerin solution, the pH is neutral compared with the case where glycerin is blended. In addition, the amount of alkaline carbonate used can be relatively increased, and adjustment to a pH suitable for oral application is facilitated, and at the same time, a higher tooth whitening effect can be exhibited.
Moreover, the whitening agent of this invention can be adjusted to preferable pH by oral application by adding ozone solution glycerol solution to alkaline carbonate.

  Furthermore, by using an ozone-dissolved glycerin solution, the amount of further whitening components such as hydrogen peroxide can be relatively reduced, and the possibility of using various components in combination can be expanded. Specifically, the lowest concentration of hydrogen peroxide used in the conventional hydrogen peroxide-containing whitening agent is about 3.5%. According to the present invention, the concentration is about 1/3 of the concentration. Even if hydrogen peroxide is used, the effect of whitening is sufficiently exhibited.

  By including an ozone-dissolved glycerin solution or a mixture of an ozone-dissolved glycerin solution and polyethylene glycol, the hypersensitive effect of glycerin can be eliminated and painless whitening can be provided.

By adding hydrogen peroxide as a further whitening component, whitening can be effectively performed in a shorter time.
By irradiating the whitening agent applied to the tooth surface with light, whitening can be effectively performed in a shorter time.
By changing the mixing ratio of the components used, it is possible to appropriately prepare a prescription according to the user's needs, usage environment, and purpose.

In the present specification, “tooth whitening” or “whitening teeth” means increasing the whiteness of the teeth or reducing the degree of coloring by a color other than white (brown, yellow, black, etc.). The degree of such “tooth whitening” can be measured using a specific scale with a shade guide. Note that “whitening teeth” or “whitening teeth” may be simply referred to as “whitening” or “whitening”.
In the present specification, “tooth” also means dentures such as natural teeth and artificial teeth.

If the whitening agent of this invention is a whitening agent used for a tooth | gear, Comprising: A carbonate is included as a whitening component, the prescription, a dosage form, etc. will not be limited. Therefore, the whitening agent of the present invention may be an ozone-dissolved glycerin solution itself (gel), or other dosage forms such as creams, ointments and toothpastes.
The dosage form of the whitening agent of the present invention is not particularly limited, but gel or cream is preferable from the viewpoint of ease of use. Moreover, it is preferable to use a cream from the viewpoint of preventing hypersensitivity.

What has a cream dosage form can be produced, for example, by introducing ozone-dissolved glycerin into one or a mixture of one or two or more kinds of polyethylene glycol (PEG) and slowly stirring the mixture with a homogenizer. In a preferred embodiment, ozone-dissolved glycerin, PEG400, and PEG4000 are mixed at a ratio of 2: 0.5: 0.5.
Those whose dosage form is an ointment can be produced, for example, by mixing macrogol ointment defined by the Japanese Pharmacopoeia.

  The carbonate used in the present invention is not particularly limited, and examples thereof include potassium carbonate, magnesium carbonate, calcium carbonate, lithium carbonate, and sodium carbonate, and sodium carbonate is preferable. The carbonate of the present invention does not include bicarbonate. The content of carbonate in the whitening agent of the present invention is not particularly limited, but is generally 0.001 to 5% by weight, preferably 0.01 to 3% by weight, more preferably 0.01 to 1% by weight.

  In certain embodiments, the whitening agent of the present invention may further comprise a bicarbonate. The bicarbonate having a pH of about 8 serves to neutralize the whitening agent containing a carbonate having a pH of about 11.5 and at the same time enhance the whitening effect. The hydrogen carbonate used in the present invention is not particularly limited, and examples thereof include potassium hydrogen carbonate, magnesium hydrogen carbonate, calcium hydrogen carbonate, lithium hydrogen carbonate, sodium hydrogen carbonate and the like, but sodium hydrogen carbonate is preferable. The content of the hydrogen carbonate is not particularly limited, but is generally 0.001 to 5% by weight, preferably 0.01 to 3% by weight, and more preferably 0.01 to 1% by weight. .

