KR102844883B1 - Compositions for whitening teeth and kits comprising thereof - Google Patents

Abstract

The present disclosure relates to a tooth whitening composition and a kit including the same, and more particularly, to a tooth whitening composition and a kit including the same that has an excellent whitening effect while minimizing tooth damage and effectively suppressing sensitivity symptoms.

Description

Composition for whitening teeth and kit containing same {COMPOSITIONS FOR WHITENING TEETH AND KITS COMPRISING THEREF}

The present disclosure relates to a tooth whitening composition and a kit including the same, and more particularly, to a tooth whitening composition and a kit including the same that has an excellent whitening effect while minimizing tooth damage and effectively suppressing sensitivity symptoms.

Tooth whitening is the most common procedure performed in cosmetic dentistry. The main causes of tooth yellowing include the deposition of staining substances such as porphyrin, a decrease in the thickness of the tooth's outer wall (enamel), and an increase in the surface area where staining substances can be deposited. The main active ingredients in currently commercially available tooth whitening products include hydrogen peroxide, which works similarly to exfoliants and oxygen-based detergents, resulting in high bleaching effects but significant side effects, and sodium metaphosphate, which prevents staining substances from adhering to teeth and acts as an abrasive to remove them.

However, these existing tooth whitening agents have serious problems. First, the demineralization process that occurs during the tooth whitening process removes minerals from the teeth, creating microscopic holes, roughening the enamel surface, and making the teeth vulnerable to acidic environments. This leads to the loss of the teeth's natural protective barrier, increasing the risk of tooth decay and weakening the teeth's structure. Second, the structural changes that occur during the whitening process cause the teeth to lose their natural luster, significantly reducing the four elements of tooth color (brightness, saturation, hue, and translucency), and increasing the surface roughness of the teeth, making new stains more likely to form. Third, existing whitening agents cause various irritations and pain, including tooth sensitivity, irritation of the oral mucosa, including gums, the risk of mucosal burns when used in high concentrations, and, in the case of mouthpiece-type whitening agents, the risk of temporomandibular joint disorder.

Most tooth whitening agents developed to date fail to fundamentally address these issues. A solution that achieves effective whitening within the legally permitted concentration limit (3.0% hydrogen peroxide) while minimizing side effects is urgently needed. Furthermore, existing whitening agents fail to address the structural weakening and sensitivity that occur after whitening, necessitating the development of a new approach that simultaneously achieves both whitening and tooth protection.

The present disclosure is intended to solve the above problems, and it is an object of the present disclosure to provide a tooth whitening composition that can minimize tooth damage while providing an excellent whitening effect, a tooth protection composition that can effectively prevent and treat sensitivity that may occur after a whitening treatment, and a kit including the same. The present disclosure is intended to solve the above problems, and it is an object of the present disclosure to provide a tooth whitening composition that can minimize damage to the tooth structure while achieving an optimal whitening effect within the legally permissible limit of 3.0% hydrogen peroxide, and a tooth protection composition that can effectively suppress the demineralization phenomenon that inevitably occurs during the tooth whitening process and immediately remineralize an area of demineralization that has already occurred.

Furthermore, the present disclosure does not simply provide temporary relief from sensitivity, but rather aims to provide a long-term solution that can effectively block nerve stimulation and prevent exposure of dentinal tubules that cause sensitivity, and to provide a system that can comprehensively improve the four optical properties of teeth, namely brightness, saturation, color, and transparency, while maintaining the natural luster and structure of teeth.

In addition, the present disclosure aims to provide a practical kit that can be used safely and effectively at home without the assistance of a professional, and that effectively prevents re-staining of teeth and maintains a long-lasting whitening effect, rather than simply providing a temporary whitening effect.

The problems to be solved by the present disclosure are not limited to the problems mentioned above, and problems to be solved by the present disclosure that are not mentioned can be clearly understood by a person having ordinary knowledge in the technical field to which the present disclosure belongs (“ordinary skilled person”) from the description below.

To solve the above problem, the first aspect of the present disclosure relates to a tooth whitening composition comprising 2.0 to 3.0 wt% of hydrogen peroxide, 0.5 to 2.0 wt% of hydroxyapatite, 0.5 to 2.0 wt% of sodium metaphosphate, and 0.1 to 10.0 wt% of colloidal silicon dioxide.

To solve the above problem, the second aspect of the present disclosure relates to a dental protective composition comprising 30.0 to 40.0 wt% of calcium hydrogen phosphate, 0.05 to 3.0 wt% of sodium monofluorophosphate, 0.3 to 8.0 wt% of potassium nitrate, and 0.5 to 2.0 wt% of hydroxyapatite.