  When bicarbonate is included, the blending ratio of carbonate and bicarbonate is not particularly limited, but in general, the blending ratio is 10: 1 to 1:10, the viewpoint of achieving suitable whitening and oral application In view of maintaining a suitable pH, the ratio is preferably 1: 0.5 to 1: 1.5, more preferably 1: 0.8 to 1: 1.2.

  The whitening component used in the present invention is most preferably sesquicarbonate in terms of pH and whitening effect. The sesquicarbonate of the present invention is obtained by appropriately mixing salts 1 to 1.5 with respect to carbonic acid 1, and usually carbonate and bicarbonate are mixed in a ratio of about 1: 1. The sesquicarbonate is not particularly limited, but is preferably sodium sesquicarbonate. The content of sesquicarbonate is not particularly limited, but is generally 0.001 to 10% by weight, preferably 0.01 to 6% by weight, more preferably 0.01 to 2% by weight. .

  In one embodiment, the whitening agent of the present invention may further include an ozone-dissolved glycerin solution, that is, a solution in which ozone is dissolved in glycerin. The ozone-dissolved glycerin solution can be obtained by aeration of ozone microbubbles in glycerin. When high-concentration glycerin of 75% or more is used, high-concentration ozone of 400 ppm or more can be dissolved. It can be easily prepared by following the method described in JP-A-2005-232094.

  The concentration of ozone in a whitening agent containing an ozone-dissolved glycerin solution means the concentration of ozone dissolved in the final whitening agent, but remains in combination with ozone or glycerin remaining in the solution as bubbles. When ozone is present, it means the ratio of ozone including these to the whole whitening agent.

  The concentration of ozone in the whitening agent containing the ozone-dissolved glycerin solution should be adjusted according to the purpose such as the needs of the user and the use environment, but is preferably 400 ppm to 4000 ppm.

  By adding an ozone-dissolved glycerin solution, the whitening agent of the present invention comprising an alkaline carbonate as a main component can be adjusted to a preferable pH (about pH 5.5 to 10) by oral application, and it is painless for teeth having hypersensitivity. In addition, since the whitening agent can be prevented from running out at the time of application of the tooth surface, an appropriate amount of the ozone-dissolved glycerin solution is added depending on the purpose. Add 1-50% by weight.

  In order to appropriately adjust the physical properties according to the purpose, an appropriate diluent may be mixed with the ozone-dissolved glycerin solution and diluted as necessary. As the diluent, those which are not easily oxidized by ozone are preferable, and water, polyethylene glycol and the like are preferable.

When water is used as a diluent, it is preferable to use pure water or ultrapure water. By using pure water or ultrapure water, the generation of oxides (peroxides) that can cause irritation to the skin or tooth surface and mucous membranes due to impurities generated by oxidation to ozone and decrease in the expression of effects is suppressed. Can do.
The blending amount of water is not limited, but can be appropriately modified within the range of 0 to 99% of the whole whitening agent for the purpose of relaxing or moisturizing the viscosity of the whitening agent of the present invention due to glycerin.

  When polyethylene glycol is used as the diluent, polyethylene glycol may be liquid or solid depending on the molecular weight, and any of them can be used in the present invention. By changing the mixing ratio of two or more types of polyethylene glycol according to the texture at the time of use, it is possible to obtain a texture that is easier to use. Therefore, the kind of polyethylene glycol is not particularly limited.

In one embodiment, the whitening agent of the present invention includes one or more additional whitening components having a whitening effect, such as glycerin, ozone-dissolved glycerin, hydrogen peroxide, peroxides such as urea peroxide, and sodium percarbonate, as appropriate. But you can. By combining these, the amount of stimulating components such as hydrogen peroxide used can be adjusted.
The concentration of hydrogen peroxide used in the present invention is not particularly limited, but it is preferably less than 3.5%, preferably 0.1 to 2% of the whitening agent from the viewpoint of reducing irritation. The lowest concentration of hydrogen peroxide used in conventional hydrogen peroxide-containing whitening agents is about 3.5%. According to the present invention, hydrogen peroxide having a concentration less than about half of the concentration is used. However, the effect of whitening is fully demonstrated.