To solve the above problem, a third aspect of the present disclosure relates to a kit including the tooth whitening composition and the tooth protection composition.

To solve the above problem, the fourth aspect of the present disclosure relates to a tooth whitening method comprising the step of applying the tooth whitening composition of claim 1 to teeth; and the step of applying the tooth protection composition of claim 2 to the teeth.

The tooth whitening composition according to the present disclosure and the kit containing the same provide the following excellent effects.

First, the tooth whitening composition of the present disclosure is designed to simultaneously utilize the powerful whitening action of hydrogen peroxide and the protective action of hydroxyapatite, thereby achieving an optimal whitening effect within legally permissible limits while minimizing tooth damage. Specifically, the physical removal, chemical decomposition, and decolorization of staining substances by hydrogen peroxide occur in stages, while simultaneously immediately filling micropores where hydroxyapatite may form, thereby maintaining the structural stability of the tooth.

Second, the dental protective composition of the present disclosure effectively prevents and treats sensitivity that can occur after whitening treatments by combining the promotion of remineralization through the supply of calcium, phosphate, and fluoride ions with the nerve-soothing action of potassium nitrate. In particular, the fluoride's enamel strengthening and protective action against acidic environments contribute to the long-term maintenance of dental health.

Third, the kit of the present disclosure is designed to sequentially achieve the dual objectives of whitening and protection, fundamentally resolving the problem of side effects, a limitation of existing whitening agents. The whitening action of the tooth whitening composition and the protective action of the tooth protection composition work synergistically, maximizing the whitening effect while maintaining dental health.

Fourth, all of the compositions of the present disclosure contain hydroxyapatite, which contributes to improving the optical properties of teeth. Specifically, they achieve a natural tooth whitening effect by restoring tooth transparency and reducing surface roughness, which is also effective in preventing restaining.

Fifth, the kit of this disclosure is manufactured in the form of a standard toothpaste, making it easy to use and safe for home use without professional assistance. Furthermore, each composition incorporates a suitable fragrance system, ensuring a superior user experience and enabling continuous use.

The excellent and/or useful effects according to the present disclosure are not limited to the effects of the present disclosure described above, and it should be understood that those skilled in the art will also be able to clearly recognize excellent and/or useful effects of the present disclosure that are not explicitly disclosed in the present disclosure based on the disclosure of the present specification, and that these are intentionally disclosed by the present specification and are clearly included in the scope of the present disclosure.

In the following description, terms such as "first," "second," etc. are used to describe various components, and are not intended to limit their meanings. They are used solely to distinguish one component from another. Furthermore, the same reference numbers used throughout this specification represent the same components.

Unless otherwise stated herein, certain steps or processes may be performed at room temperature. Room temperature may range from 15 to 30 degrees Celsius, and preferably from 20 to 25 degrees Celsius.

As used herein, singular expressions include plural expressions unless the context clearly dictates otherwise. In addition, terms such as "comprise," "include," or "have" used herein should be interpreted to indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, and should be understood to not preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

The terms or words used in this specification and claims are not intended to be construed as limited to their commonly used dictionary meanings, and those skilled in the art will clearly understand that the terms or words are used in the sense intended to convey the meaning of the present disclosure within the scope of expressing the concepts that this specification and claims are intended to self-evidently convey.

In addition, it will be clearly understood by those skilled in the art that the configurations described in the aspects, embodiments, examples, etc. of the present disclosure described in this specification are merely preferred examples presented to enable those skilled in the art to understand and reproduce the present disclosure, and are not intended to limit the present disclosure thereto.

Furthermore, the descriptions and specific embodiments of each configuration described in this specification can be readily applied to the descriptions and specific embodiments of each other configuration. That is, all possible combinations of the various configurations and specific embodiments disclosed in this specification will be clearly understood by those skilled in the art to fall within the scope disclosed in this specification.

The terms or words used in this specification and claims should not be construed as limited to their conventional dictionary meanings, but rather should be construed as meanings and concepts consistent with the technical spirit of the present disclosure, based on the principle that the inventor can appropriately define the concept of the term to best describe his or her invention. Therefore, the configurations described in the embodiments described in this specification are merely preferred embodiments of the present disclosure and do not represent all of the technical spirit of the present disclosure. Therefore, it should be understood that various equivalents and modified examples may exist as substitutes for them at the time of this application.

Meanwhile, each description and embodiment disclosed in this specification may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed in this specification fall within the scope of this disclosure, and descriptions omitted in one embodiment may be interpreted in the same manner as described in other embodiments. Furthermore, the scope of this disclosure is not limited by the specific descriptions described below.