  When the whitening agent of the present invention contains powdered carbonate, ozone-dissolved glycerin solution and hydrogen peroxide, in order to prevent the powder from becoming damped, carbonate is added to the ozone-dissolved glycerin solution, and then It is preferable to add hydrogen peroxide water. Since the concentration decreases after mixing, application within 1 hour is preferable.

  In addition, the whitening agent of the present invention may be used by appropriately adding one or more of various components such as a thickener, a pH adjuster, and a surfactant.

A thickener is used to prevent runaway when a whitening agent is applied to the tooth surface. The thickener is not particularly limited, and typically includes an ozone-dissolved glycerin solution that does not interfere with the bleaching effect and other known thickeners. The content of these thickeners relative to the entire whitening agent is not particularly limited as long as an appropriate viscosity can be imparted to the whitening agent, but is preferably 0.001 to 1% of the entire whitening agent.

  In general, it is considered that teeth are decalcified when the pH is 5.5 or less in dental clinic, and there is a concern about the use of a low pH in whitening action that directly contacts the teeth for a certain period of time. Therefore, in one embodiment, a pH adjuster is used to adjust the pH of the whitening agent of the present invention. The pH adjuster is particularly limited as long as the overall pH of the whitening agent can be adjusted to a preferable pH by oral application (pH 10 or less, preferably about pH 5.5 to 10 which is a range in which tooth protein is not denatured). Although not mentioned, the above-mentioned ozone-dissolved glycerin solution and known pH adjusters are mentioned.

  Surfactant is not particularly limited as long as it has a function to dissolve substances that are not mixed with each other in the agent of various components, but typically, sodium lauroyl sulfate, Nonionic surfactants such as polyoxyethylene sorbitan oleate, alkyl sulfate salts, anionic surfactants such as sodium normal dodecyl benzene sulfonate, and cationic surfactants such as polyoxyethylene dodecyl monomethyl ammonium chloride, Most preferred is sodium lauroyl sulfate. The content of these surfactants with respect to the entire whitening agent is not particularly limited as long as sufficient solubility can be imparted to each component.

  Furthermore, the whitening agent of the present invention can contain, for example, a stabilizer such as EDTA and an auxiliary component such as paraoxybenzoic acid ester, as long as the amount does not impair the effect of the whitening agent of the present invention. It is not limited.

The whitening agent of the present invention includes other moisturizers, antiseptics, tooth color modifying substances, abrasives, pigments, flavoring agents, sweeteners, cooling agents, and saliva secretion agents as long as the effects of the present invention are not impaired. Auxiliary components such as these may be blended. By using these auxiliary components, the whitening effect of the whitening agent of the present invention can be enhanced or the feeling of use can be improved.
In addition, about the titanium oxide currently used widely in whitening, when this is included in the whitening agent of this invention, especially the whitening agent containing sodium sesquicarbonate, it has been discovered that the whitening effect is inhibited unexpectedly. Therefore, the whitening agent in an embodiment of the present invention preferably does not contain titanium oxide.

The present invention also relates to a method for whitening teeth, which can be implemented in the following manner, but is not limited thereto.
First, the whitening agent of the present invention is applied to the tooth surface. The method of application is not particularly limited, but typical examples include application to a tooth surface, application by a normal brushing operation with a toothbrush, or application by wearing a mouthpiece to which the whitening agent is applied. The mouthpiece is used, for example, in a dental drug delivery system or the like in order to maintain the tooth whitening agent of the present invention in a state of being in contact with the tooth reliably and for a certain period of time.
The application amount is not particularly limited, but may be, for example, about 0.1 ml to 1 ml per tooth, and may be applied once or twice or more per tooth. In particular, in the case of a dosage form having a low viscosity and easily washed away, it is preferable to apply it twice or more.
In applying the whitening agent to the tooth surface, it is preferable to previously clean the tooth surface of the target tooth with a toothbrush or the like.

  The method for whitening teeth of the present invention includes a step of irradiating light to a whitening agent as a preferred embodiment. The wavelength of the light is not particularly limited, and both ultraviolet light and visible light are preferably used. The type of the light source is not particularly limited, and a halogen lamp (for example, having a wavelength of 480 to 520 nm), a metal halide lamp (for example, having a wavelength of 310 nm), a light emitting diode (for example, having a wavelength of 420 to 500 nm), and a xenon lamp (for example, having a wavelength) 460 nm) and the like.

In the method for whitening teeth of the present invention, of the above light, visible light is preferably used from the viewpoint of safety to the human body. Even if visible light is used, the same whitening effect as that obtained when ultraviolet light is used can be obtained.
The irradiation time of light can be changed according to the light source to be used and the intensity of light, but is typically about 30 seconds to 15 minutes, preferably about 1 minute to about 10 minutes.

  In the method for whitening teeth of the present invention, irradiation with light is not an essential step, and a whitening effect can be obtained without irradiation with light. Therefore, among the methods for whitening teeth of the present invention, the method that does not irradiate light is suitable for general households (home use), and in dental clinics where specific light irradiating devices are always available, A method of performing irradiation is preferable (office use).

  In the method for whitening teeth of the present invention, the tooth surface may be lightly washed by rinsing the mouth after application of the whitening agent. The time from application to water washing can be adjusted in the range of 20 seconds to 30 minutes. In the case of irradiation with light, the washing with water is performed after irradiation with light. In the method for whitening teeth of the present invention, the treatment from application to washing with water may be performed once, or may be performed twice or more with a time interval. There is no restriction | limiting in a time interval, For example, it can adjust in the range of 1 day-10 days.

The present invention also relates to a kit for whitening teeth, which kit contains carbonate, preferably bicarbonate, thickener, ozone-dissolved glycerin solution, hydrogen peroxide solution, light irradiation device and It further includes a mouthpiece.
Examples of the light irradiator include the above-described halogen lamp, metal halide lamp, light emitting diode, xenon lamp, and the like, as well as a photopolymerization resin curing irradiator. You may use these light irradiation instruments in combination of 2 or more types. Further, the wavelength of light emitted from the light irradiator is not particularly limited, but those having a wavelength of visible light are preferably used from the viewpoint of safety to the human body. The wavelength of the visible light is typically about 360 nm to about 400 nm on the short wavelength side and about 760 nm to about 830 nm on the long wavelength side (as defined in JIS Z8120).

  The present invention will be described in more detail below with reference to examples, but the examples are merely illustrative and are not intended to limit the present invention in any way.

Formulation Example 1: Preparation of sodium carbonate bleach test solution Sodium carbonate 0.1 g
pH adjuster 0.01g
50ml water
Sodium carbonate and a pH adjuster were added to water and mixed.

Formulation Example 2: Preparation of sodium sesquicarbonate bleaching test solution sodium sesquicarbonate 5 g
50ml water
Sodium sesquicarbonate was added to water and mixed.

Formulation example 3: Office use (sodium carbonate)
(Composition of liquid A)
Ozone-dissolved glycerin (concentration approximately 4000 ppm) 2 ml
(B powder composition)
Sodium carbonate 0.1g
pH adjuster 0.01g
Thickener 0.05g
(Composition of liquid C)
Oxol (concentration about 3%) 1ml
A whitening agent was produced by adding the B powder to the A liquid and stirring, and then adding the C liquid and stirring again.

Formulation example 4: Office use (sodium sesquicarbonate)
(Composition of liquid A)
Ozone-dissolved glycerin (concentration approximately 4000 ppm) 2 ml
(B powder composition)
0.01g sodium sesquicarbonate
Thickener 0.05g
(Composition of liquid C)
Oxol (concentration about 3%) 1ml
A whitening agent was produced by adding the B powder to the A liquid and stirring, and then adding the C liquid and stirring again.