A first aspect of the present disclosure relates to a tooth whitening composition comprising 2.0 to 3.0 wt% of hydrogen peroxide, 0.5 to 2.0 wt% of hydroxyapatite, 0.5 to 2.0 wt% of sodium metaphosphate, and 0.1 to 10.0 wt% of colloidal silicon dioxide, wherein the tooth whitening composition of the present disclosure can perform a multi-stage whitening action and a simultaneous protection function.

For example, hydrogen peroxide, which is the main active ingredient of the present composition, can be adjusted to a concentration of 2.0 to 3.0% (20,000 to 30,000 ppm) as hydrogen peroxide by adding 7.0 to 10.0 wt% of 35% hydrogen peroxide.

The hydrogen peroxide described above whitens teeth through three different mechanisms. First, as hydrogen peroxide decomposes, reactive oxygen species (OH2- and OH- ions) are generated, forming bubbles that physically remove stains. Second, these reactive ions break down large molecular weight stains into smaller molecules. Third, hydrogen peroxide reacts with stains such as porphyrin, the main cause of tooth yellowing, and removes electrons from the molecules through an oxidation process, transforming the yellow substances into colorless. This action of hydrogen peroxide begins on the outer wall of the tooth and gradually spreads to the shallow inner wall, providing a deep whitening effect.

The above hydroxyapatite (HAP) may be included in an amount of 0.5 to 2.5 wt%, and has special significance as it is the same component as the outer wall of the tooth. HAP has transparency, whiteness, and luminescence in itself, so it not only contributes to the visual whitening effect, but also effectively fills the micropores that inevitably occur during the whitening process of hydrogen peroxide. What is particularly noteworthy is that HAP acts simultaneously with the whitening process. As hydrogen peroxide removes staining substances, HAP is immediately deposited in the micropores that occur, thereby preventing structural weakening of the tooth and simultaneously performing its role as a transparent luminescent substance.

The sodium metaphosphate can be included in amounts of 0.5 to 2.5% by weight and performs three main functions: first, it effectively prevents the reattachment of stains to the tooth surface. second, it provides an appropriate level of abrasion to physically remove stains remaining on the surface. third, it helps stabilize minerals in the oral cavity, contributing to overall dental health.

The colloidal silicon dioxide is contained in an amount of 0.1 to 10.0 wt%, and plays an important role in the toothpaste formulation. It provides an appropriate level of abrasion, enabling effective removal of surface stains, while simultaneously stabilizing the properties of the composition and assisting in the uniform dispersion of active ingredients. The colloidal silicon dioxide is contained in an amount of 0.5 wt%, and plays an important role in the toothpaste formulation. It provides an appropriate level of abrasion, enabling effective removal of surface stains, while simultaneously stabilizing the properties of the composition and assisting in the uniform dispersion of active ingredients.

Through the complex action of these main ingredients, the tooth whitening composition of the present disclosure can exhibit the efficacy of excellent tooth whitening effect, dental plaque removal (anti-plaque) effect, oral hygiene maintenance, bad breath removal, tooth decay prevention, and overall aesthetic effect enhancement, and in particular, the composition can effectively whiten teeth while maintaining the healthy structure of teeth by simultaneously performing the protective action by HAP while performing the whitening action of hydrogen peroxide.

For example, the composition may be applied with a fragrance system including apple scent, aqua mint scent, and apple mint scent to improve the feeling of use.

For example, the present composition is manufactured in a toothpaste form and can be conveniently used in daily dental care.

For example, the present composition may additionally include various auxiliary ingredients.

For example, as the auxiliary ingredient, D-sorbitol solution is included in an amount of 25.0 to 35.0 wt% and acts as a humectant and sweetener, and concentrated glycerin is included in an amount of 5.0 to 25.0 wt% and acts as a humectant.

For example, titanium oxide as the auxiliary ingredient may be included in an amount of 0.01 to 0.5 wt% to act as an anti-coloring and light-blocking agent, and xylitol may be included in an amount of 0.001 to 1.0 wt% to act as a sweetener and caries prevention agent.

For example, enzyme-treated stevia as the auxiliary ingredient may be included at 0.1 to 0.3 wt% and may act as a natural sweetener.

For example, a thickener may be included as the auxiliary ingredient, and the thickener may include 0.05 to 0.5 wt% of sodium carboxymethyl cellulose and 0.3 to 0.7 wt% of xanthan gum.

For example, a surfactant may be included as the auxiliary ingredient, and the surfactant may include 0.1 to 2.0 wt% of sodium cocoyl glutamate and 0.8 to 1.2 wt% of lauroyl amidopropyl dimethyl glycine solution.

For example, a preservative may be included as the auxiliary agent, and the preservative may include 0.001 to 0.1 wt% of grapefruit seed extract.

This composition is a fragrance system for improving the feeling of use, and contains 0.3 to 3.0 wt% of apple fragrance, 0.01 to 0.4 wt% of mint fragrance, 0.01 to 0.4 wt% of aqua mint fragrance, and 0.01 to 0.4 wt% of apple mint fragrance, and is manufactured in a toothpaste form so that it can be conveniently used in daily dental care.

The present composition may contain 0.1 to 1.0 wt% of a prune extract as an additional ingredient. The prune extract has a strong antioxidant effect, which prevents tooth discoloration, and the polyphenol component can inhibit protein denaturation on the tooth surface, and the naturally occurring acidic components such as citric acid and malic acid can assist in cleaning the tooth surface, and the vitamin K can promote gum health. The flavonoid component of the prune extract can bind to a discoloration-inducing substance to prevent it from adsorbing to the tooth surface, and the natural acidic component can partially decompose the protein film on the tooth surface, thereby promoting the removal of the discoloration substance.

The composition may contain passion fruit seed oil as an additional ingredient in an amount of 0.05 to 0.3 wt%. The passion fruit seed oil has a unique linolenic acid that inhibits the formation of a biofilm on the tooth surface, the vitamin F component can protect the oral mucosa, the anti-inflammatory action of the phytosterol component can promote gum health, and the natural surfactant action can assist in cleaning power. The passion fruit seed oil has an oil component that forms a thin protective film on the tooth surface to prevent discoloration, and the unsaturated fatty acid can inhibit protein denaturation on the tooth surface to improve discoloration resistance.

The present composition may contain 0.1 to 0.5 wt% of a white oyster mushroom extract as an additional ingredient. The white oyster mushroom extract has a polysaccharide component that forms a protective film on the surface of teeth, and its unique moisturizing effect can prevent dry mouth, promote gingival health by stimulating collagen production, and assist remineralization by promoting mineral absorption. The white oyster mushroom extract has a high molecular weight polysaccharide that is adsorbed to the surface of teeth to form a protective film, and the polysaccharide with excellent moisture retention ability maintains a moisturizing environment in the oral cavity, and can protect teeth through a buffering effect in an acidic environment.

A second aspect of the present disclosure relates to a dental protective composition comprising 30.0 to 40.0 wt% of calcium hydrogen phosphate, 0.05 to 3.0 wt% of sodium monofluorophosphate, 0.3 to 8.0 wt% of potassium nitrate, and 0.5 to 2.0 wt% of hydroxyapatite, wherein the dental protective composition of the present disclosure can achieve the composite purposes of remineralizing teeth, alleviating sensitivity, neutralizing acidic environments, and strengthening tooth structures.

The sodium monofluorophosphate is contained in an amount of 0.5 to 1.0 wt%, which can provide 800 to 1,200 ppm as fluorine. For example, fluorine is contained in an amount of 1,000 ppm in the form of sodium monofluorophosphate, which performs a multi-stage protective action. Fluoride ions replace hydroxyl ions in the hydroxyapatite lattice to form more stable fluoroapatite. This utilizes the characteristic that the ionic radius of the fluoride ion is similar to that of the hydrogen ion, and the formed fluoroapatite has significantly increased acid resistance compared to the existing hydroxyapatite. In addition, fluorine acts as a catalyst for the absorption of calcium and phosphate ions, thereby increasing the remineralization efficiency, and when the pH is lowered, it forms calcium fluoride (CaF2) crystals to form a protective layer on the tooth surface. As the pH rises, these CaF2 crystals act as a reservoir for fluoride and calcium, which can be redeposited into the tooth structure as fluoroapatite during the remineralization phase.

Furthermore, fluoride can inhibit enolase, an intermediate enzyme in the glycolysis process, thereby inhibiting the breakdown of glucose into pyruvate as an antibacterial mechanism. This leads to a decrease in pyruvate and ATP synthesis, which not only reduces lactate synthesis but also inhibits sugar transport via the phosphoenopyruvic acid phosphate transferase system. Furthermore, fluoride can effectively suppress the metabolic activity of oral pathogenic bacteria by interfering with the ATPase-activated proton transport system, leading to the accumulation of intracellular protons and reduced glucose import.