Formula 5: Home use (sodium carbonate)
(Composition of liquid A)
Ozone-dissolved glycerin (concentration approximately 4000 ppm) 2 ml
(B powder composition)
Sodium carbonate 0.1g
pH adjuster 0.01g
Thickener 0.05g
1ml water
The whitening agent was manufactured by throwing B powder into A liquid and stirring.

Formulation example 6: Home use (sodium sesquicarbonate)
(Composition of liquid A)
Ozone-dissolved glycerin (concentration approximately 4000 ppm) 2 ml
(B powder composition)
0.01g sodium sesquicarbonate
Thickener 0.05g
1ml water
The whitening agent was manufactured by throwing B powder into A liquid and stirring.

Test Examples 1-2: Bleaching power of sodium carbonate and sodium sesquicarbonate on extracted teeth Using five human extracted teeth, the bleaching effects of sodium carbonate and sodium sesquicarbonate were examined.
1) Measurement of shade (coloration degree) of human extracted teeth was performed based on a shade guide.
2) After cleaning the tooth surface, sodium carbonate solution and sesquisodium carbonate solution were prepared in advance (Prescription Examples 1 and 2), and the human extracted teeth were immersed in each solution and left for 2 hours.
3) Thereafter, the extracted tooth was taken out from the liquid, and the tooth surface was lightly washed.
4) Shade (coloration degree) of human extracted teeth was measured based on a shade guide.

Test Example 3: Office Use Using the whitening agent of the present invention, five tests were conducted as follows.
(Method)
1) The measurement of the shade (coloration degree) of each test subject's tooth was performed based on a shade guide.
2) After cleaning the tooth surface, the whitening agent of the present invention was preliminarily adjusted (formulation example 3: sodium carbonate) with a small brush and applied to the tooth surface. (Thickness about 1mm.)
3) Immediately irradiated for 1 minute using a photocuring resin curing irradiator.
4) The tooth surface was lightly washed, and the shade (coloring degree) of the test subject tooth was measured based on the shade guide.
For Formulation Example 4 (sodium sesquicarbonate), five tests were conducted as in Test Example 3 (Test Example 4).

Test Example 5: Home use (sodium carbonate)
Using the whitening agent of the present invention, five tests were conducted as follows.
(Method)
1) The measurement of the shade (coloration degree) of each test subject's tooth was performed based on a shade guide.
2) After cleaning the tooth surface, the whitening agent of the present invention was preliminarily adjusted (prescription example 5: sodium carbonate) to a mouthpiece prepared in advance, and applied to the tooth surface with a small brush or the like. (Thickness about 1mm.)
3) Left for 1 hour.
4) The tooth surface was lightly washed with water.
5) The operations from 1) to 4) were performed every day for one week, and the shade (coloring degree) of the test target tooth was measured based on the shade guide.
As for Formulation Example 6 (sodium sesquicarbonate), 5 tests were conducted in the same manner as Test Example 5 (Test Example 6).

(Results and discussion)
Test Example 1 Bleaching power of sodium carbonate to extracted tooth As described below, sodium carbonate bleached the extracted tooth.
Extracted tooth 1 A4 → A3
Extracted tooth 2 A3 → A2
Extracted tooth 3 A3.5 → A3
Extracted tooth 4 A3 → A2
Extracted tooth 5 A4 → A2

Test Example 2 Bleaching power of sodium sesquicarbonate to extracted tooth As described below, sodium sesquicarbonate bleached the extracted tooth.
Extracted tooth 6 A4 → A3
Extracted tooth 7 A4 → A3.5
Extracted tooth 8 A3.5 → A3
Extracted tooth 9 A3 → A2
Extracted tooth 10 A4 → A3

  Sodium bicarbonate has a weaker whitening effect than sodium carbonate or sodium sesquicarbonate (data not disclosed), and sodium carbonate and sodium sesquicarbonate have the same whitening effect.

Test Example 3 Office use (sodium carbonate)
21 year old male A4 → A2
34 year old male A3 → A1
41-year-old woman A4 → A1
45-year-old male A3.5 → A2
52-year-old male A4 → A2
Without blocking the gums, the teeth could be bleached without causing any pain.