The above potassium nitrate is a key ingredient for alleviating tooth sensitivity and is contained in an amount of 4.0 to 6.0 wt%, which can provide 4,000 to 6,000 ppm as potassium, for example, potassium nitrate is contained in an amount of 5.0 wt% (50,000 ppm as potassium). Tooth sensitivity is caused by external stimuli being transmitted to the pulp nerve through exposed dentinal tubules, and potassium ions of potassium nitrate move through these tubules to reach the nerve fibers. Initially, the potassium concentration outside the cell is low, so potassium easily diffuses from within the cell to the outside, but when potassium nitrate is used, the potassium concentration outside the cell increases, reversing this concentration gradient. This prevents potassium from diffusing from within the cell to the outside, and consequently, the generation of action potentials is blocked, effectively alleviating tooth sensitivity. Hydroxyapatite included in the tooth protection composition, as in the tooth whitening composition, plays a role in structural reinforcement and improving optical properties of the tooth.

The above calcium hydrogen phosphate is contained in an amount of 34.0 to 38.0 wt%, and acts as a major source of calcium and phosphate ions. For example, calcium hydrogen phosphate may be contained in an amount of 36.0 wt%. Calcium hydrogen phosphate dissolved in saliva in the oral cavity releases calcium and phosphate ions, thereby promoting the formation of hydroxyapatite (HAP). This is achieved through the reaction of 10Ca(OH _{) 2} + _6H3PO4 + _18H2O , and the produced HAP promotes the remineralization of teeth and strengthens their structure.

The hydroxyapatite (1.0 wt%) contained in this composition is identical to the main component of the outer wall of teeth and possesses the properties of a transparent luminescent substance. It not only directly fills micropores, but also restores the transparency of teeth and improves light reflectivity, contributing to a visual whitening effect. In particular, the reduction in surface roughness due to HAP deposition also has the effect of preventing subsequent staining.

For example, the present composition may additionally include various auxiliary ingredients.

For example, as the auxiliary ingredient, D-sorbitol solution is included in an amount of 25.0 to 35.0 wt% and acts as a wetting agent and sweetener, and xylitol is included in an amount of 0.001 to 1.0 wt% and acts as a sweetener and caries prevention agent.

For example, enzyme-treated stevia as the auxiliary ingredient may be included in an amount of 0.1 to 0.3 wt% to act as a natural sweetener, and concentrated glycerin may be included in an amount of 5.0 to 25.0 wt% to act as a humectant.

For example, a thickener may be included as the auxiliary ingredient, and 0.05 to 0.5 wt% of sodium carboxymethyl cellulose may be included as the thickener.

For example, a surfactant may be included as the auxiliary ingredient, and 0.1 to 2.0 wt% of sodium cocoyl glutamate may be included as the surfactant.

For example, a refreshing agent may be included as the auxiliary ingredient, and 0.01 to 0.4 wt% of L-menthol may be included as the refreshing agent.

For example, a preservative may be included as the auxiliary ingredient, and 0.001 to 0.1 wt% of grapefruit seed extract may be included as the preservative.

The fragrance system of this composition includes 0.1 to 0.7 wt% of rooibos fragrance, 0.2 to 0.4 wt% of peach fragrance, and 0.2 to 0.4 wt% of ginger fragrance, thereby improving the feeling of use.

The present composition may contain 0.01 to 0.1 wt% of snail mucus filtrate as an additional ingredient. The snail mucus filtrate has mucin and chondroitin sulfate that form a protective film on the tooth surface, an allantoin component that can promote the regeneration of the oral mucosa, a glycoprotein that can help remineralize tooth enamel, and a natural moisturizing factor that can help maintain moisture in the oral cavity. The snail mucus filtrate has high molecular weight proteins that protect the microstructure on the tooth surface, collagen and elastin components that can enhance the elasticity of gingival tissue, and an antioxidant component that can alleviate gingival inflammation.

The composition may comprise 0.5 to 2.0 wt% of a red algae extract as an additional ingredient. The red algae extract contains calcium and magnesium that promote tooth remineralization, a carrageenan component that can form a protective film on the tooth surface, a phlorotannin component that can promote oral health through antibacterial action, and an iodine component that can regulate the pH balance in the oral cavity. The red algae extract contains polysaccharides that promote mineral absorption on the tooth surface, an amino acid complex that stabilizes the tooth remineralization process, and natural minerals that can strengthen the tooth structure.

The present composition may contain 0.1 to 0.5 wt% of Cordyceps militaris mycelia culture filtrate as an additional ingredient. The Cordyceps militaris mycelia culture filtrate has beta-glucan that enhances immunity, cordycepin that alleviates oral inflammation, adenosine that improves gingival blood circulation, and polysaccharide complex that protects oral mucosa. The Cordyceps militaris mycelia culture filtrate has physiologically active substances that promote gingival tissue regeneration, antioxidant substances that protect periodontal tissue, and immunomodulatory substances that regulate oral inflammatory responses.

A third aspect of the present disclosure relates to a kit comprising the tooth whitening composition and the tooth protection composition.

The kit of the present disclosure comprises the tooth whitening composition and the tooth protection composition, and is configured to be used sequentially. The tooth whitening composition is first applied to teeth to perform a whitening effect, and then the tooth protection composition is applied to achieve the effects of tooth protection and prevention of tooth sensitivity. The tooth whitening composition may include a flavoring such as apple, aqua mint, or apple mint, and the tooth protection composition may include a flavoring such as rooibos, peach, or ginger to improve the feeling of use.

The kit of the present disclosure comprises a tooth whitening composition and a tooth protection composition, each of which is provided in a tube-shaped container with a capacity of 80-120 ml. Each container is labeled with "Component 1 - Whitening Agent" and "Component 2 - Intense Agent" to clearly distinguish the properties and order of use of the compositions.

A fourth aspect of the present disclosure relates to a tooth whitening method comprising the step of applying the tooth whitening composition of claim 1 to teeth; and the step of applying the tooth protection composition of claim 2 to the teeth.

For example, the teeth whitening method of the present disclosure may include: first, squeezing about 1-2 cm of a teeth whitening composition onto a toothbrush and gently brushing the teeth, focusing on brushing the enamel area or heavily stained areas of the teeth while being careful not to irritate the gums, and then brushing for 2-3 minutes, rinsing thoroughly with water, and then using a teeth protection composition in a similar manner, and similarly brushing for more than 1 minute and then rinsing.

For example, the recommended frequency of use for this kit may be at least twice daily, such as during morning and evening brushing. Furthermore, as another example, this kit may be used particularly after consuming stain-inducing substances such as coffee, tea, or cigarettes. As another example, the tooth protection composition included in this kit may be used alone in addition to other tooth-protecting agents in cases of severe sensitivity.

For example, this kit can be used in a four-week treatment cycle, and consistent use during this period can provide an average improvement in tooth color by two to three shades. Alternatively, if necessary, a one- to two-week break may be taken before repeating the treatment cycle. However, continuous use is recommended not to exceed three cycles (12 weeks).

For example, the tooth whitening composition and the tooth protection composition included in the kit may each have a fragrance system applied to them, and the fragrance system applied to each composition may include fragrances of different fragrances.

For example, the tooth whitening composition may provide a refreshing feeling of use by applying a fragrance system including apple scent, aqua mint scent, apple mint scent, and mint scent.

For example, the dental care composition incorporates a fragrance system including rooibos, peach, and ginger, providing a smooth application experience. This differentiated fragrance system facilitates differentiation between application stages and is designed to ensure consistent use.

A differentiated fragrance system like the above makes it easy to distinguish between the stages of use and can ensure that there is no resistance to continuous use.

Furthermore, the kit of the present disclosure can be used as an adjunct to professional whitening procedures performed at dental clinics. In this case, the method and duration of use can be adjusted according to the dental specialist's instructions. It can be particularly effectively utilized in the maintenance phase following professional whitening procedures, where the proportion of the tooth protection composition used can be appropriately adjusted.

Hereinafter, the present disclosure will be described in more detail using the following examples. Process conditions and preparation steps not specified in the examples may be process conditions or preparation steps that are self-evident in the technical field to which the present disclosure pertains, and those skilled in the art will be able to select these conditions and reproduce the problem-solving principles of the present disclosure without much difficulty based on the present disclosure.

In addition, in the manufacturing method according to the present disclosure, unless otherwise specified, each step constituting the manufacturing method is performed at room temperature (25 degrees Celsius), and it should be understood that each step is performed by means and tools that can be derived without much difficulty by a person skilled in the art.

Example 1: Preparation of a composition for tooth whitening

A tooth whitening composition was prepared as follows. First, 8.57 parts by weight of 35% hydrogen peroxide was mixed with purified water to prepare a solution having a hydrogen peroxide concentration of 3.0%. 1.0 parts by weight of hydroxyapatite was added and uniformly dispersed. Next, 1.0 parts by weight of sodium metaphosphate was added, and 6.0 parts by weight of colloidal silicon dioxide was added and mixed. Finally, a flavoring system including apple flavor, aqua mint flavor, and apple mint flavor, as well as other auxiliary ingredients, were added and homogenized to obtain a toothpaste-like formulation.