Test Example 4 Office use (sodium sesquicarbonate)
22-year-old woman A3 → A1
25-year-old woman A3.5 → A1
33-year-old woman A3 → A1
38-year-old male A3 → A2
42-year-old male A3 → A1
Without blocking the gums, the teeth could be bleached without causing any pain.

Test Example 5 Home use (sodium carbonate)
22-year-old male A3.5 → A2
23-year-old woman A3.5 → A1
35-year-old man A4 → A1
36-year-old male A3 → A1
38-year-old woman A4 → A2
Without blocking the gums, it was possible to bleach the teeth without causing any pain by acting for a certain time without using light.

Test Example 6 Home use (sodium sesquicarbonate)
24-year-old male A4 → A2
27-year-old woman A3 → A1
37-year-old male A3 → A1
45-year-old man A4 → A1
47-year-old woman A3.5 → A1
Without blocking the gums, it was possible to bleach the teeth without causing any pain by acting for a certain time without using light.

  In both the office use and the home use, the tooth shade was significantly reduced in all five trials. Therefore, it became clear that the tooth whitening agent and the whitening method of the present invention have a sufficient whitening effect.

  In Test Example 3 (combined with hydrogen peroxide) described in Patent Document 4, 3.5% hydrogen peroxide solution is finally applied to the teeth. Since hydrogen peroxide hits the teeth, it is necessary to block out the gums, and since the pre-applied bleaching agent and hydrogen peroxide are not mixed uniformly, there was a disadvantage that whiteness was mottled. By mixing hydrogen peroxide water in advance, the hydrogen peroxide concentration was lowered and it became safe and it became possible to make it uniformly white.

  Moreover, it was soaked when the whitening agent of the present invention containing ozone gel was applied to teeth with hypersensitivity, but it did not soak at all when a whitening agent containing a mixture of ozone gel and PEG (ozone cream) was applied. It was suggested that ozone cream has an effect of suppressing hypersensitivity.

Claims (14)

  The above-mentioned bleaching agent for teeth, which contains sesquicarbonate as a bleaching component and does not contain bicarbonate. Sesquicarbonate is sodium sesquicarbonate, bleaching agent according to claim 1. The bleach of Claim 1 or 2 which does not contain a titanium oxide. The bleaching agent according to any one of claims 1 to 3 , further comprising an ozone-dissolved glycerin solution. The bleach according to any one of claims 1 to 3 , further comprising a mixture of an ozone-dissolved glycerin solution and polyethylene glycol. The bleaching agent according to any one of claims 1 to 5 , comprising a further bleaching component selected from the group consisting of hydrogen peroxide, urea peroxide and sodium percarbonate. A method for bleaching teeth, comprising the step of applying the bleaching agent according to any one of claims 1 to 6 to the tooth surface. A kit for bleaching teeth, comprising the bleaching agent according to any one of claims 1 to 6 .   A method of bleaching teeth using sesquicarbonate as a bleaching component and no bicarbonate. The method according to claim 9 , wherein the sesquicarbonate is sodium sesquicarbonate. The method according to claim 9 or 10 , wherein an ozone-dissolved glycerin solution is further used. The method according to any one of claims 9 to 11 , further comprising using a component selected from the group consisting of hydrogen peroxide, urea peroxide and sodium percarbonate. A method for bleaching teeth, wherein the bleaching agent according to any one of claims 1 to 6 is combined with one or more selected from the group consisting of hydrogen peroxide and light irradiation. The method is prepared by adjusting one or more selected from the group consisting of a pH value in the oral cavity, an application time, and a measured value of tooth color by a shade guide.   A method for bleaching teeth, wherein a bleaching agent comprising a sesquicarbonate and an ozone-dissolved glycerin solution and one or more selected from the group consisting of hydrogen peroxide and light irradiation are applied to the tooth surface in combination. The method as described above, wherein one or two or more selected from the group consisting of the pH value in the oral cavity, the application time, and the measured value of the tooth color by the shade guide are adjusted.