Example 2: Preparation of a composition for dental protection

A dental protective composition was prepared as follows. First, 36.0 parts by weight of calcium hydrogen phosphate was added to the base and uniformly dispersed. To this, 0.76 parts by weight of sodium monofluorophosphate (1,000 ppm as fluoride) was added, and 5.0 parts by weight of potassium nitrate (50,000 ppm as potassium) was added and mixed. Next, 1.0 parts by weight of hydroxyapatite was added. Finally, a flavoring system including rooibos, peach, and ginger, as well as other auxiliary ingredients, were added and homogenized to obtain a toothpaste-like formulation.

Example 3: Preparation of a tooth whitening composition containing additional ingredients

A composition was prepared by additionally including prune extract, passion fruit seed oil, and oyster mushroom extract in addition to the basic composition of a tooth whitening composition. First, a basic composition was prepared according to the method of Example 1, and then 0.5 parts by weight of prune extract, 0.1 parts by weight of passion fruit seed oil, and 0.3 parts by weight of oyster mushroom extract were sequentially added thereto and mixed uniformly. The prepared composition exhibited uniform viscosity and stability, and maintained a usability similar to that of the basic composition.

Example 4: Preparation of a dental protective composition containing additional ingredients

A composition was prepared by additionally including snail mucus filtrate, red algae extract, and Cordyceps militaris mycelia culture filtrate in addition to the basic composition of a dental protective composition. First, a basic composition was prepared according to the method of Example 2, and then 0.05 parts by weight of snail mucus filtrate, 1.0 parts by weight of red algae extract, and 0.3 parts by weight of Cordyceps militaris mycelia culture filtrate were sequentially added thereto and mixed uniformly. The prepared composition exhibited an improved mucosal protective effect compared to the basic composition.

Experimental Example 1: Evaluation of the Whitening Effect of a Tooth Whitening Composition

To objectively evaluate the whitening effect of the tooth whitening composition of the present disclosure, a clinical trial was conducted. A regular toothpaste was used as the control group, and the tooth whitening composition of the present disclosure was used as the experimental group.

Three measurement points were set for each sample, and the measurement was repeated three times. The initial value before staining was measured, and then the measurement was made after staining with wine. After that, the measurement was made after applying toothpaste (brushing teeth), and the measurement was performed for L* (lightness), a* (redness), b* (yellowness), and W* (whitening index). The whitening index W was calculated according to the following formula: W = 100-[(a*)^2+(b*)^2+(L*-100)^2]^1/2. The results are shown in Tables 1 to 4 below.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

As a result, in the case of brightness/luminance change (△L), the experimental group showed a maximum improvement effect of 19.2, and the control group showed a minimum improvement effect of -0.7, confirming that when the present disclosure was applied, there was a brightness improvement effect of approximately 20 levels.

In addition, in the case of change in redness (△a), the experimental group showed an improvement effect of up to -8.1, and the control group showed an improvement effect of at least -3.4, and it was confirmed that when the present disclosure was applied, there was a redness reduction effect of about 5 levels.

In addition, in the case of yellowness change (△b), the experimental group showed a maximum improvement effect of -2.4, and the control group showed a maximum improvement effect of 4.1, and it was confirmed that when the present disclosure was applied, there was a yellowness reduction effect of about 6 steps.

In addition, in the case of change in whitening index (△W), the experimental group showed an improvement effect of up to 17.8, and the control group showed an improvement effect of at least -1.8, and it was confirmed that when this disclosure was applied, there was an improvement effect of about 20 levels in whitening index.

Particularly noteworthy is that the experimental group showed improvements in the whitening index (W*) of up to 17.8, while the control group showed decreases of up to -1.8. This objectively demonstrates that the tooth whitening composition of the present disclosure has a significantly superior whitening effect compared to conventional toothpaste.

Experimental Example 2: Evaluation of Long-Term Use Effects

The long-term efficacy of the kit disclosed herein was evaluated in 20 subjects. Subjects brushed their teeth twice daily for four weeks with the first tooth whitening composition, followed by the second tooth protection composition. The evaluation focused on improvements in tooth color, the occurrence of sensitivity, gingival irritation, and user experience.

As a result of the test, a clear teeth whitening effect was observed in more than 90% of the subjects, and the average improvement in tooth color was 2.5 levels. In particular, the improvement effect began to be clearly observed from the second week of use. In terms of side effects, the incidence of sensitivity was less than 5%, which was significantly reduced compared to the 30-40% incidence of existing whitening agents, and no gingival irritation or changes in tooth structure were observed. In terms of usability, more than 90% of the subjects expressed satisfaction with the refreshing feeling of the first agent, and more than 85% of the subjects expressed satisfaction with the smooth feeling of the second agent. Satisfaction with the scent was also high at more than 85%.

Experimental Example 3: Evaluation of the Effect of Improving Sensitivity

The efficacy of the present disclosure's dental protective composition was evaluated in 15 subjects with tooth sensitivity. The subjects used the second dental protective composition twice daily for two weeks, and the evaluation was conducted focusing on subjective pain scales (VAS, Visual Analog Scale), pain upon consuming cold beverages, and tooth sensitivity.

The test results showed a significant reduction in numbness in over 85% of the subjects, with the average VAS score dropping significantly from 6.8 before use to 2.3 after use. The effect began to appear within 3 days of use, and in particular, pain when consuming cold beverages was reduced by more than 60%, confirming a significant increase in tolerance to temperature stimulation. Furthermore, the improvement was maintained for up to a week after discontinuation of use, and the recurrence rate of numbness was less than 15% after 2 weeks of use, confirming the continuous effect.

Experimental Example 4: Evaluation of the Effects of Additional Ingredients in a Tooth Whitening Composition

The effects of a tooth whitening composition containing additional ingredients (Example 3) and a basic tooth whitening composition (Example 1) were compared and evaluated. Thirty subjects were divided into two groups of 15 each, and the test was conducted for two weeks.

Test results showed that the group using the composition containing additional ingredients showed a 40% increase in stain prevention compared to the base composition. Specifically, in the coffee staining test, the antioxidant action of the prune extract significantly increased stain resistance, and the protective film formed by the passion fruit seed oil effectively blocked stain deposition. Furthermore, the effect of the white oyster mushroom extract reduced tooth surface roughness by 25% compared to the base composition, which was confirmed to have a significant effect on long-term re-staining prevention.

Experimental Example 5: Evaluation of the Effects of Additional Ingredients in a Dental Protection Composition

The effectiveness of a dental protection composition containing additional ingredients (Example 4) and a basic dental protection composition (Example 2) were compared and evaluated. Forty subjects with sensitive teeth were divided into two groups of 20 each, and the test was conducted for three weeks.

The test results showed that the group that used the composition containing additional ingredients showed a faster improvement in sensitivity. The time to effect was 2 days on average when using the composition containing snail secretion filtrate, which was shorter than the 3 days of the basic composition. In particular, the remineralization rate was increased by 35% due to the mineral supplying effect of red algae extract, and the gingival health index was improved by 45% due to the anti-inflammatory effect of Cordyceps sinensis mycelia culture filtrate. The oral mucosa protection effect was also shown to be improved by more than 50% compared to the basic composition, and this effect was particularly noticeable in subjects with sensitive gingiva. Scanning electron microscopy (SEM) analysis of the tooth surface showed that the microstructure of the enamel surface was formed more densely when using the composition containing the additional ingredient, which was confirmed to have a positive effect on the long-term tooth protection effect.

Although the preferred embodiments of the present disclosure have been described in detail above, the scope of the present disclosure is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concepts of the present disclosure defined in the following claims also fall within the scope of the present disclosure.

Claims (7)

2.0 to 3.0 wt% hydrogen peroxide,
0.5 to 2.0 wt% of hydroxyapatite,
0.5 to 2.0 wt% of sodium metaphosphate,
0.1 to 10.0 wt% colloidal silicon dioxide,
0.1 to 1.0 wt% of prune extract,
0.05 to 0.3 wt% of passion fruit seed oil, and
A composition for tooth whitening, comprising 0.1 to 0.5 wt% of a white oyster mushroom extract. 30.0 to 40.0 wt% of calcium hydrogen phosphate,
Sodium monofluorophosphate 0.05 to 3.0 wt%,
0.3 to 8.0 wt% potassium nitrate,
0.5 to 2.0 wt% of hydroxyapatite,
0.01 to 0.1 wt% of snail mucus filtrate,
0.5 to 2.0 wt% of red algae extract, and
A composition for protecting teeth, comprising 0.1 to 0.5 wt% of Cordyceps militaris mycelia culture filtrate. A kit comprising the tooth whitening composition of claim 1 and the tooth protection composition of claim 2. A method for teeth whitening, comprising: applying the tooth whitening composition of claim 1 to teeth; and applying the tooth protection composition of claim 2 to the teeth. A tooth whitening composition in claim 1, wherein the hydroxyapatite has a Ca10(PO4)6(OH)2 structure. A dental protective composition in claim 2, wherein the sodium monofluorophosphate has a fluorine content of 1,000 ppm. A dental protective composition in claim 2, wherein the potassium nitrate has a content of 50,000 ppm as potassium.